{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:04:44Z","timestamp":1770822284090,"version":"3.50.1"},"reference-count":93,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:p>Context.\u2014The limitations of newer cervical screening tests are still being studied.<\/jats:p>\n                  <jats:p>Objective.\u2014To investigate those limitations, we conducted a retrospective review of 287 cases of cervical squamous cell carcinoma (SCC).<\/jats:p>\n                  <jats:p>Design.\u2014A search through 5\u00a0years of records identified 287 women with cervical SCC diagnoses. Clinical history, histopathology, and liquid-based cytology (ThinPrep) and Hybrid Capture 2 (HC2) high-risk human papillomavirus (HPV) results were documented. Polymerase chain reaction HPV tests were performed on SCC tissues with prior negative HC2 results.<\/jats:p>\n                  <jats:p>Results.\u2014Of 287 women, 156 (54.4%) had abnormal cytology results, and 75 (26.1%) had abnormal clinical findings triggering tissue diagnoses of SCC. Among 156 patients with abnormal Papanicolaou (Pap) test results, more-seriously abnormal Pap test results were reported in 142 women (91.1%). Among 31 women with Pap and HC2 HPV cotesting within 1\u00a0year of SCC diagnoses, 28 (90%) were Pap+\/HPV+, 2 (15.5%) were Pap+\/HPV\u2212, and 1 (3%) was Pap\u2212\/HPV\u2212. Two of 3 women with negative HC2 results before SCC diagnosis had abnormal Pap results; 1 had negative Pap reports with questionable lesional cells mimicking atrophy. In all 3 cases of SCC with negative HC2 results, HPV-18 was detected; in 2 cases (66%), HPV-16 was also detected.<\/jats:p>\n                  <jats:p>Conclusions.\u2014Although abnormal cytology preceded most SCC diagnoses, about one-third of patients were referred for diagnostic testing because of clinical suspicion alone. Among 31 SCC cases with liquid-based cytology and high-risk HPV cotest results less than 1\u00a0year before SCC diagnoses, 2 patients (6.5%) had Pap+\/HPV\u2212 results, and 1 patient (3.2%) had Pap\u2212\/HPV\u2212 results. Polymerase chain reaction detected high-risk HPV DNA in tumor tissues of 3 SCC cases with recent HC2\u2212 results.<\/jats:p>","DOI":"10.5858\/arpa.2011-0609-oa","type":"journal-article","created":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T08:18:06Z","timestamp":1345450686000},"page":"1533-1540","source":"Crossref","is-referenced-by-count":25,"title":["Screening Test Results Associated With Cancer Diagnoses in 287 Women With Cervical Squamous Cell Carcinoma"],"prefix":"10.5858","volume":"136","author":[{"given":"Zaibo","family":"Li","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Li, Austin, and Zhao); and the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston (Dr Guo)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Marshall","family":"Austin","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Li, Austin, and Zhao); and the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston (Dr Guo)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Guo","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Li, Austin, and Zhao); and the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston (Dr Guo)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Li, Austin, and Zhao); and the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston (Dr Guo)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","published-online":{"date-parts":[[2012,2,6]]},"reference":[{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b01","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/jama.1989.03420050087046","article-title":"The Papanicolaou test for cervical cancer detection: a triumph and a tragedy","volume":"261","author":"Koss","year":"1989","journal-title":"JAMA"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b02","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1023\/A:1018435522475","article-title":"International incidence rates of invasive cervical cancer after introduction of cytological screening","volume":"8","author":"Gustafsson","year":"1997","journal-title":"Cancer Causes Control"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b03","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0029-7844(97)00228-7","article-title":"Comparison of conventional Papanicolaou smears and a fluid-based, thin-layer system for cervical cancer screening","volume":"90","author":"Lee","year":"1997","journal-title":"Obstet Gynecol"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b04","first-page":"353","article-title":"Direct-to-vial experience with AutoCyte PREP in a small New England regional cytology practice","volume":"46","author":"Marino","year":"2001","journal-title":"J Reprod