{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:27:02Z","timestamp":1770787622525,"version":"3.50.0"},"reference-count":48,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5]]},"abstract":"\n Context<\/jats:italic>\n .\u2014The incidence of obesity is increasing and contributes to the rising incidence of fatty liver. Body mass index (BMI) is used to assess the degree of obesity but does not take into account the pattern of body fat distribution.\n <\/jats:p>\n \n Objectives<\/jats:italic>\n .\u2014To confirm the increasing incidence of fatty liver in an autopsy study. We hypothesized that a standardized measurement of abdominal subcutaneous adipose tissue (ASAT) might be a good noninvasive method for differentiating steatohepatitis from steatosis.\n <\/jats:p>\n \n Design<\/jats:italic>\n .\u2014Consecutive complete adult postmortem cases were studied and liver sections were assessed with a steatohepatitis scoring system. Spleen weight, ASAT, and clinical information were obtained. Spleen histology was assessed in a subset of patients having splenomegaly in the absence of cirrhosis.\n <\/jats:p>\n \n Results<\/jats:italic>\n .\u2014Patients with human immunodeficiency virus, hepatitis C virus, and appreciable alcohol use were excluded. Of 306 cases, the frequency of fatty liver was 51.6% with 33.3% having simple steatosis and 18.3%, having steatohepatitis. Mean ASAT was 3.7 cm in the steatohepatitis group versus 2.6 cm in the steatosis group (\n P<\/jats:italic>\n < .001); this difference was greater in patients with a BMI less than 25 kg\/m\n 2<\/jats:sup>\n (\n P<\/jats:italic>\n = .05). Fibrocongestive splenomegaly was noted in 9 of 38 patients with nonalcoholic steatohepatitis (24%) in the absence of cirrhosis.\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n .\u2014In this series of autopsy cases, a dramatic increase in the prevalence of fatty liver disease is demonstrated. Thicker ASAT is associated more with steatohepatitis than with simple steatosis, especially in patients with BMI below 25 kg\/m\n 2<\/jats:sup>\n . Fibrocongestive splenomegaly may occur in the absence of cirrhosis in the presence of steatohepatitis.\n <\/jats:p>","DOI":"10.5858\/arpa.2012-0050-oa","type":"journal-article","created":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T14:08:53Z","timestamp":1367244533000},"page":"642-646","source":"Crossref","is-referenced-by-count":2,"title":["Increased Thickness of Abdominal Subcutaneous Adipose Tissue Occurs More Frequently in Steatohepatitis Than in Simple Steatosis"],"prefix":"10.5858","volume":"137","author":[{"given":"M. Isabel","family":"Fiel","sequence":"first","affiliation":[{"name":"From the Lillian and Henry M. Stratton-Hans Popper Department of Pathology (Drs Fiel, Desman, and Lento) and the Division of Liver Diseases (Drs Sima and Schiano), Mount Sinai School of Medicine, New York, New York; and the Department of Medicine, Imam Reza Hospital (Dr Sima) and the Division of Statistics (Mr Azarian), Mashhad University of Medical Sciences, Mashhad, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Sima","sequence":"additional","affiliation":[{"name":"From the Lillian and Henry M. Stratton-Hans Popper Department of Pathology (Drs Fiel, Desman, and Lento) and the Division of Liver Diseases (Drs Sima and Schiano), Mount Sinai School of Medicine, New York, New York; and the Department of Medicine, Imam Reza Hospital (Dr Sima) and the Division of Statistics (Mr Azarian), Mashhad University of Medical Sciences, Mashhad, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garrett","family":"Desman","sequence":"additional","affiliation":[{"name":"From the Lillian and Henry M. Stratton-Hans Popper Department of Pathology (Drs Fiel, Desman, and Lento) and the Division of Liver Diseases (Drs Sima and Schiano), Mount Sinai School of Medicine, New York, New York; and the Department of Medicine, Imam Reza Hospital (Dr Sima) and the Division of Statistics (Mr Azarian), Mashhad University of Medical Sciences, Mashhad, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirabbas","family":"Azarian","sequence":"additional","affiliation":[{"name":"From the Lillian and Henry M. Stratton-Hans Popper Department of Pathology (Drs Fiel, Desman, and Lento) and the Division of Liver Diseases (Drs Sima and Schiano), Mount Sinai School of Medicine, New York, New York; and the Department of Medicine, Imam Reza Hospital (Dr Sima) and the Division of Statistics (Mr Azarian), Mashhad University of Medical Sciences, Mashhad, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Lento","sequence":"additional","affiliation":[{"name":"From the Lillian and Henry M. Stratton-Hans Popper Department of Pathology (Drs Fiel, Desman, and Lento) and the Division of Liver Diseases (Drs Sima and Schiano), Mount Sinai School of Medicine, New York, New York; and the Department of Medicine, Imam Reza Hospital (Dr Sima) and the Division of Statistics (Mr Azarian), Mashhad University of Medical Sciences, Mashhad, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Schiano","sequence":"additional","affiliation":[{"name":"From the Lillian and Henry M. Stratton-Hans Popper Department of Pathology (Drs Fiel, Desman, and Lento) and the Division of Liver Diseases (Drs Sima and Schiano), Mount Sinai School of Medicine, New York, New York; and the Department of Medicine, Imam Reza Hospital (Dr Sima) and the Division of Statistics (Mr Azarian), Mashhad University of Medical Sciences, Mashhad, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"4","key":"i1543-2165-137-5-642-b01","series-title":"Semin Liver Dis","first-page":"339","article-title":"The epidemiology of nonalcoholic fatty liver disease: a global perspective","volume":"28","author":"Lazo\n M,","year":"2008","unstructured":"Lazo\n M, \n \n Clark\n JM. \n \n The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis. 2008;28(4):339\u2013350."},{"issue":"suppl 1","key":"i1543-2165-137-5-642-b02","series-title":"J Clin Gastroenterol","first-page":"S39","article-title":"The epidemiology of nonalcoholic fatty liver disease in adults","volume":"40","author":"Clark\n JM.","year":"2006","unstructured":"Clark\n JM. \n \n The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol. 2006;40(suppl 1):S39\u2013S43."},{"issue":"5","key":"i1543-2165-137-5-642-b03","series-title":"Hepatology","first-page":"1106","article-title":"Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors","volume":"12","author":"Wanless\n IR,","year":"1990","unstructured":"Wanless\n IR, \n \n Lentz\n JS. \n \n Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology. 1990;12(5):1106\u20131110."},{"issue":"5","key":"i1543-2165-137-5-642-b04","series-title":"Eur Rev Med Pharmacol Sci","first-page":"285","article-title":"Steatosis and portal hypertension","volume":"9","author":"Puoti\n C,","year":"2005","unstructured":"Puoti\n C, \n \n Bellis\n L. \n \n Steatosis and portal hypertension. Eur Rev Med Pharmacol Sci. 2005;9(5):285\u2013290."},{"issue":"1","key":"i1543-2165-137-5-642-b05","series-title":"J Hepatol","first-page":"132","article-title":"The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies","volume":"42","author":"Adams\n LA,","year":"2005","unstructured":"Adams\n LA, \n \n Sanderson\n S, \n \n Lindor\n KD, \n \n Angulo\n P. \n \n The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol. 2005;42(1):132\u2013138."