{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:37:00Z","timestamp":1792147020356,"version":"4.4.0"},"reference-count":34,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>We report a case of indolent mantle cell lymphoma with progression to pleomorphic mantle cell lymphoma 8 years after initial presentation. The first lymph node biopsy showed expanded mantle zones composed of uniformly small B lymphocytes. A cyclin D1 immunohistochemical stain was negative and the patient was observed. Eight years later, the patient developed symptomatic splenomegaly. Microscopic examination of the spleen revealed expanded mantle zones with an increased number of large cells with irregular nuclear contours. Immunohistochemistry for cyclin D1 was positive. A repeat cyclin D1 immunohistochemical staining performed on the initial lymph node biopsy was positive, indicating an inadequate initial study. Immunoglobulin heavy-chain gene rearrangement studies confirmed clonal identity. A revised diagnosis of indolent mantle cell lymphoma with progression to pleomorphic mantle cell lymphoma was rendered. The differential diagnosis of mantle cell lymphoma, including clinical and morphologic variants, is discussed.<\/jats:p>","DOI":"10.5858\/arpa.2012-0197-cr","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T11:01:31Z","timestamp":1343732491000},"page":"871-875","source":"Crossref","is-referenced-by-count":11,"title":["Transformation of Indolent Mantle Cell Lymphoma to Pleomorphic Mantle Cell Lymphoma: Case Report and Review of Clinical and Morphologic Variants"],"prefix":"10.5858","volume":"136","author":[{"given":"Mark J.","family":"Kiel","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren B.","family":"Smith","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"issue":"2","key":"i1543-2165-136-8-871-b01","series-title":"Br J Haematol","first-page":"149","article-title":"Advances in the understanding of mantle cell lymphoma","volume":"142","author":"Jares\n              P,","year":"2008;","unstructured":"Jares\n              P, \n            \n              Campo\n              E. \n          \n          Advances in the understanding of mantle cell lymphoma. Br J Haematol. 2008;142(2):149\u2013165."},{"issue":"3","key":"i1543-2165-136-8-871-b02","series-title":"Cancer","first-page":"567","article-title":"Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors","volume":"82","author":"Bosch\n              F,","year":"1998;","unstructured":"Bosch\n              F, \n            \n              Lopez-Guillermo\n              A, \n            \n              Campo\n              E, \n            et al\n          . Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors. Cancer. 1998;82(3):567\u2013575."},{"issue":"11","key":"i1543-2165-136-8-871-b03","series-title":"Haematologica","first-page":"1488","article-title":"Mantle cell lymphoma","volume":"94","author":"Pileri\n              SA,","year":"2009;","unstructured":"Pileri\n              SA, \n            \n              Falini\n              B. \n          \n          Mantle cell lymphoma. Haematologica. 2009;94(11):1488\u20131492."},{"issue":"2","key":"i1543-2165-136-8-871-b04","series-title":"J Exp Med","first-page":"392","article-title":"The surface morphology of human B lymphocytes as revealed by immunoelectron microscopy","volume":"141","author":"Lejonc\n              RJ,","year":"1975;","unstructured":"Lejonc\n              RJ, \n            \n              Gourdin\n              MF, \n            \n              Mannoni\n              P, \n            \n              Dreyfus\n              B, \n            \n              Reyes\n              F. \n          \n          The surface morphology of human B lymphocytes as revealed by immunoelectron microscopy. J Exp Med. 1975;141(2):392\u2013410."},{"issue":"5","key":"i1543-2165-136-8-871-b05","series-title":"Mod Pathol","first-page":"517","article-title":"A comparative analysis of FISH, RT-PCR, PCR, and immunohistochemistry for the diagnosis of mantle cell lymphomas","volume":"15","author":"Belaud-Rotureau\n              MA,","year":"2002;","unstructured":"Belaud-Rotureau\n              MA, \n            \n              Parrens\n              M, \n            \n              Dubus\n              P, \n            \n              Garroste\n              JC, \n            \n              de Mascarel\n              A, \n            \n              Merlio\n              JP. \n          \n          A comparative analysis of FISH, RT-PCR, PCR, and immunohistochemistry for the diagnosis of mantle cell lymphomas. Mod Pathol. 2002;15(5):517\u2013525."},{"issue":"4","key":"i1543-2165-136-8-871-b06","series-title":"Blood","first-page":"1177","article-title":"Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization","volume":"88","author":"Vaandrager\n              JW,","year":"1996;","unstructured":"Vaandrager\n              JW, \n            \n              Schuuring\n              E, \n            \n              Zwikstra\n              E, \n            et al\n          . Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization. Blood. 1996;88(4):1177\u20131182."},{"issue":"5","key":"i1543-2165-136-8-871-b07","series-title":"Am J Clin Pathol","first-page":"699","article-title":"Immunophenotypic variations in mantle cell lymphoma","volume":"132","author":"Gao\n              J,","year":"2009;","unstructured":"Gao\n              J, \n            \n              Peterson\n              L, \n            \n              Nelson\n              B, \n            \n              Goolsby\n              C, \n            \n              Chen\n              YH. \n          \n          Immunophenotypic variations in mantle cell lymphoma. Am J Clin Pathol. 2009;132(5):699\u2013706."},{"issue":"13","key":"i1543-2165-136-8-871-b08","series-title":"Blood","first-page":"4315","article-title":"Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling","volume":"106","author":"Fu\n              K,","year":"2005;","unstructured":"Fu\n              K, \n            \n              Weisenburger\n              DD, \n            \n              Greiner\n              TC, \n            et al\n          . Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood. 2005;106(13):4315\u20134321."},{"issue":"10","key":"i1543-2165-136-8-871-b09","series-title":"J Clin Oncol","first-page":"1216","article-title":"Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature","volume":"25","author":"Salaverria\n              I,","year":"2007;","unstructured":"Salaverria\n              I, \n            \n              Zettl\n              A, \n            \n              Bea\n              S, \n            et al\n          . Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. J Clin Oncol. 2007;25(10):1216\u20131222."},{"issue":"4","key":"i1543-2165-136-8-871-b10","series-title":"Cancer Res","first-page":"1408","article-title":"Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma","volume":"70","author":"Fernandez\n              V,","year":"2010;","unstructured":"Fernandez\n              V, \n            \n              Salamero, \n            \n              Espinet\n              B, \n            et al\n          . Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma. 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Hum Pathol. 2003;34(10):1022\u20131029."},{"key":"i1543-2165-136-8-871-b14","series-title":"Mod Pathol","first-page":"105","article-title":"Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms","volume":"23","author":"Chen\n              YH,","year":"2010;","unstructured":"Chen\n              YH, \n            \n              Gao\n              J, \n            \n              Fan\n              G, \n            \n              Peterson\n              LC. \n          \n          Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. Mod Pathol. 2010;23:105\u2013112."},{"issue":"2","key":"i1543-2165-136-8-871-b15","series-title":"Am J Surg Pathol","first-page":"214","article-title":"Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression","volume":"36","author":"Zeng\n              W,","year":"2012;","unstructured":"Zeng\n              W, \n            \n              Fu\n              K, \n            \n              Quintanilla-Fend\n              L, \n            \n              Lim\n              M, \n            \n              Ondreijka\n              S, \n            \n              Hsi\n              D. \n          \n          Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression. Am J Surg Pathol. 2012;36(2):214\u2013219."},{"issue":"8","key":"i1543-2165-136-8-871-b16","series-title":"Haematologica","first-page":"1121","article-title":"Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis","volume":"96","author":"Ondrejka\n              SL,","year":"2011;","unstructured":"Ondrejka\n              SL, \n            \n              Lai\n              R, \n            \n              Smith\n              SD, \n            \n              Hsi\n              D. \n          \n          Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis. Haematologica. 2011;96(8):1121\u20131127."},{"issue":"18","key":"i1543-2165-136-8-871-b17","series-title":"Blood","first-page":"4215","article-title":"Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma","volume":"119","author":"Nygren\n              L,","year":"2012","unstructured":"Nygren\n              L, \n            \n              Baumgartner Wennerhold\n              M, \n            \n              Klimowska\n              M, \n          \n          et al. Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma. Blood. 2012;119(18):4215\u20134223."},{"issue":"2","key":"i1543-2165-136-8-871-b01","series-title":"Br J Haematol","first-page":"149","article-title":"Advances in the understanding of mantle cell lymphoma","volume":"142","author":"Jares\n              P,","year":"2008;","unstructured":"Jares\n              P, \n            \n              Campo\n              E. \n          \n          Advances in the understanding of mantle cell lymphoma. Br J Haematol. 