{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T09:51:43Z","timestamp":1794649903499,"version":"4.9.1"},"reference-count":18,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>We describe a case of a vesical mass in a young patient, histologically characterized by an intramural lesion composed of spindle and epithelioid histiocytes arranged in a palisaded pattern, with central necrosis similar to a rheumatoid nodule. There was no clinical history of autoimmunity or previous bladder procedures, infections, or trauma. However, the smooth muscle actin and desmin positivities seen in residual ghost cells within necrotic areas argued against a granulomatous process. Reactive processes, such as myofibroblastic proliferations, can overlap neoplastic disorders, including true smooth muscle tumors. We did not observe atypia in the viable cells and mitotic figures. These features did not support a diagnosis of malignancy. The fascicular pattern, spindle cell morphology, lack of marked cytologic atypia, and smooth muscle actin and desmin reactivities, with a lack of other lineage marker expression, all supported a diagnosis of an infarcted leiomyoma. The intramural location in the bladder also favored the diagnosis.<\/jats:p>","DOI":"10.5858\/arpa.2011-0401-cr","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T12:57:32Z","timestamp":1338382652000},"page":"679-680","source":"Crossref","is-referenced-by-count":5,"title":["Necrotizing Palisading Granuloma of the Bladder in an Otherwise Healthy Young Man"],"prefix":"10.5858","volume":"136","author":[{"given":"Maria Rosaria","family":"Raspollini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto delle","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Balzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahul B.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"issue":"1","key":"i1543-2165-136-6-679-b01","series-title":"J Urol","first-page":"121","article-title":"Palisading granulomas of the prostate associated with prior prostatic surgery","volume":"136","author":"Eyre\n              RC,","year":"1986","unstructured":"Eyre\n              RC, \n            \n              Aaronson\n              AG, \n            \n              Weinstein\n              BJ\n            \n          . Palisading granulomas of the prostate associated with prior prostatic surgery. J Urol. 1986;136(1):121\u2013122."},{"issue":"9","key":"i1543-2165-136-6-679-b02","series-title":"Hum Pathol","first-page":"818","article-title":"Granulomatous prostatitis: distinction among allergic, nonspecific, and post-transurethral resection lesions","volume":"15","author":"Epstein\n              JI,","year":"1984","unstructured":"Epstein\n              JI, \n            \n              Hutchins\n              GM\n            \n          . Granulomatous prostatitis: distinction among allergic, nonspecific, and post-transurethral resection lesions. Hum Pathol. 1984;15(9):818\u2013825."},{"issue":"1","key":"i1543-2165-136-6-679-b03","series-title":"Am J Obstet Gynecol","first-page":"112","article-title":"Indolent granulomatous necrosis in patients with previous tubal diathermy","volume":"129","author":"Roberts\n              JT,","year":"1977","unstructured":"Roberts\n              JT, \n            \n              Roberts\n              GT, \n            \n              Maudsley\n              RF\n            \n          . Indolent granulomatous necrosis in patients with previous tubal diathermy. Am J Obstet Gynecol. 1977;129(1):112\u2013113."},{"issue":"11","key":"i1543-2165-136-6-679-b04","series-title":"Am J Surg Pathol","first-page":"841","article-title":"Necrobiotic granulomas of the uterine cervix: a probable postoperative reaction","volume":"8","author":"Evans\n              CS,","year":"1984","unstructured":"Evans\n              CS, \n            \n              Goldman\n              RL, \n            \n              Klein\n              HZ, \n            \n              Kohout\n              ND\n            \n          . Necrobiotic granulomas of the uterine cervix: a probable postoperative reaction. Am J Surg Pathol. 1984;8(11):841\u2013844."},{"issue":"4","key":"i1543-2165-136-6-679-b05","series-title":"Am J Clin Pathol","first-page":"430","article-title":"Bladder granulomata after bladder surgery","volume":"86","author":"Spagnolo\n              DV,","year":"1986","unstructured":"Spagnolo\n              DV, \n            \n              Waring\n              PM\n            \n          . Bladder granulomata after bladder surgery. Am J Clin Pathol. 1986;86(4):430\u2013437."},{"issue":"12","key":"i1543-2165-136-6-679-b06","series-title":"Acta Pathol Jpn","first-page":"1813","article-title":"Focal palisading granuloma in the prostate and bladder: a clinicopathologic study of 88 total cystectomy specimens","volume":"36","author":"Yamada\n              Y","year":"1986","unstructured":"Yamada\n              Y\n            \n          . Focal palisading granuloma in the prostate and bladder: a clinicopathologic study of 88 total cystectomy specimens. Acta Pathol Jpn. 1986;36(12):1813\u20131822."},{"issue":"7","key":"i1543-2165-136-6-679-b07","series-title":"J Dermatol","first-page":"452","article-title":"Palisading granuloma presenting in a patient with systemic lupus erythematosus","volume":"35","author":"Ohtsuka\n              T","year":"2008","unstructured":"Ohtsuka\n              T\n            \n          . Palisading granuloma presenting in a patient with systemic lupus erythematosus. 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Am J Surg Pathol. 2002;26(3):292\u2013300."},{"issue":"1","key":"i1543-2165-136-6-679-b09","series-title":"Am J Surg Pathol","first-page":"99","article-title":"Utility of a comprehensive immunohistochemical panel in the differential diagnosis of spindle cell lesions of the urinary bladder","volume":"33","author":"Westfall\n              DE,","year":"2009","unstructured":"Westfall\n              DE, \n            \n              Folpe\n              AL, \n            \n              Paner\n              GP\n            , et al. \n          Utility of a comprehensive immunohistochemical panel in the differential diagnosis of spindle cell lesions of the urinary bladder. 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Acta Pathol Jpn. 1986;36(12):1813\u20131822."},{"issue":"7","key":"i1543-2165-136-6-679-b07","series-title":"J Dermatol","first-page":"452","article-title":"Palisading granuloma presenting in a patient with systemic lupus erythematosus","volume":"35","author":"Ohtsuka\n              T","year":"2008","unstructured":"Ohtsuka\n              T\n            \n          . Palisading granuloma presenting in a patient with systemic lupus erythematosus. 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