},{"issue":"1","key":"i1543-2165-137-5-642-b06","series-title":"Clin Gastroenterol Hepatol","first-page":"67","article-title":"Is central obesity associated with cirrhosis-related death or hospitalization: a population-based, cohort study","volume":"3","author":"Ioannou\n GN,","year":"2005","unstructured":"Ioannou\n GN, \n \n Weiss\n NS, \n \n Boyko\n EJ, \n et al\n . Is central obesity associated with cirrhosis-related death or hospitalization: a population-based, cohort study. Clin Gastroenterol Hepatol. 2005;3(1):67\u201374."},{"issue":"15","key":"i1543-2165-137-5-642-b07","series-title":"Arch Intern Med","first-page":"1293","article-title":"Waist circumference and all-cause mortality in a large US cohort","volume":"170","author":"Jacobs\n EJ,","year":"2010","unstructured":"Jacobs\n EJ, \n \n Newton\n CC, \n \n Wang\n Y, \n et al\n . Waist circumference and all-cause mortality in a large US cohort. Arch Intern Med. 2010;170(15):1293\u20131301."},{"issue":"4\u20135","key":"i1543-2165-137-5-642-b08","series-title":"Aging Clin Exp Res","first-page":"349","article-title":"Relationship between the abdominal wall fat index and blood pressure in elderly women: a comparison with the body mass index","volume":"21","author":"Kotani\n K,","year":"2009","unstructured":"Kotani\n K, \n \n Adachi\n S, \n \n Tsuzaki\n K, \n \n Sakane\n N. \n \n Relationship between the abdominal wall fat index and blood pressure in elderly women: a comparison with the body mass index. Aging Clin Exp Res. 2009;21(4\u20135):349\u2013352."},{"issue":"5","key":"i1543-2165-137-5-642-b09","series-title":"Metabolism","first-page":"548","article-title":"Body fat topography as an independent predictor of fatty liver","volume":"42","author":"Kral\n JG,","year":"1993","unstructured":"Kral\n JG, \n \n Schaffner\n F, \n \n Pierson\n RN\n Jr, \n \n Wang\n J. \n \n Body fat topography as an independent predictor of fatty liver. Metabolism. 1993;42(5):548\u2013551."},{"issue":"7","key":"i1543-2165-137-5-642-b10","series-title":"Am J Gastroenterol","first-page":"1796","article-title":"Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults","volume":"97","author":"Nakao\n K,","year":"2002","unstructured":"Nakao\n K, \n \n Nakata\n K, \n \n Ohtsubo\n N, \n et al\n . Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults. Am J Gastroenterol. 2002;97(7):1796\u20131801."},{"issue":"7","key":"i1543-2165-137-5-642-b11","series-title":"Int J Obes Relat Metab Disord","first-page":"495","article-title":"Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships","volume":"16","author":"Zamboni\n M,","year":"1992","unstructured":"Zamboni\n M, \n \n Armellini\n F, \n \n Milani\n MP, \n et al\n . Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships. Int J Obes Relat Metab Disord. 1992;16(7):495\u2013504."},{"key":"i1543-2165-137-5-642-b12","series-title":"The Complete Spleen. 2nd ed","first-page":"6","article-title":"The anatomy of the spleen","author":"Bergman\n RA,","year":"2002","unstructured":"Bergman\n RA, \n \n Heidger\n PM, \n \n Scott-Conner\n CE. \n \n The anatomy of the spleen. In: BowdlerJA, ed. The Complete Spleen. 2nd ed. Totowa, NJ: Humana Press;2002:6."},{"issue":"9","key":"i1543-2165-137-5-642-b13","series-title":"Am J Gastroenterol","first-page":"2467","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt\n EM,","year":"1999","unstructured":"Brunt\n EM, \n \n Janney\n CG, \n \n Di Bisceglie\n AM, \n \n Neuschwander-Tetri\n BA, \n \n Bacon\n BR. \n \n Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94(9):2467\u20132474."},{"issue":"4","key":"i1543-2165-137-5-642-b14","series-title":"Semin Liver Dis","first-page":"329","article-title":"Hepatoportal sclerosis","volume":"15","author":"Bioulac-Sage\n P,","year":"1995","unstructured":"Bioulac-Sage\n P, \n \n Le Bail\n B, \n \n Bernard\n PH, \n \n Balabaud\n C. \n \n Hepatoportal sclerosis. Semin Liver Dis. 1995;15(4):329\u2013339."