{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:48:40Z","timestamp":1775677720693,"version":"3.50.1"},"reference-count":22,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    <jats:italic>Context<\/jats:italic>\n                    .\u2014Chronic histiocytic intervillositis is an uncommon and poorly recognized lesion associated with poor perinatal outcomes, including intrauterine growth retardation and stillbirth. It has a high recurrence rate.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    .\u2014To evaluate utility of CD68 immunostaining in the evaluation of chronic histiocytic intervillositis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Design<\/jats:italic>\n                    .\u2014Institutional review board\u2013approved retrospective review was performed. Cases were selected from the departmental archives of University Hospital, Newark, New Jersey, between 2002 and 2009. Controls were from second-trimester pregnancies with chromosomal abnormalities or multiple severe anomalies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    .\u2014There were 9 cases and 11 controls. The mean CD68\n                    <jats:sup>+<\/jats:sup>\n                    count per high-power field for the cases was 88 \u00b1 23 (range, 51\u2013180) and for the controls, 8 \u00b1 5 (range, 0\u201324),\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    .\u2014This study establishes a range for histiocyte counts in chronic histiocytic intervillositis and pregnancies without chronic histiocytic intervillositis, and suggests that CD68 staining may have utility in the diagnosis, particularly for nonperinatal pathologists, who may be less familiar with this lesion.\n                  <\/jats:p>","DOI":"10.5858\/arpa.2011-0328-oa","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T12:57:32Z","timestamp":1338382652000},"page":"657-659","source":"Crossref","is-referenced-by-count":25,"title":["CD68 Immunostaining in the Evaluation of Chronic Histiocytic Intervillositis"],"prefix":"10.5858","volume":"136","author":[{"given":"Debra S.","family":"Heller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"11","key":"i1543-2165-136-6-657-b01","series-title":"Hum Pathol","first-page":"1245","article-title":"Massive chronic intervillositis associated with recurrent abortions","volume":"26","author":"Doss\n              BJ,","year":"1995","unstructured":"Doss\n              BJ, \n            \n              Greene\n              MF, \n            \n              Hill\n              J, \n            \n              Heffner\n              LJ, \n            \n              Bieber\n              FR, \n            \n              Genest\n              DR\n            \n          . Massive chronic intervillositis associated with recurrent abortions. Hum Pathol. 1995;26(11);1245\u20131251."},{"issue":"1","key":"i1543-2165-136-6-657-b02","series-title":"Eur J Obstet Gynecol Reprod Biol","first-page":"9","article-title":"Chronic intervillositis of unknown etiology (CIUE): relation between placental lesions and perinatal outcome","volume":"143","author":"Parant\n              O,","year":"2009","unstructured":"Parant\n              O, \n            \n              Capdet\n              J, \n            \n              Kessler\n              S, \n            \n              Aziza\n              J, \n            \n              Berrebi\n              A\n            \n          . Chronic intervillositis of unknown etiology (CIUE): relation between placental lesions and perinatal outcome. Eur J Obstet Gynecol Reprod Biol. 2009;143(1):9\u201313."},{"issue":"11","key":"i1543-2165-136-6-657-b03","series-title":"Hum Pathol","first-page":"1389","article-title":"Chronic histiocytic intervillositis: a placental lesion associated with recurrent pregnancy loss","volume":"31","author":"Boyd\n              TK,","year":"2000","unstructured":"Boyd\n              TK, \n            \n              Redline\n              RW\n            \n          . Chronic histiocytic intervillositis: a placental lesion associated with recurrent pregnancy loss. Hum Pathol. 2000;31(11):1389\u20131395."},{"issue":"12","key":"i1543-2165-136-6-657-b04","series-title":"Placenta","first-page":"1116","article-title":"Pathological characteristics of a series of rare chronic histiocytic intervillositis of the placenta","volume":"31","author":"Traeder\n              J,","year":"2010","unstructured":"Traeder\n              J, \n            \n              Jonigk\n              D, \n            \n              Feist\n              H\n            , et al. \n          Pathological characteristics of a series of rare chronic histiocytic intervillositis of the placenta. Placenta. 2010:31(12):1116\u20131119."},{"issue":"3","key":"i1543-2165-136-6-657-b05","series-title":"Am J Reprod Immunol Microbiol","first-page":"85","article-title":"Fibrinoid and trophoblastic necrosis with massive chronic intervillositis: an extreme variant of villitis of unknown etiology","volume":"15","author":"Labarrere\n              C,","year":"1987","unstructured":"Labarrere\n              C, \n            \n              Mullen\n              E\n            \n          . Fibrinoid and trophoblastic necrosis with massive chronic intervillositis: an extreme variant of villitis of unknown etiology. Am J Reprod Immunol Microbiol. 1987;15(3):85\u201391."},{"issue":"3","key":"i1543-2165-136-6-657-b06","series-title":"Pediatr Dev Pathol","first-page":"234","article-title":"Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: case report","volume":"9","author":"Weber\n              MA,","year":"2006","unstructured":"Weber\n              MA, \n            \n              Nikkels\n              PG, \n            \n              Hamoen\n              K, \n            \n              Duvekot\n              JJ, \n            \n              de Krijger\n              RR\n            \n          . Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: case report. Pediatr Dev Pathol. 2006;9(3):234\u2013238."},{"issue":"10","key":"i1543-2165-136-6-657-b07","series-title":"Arch Pathol Lab Med","first-page":"1032","article-title":"Chronic intervillositis of the placenta","volume":"117","author":"Jacques\n              SM,","year":"1993","unstructured":"Jacques\n              SM, \n            \n              Qureshi\n              F\n            \n          . Chronic intervillositis of the placenta. Arch Pathol Lab Med. 1993;117(10):1032\u20131035."},{"issue":"4","key":"i1543-2165-136-6-657-b08","series-title":"J Gynecol Obstet Biol Reprod","first-page":"396","article-title":"Combining corticosteroid and aspirin for the prevention of recurrent villitis or intervillositis of unknown etiology [in French]","volume":"35","author":"Boog\n              G,","year":"2006","unstructured":"Boog\n              G, \n            \n              Le Vaillant\n              C, \n            \n              Alnoukari\n              F, \n            \n              Jossic\n              F, \n            \n              Barrier\n              J, \n            \n              Muller\n              JY\n            \n          . Combining corticosteroid and aspirin for the prevention of recurrent villitis or intervillositis of unknown etiology [in French]. J Gynecol Obstet Biol Reprod. 2006; 35(4):396\u2013404."},{"issue":"2","key":"i1543-2165-136-6-657-b09","series-title":"Hum Reprod","first-page":"313","article-title":"Placental pathology of recurrent spontaneous abortion: the role of histopathological examination of products of conception in routine clinical practice: a mini review","volume":"22","author":"Jindal\n              P,","year":"2007","unstructured":"Jindal\n              P, \n            \n              Regan\n              L, \n            \n              Fourkala\n              EO\n            , et al. \n          Placental pathology of recurrent spontaneous abortion: the role of histopathological examination of products of conception in routine clinical practice: a mini review. Hum Reprod. 2007;22(2):313\u2013316."},{"issue":"7","key":"i1543-2165-136-6-657-b10","series-title":"J Gynecol Obstet Biol Reprod","first-page":"711","article-title":"Perinatal prognosis of pregnancies complicated by placental chronic intervillitis [in French]","volume":"35","author":"Rota\n              C,","year":"2006","unstructured":"Rota\n              C, \n            \n              Carles\n              D, \n            \n              Schaeffer\n              V, \n            \n              Guyon\n              F, \n            \n              Saura\n              R, \n            \n              Horovitz\n              J\n            \n          . Perinatal prognosis of pregnancies complicated by placental chronic intervillitis [in French]. J Gynecol Obstet Biol Reprod. 2006;35(7):711\u2013719."},{"issue":"2","key":"i1543-2165-136-6-657-b11","series-title":"Placenta","first-page":"140","article-title":"Chronic histiocytic intervillositis of unknown etiology: clinical features in a consecutive series of 69 cases","volume":"32","author":"Marchaudon\n              V,","year":"2011","unstructured":"Marchaudon\n              V, \n            \n              Devisme\n              L, \n            \n              Petit\n              S, \n            \n              Ansart-Franquet\n              H, \n            \n              Vaast\n              P, \n            \n              Subtil\n              D\n            \n          . Chronic histiocytic intervillositis of unknown etiology: clinical features in a consecutive series of 69 cases. Placenta. 2011;32(2):140\u2013145."},{"issue":"11","key":"i1543-2165-136-6-657-b01","series-title":"Hum Pathol","first-page":"1245","article-title":"Massive chronic intervillositis associated with recurrent abortions","volume":"26","author":"Doss\n              BJ,","year":"1995","unstructured":"Doss\n              BJ, \n            \n              Greene\n              MF, \n            \n              Hill\n              J, \n            \n              Heffner\n              LJ, \n            \n              Bieber\n              FR, \n            \n              Genest\n              DR\n            \n          . Massive chronic intervillositis associated with recurrent abortions. Hum Pathol. 1995;26(11);1245\u20131251."},{"issue":"1","key":"i1543-2165-136-6-657-b02","series-title":"Eur J Obstet Gynecol Reprod Biol","first-page":"9","article-title":"Chronic intervillositis of unknown etiology (CIUE): relation between placental lesions and perinatal outcome","volume":"143","author":"Parant\n              O,","year":"2009","unstructured":"Parant\n              O, \n            \n              Capdet\n              J, \n            \n              Kessler\n              S, \n            \n              Aziza\n              J, \n            \n              Berrebi\n              A\n            \n          . Chronic intervillositis of unknown etiology (CIUE): relation between placental lesions and perinatal outcome. Eur J Obstet Gynecol Reprod Biol. 2009;143(1):9\u201313."},{"issue":"11","key":"i1543-2165-136-6-657-b03","series-title":"Hum Pathol","first-page":"1389","article-title":"Chronic histiocytic intervillositis: a placental lesion associated with recurrent pregnancy loss","volume":"31","author":"Boyd\n              TK,","year":"2000","unstructured":"Boyd\n              TK, \n            \n              Redline\n              RW\n            \n          . Chronic histiocytic intervillositis: a placental lesion associated with recurrent pregnancy loss. Hum Pathol. 