Med"},{"issue":"7609","key":"2020081220135857000_i1543-2165-136-12-1533-b05","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/bmj.39219.645475.55","article-title":"Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study","volume":"335","author":"Davey","year":"2007","journal-title":"BMJ"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b06","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1309\/AJCP8VE7AWBZCVQT","article-title":"The Becton Dickinson FocalPoint GS Imaging System: clinical trials demonstrate significantly improved sensitivity for the detection of important cervical lesions","volume":"132","author":"Wilbur","year":"2009","journal-title":"Am J Clin Pathol"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b07","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jnci\/93.4.293","article-title":"Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial","volume":"93","author":"Solomon","year":"2001","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b08","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ygyno.2010.04.013","article-title":"Clinical validation of the Cervista HPV HR and 16\/18 genotyping tests for use in women with ASC-US cytology","volume":"118","author":"Einstein","year":"2010","journal-title":"Gynecol Oncol"},{"issue":"6","key":"2020081220135857000_i1543-2165-136-12-1533-b09","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1056\/NEJMp020178","article-title":"Adding a test for human papillomavirus DNA to cervical-cancer screening","volume":"348","author":"Wright","year":"2003","journal-title":"N Engl J Med"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/01.AOG.0000109426.82624.f8","article-title":"Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening","volume":"103","author":"Wright","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"11","key":"2020081220135857000_i1543-2165-136-12-1533-b11","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1001\/archinternmed.2010.133","article-title":"Rightsizing cervical cancer screening: comment on \u201cCervical cancer screening with both human papillomavirus and Papanicolaou testing vs Papanicolaou testing alone.\u201d","volume":"170","author":"Sawaya","year":"2010","journal-title":"Arch Intern Med"},{"issue":"3","key":"2020081220135857000_i1543-2165-136-12-1533-b12","doi-asserted-by":"crossref","first-page":"iii","DOI":"10.3310\/hta15030","article-title":"MAVARIC\u2014a comparison of automation-assisted and manual cervical screening: a randomised controlled trial","volume":"15","author":"Kitchener","year":"2011","journal-title":"Health Technol Assess"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0090-8258(03)00176-8","article-title":"Performance of ThinPrep liquid-based cervical cytology in comparison with conventionally prepared Papanicolaou smears: a quantitative survey","volume":"90","author":"Abulafia","year":"2003","journal-title":"Gynecol Oncol"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b14","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1067\/mob.2001.116736","article-title":"Liquid-based cervical cytologic smear study and conventional Papanicolaou smears: a metaanalysis of prospective studies comparing cytologic diagnosis and sample adequacy","volume":"185","author":"Bernstein","year":"2001","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"2020081220135857000_i1543-2165-136-12-1533-b15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/dc.20607","article-title":"Evolution of Pap testing at a community hospital\u2014a ten year experience","volume":"35","author":"Nance","year":"2007","journal-title":"Diagn Cytopathol"},{"issue":"7609","key":"2020081220135857000_i1543-2165-136-12-1533-b16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/bmj.39196.740995.BE","article-title":"Accuracy of liquid based versus conventional cytology: overall results of new technologies for cervical cancer screening: randomised controlled trial","volume":"335","author":"Ronco","year":"2007","journal-title":"BMJ"},{"issue":"16","key":"2020081220135857000_i1543-2165-136-12-1533-b17","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1001\/jama.2009.1569","article-title":"Comparison of liquid-based cytology with conventional cytology for detection of cervical cancer precursors: a randomized controlled trial","volume":"302","author":"Siebers","year":"2009","journal-title":"JAMA"},{"issue":"11","key":"2020081220135857000_i1543-2165-136-12-1533-b18","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1001\/archinternmed.2010.134","article-title":"Cervical cancer screening with both human papillomavirus and Papanicolaou testing vs Papanicolaou testing alone: what screening intervals are physicians recommending","volume":"170","author":"Saraiya","year":"2010","journal-title":"Arch Intern Med"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/AOG.0b013e3182210034","article-title":"Low-risk human papillomavirus testing and other nonrecommended human papillomavirus testing practices among US health care