{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T13:37:08Z","timestamp":1771076228682,"version":"3.50.1"},"reference-count":32,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neoplasia is an unusual complication of Meckel diverticulum. Most tumors of Meckel diverticulum are neuroendocrine or mesenchymal in origin. Adenocarcinomas represent a minority of the tumors that arise in Meckel diverticulum and are generally thought to develop from either endogenous small intestinal epithelium or heterotopic gastric epithelium. Despite the presence of ectopic pancreas in a small fraction of Meckel diverticula, convincing evidence of tumors that arise from heterotopic pancreatic exocrine tissue has not been described in this setting. Intraductal papillary mucinous neoplasms are relatively uncommon tumors of pancreatic ductal epithelial cells that line the main pancreatic duct or its major side branches. We present an unusual case of an intraductal papillary mucinous neoplasm that arose in a heterotopic pancreas within a Meckel diverticulum.<\/jats:p>","DOI":"10.5858\/2005-129-e67-ipmata","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T20:41:21Z","timestamp":1612989681000},"page":"e67-e69","source":"Crossref","is-referenced-by-count":26,"title":["Intraductal Papillary Mucinous Adenoma That Arises From Pancreatic Heterotopia Within a Meckel Diverticulum"],"prefix":"10.5858","volume":"129","author":[{"given":"Justin M. M.","family":"Cates","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Lebanon, NH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy L.","family":"Williams","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Lebanon, NH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arief A.","family":"Suriawinata","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Lebanon, NH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-129-3-e67-b1","series-title":"Acta Chir Scand","first-page":"1","article-title":"Meckel's diverticulum: a clinical and histologic study.","volume":"248","author":"S\u00f6derlund, S.","year":"1959","unstructured":"S\u00f6derlund, S.\n          \n          Meckel's diverticulum: a clinical and histologic study.\n          Acta Chir Scand\n          1959. 248:1\u2013233."},{"key":"i1543-2165-129-3-e67-b2","series-title":"JAMA","first-page":"251","article-title":"Meckel's diverticulum: 55 years of clinical and surgical experience.","volume":"182","author":"Weinstein, E. C.","year":"1962","unstructured":"Weinstein, E. C., J. C.Cain, and W. H.ReMine. Meckel's diverticulum: 55 years of clinical and surgical experience.JAMA1962. 182:251\u2013253."},{"key":"i1543-2165-129-3-e67-b3","series-title":"Br J Surg","first-page":"477","article-title":"Management of Meckel's diverticulum.","volume":"68","author":"Williams, R. S.","year":"1981","unstructured":"Williams, R. S.\n          \n          Management of Meckel's diverticulum.\n          Br J Surg\n          1981. 68:477\u2013480."},{"key":"i1543-2165-129-3-e67-b4","series-title":"Surg Gynecol Obstet","first-page":"56","article-title":"A fifty year experience with Meckel's diverticulum.","volume":"156","author":"Mackey, W. C.","year":"1983","unstructured":"Mackey, W. C. and P.Dineen. A fifty year experience with Meckel's diverticulum.Surg Gynecol Obstet1983. 156:56\u201364."},{"key":"i1543-2165-129-3-e67-b5","series-title":"Am J Gastroenterol","first-page":"1283","article-title":"Dual carcinoid tumors of Meckel's diverticulum presenting as metastasis in an inguinal hernia sac: case report with literature review.","volume":"83","author":"Dixon, A. Y.","year":"1988","unstructured":"Dixon, A. Y., M.McAnaw, D. H.McGregor, S.Keushkerian, L. K.Miller, and P. D.Pierce. Dual carcinoid tumors of Meckel's diverticulum presenting as metastasis in an inguinal hernia sac: case report with literature review.Am J Gastroenterol1988. 83:1283\u20131288."