{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:24:36Z","timestamp":1785209076335,"version":"3.55.0"},"reference-count":22,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>A 58-year-old woman presented with a cystic skin lesion. Microscopic examination showed an intradermal cyst lined by acanthotic squamous epithelium with squamous eddies and compact hyperkeratosis, and changes typical of verrucous lesions. Mature sebaceous cells and dendritic melanocytes were present as well. To our knowledge, this is the first report of a verrucous cyst with areas of sebaceous differentiation and melanocytes. Verrucous cysts are well-known, benign lesions with a clear histologic pattern. Histologically, they resemble verruca vulgaris with acanthosis, hypergranulosis, dense keratohyaline granules, and viral cytopathic effects seen. Until now, melanocytes and mature sebaceous cells in the cyst lining have not been reported. We do not feel that these findings alter the expected benign nature of this lesion. Instead, we report this case to suggest the possible adnexal embryonic origin, given the presence of sebaceous cells and dendritic melanocytes that support this histologic lineage in our specific case.<\/jats:p>","DOI":"10.5858\/arpa.2011-0381-cr","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T16:29:13Z","timestamp":1364833753000},"page":"576-579","source":"Crossref","is-referenced-by-count":8,"title":["Verrucous Cyst With Melanocytic and Sebaceous Differentiation: A Case Report and Review of the Literature"],"prefix":"10.5858","volume":"137","author":[{"given":"Justin","family":"Hardin","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas (Drs Hardin and Ch\u00e9vez-Barrios); the Department of Pathology and Laboratory Medicine and Ophthalmology, Weill Cornell Medical College, Cornell University, Houston, Texas (Dr Ch\u00e9vez-Barrios); the Department of Pathology, Emory University, Atlanta, Georgia (Dr Gardner); and the Department of Dermatology, University of Texas Medical School, Houston (Dr Colom\u00e9)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerad M.","family":"Gardner","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas (Drs Hardin and Ch\u00e9vez-Barrios); the Department of Pathology and Laboratory Medicine and Ophthalmology, Weill Cornell Medical College, Cornell University, Houston, Texas (Dr Ch\u00e9vez-Barrios); the Department of Pathology, Emory University, Atlanta, Georgia (Dr Gardner); and the Department of Dermatology, University of Texas Medical School, Houston (Dr Colom\u00e9)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Colom\u00e9","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas (Drs Hardin and Ch\u00e9vez-Barrios); the Department of Pathology and Laboratory Medicine and Ophthalmology, Weill Cornell Medical College, Cornell University, Houston, Texas (Dr Ch\u00e9vez-Barrios); the Department of Pathology, Emory University, Atlanta, Georgia (Dr Gardner); and the Department of Dermatology, University of Texas Medical School, Houston (Dr Colom\u00e9)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ch\u00e9vez-Barrios","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas (Drs Hardin and Ch\u00e9vez-Barrios); the Department of Pathology and Laboratory Medicine and Ophthalmology, Weill Cornell Medical College, Cornell University, Houston, Texas (Dr Ch\u00e9vez-Barrios); the Department of Pathology, Emory University, Atlanta, Georgia (Dr Gardner); and the Department of Dermatology, University of Texas Medical School, Houston (Dr Colom\u00e9)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"issue":"12","key":"i1543-2165-137-4-576-b01","series-title":"Arch Dermatol","first-page":"1810","article-title":"Verrucous cyst","volume":"127","author":"Meyer\n              LM,","year":"1991;","unstructured":"Meyer\n              LM, \n            \n              Trying\n              SK, \n            \n              Little\n              WP. \n          \n          Verrucous cyst. Arch Dermatol. 1991;127(12):1810\u20131812."},{"issue":"3","key":"i1543-2165-137-4-576-b02","series-title":"Eur J Dermatol","first-page":"254","article-title":"Human papillomavirus 59 identified in verrucous cyst of the flank","volume":"16","author":"Kim\n              H,","year":"2006;","unstructured":"Kim\n              H, \n            \n              Seok\n              J, \n            \n              Kim\n              S, \n            et al\n          . Human papillomavirus 59 identified in verrucous cyst of the flank. Eur J Dermatol. 2006;16(3):254\u2013257."