providers","volume":"118","author":"Lee","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"40","key":"2020081220135857000_i1543-2165-136-12-1533-b20","first-page":"1","article-title":"Liquid-based cytology test use by office-based physicians: United States, 2006\u20132007","author":"Hing","year":"2011","journal-title":"Natl Health Stat Report"},{"issue":"10","key":"2020081220135857000_i1543-2165-136-12-1533-b21","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1089\/jwh.2010.2530","article-title":"Breast and cervical cancer screening practices among physicians in the national breast and cervical cancer early detection program","volume":"20","author":"Benard","year":"2011","journal-title":"J Womens Health (Larchmt)"},{"key":"2020081220135857000_i1543-2165-136-12-1533-b22","article-title":"30\u00a0Year trends in cervical cancer incidence rates: a surveillance, epidemiology, and end results program population-based study","author":"Smith","journal-title":"Proceedings from the Society of Gynecologic Oncologists; March 4\u20137, 2007"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/gyno.2000.5826","article-title":"The rising incidence of adenocarcinomas relative to squamous cell carcinoma of the uterine cervix in the United States\u2014a 24-year population-based study","volume":"78","author":"Smith","year":"2000","journal-title":"Gynecol Oncol"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0090-8258(91)90011-S","article-title":"Screening as a prognostic factor in cervical cancer: analysis of survival and prognostic factors based on Icelandic population data, 1964\u20131988","volume":"43","author":"Sigurdsson","year":"1991","journal-title":"Gynecol Oncol"},{"issue":"10","key":"2020081220135857000_i1543-2165-136-12-1533-b25","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2283::AID-CNCR12>3.0.CO;2-D","article-title":"Papanicolaou smear history and diagnosis of invasive cervical carcinoma among members of a large prepaid health plan","volume":"88","author":"Sung","year":"2000","journal-title":"Cancer"},{"issue":"9","key":"2020081220135857000_i1543-2165-136-12-1533-b26","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/jnci\/djn099","article-title":"Screening-preventable cervical cancer risks: evidence from a nationwide audit in Sweden","volume":"100","author":"Andrae","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"8","key":"2020081220135857000_i1543-2165-136-12-1533-b27","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/bjc.1996.196","article-title":"Estimating the efficacy of screening by auditing smear histories of women with and without cervical cancer","volume":"73","author":"Sasieni","year":"1996","journal-title":"Br J Cancer"},{"issue":"6","key":"2020081220135857000_i1543-2165-136-12-1533-b28","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1471-0528.2008.01990.x","article-title":"Invasive cervical cancer audit: a relative increase in interval cancers while coverage increased and incidence declined","volume":"116","author":"Herbert","year":"2009","journal-title":"BJOG"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b29","doi-asserted-by":"crossref","first-page":"744","DOI":"10.5858\/134.5.744","article-title":"The Pittsburgh cervical cancer screening model: a risk assessment tool","volume":"134","author":"Austin","year":"2010","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ygyno.2007.06.025","article-title":"Human papillomavirus DNA detection in ThinPrep Pap test vials is independent of cytologic sampling of the transformation zone","volume":"107","author":"Zhao","year":"2007","journal-title":"Gynecol Oncol"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/cncr.23598","article-title":"Adjunctive high-risk human papillomavirus DNA testing is a useful option for disease risk assessment in patients with negative Papanicolaou tests without an endocervical\/transformation zone sample","volume":"114","author":"Zhao","year":"2008","journal-title":"Cancer"},{"issue":"3","key":"2020081220135857000_i1543-2165-136-12-1533-b32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ygyno.2009.05.019","article-title":"Histologic follow-up results in 662 patients with Pap test findings of atypical glandular cells: results from a large academic womens hospital laboratory employing sensitive screening methods","volume":"114","author":"Zhao","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5858\/2008-0755-OAR1.1","article-title":"Clinical utility of adjunctive high risk HPV DNA testing in women with pap test findings of atypical glandular cells","volume":"134","author":"Zhao","year":"2010","journal-title":"Arch Pathol Lab Med"},{"issue":"12","key":"2020081220135857000_i1543-2165-136-12-1533-b34","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.5858\/132.12.1874","article-title":"Adjunctive human papillomavirus DNA testing is a useful option in some clinical settings