},{"issue":"1","key":"i1543-2165-137-5-642-b15","series-title":"Gastroenterology","first-page":"113","article-title":"The natural history of nonalcoholic fatty liver disease: a population-based cohort study","volume":"129","author":"Adams\n LA,","year":"2005","unstructured":"Adams\n LA, \n \n Lymp\n JF, \n \n St Sauver\n J, \n et al\n . The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129(1):113\u2013121."},{"issue":"2","key":"i1543-2165-137-5-642-b16","series-title":"Hepatol Res","first-page":"92","article-title":"Insulin resistance and clinical aspects of non-alcoholic steatohepatitis (NASH)","volume":"33","author":"Agarwal\n N,","year":"2005","unstructured":"Agarwal\n N, \n \n Sharma\n BC. \n \n Insulin resistance and clinical aspects of non-alcoholic steatohepatitis (NASH). Hepatol Res. 2005;33(2):92\u201396."},{"issue":"2","key":"i1543-2165-137-5-642-b17","series-title":"Hepatology","first-page":"449","article-title":"Visceral fat: a key mediator of steatohepatitis in metabolic liver disease","volume":"48","author":"van der Poorten\n D,","year":"2008","unstructured":"van der Poorten\n D, \n \n Milner\n KL, \n \n Hui\n J, \n et al\n . Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology. 2008;48(2):449\u2013457."},{"issue":"6","key":"i1543-2165-137-5-642-b18","series-title":"J Physiol Anthropol Appl Human Sci","first-page":"293","article-title":"Reference norms for a fat-free mass index and fat mass index in the Japanese child population","volume":"22","author":"Nakao\n T,","year":"2003","unstructured":"Nakao\n T, \n \n Komiya\n S. \n \n Reference norms for a fat-free mass index and fat mass index in the Japanese child population. J Physiol Anthropol Appl Human Sci. 2003;22(6):293\u2013298."},{"issue":"4","key":"i1543-2165-137-5-642-b19","series-title":"Nat Rev Gastroenterol Hepatol","first-page":"195","article-title":"Pathology of nonalcoholic fatty liver disease","volume":"7","author":"Brunt\n EM.","unstructured":"Brunt\n EM. \n \n Pathology of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 7(4):195\u2013203."},{"issue":"2","key":"i1543-2165-137-5-642-b20","series-title":"Ann Plast Surg","first-page":"130","article-title":"Regional differences in ultrasonic assessment of subcutaneous fat thickness in the abdomen: effects on the TRAM flap","volume":"51","author":"Yano\n K,","year":"2003","unstructured":"Yano\n K, \n \n Hosokawa\n K, \n \n Nakai\n K, \n \n Kubo\n T, \n \n Matsuo\n Y. \n \n Regional differences in ultrasonic assessment of subcutaneous fat thickness in the abdomen: effects on the TRAM flap. Ann Plast Surg. 2003;51(2):130\u2013135."},{"issue":"5","key":"i1543-2165-137-5-642-b21","series-title":"JAMA","first-page":"491","article-title":"Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999\u20132010","volume":"307","author":"Flegal\n KM,","year":"2012","unstructured":"Flegal\n KM, \n \n Carroll\n MD, \n \n Kit\n BK, \n \n Ogden\n CL. \n \n Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999\u20132010. JAMA. 2012;307(5):491\u2013497."},{"issue":"5","key":"i1543-2165-137-5-642-b22","series-title":"JAMA","first-page":"483","article-title":"Prevalence of obesity and trends in body mass index among US children and adolescents, 1999\u20132010","volume":"307","author":"Ogden\n CL,","year":"2012","unstructured":"Ogden\n CL, \n \n Carroll\n MD, \n \n Kit\n BK, \n \n Flegal\n KM. \n \n Prevalence of obesity and trends in body mass index among US children and adolescents, 1999\u20132010. JAMA. 2012;307(5):483\u2013490."},{"issue":"1","key":"i1543-2165-137-5-642-b23","series-title":"Clin Liver Dis","first-page":"37","article-title":"Morphology of alcoholic liver disease","volume":"9","author":"Lefkowitch\n JH.","year":"2005","unstructured":"Lefkowitch\n JH. \n \n Morphology of alcoholic liver disease. Clin Liver Dis. 2005;9(1):37\u201353."