{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T08:55:35Z","timestamp":1770800135321,"version":"3.50.0"},"reference-count":30,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"abstract":"The \u201ccorded and hyalinized\u201d pattern, described in endometrioid carcinoma, has not been previously reported in association with serous carcinoma. We describe a unique case of serous neoplasm of low malignant potential with low-grade serous carcinoma combined with a distinct pattern of high-grade carcinoma characterized by cords of epithelioid and spindled cells enmeshed in a hyalinized, collagenous stroma. This pattern was the predominant architecture in the patient's recurrence and caused a diagnostic challenge, as the splenic recurrence was initially diagnosed as a second primary high-grade spindle cell neoplasm. Both ovarian and splenic tumors displayed positive immunohistochemical staining for cytokeratin 7, cytokeratin 8\/18, estrogen receptor, and paired box gene 8 (PAX-8) in the conventional serous carcinoma and the corded and hyalinized component, confirming the diagnosis of recurrent carcinoma. The behavior in this unique case of serous carcinoma associated with a distinct corded and hyalinized pattern was more aggressive than low-grade serous carcinoma, but more favorable than malignant mixed mullerian tumor.<\/jats:p>","DOI":"10.5858\/arpa.2011-0200-cr","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T13:59:27Z","timestamp":1359640767000},"page":"275-279","source":"Crossref","is-referenced-by-count":3,"title":["Ovarian Serous Carcinoma Associated With a Distinct \u201cCorded and Hyalinized\u201d Pattern"],"prefix":"10.5858","volume":"137","author":[{"given":"Jeannelyn S.","family":"Estrella","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (Drs Estrella and Deavers) and Gynecologic Oncology (Dr Deavers), The University of Texas MD Anderson Cancer Center, Houston; and the Department of Gynecologic Oncology, Banner MD Anderson Cancer Center, Gilbert, Arizona (Dr Wolf)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith K.","family":"Wolf","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Estrella and Deavers) and Gynecologic Oncology (Dr Deavers), The University of Texas MD Anderson Cancer Center, Houston; and the Department of Gynecologic Oncology, Banner MD Anderson Cancer Center, Gilbert, Arizona (Dr Wolf)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Deavers","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Estrella and Deavers) and Gynecologic Oncology (Dr Deavers), The University of Texas MD Anderson Cancer Center, Houston; and the Department of Gynecologic Oncology, Banner MD Anderson Cancer Center, Gilbert, Arizona (Dr Wolf)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-137-2-275-b01","series-title":"Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament","year":"1998","unstructured":"Scully\n R, \n \n Young\n R, \n \n Clement\n P\n \n , eds. Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament. Washington, DC: Armed Forces Institute of Pathology; 1998. Atlas of Tumor Pathology; 3rd series, fascile 23."},{"key":"i1543-2165-137-2-275-b02","series-title":"Pathology and Genetics of Tumours of the Breast and Female Genital Organs","year":"2003","unstructured":"Tavassoli\n F, \n \n Devilee\n P\n \n , eds. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press; 2003. World Health Organization Classification of Tumours; vol\u00a05."},{"issue":"12","key":"i1543-2165-137-2-275-b03","series-title":"Am J Surg Pathol","first-page":"1343","article-title":"Endometrioid carcinoma of the ovary with a prominent spindle-cell component, a source of diagnostic confusion: a report of 14 cases","volume":"19","author":"Tornos\n C,","year":"1995","unstructured":"Tornos\n C, \n \n Silva\n EG, \n \n Ordonez\n NG, \n \n Gershenson\n DM, \n \n Young\n RH, \n \n Scully\n RE\n \n . Endometrioid carcinoma of the ovary with a prominent spindle-cell component, a source of diagnostic confusion: a report of 14 cases. Am J Surg Pathol. 1995;19(12):1343\u20131353."