2008;142(2):149\u2013165."},{"issue":"3","key":"i1543-2165-136-8-871-b02","series-title":"Cancer","first-page":"567","article-title":"Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors","volume":"82","author":"Bosch\n              F,","year":"1998;","unstructured":"Bosch\n              F, \n            \n              Lopez-Guillermo\n              A, \n            \n              Campo\n              E, \n            et al\n          . Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors. Cancer. 1998;82(3):567\u2013575."},{"issue":"11","key":"i1543-2165-136-8-871-b03","series-title":"Haematologica","first-page":"1488","article-title":"Mantle cell lymphoma","volume":"94","author":"Pileri\n              SA,","year":"2009;","unstructured":"Pileri\n              SA, \n            \n              Falini\n              B. \n          \n          Mantle cell lymphoma. Haematologica. 2009;94(11):1488\u20131492."},{"issue":"2","key":"i1543-2165-136-8-871-b04","series-title":"J Exp Med","first-page":"392","article-title":"The surface morphology of human B lymphocytes as revealed by immunoelectron microscopy","volume":"141","author":"Lejonc\n              RJ,","year":"1975;","unstructured":"Lejonc\n              RJ, \n            \n              Gourdin\n              MF, \n            \n              Mannoni\n              P, \n            \n              Dreyfus\n              B, \n            \n              Reyes\n              F. \n          \n          The surface morphology of human B lymphocytes as revealed by immunoelectron microscopy. J Exp Med. 1975;141(2):392\u2013410."},{"issue":"5","key":"i1543-2165-136-8-871-b05","series-title":"Mod Pathol","first-page":"517","article-title":"A comparative analysis of FISH, RT-PCR, PCR, and immunohistochemistry for the diagnosis of mantle cell lymphomas","volume":"15","author":"Belaud-Rotureau\n              MA,","year":"2002;","unstructured":"Belaud-Rotureau\n              MA, \n            \n              Parrens\n              M, \n            \n              Dubus\n              P, \n            \n              Garroste\n              JC, \n            \n              de Mascarel\n              A, \n            \n              Merlio\n              JP. \n          \n          A comparative analysis of FISH, RT-PCR, PCR, and immunohistochemistry for the diagnosis of mantle cell lymphomas. Mod Pathol. 2002;15(5):517\u2013525."},{"issue":"4","key":"i1543-2165-136-8-871-b06","series-title":"Blood","first-page":"1177","article-title":"Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization","volume":"88","author":"Vaandrager\n              JW,","year":"1996;","unstructured":"Vaandrager\n              JW, \n            \n              Schuuring\n              E, \n            \n              Zwikstra\n              E, \n            et al\n          . Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization. Blood. 1996;88(4):1177\u20131182."},{"issue":"5","key":"i1543-2165-136-8-871-b07","series-title":"Am J Clin Pathol","first-page":"699","article-title":"Immunophenotypic variations in mantle cell lymphoma","volume":"132","author":"Gao\n              J,","year":"2009;","unstructured":"Gao\n              J, \n            \n              Peterson\n              L, \n            \n              Nelson\n              B, \n            \n              Goolsby\n              C, \n            \n              Chen\n              YH. \n          \n          Immunophenotypic variations in mantle cell lymphoma. Am J Clin Pathol. 2009;132(5):699\u2013706."},{"issue":"13","key":"i1543-2165-136-8-871-b08","series-title":"Blood","first-page":"4315","article-title":"Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling","volume":"106","author":"Fu\n              K,","year":"2005;","unstructured":"Fu\n              K, \n            \n              Weisenburger\n              DD, \n            \n              Greiner\n              TC, \n            et al\n          . Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood. 2005;106(13):4315\u20134321."},{"issue":"10","key":"i1543-2165-136-8-871-b09","series-title":"J Clin Oncol","first-page":"1216","article-title":"Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature","volume":"25","author":"Salaverria\n              I,","year":"2007;","unstructured":"Salaverria\n              I, \n            \n              Zettl\n              A, \n            \n              Bea\n              S, \n            et al\n          . Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. J Clin Oncol. 2007;25(10):1216\u20131222."},{"issue":"4","key":"i1543-2165-136-8-871-b10","series-title":"Cancer Res","first-page":"1408","article-title":"Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma","volume":"70","author":"Fernandez\n              V,","year":"2010;","unstructured":"Fernandez\n              V, \n            \n              Salamero, \n            \n              Espinet\n              B, \n            et al\n          . Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma. Cancer Res. 2010;70(4):1408\u20131418."},{"issue":"11","key":"i1543-2165-136-8-871-b11","series-title":"Haematologica","first-page":"1555","article-title":"SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype","volume":"94","author":"Mozos\n              A,","year":"2009;","unstructured":"Mozos\n              A, \n            \n              Royo\n              C, \n            \n              Hartmann\n              E, \n            et al\n          . SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica. 2009;94(11):1555\u20131562."},{"issue":"4","key":"i1543-2165-136-8-871-b12","series-title":"Histopathology","first-page":"353","article-title":"Blastoid and common variants of mantle cell lymphoma exhibit distinct immunophenotypic and interphase FISH features","volume":"48","author":"Parrens\n              M,","year":"2006;","unstructured":"Parrens\n              M, \n            \n              Belaud-Rotureau\n              MA, \n            \n              Fitoussi\n              O, \n            et al\n          . Blastoid and common variants of mantle cell lymphoma exhibit distinct immunophenotypic and interphase FISH features. Histopathology. 2006;48(4):353\u2013362."},{"issue":"10","key":"i1543-2165-136-8-871-b13","series-title":"Hum Pathol","first-page":"1022","article-title":"Cytogenetic findings in blastoid mantle cell lymphoma","volume":"34","author":"Khoury\n              JD,","year":"2003;","unstructured":"Khoury\n              JD, \n            \n              Sen\n              F, \n            \n              Abruzzo\n              LV, \n            \n              Hayes\n              K, \n            \n              Glassman\n              A, \n            \n              Medeiros\n              LJ. \n          \n          Cytogenetic findings in blastoid mantle cell lymphoma. Hum Pathol. 2003;34(10):1022\u20131029."},{"key":"i1543-2165-136-8-871-b14","series-title":"Mod Pathol","first-page":"105","article-title":"Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms","volume":"23","author":"Chen\n              YH,","year":"2010;","unstructured":"Chen\n              YH, \n            \n              Gao\n              J, \n            \n              Fan\n              G, \n            \n              Peterson\n              LC. \n          \n          Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. Mod Pathol. 2010;23:105\u2013112."},{"issue":"2","key":"i1543-2165-136-8-871-b15","series-title":"Am J Surg Pathol","first-page":"214","article-title":"Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression","volume":"36","author":"Zeng\n              W,","year":"2012;","unstructured":"Zeng\n              W, \n            \n              Fu\n              K, \n            \n              Quintanilla-Fend\n              L, \n            \n              Lim\n              M, \n            \n              Ondreijka\n              S, \n            \n              Hsi\n              D. \n          \n          Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression. Am J Surg Pathol. 2012;36(2):214\u2013219."},{"issue":"8","key":"i1543-2165-136-8-871-b16","series-title":"Haematologica","first-page":"1121","article-title":"Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis","volume":"96","author":"Ondrejka\n              SL,","year":"2011;","unstructured":"Ondrejka\n              SL, \n            \n              Lai\n              R, \n            \n              Smith\n              SD, \n            \n              Hsi\n              D. \n          \n          Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis. Haematologica. 2011;96(8):1121\u20131127."},{"issue":"18","key":"i1543-2165-136-8-871-b17","series-title":"Blood","first-page":"4215","article-title":"Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma","volume":"119","author":"Nygren\n              L,","year":"2012","unstructured":"Nygren\n              L, \n            \n              Baumgartner Wennerhold\n              M, \n            \n              Klimowska\n              M, \n          \n          et al. Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma. Blood. 2012;119(18):4215\u20134223."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/136\/8\/article-p871.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/136\/8\/871\/2263891\/arpa_2012-0197-cr.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/136\/8\/article-p871.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/136\/8\/article-p871.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:14:02Z","timestamp":1770772442000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/136\/8\/article-p871.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":34,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.5858\/arpa.2012-0197-cr","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}