},{"key":"i1543-2165-129-3-e67-b6","series-title":"Am J Surg","first-page":"247","article-title":"Meckel's diverticulum: investigation of 600 patients in Japanese literature.","volume":"136","author":"Yamaguchi, M.","year":"1978","unstructured":"Yamaguchi, M., S.Takeuchi, and S.Awazu. Meckel's diverticulum: investigation of 600 patients in Japanese literature.Am J Surg1978. 136:247\u2013249."},{"key":"i1543-2165-129-3-e67-b7","series-title":"Tumori","first-page":"703","article-title":"Malignant stromal tumor consistent with fibrosarcoma arising from Meckel's diverticulum: clinicopathological study of an incidentally discovered tumor and review of the literature.","volume":"83","author":"Calderale, S. M.","year":"1997","unstructured":"Calderale, S. M., L.Marchioni, A.Malizia, M.Riminucci, and A.Corsi. Malignant stromal tumor consistent with fibrosarcoma arising from Meckel's diverticulum: clinicopathological study of an incidentally discovered tumor and review of the literature.Tumori1997. 83:703\u2013708."},{"key":"i1543-2165-129-3-e67-b8","series-title":"Int Abstr Surg","first-page":"103","article-title":"Neoplasms of Meckel's diverticulum.","volume":"116","author":"Weinstein, E. C.","year":"1963","unstructured":"Weinstein, E. C., M. B.Dockerty, and J. M.Waugh. Neoplasms of Meckel's diverticulum.Int Abstr Surg1963. 116:103\u2013111."},{"key":"i1543-2165-129-3-e67-b9","series-title":"JAMA","first-page":"893","article-title":"Aberrant pancreas: a cause of duodenal syndrome.","volume":"148","author":"Feldman, M.","year":"1952","unstructured":"Feldman, M. and T.Weinberg. Aberrant pancreas: a cause of duodenal syndrome.JAMA1952. 148:893\u2013898."},{"key":"i1543-2165-129-3-e67-b10","series-title":"Eur J Gastroenterol Hepatol","first-page":"793","article-title":"Heterotopic pancreas in the spleen: malignant degeneration to mucinous cystadenocarcinoma.","volume":"14","author":"Nisar, P. J.","year":"2002","unstructured":"Nisar, P. J., A. M.Zaitoun, D. N.Lobo, and B. J.Rowlands. Heterotopic pancreas in the spleen: malignant degeneration to mucinous cystadenocarcinoma.Eur J Gastroenterol Hepatol2002. 14:793\u2013796."},{"key":"i1543-2165-129-3-e67-b11","series-title":"J Clin Ultrasound","first-page":"265","article-title":"Carcinoma arising from ectopic pancreas in the stomach: endosonographic detection of malignant change.","volume":"26","author":"Ura, H.","year":"1998","unstructured":"Ura, H., R.Denno, K.Hirata, A.Saeki, K.Hirata, and H.Natori. Carcinoma arising from ectopic pancreas in the stomach: endosonographic detection of malignant change.J Clin Ultrasound1998. 26:265\u2013268."},{"key":"i1543-2165-129-3-e67-b12","series-title":"Semin Diagn Pathol","first-page":"16","article-title":"Pancreatic tumors with cystic dilatation of the ducts: intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms.","volume":"17","author":"Adsay, N. V.","year":"2000","unstructured":"Adsay, N. V., D. S.Longnecker, and D. S.Klimstra. Pancreatic tumors with cystic dilatation of the ducts: intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms.Semin Diagn Pathol2000. 17:16\u201330."},{"key":"i1543-2165-129-3-e67-b13","series-title":"Arch Pathol Lab Med","first-page":"568","article-title":"Ductal adenocarcinoma arising in a heterotopic pancreas situated in a hiatal hernia.","volume":"118","author":"Guillou, L.","year":"1994","unstructured":"Guillou, L., P.Nordback, C.Gerber, and R. P.Schneider. Ductal adenocarcinoma arising in a heterotopic pancreas situated in a hiatal hernia.Arch Pathol Lab Med1994. 118:568\u2013571."},{"key":"i1543-2165-129-3-e67-b14","series-title":"Ito Cho","first-page":"267","article-title":"Carcinoma originating from the heterotopic pancreas in the stomach: report of a case.","volume":"18","author":"Mibayashi, Y.","year":"1983","unstructured":"Mibayashi, Y., Y.Ishikawa, A.Takegawa, H.Mori, Y.Tunamura, and M.Miyanaga. 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Meckel's diverticulum: 55 years of clinical and surgical experience.JAMA1962. 182:251\u2013253."},{"key":"i1543-2165-129-3-e67-b3","series-title":"Br J Surg","first-page":"477","article-title":"Management of Meckel's diverticulum.","volume":"68","author":"Williams, R. S.","year":"1981","unstructured":"Williams, R. S.