},{"issue":"10","key":"i1543-2165-137-5-642-b24","series-title":"Transplantation","first-page":"1152","article-title":"Acute cellular rejection resulting in sinusoidal obstruction syndrome and ascites post-liver transplantation","volume":"92","author":"Sanei\n MH,","year":"2011","unstructured":"Sanei\n MH, \n \n Schiano\n TD, \n \n Sempoux\n C, \n \n Fan\n C, \n \n Fiel\n MI. \n \n Acute cellular rejection resulting in sinusoidal obstruction syndrome and ascites post-liver transplantation. Transplantation. 2011;92(10):1152\u20131158."},{"issue":"4","key":"i1543-2165-137-5-642-b01","series-title":"Semin Liver Dis","first-page":"339","article-title":"The epidemiology of nonalcoholic fatty liver disease: a global perspective","volume":"28","author":"Lazo\n M,","year":"2008","unstructured":"Lazo\n M, \n \n Clark\n JM. \n \n The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis. 2008;28(4):339\u2013350."},{"issue":"suppl 1","key":"i1543-2165-137-5-642-b02","series-title":"J Clin Gastroenterol","first-page":"S39","article-title":"The epidemiology of nonalcoholic fatty liver disease in adults","volume":"40","author":"Clark\n JM.","year":"2006","unstructured":"Clark\n JM. \n \n The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol. 2006;40(suppl 1):S39\u2013S43."},{"issue":"5","key":"i1543-2165-137-5-642-b03","series-title":"Hepatology","first-page":"1106","article-title":"Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors","volume":"12","author":"Wanless\n IR,","year":"1990","unstructured":"Wanless\n IR, \n \n Lentz\n JS. \n \n Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology. 1990;12(5):1106\u20131110."},{"issue":"5","key":"i1543-2165-137-5-642-b04","series-title":"Eur Rev Med Pharmacol Sci","first-page":"285","article-title":"Steatosis and portal hypertension","volume":"9","author":"Puoti\n C,","year":"2005","unstructured":"Puoti\n C, \n \n Bellis\n L. \n \n Steatosis and portal hypertension. Eur Rev Med Pharmacol Sci. 2005;9(5):285\u2013290."},{"issue":"1","key":"i1543-2165-137-5-642-b05","series-title":"J Hepatol","first-page":"132","article-title":"The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies","volume":"42","author":"Adams\n LA,","year":"2005","unstructured":"Adams\n LA, \n \n Sanderson\n S, \n \n Lindor\n KD, \n \n Angulo\n P. \n \n The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol. 2005;42(1):132\u2013138."},{"issue":"1","key":"i1543-2165-137-5-642-b06","series-title":"Clin Gastroenterol Hepatol","first-page":"67","article-title":"Is central obesity associated with cirrhosis-related death or hospitalization: a population-based, cohort study","volume":"3","author":"Ioannou\n GN,","year":"2005","unstructured":"Ioannou\n GN, \n \n Weiss\n NS, \n \n Boyko\n EJ, \n et al\n . Is central obesity associated with cirrhosis-related death or hospitalization: a population-based, cohort study. Clin Gastroenterol Hepatol. 2005;3(1):67\u201374."},{"issue":"15","key":"i1543-2165-137-5-642-b07","series-title":"Arch Intern Med","first-page":"1293","article-title":"Waist circumference and all-cause mortality in a large US cohort","volume":"170","author":"Jacobs\n EJ,","year":"2010","unstructured":"Jacobs\n EJ, \n \n Newton\n CC, \n \n Wang\n Y, \n et al\n . Waist circumference and all-cause mortality in a large US cohort. Arch Intern Med. 2010;170(15):1293\u20131301."},{"issue":"4\u20135","key":"i1543-2165-137-5-642-b08","series-title":"Aging Clin Exp Res","first-page":"349","article-title":"Relationship between the abdominal wall fat index and blood pressure in elderly women: a comparison with the body mass index","volume":"21","author":"Kotani\n K,","year":"2009","unstructured":"Kotani\n K, \n \n Adachi\n S, \n \n Tsuzaki\n K, \n \n Sakane\n N. \n \n Relationship between the abdominal wall fat index and blood pressure in elderly women: a comparison with the body mass index. Aging Clin Exp Res. 2009;21(4\u20135):349\u2013352."