for disease risk assessment and triage of females with ASC-H Papanicolaou test results","volume":"132","author":"Bandyopadhyay","year":"2008","journal-title":"Arch Pathol Lab Med"},{"issue":"9","key":"2020081220135857000_i1543-2165-136-12-1533-b35","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.5858\/133.9.1426","article-title":"Follow-up findings for women with human papillomavirus-positive and atypical squamous cells of undetermined significance screening test results in a large women's hospital practice","volume":"133","author":"Armah","year":"2009","journal-title":"Arch Pathol Lab Med"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b36","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/cncr.22949","article-title":"Very low human papillomavirus DNA prevalence in mature women with negative computer-imaged liquid-based Pap tests","volume":"111","author":"Zhao","year":"2007","journal-title":"Cancer"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ygyno.2009.07.010","article-title":"High-risk HPV DNA detected in less than 2% of over 25,000 cytology negative imaged liquid-based Pap test samples from women 30 and older","volume":"115","author":"Bansal","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"8","key":"2020081220135857000_i1543-2165-136-12-1533-b38","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.5858\/2009-0624-OA.1","article-title":"Significance of high risk HPV DNA detection in women 50 and older with squamous cell pap test abnormalities","volume":"134","author":"Zhao","year":"2010","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000320877","article-title":"HPV test results stratify risk for histopathologic follow-up findings of high-grade cervical intra-epithelial neoplasia in women with low-grade squamous intra-epithelial lesion Pap results","volume":"55","author":"Heider","year":"2011","journal-title":"Acta Cytol"},{"issue":"3","key":"2020081220135857000_i1543-2165-136-12-1533-b40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5858\/2010-0121-OA.1","article-title":"Follow-up findings in adolescents with HSIL Pap test results","volume":"135","author":"Zhao","year":"2011","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ygyno.2011.04.037","article-title":"Follow-up outcomes for a large cohort of US women with negative imaged liquid-based cytology findings and positive high risk human papillomavirus test results","volume":"122","author":"Zhao","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"6","key":"2020081220135857000_i1543-2165-136-12-1533-b42","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cncy.20176","article-title":"Histopathologic follow-up and human papillomavirus DNA test results in 290 patients with high-grade squamous intraepithelial lesion Papanicolaou test results","volume":"119","author":"Gao","year":"2011","journal-title":"Cancer Cytopathol"},{"issue":"10","key":"2020081220135857000_i1543-2165-136-12-1533-b43","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/jcp.51.10.737","article-title":"Hybrid capture II, a new sensitive test for human papillomavirus detection: comparison with hybrid capture I and PCR results in cervical lesions","volume":"51","author":"Clavel","year":"1998","journal-title":"J Clin Pathol"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b44","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1128\/JCM.01299-07","article-title":"Evaluation of a commercialized in situ hybridization assay for detecting human papillomavirus DNA in tissue specimens from patients with cervical intraepithelial neoplasia and cervical carcinoma","volume":"46","author":"Guo","year":"2008","journal-title":"J Clin Microbiol"},{"issue":"12","key":"2020081220135857000_i1543-2165-136-12-1533-b45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jviromet.2006.10.004","article-title":"Quality assurance of genotyping array for detection and typing of human papillomavirus","volume":"140","author":"Lin","year":"2007","journal-title":"J Virol Methods"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b46","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/LGT.0b013e3181f515a2","article-title":"Invasive cervical cancer and screening: what are the rates of unscreened and underscreened women in the modern era","volume":"15","author":"Subramaniam","year":"2011","journal-title":"J Low Genit Tract Dis"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b47","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ygyno.2010.09.021","article-title":"Screening history in women with cervical cancer in a Danish population-based screening program","volume":"120","author":"Kirschner","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"7","key":"2020081220135857000_i1543-2165-136-12-1533-b48","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1470-2045(11)70145-0","article-title":"Cervical cancer risk for women