},{"issue":"4","key":"i1543-2165-137-4-576-b03","series-title":"Br J Dermatol","first-page":"533","article-title":"Detection of human papillomaviruses and eccrine ducts in palmoplantar epidermoid cysts","volume":"132","author":"Egawa\n              K,","year":"1995;","unstructured":"Egawa\n              K, \n            \n              Honda\n              Y, \n            \n              Inaba\n              Y, \n            \n              Ono\n              T, \n            \n              De Villiers\n              EM. \n          \n          Detection of human papillomaviruses and eccrine ducts in palmoplantar epidermoid cysts. Br J Dermatol. 1995;132(4):533\u2013542."},{"issue":"3","key":"i1543-2165-137-4-576-b04","series-title":"Br J Dermatol","first-page":"627","article-title":"Recurrent \u2018sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption with idiopathic CD4 lymphopenia","volume":"149","author":"Tobin\n              E,","year":"2003;","unstructured":"Tobin\n              E, \n            \n              Rohwedder\n              A, \n            \n              Holland\n              SM, \n            \n              Philips\n              B, \n            \n              Carlson\n              JA. \n          \n          Recurrent \u2018sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption with idiopathic CD4 lymphopenia. Br J Dermatol. 2003;149(3):627\u2013633."},{"issue":"5","key":"i1543-2165-137-4-576-b05","series-title":"J Am Acad Dermatol","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.01.032","article-title":"Human papillomavirus infection and ultraviolet light exposure as epidermoid inclusion cyst risk factors in a patient with epidermodysplasia verruciformis?","volume":"58","author":"Ramagosa\n              R,","year":"2008;","unstructured":"Ramagosa\n              R, \n            \n              de Villiers\n              E-M, \n            \n              Fitzpatrick\n              JE, \n            \n              Dellavalle\n              RP. \n          \n          Human papillomavirus infection and ultraviolet light exposure as epidermoid inclusion cyst risk factors in a patient with epidermodysplasia verruciformis?\n          J Am Acad Dermatol. 2008;58(5)(suppl 1):S68:e1\u2013e6. doi:10.1016\/j.jaad.2007.01.032."},{"issue":"1","key":"i1543-2165-137-4-576-b06","series-title":"Clin Exp Dermatol","first-page":"38","article-title":"Verrucous trichilemmal cyst containing human papillomavirus","volume":"30","author":"Misago\n              N,","year":"2005;","unstructured":"Misago\n              N, \n            \n              Narisawa\n              Y. \n          \n          Verrucous trichilemmal cyst containing human papillomavirus. Clin Exp Dermatol. 2005;30(1):38\u201339."},{"issue":"2","key":"i1543-2165-137-4-576-b07","series-title":"Am J Dermatopathol","first-page":"199","article-title":"Morphologic image on infundibular origin of verrucous cyst","volume":"30","author":"Fernandez-Flores\n              A.","year":"2008;","unstructured":"Fernandez-Flores\n              A. \n          \n          Morphologic image on infundibular origin of verrucous cyst. Am J Dermatopathol. 2008;30(2):199\u2013200."},{"issue":"3","key":"i1543-2165-137-4-576-b08","series-title":"J Invest Dermatol","first-page":"410","article-title":"Role of hair follicles in the regimentation of vitiligo","volume":"97","author":"Cui\n              J,","year":"1991;","unstructured":"Cui\n              J, \n            \n              Shen\n              L, \n            \n              Wang\n              G. \n          \n          Role of hair follicles in the regimentation of vitiligo. J Invest Dermatol. 1991;97(3):410\u2013416."},{"issue":"1","key":"i1543-2165-137-4-576-b09","series-title":"Mod Pathol","first-page":"90","article-title":"Stem cell markers (cytokeratin 15, 19, and p63) in in situ and invasive cutaneous epithelial lesions","volume":"24","author":"Abbas\n              O,","year":"2011;","unstructured":"Abbas\n              O, \n            \n              Richards\n              JE, \n            \n              Yaar\n              R, \n            \n              Mahalingam\n              M. \n          \n          Stem cell markers (cytokeratin 15, 19, and p63) in in situ and invasive cutaneous epithelial lesions. Mod Pathol. 2011;24(1):90\u201397."