{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T04:17:47Z","timestamp":1770783467136,"version":"3.50.0"},"reference-count":106,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>\n                    <jats:italic>Context<\/jats:italic>\n                    .\u2014Cervical screening in the United States increasingly involves newer US Food and Drug Administration\u2013approved cytologic methods and adjunctive high-risk human papillomavirus (hrHPV) DNA testing.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    .\u2014To document cervical screening test performance preceding histopathologic cervical intraepithelial neoplasia (CIN) 2\/3 diagnoses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Design<\/jats:italic>\n                    .\u2014Preceding screening test results with computer-imaged, liquid-based cytology (LBC) and hrHPV results were analyzed for 2827 patients with histopathologic CIN 2\/3 diagnoses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    .\u2014Of 2827 patients with CIN 2\/3 diagnoses, 2074 (73.4%) had system LBC findings within 4 months of CIN 2\/3 diagnoses: high-grade squamous intraepithelial lesion (n = 862; 41.6%), low-grade squamous intraepithelial lesion (n = 464; 22.4%), atypical squamous cells of undetermined significance (n = 445; 21.5%), atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (n = 288; 13.9%), and atypical glandular cells\/adenocarcinoma in situ (n = 15; 0.7%). Of the 2827 patients, 1488 (52.6%) also had earlier system LBC results at more than 4 months to 3 years before CIN 2\/3 diagnoses: one or more abnormal LBC results (n = 978; 65.7%), one or more negative LBC results (n = 911; 61.2%), both abnormal and negative LBC (n = 401; 26.9%). Of 807 patients with hrHPV cotest results within 4 months of CIN 2\/3 diagnoses, 786 (97.4%) had hrHPV\n                    <jats:sup>+<\/jats:sup>\n                    results. Of 454 patients who also had earlier hrHPV results at more than 4 months to 3 years before CIN 2\/3 diagnoses: 377 (83.0%) had one or more hrHPV\n                    <jats:sup>+<\/jats:sup>\n                    result, 110 (24.2%) had one or more hrHPV\n                    <jats:sup>\u2212<\/jats:sup>\n                    result, and 33 (7.3%) had both positive and negative HPV results.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    .\u2014Patients with histopathologic CIN 2\/3 had recent abnormal LBC results, most often, high-grade squamous intraepithelial lesions. Among cotested patients, 97.4% (786 of 807) tested hrHPV\n                    <jats:sup>+<\/jats:sup>\n                    . However, a significant number of patients tested during an extended period of several years had earlier negative Papanicolaou or negative HPV test results, suggesting the recent development of some CIN 2\/3 lesions and supporting the value of cotesting for enhanced detection of other developing, small, inaccessible, or nondiagnostic precursor lesions.\n                  <\/jats:p>","DOI":"10.5858\/arpa.2012-0307-oa","type":"journal-article","created":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T14:54:02Z","timestamp":1349880842000},"page":"942-947","source":"Crossref","is-referenced-by-count":7,"title":["Cytology and Human Papillomavirus Screening Test Results Associated With 2827 Histopathologic Diagnoses of Cervical Intraepithelial Neoplasia 2\/3"],"prefix":"10.5858","volume":"137","author":[{"given":"Chengquan","family":"Zhao","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Zhao, Amin, Kanbour-Shakir, and Austin; and the Department of Pathology, Conemaugh Health System, Johnstown, Pennsylvania (Drs Weng and Chen)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milon","family":"Amin","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Zhao, Amin, Kanbour-Shakir, and Austin; and the Department of Pathology, Conemaugh Health System, Johnstown, Pennsylvania (Drs Weng and Chen)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoying","family":"Weng","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Zhao, Amin, Kanbour-Shakir, and Austin; and the Department of Pathology, Conemaugh Health System, Johnstown, Pennsylvania (Drs Weng and Chen)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangbai","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Zhao, Amin, Kanbour-Shakir, and Austin; and the Department of Pathology, Conemaugh Health System, Johnstown, Pennsylvania (Drs Weng and Chen)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Kanbour-Shakir","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Zhao, Amin, Kanbour-Shakir, and Austin; and the Department of Pathology, Conemaugh Health System, Johnstown, Pennsylvania (Drs Weng and Chen)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Marshall","family":"Austin","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Zhao, Amin, Kanbour-Shakir, and Austin; and the Department of Pathology, Conemaugh Health System, Johnstown, Pennsylvania (Drs Weng and Chen)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"1","key":"i1543-2165-137-7-942-b01","series-title":"Gynecol Oncol","first-page":"64","article-title":"Screening as a prognostic factor in cervical cancer: analysis of survival and prognostic factors based on Icelandic population data, 1964\u20131988","volume":"43","author":"Sigurdsson\n              K,","year":"1991","unstructured":"Sigurdsson\n              K, \n            \n              Hrafnkelsson\n              J, \n            \n              Geirsson\n              G, \n            \n              Gudmundsson\n              J, \n            \n              Salvarsd\u00f3ttir\n              A. \n          \n          Screening as a prognostic factor in cervical cancer: analysis of survival and prognostic factors based on Icelandic population data, 1964\u20131988. 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