undergoing concurrent testing for human papillomavirus and cervical cytology: a population-based study in routine clinical practice","volume":"12","author":"Katki","year":"2011","journal-title":"Lancet Oncol"},{"issue":"6","key":"2020081220135857000_i1543-2165-136-12-1533-b49","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1471-0528.2010.02511.x","article-title":"Invasive cervical cancer audit: why cancers developed in a high-risk population with an organised screening programme","volume":"117","author":"Herbert","year":"2010","journal-title":"BJOG"},{"issue":"6","key":"2020081220135857000_i1543-2165-136-12-1533-b50","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1471-0528.2008.01989.x","article-title":"Screen-detected invasive cervical carcinoma and its clinical significance during the introduction of organized screening","volume":"116","author":"Herbert","year":"2009","journal-title":"BJOG"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b51","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/ijc.20955","article-title":"Cumulative 5-year diagnoses of CIN2, CIN3 or cervical cancer after concurrent high-risk HPV and cytology testing in a primary screening setting","volume":"116","author":"Hoyer","year":"2005","journal-title":"Int J Cancer"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b52","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10552-004-6295-z","article-title":"Screening histories of women with CIN 2\/3 compared with women diagnosed with invasive cervical cancer: a retrospective analysis of the Norwegian Coordinated Cervical Cancer Screening Program","volume":"16","author":"Nyg\u00e5rd","year":"2005","journal-title":"Cancer Causes Control"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1365-2303.2001.00288.x","article-title":"Adenocarcinoma of the uterine cervix compared with squamous cell carcinoma: a 12-year study in Southampton and South-west Hampshire","volume":"12","author":"Herbert","year":"2001","journal-title":"Cytopathology"},{"issue":"22","key":"2020081220135857000_i1543-2165-136-12-1533-b54","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1056\/NEJM199911253412201","article-title":"Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer","volume":"341","author":"Wallin","year":"1999","journal-title":"N Engl J Med"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b55","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3109\/00016349609033339","article-title":"The cytological screening history of 469 patients with squamous cell carcinoma of the cervix uteri; does interval carcinoma exist","volume":"75","author":"Kenter","year":"1996","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"6","key":"2020081220135857000_i1543-2165-136-12-1533-b56","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2105\/AJPH.85.6.791","article-title":"The screening histories of women with invasive cervical cancer, Connecticut","volume":"85","author":"Janerich","year":"1995","journal-title":"Am J Public Health"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jcp.47.1.27","article-title":"Audit of deaths from cervical cancer: proposal for an essential component of the National Screening Programme","volume":"47","author":"Slater","year":"1994","journal-title":"J Clin Pathol"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/AOG.0000000000003348","article-title":"Invasive cancer of the cervix in British Columbia: a review of the demography and screening histories of 437 cases seen from 1985\u20131988","volume":"80","author":"Anderson","year":"1992","journal-title":"Obstet Gynecol"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b59","first-page":"152","article-title":"An epidemiologic study of Pap screening histories in women with invasive carcinomas of the uterine cervix","volume":"91","author":"Nasca","year":"1991","journal-title":"N Y State J Med"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b60","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0002-9378(84)90774-9","article-title":"The cytologic history of 245 patients developing invasive cervical carcinoma","volume":"148","author":"Carmichael","year":"1984","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b61","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/jnci\/57.5.1037","article-title":"Uterine cervical carcinoma in Connecticut, 1935\u20131973:evidence for two classes of invasive disease","volume":"57","author":"Laskey","year":"1976","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b62","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0002-9378(15)32505-9","article-title":"How preventable is invasive cervical cancer?: a community study of preventable factors","volume":"113","author":"Martin","year":"1972","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"2020081220135857000_i1543-2165-136-12-1533-b63","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1046\/j.1532-5415.2001.4911243.x","article-title":"Advancing