\n          \n          Management of Meckel's diverticulum.\n          Br J Surg\n          1981. 68:477\u2013480."},{"key":"i1543-2165-129-3-e67-b4","series-title":"Surg Gynecol Obstet","first-page":"56","article-title":"A fifty year experience with Meckel's diverticulum.","volume":"156","author":"Mackey, W. C.","year":"1983","unstructured":"Mackey, W. C. and P.Dineen. A fifty year experience with Meckel's diverticulum.Surg Gynecol Obstet1983. 156:56\u201364."},{"key":"i1543-2165-129-3-e67-b5","series-title":"Am J Gastroenterol","first-page":"1283","article-title":"Dual carcinoid tumors of Meckel's diverticulum presenting as metastasis in an inguinal hernia sac: case report with literature review.","volume":"83","author":"Dixon, A. Y.","year":"1988","unstructured":"Dixon, A. Y., M.McAnaw, D. H.McGregor, S.Keushkerian, L. K.Miller, and P. D.Pierce. Dual carcinoid tumors of Meckel's diverticulum presenting as metastasis in an inguinal hernia sac: case report with literature review.Am J Gastroenterol1988. 83:1283\u20131288."},{"key":"i1543-2165-129-3-e67-b6","series-title":"Am J Surg","first-page":"247","article-title":"Meckel's diverticulum: investigation of 600 patients in Japanese literature.","volume":"136","author":"Yamaguchi, M.","year":"1978","unstructured":"Yamaguchi, M., S.Takeuchi, and S.Awazu. Meckel's diverticulum: investigation of 600 patients in Japanese literature.Am J Surg1978. 136:247\u2013249."},{"key":"i1543-2165-129-3-e67-b7","series-title":"Tumori","first-page":"703","article-title":"Malignant stromal tumor consistent with fibrosarcoma arising from Meckel's diverticulum: clinicopathological study of an incidentally discovered tumor and review of the literature.","volume":"83","author":"Calderale, S. M.","year":"1997","unstructured":"Calderale, S. M., L.Marchioni, A.Malizia, M.Riminucci, and A.Corsi. Malignant stromal tumor consistent with fibrosarcoma arising from Meckel's diverticulum: clinicopathological study of an incidentally discovered tumor and review of the literature.Tumori1997. 83:703\u2013708."},{"key":"i1543-2165-129-3-e67-b8","series-title":"Int Abstr Surg","first-page":"103","article-title":"Neoplasms of Meckel's diverticulum.","volume":"116","author":"Weinstein, E. C.","year":"1963","unstructured":"Weinstein, E. C., M. B.Dockerty, and J. M.Waugh. Neoplasms of Meckel's diverticulum.Int Abstr Surg1963. 116:103\u2013111."},{"key":"i1543-2165-129-3-e67-b9","series-title":"JAMA","first-page":"893","article-title":"Aberrant pancreas: a cause of duodenal syndrome.","volume":"148","author":"Feldman, M.","year":"1952","unstructured":"Feldman, M. and T.Weinberg. Aberrant pancreas: a cause of duodenal syndrome.JAMA1952. 148:893\u2013898."},{"key":"i1543-2165-129-3-e67-b10","series-title":"Eur J Gastroenterol Hepatol","first-page":"793","article-title":"Heterotopic pancreas in the spleen: malignant degeneration to mucinous cystadenocarcinoma.","volume":"14","author":"Nisar, P. J.","year":"2002","unstructured":"Nisar, P. J., A. M.Zaitoun, D. N.Lobo, and B. J.Rowlands. Heterotopic pancreas in the spleen: malignant degeneration to mucinous cystadenocarcinoma.Eur J Gastroenterol Hepatol2002. 14:793\u2013796."},{"key":"i1543-2165-129-3-e67-b11","series-title":"J Clin Ultrasound","first-page":"265","article-title":"Carcinoma arising from ectopic pancreas in the stomach: endosonographic detection of malignant change.","volume":"26","author":"Ura, H.","year":"1998","unstructured":"Ura, H., R.Denno, K.Hirata, A.Saeki, K.Hirata, and H.Natori. Carcinoma arising from ectopic pancreas in the stomach: endosonographic detection of malignant change.J Clin Ultrasound1998. 26:265\u2013268."},{"key":"i1543-2165-129-3-e67-b12","series-title":"Semin Diagn Pathol","first-page":"16","article-title":"Pancreatic tumors with cystic dilatation of the ducts: intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms.","volume":"17","author":"Adsay, N. V.","year":"2000","unstructured":"Adsay, N. V., D. S.Longnecker, and D. S.Klimstra. 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