2000;31(11):1389\u20131395."},{"issue":"12","key":"i1543-2165-136-6-657-b04","series-title":"Placenta","first-page":"1116","article-title":"Pathological characteristics of a series of rare chronic histiocytic intervillositis of the placenta","volume":"31","author":"Traeder\n              J,","year":"2010","unstructured":"Traeder\n              J, \n            \n              Jonigk\n              D, \n            \n              Feist\n              H\n            , et al. \n          Pathological characteristics of a series of rare chronic histiocytic intervillositis of the placenta. Placenta. 2010:31(12):1116\u20131119."},{"issue":"3","key":"i1543-2165-136-6-657-b05","series-title":"Am J Reprod Immunol Microbiol","first-page":"85","article-title":"Fibrinoid and trophoblastic necrosis with massive chronic intervillositis: an extreme variant of villitis of unknown etiology","volume":"15","author":"Labarrere\n              C,","year":"1987","unstructured":"Labarrere\n              C, \n            \n              Mullen\n              E\n            \n          . Fibrinoid and trophoblastic necrosis with massive chronic intervillositis: an extreme variant of villitis of unknown etiology. Am J Reprod Immunol Microbiol. 1987;15(3):85\u201391."},{"issue":"3","key":"i1543-2165-136-6-657-b06","series-title":"Pediatr Dev Pathol","first-page":"234","article-title":"Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: case report","volume":"9","author":"Weber\n              MA,","year":"2006","unstructured":"Weber\n              MA, \n            \n              Nikkels\n              PG, \n            \n              Hamoen\n              K, \n            \n              Duvekot\n              JJ, \n            \n              de Krijger\n              RR\n            \n          . Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: case report. Pediatr Dev Pathol. 2006;9(3):234\u2013238."},{"issue":"10","key":"i1543-2165-136-6-657-b07","series-title":"Arch Pathol Lab Med","first-page":"1032","article-title":"Chronic intervillositis of the placenta","volume":"117","author":"Jacques\n              SM,","year":"1993","unstructured":"Jacques\n              SM, \n            \n              Qureshi\n              F\n            \n          . Chronic intervillositis of the placenta. Arch Pathol Lab Med. 1993;117(10):1032\u20131035."},{"issue":"4","key":"i1543-2165-136-6-657-b08","series-title":"J Gynecol Obstet Biol Reprod","first-page":"396","article-title":"Combining corticosteroid and aspirin for the prevention of recurrent villitis or intervillositis of unknown etiology [in French]","volume":"35","author":"Boog\n              G,","year":"2006","unstructured":"Boog\n              G, \n            \n              Le Vaillant\n              C, \n            \n              Alnoukari\n              F, \n            \n              Jossic\n              F, \n            \n              Barrier\n              J, \n            \n              Muller\n              JY\n            \n          . Combining corticosteroid and aspirin for the prevention of recurrent villitis or intervillositis of unknown etiology [in French]. J Gynecol Obstet Biol Reprod. 2006; 35(4):396\u2013404."},{"issue":"2","key":"i1543-2165-136-6-657-b09","series-title":"Hum Reprod","first-page":"313","article-title":"Placental pathology of recurrent spontaneous abortion: the role of histopathological examination of products of conception in routine clinical practice: a mini review","volume":"22","author":"Jindal\n              P,","year":"2007","unstructured":"Jindal\n              P, \n            \n              Regan\n              L, \n            \n              Fourkala\n              EO\n            , et al. \n          Placental pathology of recurrent spontaneous abortion: the role of histopathological examination of products of conception in routine clinical practice: a mini review. Hum Reprod. 2007;22(2):313\u2013316."},{"issue":"7","key":"i1543-2165-136-6-657-b10","series-title":"J Gynecol Obstet Biol Reprod","first-page":"711","article-title":"Perinatal prognosis of pregnancies complicated by placental chronic intervillitis [in French]","volume":"35","author":"Rota\n              C,","year":"2006","unstructured":"Rota\n              C, \n            \n              Carles\n              D, \n            \n              Schaeffer\n              V, \n            \n              Guyon\n              F, \n            \n              Saura\n              R, \n            \n              Horovitz\n              J\n            \n          . Perinatal prognosis of pregnancies complicated by placental chronic intervillitis [in French]. J Gynecol Obstet Biol Reprod. 2006;35(7):711\u2013719."},{"issue":"2","key":"i1543-2165-136-6-657-b11","series-title":"Placenta","first-page":"140","article-title":"Chronic histiocytic intervillositis of unknown etiology: clinical features in a consecutive series of 69 cases","volume":"32","author":"Marchaudon\n              V,","year":"2011","unstructured":"Marchaudon\n              V, \n            \n              Devisme\n              L, \n            \n              Petit\n              S, \n            \n              Ansart-Franquet\n              H, \n            \n              Vaast\n              P, \n            \n              Subtil\n              D\n            \n          . Chronic histiocytic intervillositis of unknown etiology: clinical features in a consecutive series of 69 cases. 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