age and cervical cancer screening and prognosis","volume":"49","author":"Sawaya","year":"2001","journal-title":"J Am Geriatr Soc"},{"key":"2020081220135857000_i1543-2165-136-12-1533-b64","volume-title":"Screening for Cervical Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force","author":"Vesco","year":"2011"},{"issue":"suppl 5","key":"2020081220135857000_i1543-2165-136-12-1533-b65","first-page":"369","article-title":"Cervical cancer reduction through higher sensitivity Pap testing: observed versus calculated effects","volume":"111","author":"Linder","year":"2007","journal-title":"Cancer Cytopathol"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b66","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1128\/JCM.37.4.1030-1034.1999","article-title":"Tucker RA, Tortolero-Luna G, et al. Human papillomavirus (HPV) DNA copy number is dependent on grade of cervical disease and HPV type","volume":"37","author":"Swan, D","year":"1999","journal-title":"J Clin Microbiol"},{"issue":"6","key":"2020081220135857000_i1543-2165-136-12-1533-b67","first-page":"477","article-title":"A comparison between real-time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitation","volume":"12","author":"Gravitt","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"2020081220135857000_i1543-2165-136-12-1533-b68","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ygyno.2005.07.004","article-title":"Detection and quantitation of human papillomavirus type 16, 18, and 52 DNA in the peripheral blood of cervical cancer patients","volume":"99","author":"Ho","year":"2005","journal-title":"Gynecol Oncol"},{"issue":"9351","key":"2020081220135857000_i1543-2165-136-12-1533-b69","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(03)12120-4","article-title":"Human papillomavirus type 18 and rapidly progressing cervical intraepithelial neoplasia","volume":"361","author":"Woodman","year":"2003","journal-title":"Lancet"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b70","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc2050","article-title":"The natural history of cervical HPV infection: unresolved issues","volume":"7","author":"Woodman","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b71","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jcv.2009.01.015","article-title":"Human Papillomavirus negative but dyskaryotic cervical cytology: re-analysis of molecular testing","volume":"44","author":"Peevor","year":"2009","journal-title":"J Clin Virol"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b72","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ygyno.2010.12.361","article-title":"Characteristics of 44 cervical cancers diagnosed following Pap negative HPV positive screening in routine clinical practice","volume":"121","author":"Kinney","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b73","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/ijc.21955","article-title":"Overview of North American studies on HPV testing in primary cervical cancer screening","volume":"119","author":"Cuzick","year":"2006","journal-title":"Int J Cancer"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b74","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ygyno.2006.08.053","article-title":"Diagnostic accuracy of human papillomavirus testing in primary cervical screening: a systematic review and meta-analysis of non-randomized studies","volume":"104","author":"Koliopoulos","year":"2007","journal-title":"Gynecol Oncol"},{"issue":"12","key":"2020081220135857000_i1543-2165-136-12-1533-b75","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrclinonc.2009.167","article-title":"Primary HPV screening for cervical cancer prevention: results from European trials","volume":"6","author":"Lynge","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1258\/jms.2009.009098","article-title":"Has cytology become obsolete as a primary test in screening for cervical cancer","volume":"17","author":"Rebolj","year":"2010","journal-title":"J Med Screen"},{"issue":"7","key":"2020081220135857000_i1543-2165-136-12-1533-b77","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S1470-2045(09)70156-1","article-title":"HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial","volume":"10","author":"Kitchener","year":"2009","journal-title":"Lancet Oncol"},{"issue":"6","key":"2020081220135857000_i1543-2165-136-12-1533-b78","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.ejca.2011.01.008","article-title":"A comparison of HPV DNA testing and liquid based cytology over three rounds of primary cervical screening: extended follow up in the ARTISTIC trial","volume":"47","author":"Kitchener","year":"2011","journal-title":"Eur J