},{"issue":"2, pt 1","key":"i1543-2165-137-4-576-b10","series-title":"J Cell Biol","first-page":"580","article-title":"Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies","volume":"95","author":"Woodcock-Mitchell\n              J,","year":"1982;","unstructured":"Woodcock-Mitchell\n              J, \n            \n              Eichner\n              R, \n            \n              Nelson\n              W, \n            \n              Tung-Tien\n              S. \n          \n          Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol. 1982;95(2, pt 1):580\u2013588."},{"issue":"11","key":"i1543-2165-137-4-576-b11","series-title":"Arch Pathol Lab Med","first-page":"1798","article-title":"Association of cystic neck metastases and human papillomavirus positive oropharyngeal squamous cell carcinoma","volume":"133","author":"McHugh\n              J.","year":"2009;","unstructured":"McHugh\n              J. \n          \n          Association of cystic neck metastases and human papillomavirus positive oropharyngeal squamous cell carcinoma. Arch Pathol Lab Med. 2009;133(11):1798\u20131803."},{"issue":"12","key":"i1543-2165-137-4-576-b01","series-title":"Arch Dermatol","first-page":"1810","article-title":"Verrucous cyst","volume":"127","author":"Meyer\n              LM,","year":"1991;","unstructured":"Meyer\n              LM, \n            \n              Trying\n              SK, \n            \n              Little\n              WP. \n          \n          Verrucous cyst. 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Br J Dermatol. 1995;132(4):533\u2013542."},{"issue":"3","key":"i1543-2165-137-4-576-b04","series-title":"Br J Dermatol","first-page":"627","article-title":"Recurrent \u2018sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption with idiopathic CD4 lymphopenia","volume":"149","author":"Tobin\n              E,","year":"2003;","unstructured":"Tobin\n              E, \n            \n              Rohwedder\n              A, \n            \n              Holland\n              SM, \n            \n              Philips\n              B, \n            \n              Carlson\n              JA. \n          \n          Recurrent \u2018sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption with idiopathic CD4 lymphopenia. Br J Dermatol. 2003;149(3):627\u2013633."},{"issue":"5","key":"i1543-2165-137-4-576-b05","series-title":"J Am Acad Dermatol","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.01.032","article-title":"Human papillomavirus infection and ultraviolet light exposure as epidermoid inclusion cyst risk factors in a patient with epidermodysplasia verruciformis?","volume":"58","author":"Ramagosa\n              R,","year":"2008;","unstructured":"Ramagosa\n              R, \n            \n              de Villiers\n              E-M, \n            \n              Fitzpatrick\n              JE, \n            \n              Dellavalle\n              RP. \n          \n          Human papillomavirus infection and ultraviolet light exposure as epidermoid inclusion cyst risk factors in a patient with epidermodysplasia verruciformis?\n          J Am Acad Dermatol. 2008;58(5)(suppl 1):S68:e1\u2013e6. doi:10.1016\/j.jaad.2007.01.032."},{"issue":"1","key":"i1543-2165-137-4-576-b06","series-title":"Clin Exp Dermatol","first-page":"38","article-title":"Verrucous trichilemmal cyst containing human papillomavirus","volume":"30","author":"Misago\n              N,","year":"2005;","unstructured":"Misago\n              N, \n            \n              Narisawa\n              Y. \n          \n          Verrucous trichilemmal cyst containing human papillomavirus. 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Mod Pathol. 2011;24(1):90\u201397."},{"issue":"2, pt 1","key":"i1543-2165-137-4-576-b10","series-title":"J Cell Biol","first-page":"580","article-title":"Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies","volume":"95","author":"Woodcock-Mitchell\n              J,","year":"1982;","unstructured":"Woodcock-Mitchell\n              J, \n            \n              Eichner\n              R, \n            \n              Nelson\n              W, \n            \n              Tung-Tien\n              S. \n          \n          Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol. 1982;95(2, pt 1):580\u2013588."},{"issue":"11","key":"i1543-2165-137-4-576-b11","series-title":"Arch Pathol Lab Med","first-page":"1798","article-title":"Association of cystic neck metastases and human papillomavirus positive oropharyngeal squamous cell carcinoma","volume":"133","author":"McHugh\n              J.","year":"2009;","unstructured":"McHugh\n              J. \n          \n          Association of cystic neck metastases and human papillomavirus positive oropharyngeal squamous cell carcinoma. 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