{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:55:22Z","timestamp":1789710922988,"version":"4.0.1"},"reference-count":52,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    <jats:italic>Context<\/jats:italic>\n                    .\u2014Autopsy evaluation of the brain of a patient with frontotemporal dementia (FTD) can be daunting to the general pathologist. At some point in their training, most pathologists learn about Pick disease, and can recognize Pick bodies, the morphologic hallmark of Pick disease. Pick disease is a type of frontotemporal lobar degeneration (FTLD), the general category of pathologic process underlying most cases of FTD. The 2 major categories of pathologic FTLD are tauopathies (FTLD-tau) and ubiquitinopathies (FTLD-U). Pick disease is one of the FTLD-tau subtypes and is termed\n                    <jats:italic>FTLD-tau (PiD)<\/jats:italic>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    .\u2014To \u201cdemystify\u201d FTLDs, and to demonstrate that subtypes of FTLD-tau and FTLD-U can be easily determined by following a logical, stepwise, histochemical, and immunohistochemical investigation of the FTD autopsy brain.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Data Sources<\/jats:italic>\n                    .\u2014Previously published peer-reviewed articles.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    .\u2014The hope is that this article will be a useful reference for the general pathologist faced with performing a brain autopsy on a decedent with frontotemporal dementia.\n                  <\/jats:p>","DOI":"10.5858\/arpa.2012-0075-ra","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T16:02:14Z","timestamp":1362153734000},"page":"314-325","source":"Crossref","is-referenced-by-count":28,"title":["Making the Diagnosis of Frontotemporal Lobar Degeneration"],"prefix":"10.5858","volume":"137","author":[{"given":"Eileen H.","family":"Bigio","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"issue":"2","key":"i1543-2165-137-3-314-b01","series-title":"Arch Pathol Lab Med","first-page":"132","article-title":"Making the diagnosis of Alzheimer's disease: a primer for practicing pathologists","volume":"117","author":"Mirra\n              SS,","year":"1993","unstructured":"Mirra\n              SS, \n            \n              Hart\n              MN, \n            \n              Terry\n              RD\n            \n          . 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