Cancer"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b79","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/AOG.0b013e31818f5008","article-title":"Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2","volume":"113","author":"Castle","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b80","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/pgp.0b013e31805152ab","article-title":"CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samples","volume":"26","author":"Carreon","year":"2007","journal-title":"Int J Gynecol Pathol"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b81","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(08)70103-7","article-title":"Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study","volume":"9","author":"McCredie","year":"2008","journal-title":"Lancet Oncol"},{"issue":"7","key":"2020081220135857000_i1543-2165-136-12-1533-b82","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1086\/591625","article-title":"Persistence of genital human papillomavirus infection in a long-term follow-up study of female university students","volume":"198","author":"Sycuro","year":"2008","journal-title":"J Infect Dis"},{"issue":"7","key":"2020081220135857000_i1543-2165-136-12-1533-b83","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/jnci\/djn044","article-title":"Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections","volume":"100","author":"Rodr\u00edguez","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b84","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/jnci\/djq001","article-title":"Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2\/3: critical role of duration of infection","volume":"102","author":"Rodr\u00edguez","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b85","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J Pathol"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b86","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1309\/AJCPMF4DSDIW3ILO","article-title":"Patient safety and the next generation of HPV tests","volume":"135","author":"Simon","year":"2011","journal-title":"Am J Clin Pathol"},{"issue":"51","key":"2020081220135857000_i1543-2165-136-12-1533-b87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta13510","article-title":"ARTISTIC: a randomised trial of human papillomavirus (HPV) testing in primary cervical screening","volume":"13","author":"Kitchener","year":"2009","journal-title":"Health Technol Assess"},{"issue":"5","key":"2020081220135857000_i1543-2165-136-12-1533-b88","first-page":"679","article-title":"Stability of integrated HPV 16 DNA in various sample transport media","volume":"9","author":"Anekella","year":"2007","journal-title":"J Mol Diagn"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b89","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jviromet.2006.05.033","article-title":"Recovery of human papillomavirus nucleic acids from liquid-based cytology media","volume":"137","author":"Powell","year":"2006","journal-title":"J Virol Methods"},{"issue":"6","key":"2020081220135857000_i1543-2165-136-12-1533-b90","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/cncr.22285","article-title":"Human papillomavirus testing using hybrid capture II with SurePath collection: initial evaluation and longitudinal data provide clinical validation for this method","volume":"108","author":"Ko","year":"2006","journal-title":"Cancer"},{"issue":"1","key":"2020081220135857000_i1543-2165-136-12-1533-b91","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5858\/arpa.2011-0212-ED","article-title":"Test validation and verification for molecular diagnostic assays","volume":"136","author":"Halling","year":"2012","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"2020081220135857000_i1543-2165-136-12-1533-b92","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000326956","article-title":"Screening for the prevention of cervical cancer in the era of human papillomavirus vaccination: an Australian perspective","volume":"55","author":"Farnsworth","year":"2011","journal-title":"Acta Cytol"},{"issue":"2","key":"2020081220135857000_i1543-2165-136-12-1533-b93","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/PCR.0b013e31820fff8a","article-title":"Observations from Pap litigation consultations","volume":"16","author":"Austin","year":"2011","journal-title":"Pathol Case Rev"}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/136\/12\/1533\/2262853\/arpa_2011-0609-oa.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/136\/12\/1533\/2262853\/arpa_2011-0609-oa.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:34:13Z","timestamp":1764790453000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/136\/12\/article-p1533.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,6]]},"references-count":93,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,2,6]]},"published-print":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.5858\/arpa.2011-0609-oa","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2,6]]}}}