{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:35:30Z","timestamp":1776879330257,"version":"3.51.2"},"reference-count":12,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:p>Context.\u2014Loop electrosurgical excision procedure (LEEP) is a therapeutic option following biopsy diagnosis of high-grade squamous intraepithelial lesion (HSIL). Most LEEPs will confirm the HSIL biopsy diagnosis but a number of them will not. Such negative findings suggest the possibility of an incorrect biopsy diagnosis, removal of the lesion by biopsy, or insufficient LEEP sampling.<\/jats:p>\n                  <jats:p>Objective.\u2014To determine the frequency of negative LEEP findings following HSIL biopsies and better understand the clinical significance of negative LEEP findings.<\/jats:p>\n                  <jats:p>Design.\u2014The Department of Pathology's records were searched for all patients undergoing LEEP excision who had prior cervical biopsies and subsequent clinical follow-up.<\/jats:p>\n                  <jats:p>Results.\u2014Three hundred seventy-eight women were found who had index biopsies, subsequent LEEPs, and clinical follow-up averaging 25.8\u00a0months. Three hundred six women had HSIL on biopsy with 223 (73%) showing HSIL on LEEP. Seventy-three (24%) LEEPs in women with HSIL index biopsy results yielded negative findings or disclosed low-grade squamous intraepithelial lesion (LSIL). Twenty-nine of 223 patients (13%) with an HSIL result both on biopsies and LEEPs had HSIL on biopsy and\/or excisional clinical follow-up. Seven of 73 patients (10%) with positive (HSIL) biopsy results but negative LEEP findings or LSIL had HSIL on biopsy and\/or excisional follow-up.<\/jats:p>\n                  <jats:p>Conclusions.\u2014Twenty-four percent of patients with HSIL on biopsy had negative findings or LSIL on LEEP. There is no statistical difference in development of HSIL after LEEP for those with positive biopsy and positive LEEP results (13%) versus positive biopsy and negative LEEP results (10%). The occurrence of a negative LEEP finding following a positive biopsy finding was frequent (24%) and does not portend a different clinical follow-up from a positive biopsy and positive LEEP result.<\/jats:p>","DOI":"10.5858\/arpa.2011-0494-oa","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T18:34:30Z","timestamp":1349030070000},"page":"1259-1261","source":"Crossref","is-referenced-by-count":28,"title":["Negative Loop Electrosurgical Cone Biopsy Finding Following a Biopsy Diagnosis of High-Grade Squamous Intraepithelial Lesion: Frequency and Clinical Significance"],"prefix":"10.5858","volume":"136","author":[{"given":"Benjamin L.","family":"Witt","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E.","family":"Factor","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke A.","family":"Jarboe","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester J.","family":"Layfield","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"2","key":"2020081300342263700_i1543-2165-136-10-1259-b01","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/gyno.1994.1027","article-title":"Prospective randomized trial of LLETZ versus laser ablation in patients with cervical intraepithelial neoplasia","volume":"52","author":"Alvarez","year":"1994","journal-title":"Gynecol Oncol"},{"issue":"2","key":"2020081300342263700_i1543-2165-136-10-1259-b02","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/gyno.1996.0132","article-title":"Loop electrocautery excisional procedure: therapeutic effectiveness as an ablation and a conization equivalent","volume":"61","author":"Gold","year":"1996","journal-title":"Gynecol Oncol"},{"key":"2020081300342263700_i1543-2165-136-10-1259-b03","first-page":"151","article-title":"A comparison of three cone biopsy techniques for evaluation and treatment of squamous intraepithelial lesions","volume":"3","author":"Linares","year":"1997","journal-title":"J Gynecol Tech"},{"issue":"6741","key":"2020081300342263700_i1543-2165-136-10-1259-b04","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1136\/bmj.300.6741.1690","article-title":"Loop diathermy excision of the cervical transformation zone in patients with abnormal cervical smears","volume":"300","author":"Luesley","year":"1990","journal-title":"BMJ"},{"issue":"2","key":"2020081300342263700_i1543-2165-136-10-1259-b05","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/gyno.1994.1281","article-title":"LLETZ is an acceptable alternative to diagnostic cold-knife conization","volume":"55","author":"Naumann","year":"1994","journal-title":"Gynecol Oncol"},{"issue":"2","key":"2020081300342263700_i1543-2165-136-10-1259-b06","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/gyno.1994.1189","article-title":"A randomized prospective study comparing three techniques of conization: cold knife, laser, and LEEP","volume":"54","author":"Mathevet","year":"1994","journal-title":"Gynecol Oncol"},{"issue":"1","key":"2020081300342263700_i1543-2165-136-10-1259-b07","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/gyno.1993.1168","article-title":"A comparison between loop diathermy conization and cold-knife conization for management of cervical dysplasia associated with unsatisfactory colposcopy","volume":"50","author":"Oyesanya","year":"1993","journal-title":"Gynecol Oncol"},{"issue":"9","key":"2020081300342263700_i1543-2165-136-10-1259-b08","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/j.1471-0528.1989.tb03380.x","article-title":"Large loop excision of the transformation zone (LLETZ): a new method of management for women with cervical intraepithelial neoplasia","volume":"96","author":"Prendiville","year":"1989","journal-title":"Br J Obstet Gynaecol"},{"issue":"2","key":"2020081300342263700_i1543-2165-136-10-1259-b09","first-page":"173","article-title":"Treatment of cervical intraepithelial neoplasia using the loop electrosurgical excision procedure","volume":"79","author":"Wright","year":"1992","journal-title":"Obstet Gynecol"},{"issue":"2","key":"2020081300342263700_i1543-2165-136-10-1259-b10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/01.AOG.0000132803.88049.84","article-title":"The clinical significance of a negative loop electrosurgical cone biopsy for high-grade dysplasia","volume":"104","author":"Livasy","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"8","key":"2020081300342263700_i1543-2165-136-10-1259-b11","first-page":"617","article-title":"Negative cone biopsies: a reappraisal [erratum in J Reprod Med. 2003;48(10):833]","volume":"48","author":"Diakomanolis","year":"2003","journal-title":"J Reprod Med"},{"issue":"6","key":"2020081300342263700_i1543-2165-136-10-1259-b12","first-page":"996","article-title":"The significance of positive margins in loop electrosurgical cone biopsies","volume":"84","author":"Felix","year":"1994","journal-title":"Obstet Gynecol"}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/136\/10\/1259\/1444074\/arpa_2011-0494-oa.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/136\/10\/1259\/1444074\/arpa_2011-0494-oa.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:32:09Z","timestamp":1764790329000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/136\/10\/article-p1259.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,1]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10,1]]}},"URL":"https:\/\/doi.org\/10.5858\/arpa.2011-0494-oa","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10,1]]}}}