},{"issue":"2","key":"i1543-2165-137-2-275-b04","series-title":"Am J Surg Pathol","first-page":"157","article-title":"Endometrioid carcinomas of the uterine corpus with sex cord-like formations, hyalinization, and other unusual morphologic features: a report of 31 cases of a neoplasm that may be confused with carcinosarcoma and other uterine neoplasms","volume":"29","author":"Murray\n SK,","year":"2005","unstructured":"Murray\n SK, \n \n Clement\n PB, \n \n Young\n RH\n \n . Endometrioid carcinomas of the uterine corpus with sex cord-like formations, hyalinization, and other unusual morphologic features: a report of 31 cases of a neoplasm that may be confused with carcinosarcoma and other uterine neoplasms. Am J Surg Pathol. 2005;29(2):157\u2013166."},{"issue":"2","key":"i1543-2165-137-2-275-b05","series-title":"Int J Gynecol Pathol","first-page":"175","article-title":"Grading of ovarian cancer: a histotype-specific approach","volume":"27","author":"Malpica","year":"2008","unstructured":"Malpica\n A\n \n . Grading of ovarian cancer: a histotype-specific approach. Int J Gynecol Pathol. 2008;27(2):175\u2013181."},{"issue":"4","key":"i1543-2165-137-2-275-b06","series-title":"Am J Surg Pathol","first-page":"496","article-title":"Grading ovarian serous carcinoma using a two-tier system","volume":"28","author":"Malpica\n A,","year":"2004","unstructured":"Malpica\n A, \n \n Deavers\n MT, \n \n Lu\n K\n , et al. \n Grading ovarian serous carcinoma using a two-tier system. Am J Surg Pathol. 2004;28(4):496\u2013504."},{"issue":"2","key":"i1543-2165-137-2-275-b07","series-title":"Obstet Gynecol","first-page":"361","article-title":"Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary","volume":"108","author":"Gershenson\n DM,","year":"2006","unstructured":"Gershenson\n DM, \n \n Sun\n CC, \n \n Lu\n KH\n , et al. \n Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary. Obstet Gynecol. 2006;108(2):361\u2013368."},{"issue":"3","key":"i1543-2165-137-2-275-b08","series-title":"Am J Surg Pathol","first-page":"433","article-title":"The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory","volume":"34","author":"Kurman\n RJ,","year":"2010","unstructured":"Kurman\n RJ, \n \n Shih\n IeM\n \n . The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol; 2010;34(3):433\u2013443."},{"issue":"4","key":"i1543-2165-137-2-275-b09","series-title":"Obstet Gynecol","first-page":"660","article-title":"Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases","volume":"80","author":"Barakat\n RR,","year":"1992","unstructured":"Barakat\n RR, \n \n Rubin\n SC, \n \n Wong\n G, \n \n Saigo\n PE, \n \n Markman\n M, \n \n Hoskins\n WJ\n \n . Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases. Obstet Gynecol. 1992;80(4):660\u2013664."},{"issue":"10","key":"i1543-2165-137-2-275-b10","series-title":"Cancer","first-page":"2148","article-title":"Carcinosarcoma of the ovary: 19\u00a0years of prospective data from a single center","volume":"100","author":"Brown\n E,","year":"2004","unstructured":"Brown\n E, \n \n Stewart\n M, \n \n Rye\n T\n , et al. \n Carcinosarcoma of the ovary: 19\u00a0years of prospective data from a single center. 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Hum Pathol. 2007;38(4):668\u2013672."},{"issue":"7","key":"i1543-2165-137-2-275-b13","series-title":"Am J Surg Pathol","first-page":"1007","article-title":"The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis","volume":"31","author":"Dehari\n R,","year":"2007","unstructured":"Dehari\n R, \n \n Kurman\n RJ, \n \n Logani\n S, \n \n Shih\n IeM\n \n . The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis. Am J Surg Pathol. 2007;31(7):1007\u20131012."},{"issue":"7","key":"i1543-2165-137-2-275-b14","series-title":"Mod Pathol","first-page":"663","article-title":"Ovarian serous neoplasms of low malignant potential associated with focal areas of serous carcinoma","volume":"10","author":"Silva\n EG,","year":"1997","unstructured":"Silva\n EG, \n \n Tornos\n CS, \n \n Malpica\n A, \n \n Gershenson\n DM\n \n . Ovarian serous neoplasms of low malignant potential associated with focal areas of serous carcinoma. Mod Pathol. 