},{"issue":"5","key":"i1543-2165-137-5-642-b09","series-title":"Metabolism","first-page":"548","article-title":"Body fat topography as an independent predictor of fatty liver","volume":"42","author":"Kral\n JG,","year":"1993","unstructured":"Kral\n JG, \n \n Schaffner\n F, \n \n Pierson\n RN\n Jr, \n \n Wang\n J. \n \n Body fat topography as an independent predictor of fatty liver. Metabolism. 1993;42(5):548\u2013551."},{"issue":"7","key":"i1543-2165-137-5-642-b10","series-title":"Am J Gastroenterol","first-page":"1796","article-title":"Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults","volume":"97","author":"Nakao\n K,","year":"2002","unstructured":"Nakao\n K, \n \n Nakata\n K, \n \n Ohtsubo\n N, \n et al\n . Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults. Am J Gastroenterol. 2002;97(7):1796\u20131801."},{"issue":"7","key":"i1543-2165-137-5-642-b11","series-title":"Int J Obes Relat Metab Disord","first-page":"495","article-title":"Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships","volume":"16","author":"Zamboni\n M,","year":"1992","unstructured":"Zamboni\n M, \n \n Armellini\n F, \n \n Milani\n MP, \n et al\n . Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships. Int J Obes Relat Metab Disord. 1992;16(7):495\u2013504."},{"key":"i1543-2165-137-5-642-b12","series-title":"The Complete Spleen. 2nd ed","first-page":"6","article-title":"The anatomy of the spleen","author":"Bergman\n RA,","year":"2002","unstructured":"Bergman\n RA, \n \n Heidger\n PM, \n \n Scott-Conner\n CE. \n \n The anatomy of the spleen. In: BowdlerJA, ed. The Complete Spleen. 2nd ed. Totowa, NJ: Humana Press;2002:6."},{"issue":"9","key":"i1543-2165-137-5-642-b13","series-title":"Am J Gastroenterol","first-page":"2467","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt\n EM,","year":"1999","unstructured":"Brunt\n EM, \n \n Janney\n CG, \n \n Di Bisceglie\n AM, \n \n Neuschwander-Tetri\n BA, \n \n Bacon\n BR. \n \n Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94(9):2467\u20132474."},{"issue":"4","key":"i1543-2165-137-5-642-b14","series-title":"Semin Liver Dis","first-page":"329","article-title":"Hepatoportal sclerosis","volume":"15","author":"Bioulac-Sage\n P,","year":"1995","unstructured":"Bioulac-Sage\n P, \n \n Le Bail\n B, \n \n Bernard\n PH, \n \n Balabaud\n C. \n \n Hepatoportal sclerosis. Semin Liver Dis. 1995;15(4):329\u2013339."},{"issue":"1","key":"i1543-2165-137-5-642-b15","series-title":"Gastroenterology","first-page":"113","article-title":"The natural history of nonalcoholic fatty liver disease: a population-based cohort study","volume":"129","author":"Adams\n LA,","year":"2005","unstructured":"Adams\n LA, \n \n Lymp\n JF, \n \n St Sauver\n J, \n et al\n . The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129(1):113\u2013121."},{"issue":"2","key":"i1543-2165-137-5-642-b16","series-title":"Hepatol Res","first-page":"92","article-title":"Insulin resistance and clinical aspects of non-alcoholic steatohepatitis (NASH)","volume":"33","author":"Agarwal\n N,","year":"2005","unstructured":"Agarwal\n N, \n \n Sharma\n BC. \n \n Insulin resistance and clinical aspects of non-alcoholic steatohepatitis (NASH). Hepatol Res. 2005;33(2):92\u201396."},{"issue":"2","key":"i1543-2165-137-5-642-b17","series-title":"Hepatology","first-page":"449","article-title":"Visceral fat: a key mediator of steatohepatitis in metabolic liver disease","volume":"48","author":"van der Poorten\n D,","year":"2008","unstructured":"van der Poorten\n D, \n \n Milner\n KL, \n \n Hui\n J, \n et al\n . Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology. 2008;48(2):449\u2013457."