{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:45:54Z","timestamp":1770986754241,"version":"3.50.1"},"reference-count":80,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"abstract":"\n Context<\/jats:italic>\n .\u2014Patients who undergo hematopoietic stem cell transplant are at an increased risk of developing iron overload.\n <\/jats:p>\n \n Objectives<\/jats:italic>\n .\u2014To describe the effect of hepatic iron overload on hematopoietic stem cell transplant recipients and to validate the utility of histologic scoring system of iron granules in the liver.\n <\/jats:p>\n \n Design<\/jats:italic>\n .\u2014Records of 154 post allogeneic hematopoietic stem cell transplant patients were reviewed. Forty-nine patients underwent liver biopsy. Histologic hepatic iron overload was defined as a score of 2 or greater (scale, 0\u20134).\n <\/jats:p>\n \n Results<\/jats:italic>\n .\u2014Twenty-eight of 49 patients (57%) evaluated by liver biopsy had hepatic iron overload; 17 had moderate to severe hepatic iron overload (score, 3 or 4). In multivariate analysis, a significant correlation was discovered between hepatic iron overload and the number of transfusions (\n P<\/jats:italic>\n < .001), posttransplant serum ferritin levels (\n P<\/jats:italic>\n \u200a=\u200a .004), lactate dehydrogenase levels (\n P<\/jats:italic>\n \u200a=\u200a .03), and the development of blood stream infections (\n P<\/jats:italic>\n \u200a=\u200a .02). There was no correlation between hepatic iron overload and abnormal liver function test results. While 37 patients (76%) died after receiving a transplant, mortality was not influenced by hepatic iron overload but was significantly higher in older patients, in patients with lower serum albumin levels, higher serum bilirubin levels, and higher clinical grade of acute graft-versus-host disease (\n P<\/jats:italic>\n \u200a=\u200a .04,\n P<\/jats:italic>\n \u200a=\u200a .001,\n P<\/jats:italic>\n \u200a=\u200a <.001, and\n P<\/jats:italic>\n \u200a=\u200a .004, respectively).\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n .\u2014Hepatic iron overload is commonly identified in hematopoietic stem cell transplant patients and can be accurately diagnosed by liver biopsy. In addition, hepatic iron overload has been identified in patients receiving as few as 25 units of packed red blood cells, with elevated posttransplant serum ferritin levels, and with blood stream infections.\n <\/jats:p>","DOI":"10.5858\/arpa.2011-0190-oa","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T15:31:05Z","timestamp":1335540665000},"page":"532-538","source":"Crossref","is-referenced-by-count":11,"title":["Iron Overload in Allogeneic Hematopoietic Stem Cell Transplant Recipients"],"prefix":"10.5858","volume":"136","author":[{"given":"Sharif","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D.","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Munoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Divine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalini","family":"Janakiraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"12","key":"i1543-2165-136-5-532-b01","series-title":"Bone Marrow Transplant","first-page":"799","article-title":"Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation","volume":"42","author":"Pullarkat\n V,","year":"2008","unstructured":"Pullarkat\n V, \n \n Blanchard\n S, \n \n Tegtmeier\n B\n , et al. \n Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation. 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Bone Marrow Transplant. 2008;42(12):799\u2013805."},{"issue":"11","key":"i1543-2165-136-5-532-b02","series-title":"Biol Blood Marrow Transplant","first-page":"1239","article-title":"Elevated ferritin is associated with relapse after autologous hematopoietic stem cell transplantation for lymphoma","volume":"14","author":"Mahindra\n A,","year":"2008","unstructured":"Mahindra\n A, \n \n Bolwell\n B, \n \n Sobecks\n R\n , et al. \n Elevated ferritin is associated with relapse after autologous hematopoietic stem cell transplantation for lymphoma. 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