1997;10(7):663\u2013667."},{"issue":"6","key":"i1543-2165-137-2-275-b15","series-title":"Histopathology","first-page":"771","article-title":"High-grade serous carcinoma arising in a low-grade serous carcinoma and micropapillary serous borderline tumour of the ovary in a 23-year-old woman","volume":"54","author":"Quddus\n MR,","year":"2009","unstructured":"Quddus\n MR, \n \n Rashid\n LB, \n \n Hansen\n K, \n \n Sung\n CJ, \n \n Lawrence\n WD\n \n . High-grade serous carcinoma arising in a low-grade serous carcinoma and micropapillary serous borderline tumour of the ovary in a 23-year-old woman. Histopathology. 2009;54(6):771\u2013773."},{"key":"i1543-2165-137-2-275-b01","series-title":"Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament","year":"1998","unstructured":"Scully\n R, \n \n Young\n R, \n \n Clement\n P\n \n , eds. Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament. Washington, DC: Armed Forces Institute of Pathology; 1998. Atlas of Tumor Pathology; 3rd series, fascile 23."},{"key":"i1543-2165-137-2-275-b02","series-title":"Pathology and Genetics of Tumours of the Breast and Female Genital Organs","year":"2003","unstructured":"Tavassoli\n F, \n \n Devilee\n P\n \n , eds. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press; 2003. World Health Organization Classification of Tumours; vol\u00a05."},{"issue":"12","key":"i1543-2165-137-2-275-b03","series-title":"Am J Surg Pathol","first-page":"1343","article-title":"Endometrioid carcinoma of the ovary with a prominent spindle-cell component, a source of diagnostic confusion: a report of 14 cases","volume":"19","author":"Tornos\n C,","year":"1995","unstructured":"Tornos\n C, \n \n Silva\n EG, \n \n Ordonez\n NG, \n \n Gershenson\n DM, \n \n Young\n RH, \n \n Scully\n RE\n \n . Endometrioid carcinoma of the ovary with a prominent spindle-cell component, a source of diagnostic confusion: a report of 14 cases. Am J Surg Pathol. 1995;19(12):1343\u20131353."},{"issue":"2","key":"i1543-2165-137-2-275-b04","series-title":"Am J Surg Pathol","first-page":"157","article-title":"Endometrioid carcinomas of the uterine corpus with sex cord-like formations, hyalinization, and other unusual morphologic features: a report of 31 cases of a neoplasm that may be confused with carcinosarcoma and other uterine neoplasms","volume":"29","author":"Murray\n SK,","year":"2005","unstructured":"Murray\n SK, \n \n Clement\n PB, \n \n Young\n RH\n \n . Endometrioid carcinomas of the uterine corpus with sex cord-like formations, hyalinization, and other unusual morphologic features: a report of 31 cases of a neoplasm that may be confused with carcinosarcoma and other uterine neoplasms. Am J Surg Pathol. 2005;29(2):157\u2013166."},{"issue":"2","key":"i1543-2165-137-2-275-b05","series-title":"Int J Gynecol Pathol","first-page":"175","article-title":"Grading of ovarian cancer: a histotype-specific approach","volume":"27","author":"Malpica","year":"2008","unstructured":"Malpica\n A\n \n . Grading of ovarian cancer: a histotype-specific approach. Int J Gynecol Pathol. 2008;27(2):175\u2013181."},{"issue":"4","key":"i1543-2165-137-2-275-b06","series-title":"Am J Surg Pathol","first-page":"496","article-title":"Grading ovarian serous carcinoma using a two-tier system","volume":"28","author":"Malpica\n A,","year":"2004","unstructured":"Malpica\n A, \n \n Deavers\n MT, \n \n Lu\n K\n , et al. \n Grading ovarian serous carcinoma using a two-tier system. Am J Surg Pathol. 2004;28(4):496\u2013504."},{"issue":"2","key":"i1543-2165-137-2-275-b07","series-title":"Obstet Gynecol","first-page":"361","article-title":"Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary","volume":"108","author":"Gershenson\n DM,","year":"2006","unstructured":"Gershenson\n DM, \n \n Sun\n CC, \n \n Lu\n KH\n , et al. \n Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary. Obstet Gynecol. 2006;108(2):361\u2013368."