},{"issue":"6","key":"i1543-2165-137-5-642-b18","series-title":"J Physiol Anthropol Appl Human Sci","first-page":"293","article-title":"Reference norms for a fat-free mass index and fat mass index in the Japanese child population","volume":"22","author":"Nakao\n T,","year":"2003","unstructured":"Nakao\n T, \n \n Komiya\n S. \n \n Reference norms for a fat-free mass index and fat mass index in the Japanese child population. J Physiol Anthropol Appl Human Sci. 2003;22(6):293\u2013298."},{"issue":"4","key":"i1543-2165-137-5-642-b19","series-title":"Nat Rev Gastroenterol Hepatol","first-page":"195","article-title":"Pathology of nonalcoholic fatty liver disease","volume":"7","author":"Brunt\n EM.","unstructured":"Brunt\n EM. \n \n Pathology of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 7(4):195\u2013203."},{"issue":"2","key":"i1543-2165-137-5-642-b20","series-title":"Ann Plast Surg","first-page":"130","article-title":"Regional differences in ultrasonic assessment of subcutaneous fat thickness in the abdomen: effects on the TRAM flap","volume":"51","author":"Yano\n K,","year":"2003","unstructured":"Yano\n K, \n \n Hosokawa\n K, \n \n Nakai\n K, \n \n Kubo\n T, \n \n Matsuo\n Y. \n \n Regional differences in ultrasonic assessment of subcutaneous fat thickness in the abdomen: effects on the TRAM flap. Ann Plast Surg. 2003;51(2):130\u2013135."},{"issue":"5","key":"i1543-2165-137-5-642-b21","series-title":"JAMA","first-page":"491","article-title":"Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999\u20132010","volume":"307","author":"Flegal\n KM,","year":"2012","unstructured":"Flegal\n KM, \n \n Carroll\n MD, \n \n Kit\n BK, \n \n Ogden\n CL. \n \n Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999\u20132010. JAMA. 2012;307(5):491\u2013497."},{"issue":"5","key":"i1543-2165-137-5-642-b22","series-title":"JAMA","first-page":"483","article-title":"Prevalence of obesity and trends in body mass index among US children and adolescents, 1999\u20132010","volume":"307","author":"Ogden\n CL,","year":"2012","unstructured":"Ogden\n CL, \n \n Carroll\n MD, \n \n Kit\n BK, \n \n Flegal\n KM. \n \n Prevalence of obesity and trends in body mass index among US children and adolescents, 1999\u20132010. JAMA. 2012;307(5):483\u2013490."},{"issue":"1","key":"i1543-2165-137-5-642-b23","series-title":"Clin Liver Dis","first-page":"37","article-title":"Morphology of alcoholic liver disease","volume":"9","author":"Lefkowitch\n JH.","year":"2005","unstructured":"Lefkowitch\n JH. \n \n Morphology of alcoholic liver disease. Clin Liver Dis. 2005;9(1):37\u201353."},{"issue":"10","key":"i1543-2165-137-5-642-b24","series-title":"Transplantation","first-page":"1152","article-title":"Acute cellular rejection resulting in sinusoidal obstruction syndrome and ascites post-liver transplantation","volume":"92","author":"Sanei\n MH,","year":"2011","unstructured":"Sanei\n MH, \n \n Schiano\n TD, \n \n Sempoux\n C, \n \n Fan\n C, \n \n Fiel\n MI. \n \n Acute cellular rejection resulting in sinusoidal obstruction syndrome and ascites post-liver transplantation. Transplantation. 2011;92(10):1152\u20131158."}],"container-title":["Archives of Pathology and Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/137\/5\/article-p642.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/137\/5\/642\/1612395\/arpa_2012-0050-oa.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/137\/5\/article-p642.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/137\/5\/article-p642.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:59:00Z","timestamp":1770771540000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/137\/5\/article-p642.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":48,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.5858\/arpa.2012-0050-oa","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}