},{"issue":"3","key":"i1543-2165-137-2-275-b08","series-title":"Am J Surg Pathol","first-page":"433","article-title":"The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory","volume":"34","author":"Kurman\n RJ,","year":"2010","unstructured":"Kurman\n RJ, \n \n Shih\n IeM\n \n . The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol; 2010;34(3):433\u2013443."},{"issue":"4","key":"i1543-2165-137-2-275-b09","series-title":"Obstet Gynecol","first-page":"660","article-title":"Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases","volume":"80","author":"Barakat\n RR,","year":"1992","unstructured":"Barakat\n RR, \n \n Rubin\n SC, \n \n Wong\n G, \n \n Saigo\n PE, \n \n Markman\n M, \n \n Hoskins\n WJ\n \n . Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases. Obstet Gynecol. 1992;80(4):660\u2013664."},{"issue":"10","key":"i1543-2165-137-2-275-b10","series-title":"Cancer","first-page":"2148","article-title":"Carcinosarcoma of the ovary: 19\u00a0years of prospective data from a single center","volume":"100","author":"Brown\n E,","year":"2004","unstructured":"Brown\n E, \n \n Stewart\n M, \n \n Rye\n T\n , et al. \n Carcinosarcoma of the ovary: 19\u00a0years of prospective data from a single center. Cancer. 2004;100(10):2148\u20132153."},{"key":"i1543-2165-137-2-275-b11","series-title":"Tumors of the Lymph Nodes and Spleen","year":"1994","unstructured":"Warnke\n R, \n \n Weiss\n L, \n \n Chan\n J, \n \n Cleary\n M, \n \n Dorfman\n R\n \n , eds. Tumors of the Lymph Nodes and Spleen. Washington, DC: Armed Forces Institute of Pathology; 1994. Atlas of Tumor Pathology. 3rd series, fascicle 14."},{"issue":"4","key":"i1543-2165-137-2-275-b12","series-title":"Hum Pathol","first-page":"668","article-title":"Follicular dendritic cell sarcoma of the spleen","volume":"38","author":"Sander\n B,","year":"2007","unstructured":"Sander\n B, \n \n Middel\n P, \n \n Gunawan\n B\n , et al. \n Follicular dendritic cell sarcoma of the spleen. Hum Pathol. 2007;38(4):668\u2013672."},{"issue":"7","key":"i1543-2165-137-2-275-b13","series-title":"Am J Surg Pathol","first-page":"1007","article-title":"The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis","volume":"31","author":"Dehari\n R,","year":"2007","unstructured":"Dehari\n R, \n \n Kurman\n RJ, \n \n Logani\n S, \n \n Shih\n IeM\n \n . The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis. Am J Surg Pathol. 2007;31(7):1007\u20131012."},{"issue":"7","key":"i1543-2165-137-2-275-b14","series-title":"Mod Pathol","first-page":"663","article-title":"Ovarian serous neoplasms of low malignant potential associated with focal areas of serous carcinoma","volume":"10","author":"Silva\n EG,","year":"1997","unstructured":"Silva\n EG, \n \n Tornos\n CS, \n \n Malpica\n A, \n \n Gershenson\n DM\n \n . Ovarian serous neoplasms of low malignant potential associated with focal areas of serous carcinoma. Mod Pathol. 1997;10(7):663\u2013667."},{"issue":"6","key":"i1543-2165-137-2-275-b15","series-title":"Histopathology","first-page":"771","article-title":"High-grade serous carcinoma arising in a low-grade serous carcinoma and micropapillary serous borderline tumour of the ovary in a 23-year-old woman","volume":"54","author":"Quddus\n MR,","year":"2009","unstructured":"Quddus\n MR, \n \n Rashid\n LB, \n \n Hansen\n K, \n \n Sung\n CJ, \n \n Lawrence\n WD\n \n . High-grade serous carcinoma arising in a low-grade serous carcinoma and micropapillary serous borderline tumour of the ovary in a 23-year-old woman. Histopathology. 2009;54(6):771\u2013773."}],"container-title":["Archives of Pathology & Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/137\/2\/article-p275.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/137\/2\/275\/1611144\/arpa_2011-0200-cr.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/137\/2\/article-p275.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/137\/2\/article-p275.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:57:57Z","timestamp":1770771477000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/137\/2\/article-p275.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":30,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5858\/arpa.2011-0200-cr","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}