{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:16:22Z","timestamp":1770786982700,"version":"3.50.0"},"reference-count":24,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2]]},"abstract":"\n Spindle cell neoplasms are rarely reported in liver allografts; most are benign and associated with Epstein\u2013Barr virus infection. We present a case of a malignant spindle cell neoplasm arising in a liver allograft. The patient underwent orthotopic liver transplant for cirrhosis secondary to nonalcoholic steatohepatitis. After 2 years, he presented with vague abdominal complaints. Imaging studies revealed a 10-cm right hepatic lobe mass. The patient underwent right-sided hepatectomy. The tumor displayed areas of broad, relatively hypocellular fascicles, whorls, and perivascular clustering; spindle cells with mild to moderate nuclear pleomorphism; and relatively abundant eosinophilic cytoplasm. Mitotic activity ranged from 2 to 4 mitotic figures per 20 high-power fields. Immunostaining displayed positivity for epithelial membrane antigen, vimentin, CD99, BCL2, cytokeratin, and human herpesvirus 8. Interphase fluorescence in situ hybridization findings were negative for a translocation involving the\n SS18<\/jats:italic>\n gene (18q11). We believe the tumor represents the first reported case of a novel unclassified spindle cell malignant neoplasm in a liver allograft.\n <\/jats:p>","DOI":"10.5858\/arpa.2012-0480-cr","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T08:29:13Z","timestamp":1391070553000},"page":"274-277","source":"Crossref","is-referenced-by-count":4,"title":["A De Novo Unclassified Malignant Spindle Cell Neoplasm of Liver Allograft"],"prefix":"10.5858","volume":"138","author":[{"given":"Jessica A.","family":"Clevenger","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romil","family":"Saxena","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad T.","family":"Idrees","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"suppl 2","key":"i1543-2165-138-2-274-b01","series-title":"Liver Transpl","first-page":"S90","article-title":"De novo malignancies following liver transplantation: impact and recommendations","volume":"15","author":"Herrero\n JI.","year":"2009","unstructured":"Herrero\n JI. \n \n De novo malignancies following liver transplantation: impact and recommendations. Liver Transpl. 2009;15(suppl 2):S90\u2013S94."},{"issue":"7","key":"i1543-2165-138-2-274-b02","series-title":"Am J Transplant","first-page":"1908","article-title":"Molecular and clinicopathological analysis of Epstein-Barr virus-associated posttransplant smooth muscle tumors","volume":"12","author":"Jonigk\n D,","year":"2012","unstructured":"Jonigk\n D, \n \n Laenger\n F, \n \n Maegel\n L, \n et al\n . Molecular and clinicopathological analysis of Epstein-Barr virus-associated posttransplant smooth muscle tumors. Am J Transplant. 2012;12(7):1908\u20131917."},{"issue":"2","key":"i1543-2165-138-2-274-b03","series-title":"Liver Transpl","first-page":"320","article-title":"De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report","volume":"10","author":"Chan\n SC,","year":"2004","unstructured":"Chan\n SC, \n \n Cheung\n ST, \n \n Leung\n SY, \n et al\n . De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report. Liver Transpl. 2004;10(2):320\u2013323."},{"issue":"2","key":"i1543-2165-138-2-274-b04","series-title":"Transplant Proc","first-page":"709","article-title":"De novo malignancies in liver transplantation","volume":"35","author":"Valero\n JM,","year":"2003","unstructured":"Valero\n JM, \n \n Rubio\n E, \n \n Moreno\n JM, \n et al\n . De novo malignancies in liver transplantation. Transplant Proc. 2003;35(2):709\u2013711."},{"issue":"1","key":"i1543-2165-138-2-274-b05","series-title":"Am J Surg Pathol","first-page":"75","article-title":"Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients","volume":"30","author":"Deyrup\n AT,","year":"2006","unstructured":"Deyrup\n AT, \n \n Lee\n VK, \n \n Hill\n CE, \n et al\n . Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol. 2006;30(1):75\u201382."},{"issue":"1","key":"i1543-2165-138-2-274-b06","series-title":"N Engl J Med","first-page":"19","article-title":"The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation","volume":"332","author":"Lee\n ES,","year":"1995","unstructured":"Lee\n ES, \n \n Locker\n J, \n \n Nalesnik\n M, \n et al\n . The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation. N Engl J Med. 1995;332(1):19\u201325."},{"issue":"11","key":"i1543-2165-138-2-274-b07","series-title":"J Heart Lung Transplant","first-page":"1217","article-title":"EBV-associated hepatic smooth muscle tumor after lung transplantation: report of a case and review of the literature","volume":"28","author":"Salamanca\n J,","year":"2009","unstructured":"Salamanca\n J, \n \n Massa\n DS. \n \n EBV-associated hepatic smooth muscle tumor after lung transplantation: report of a case and review of the literature. J Heart Lung Transplant. 2009;28(11):1217\u20131220."},{"issue":"3","key":"i1543-2165-138-2-274-b08","series-title":"Pathology","first-page":"245","article-title":"Epstein-Barr virus-associated smooth muscle tumour: a distinctive mesenchymal tumour of immunocompromised individuals","volume":"34","author":"Cheuk\n W,","year":"2002","unstructured":"Cheuk\n W, \n \n Li\n PC, \n \n Chan\n JK. \n \n Epstein-Barr virus-associated smooth muscle tumour: a distinctive mesenchymal tumour of immunocompromised individuals. Pathology. 2002;34(3):245\u2013249."},{"issue":"11","key":"i1543-2165-138-2-274-b09","series-title":"Oncogene","first-page":"1656","article-title":"Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13","volume":"26","author":"Matta\n H,","year":"2007","unstructured":"Matta\n H, \n \n Surabhi\n RM, \n \n Zhao\n J, \n et al\n . Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13. Oncogene. 2007;26(11):1656\u20131660."},{"issue":"5417","key":"i1543-2165-138-2-274-b10","series-title":"Science","first-page":"1168","article-title":"Bone marrow as a potential source of hepatic oval cells","volume":"284","author":"Petersen\n BE,","year":"1999","unstructured":"Petersen\n BE, \n \n Bowen\n WC, \n \n Patrene\n KD, \n et al\n . Bone marrow as a potential source of hepatic oval cells. Science. 1999;284(5417):1168\u20131170."},{"issue":"1","key":"i1543-2165-138-2-274-b11","series-title":"Hepatology","first-page":"11","article-title":"Liver from bone marrow in humans","volume":"32","author":"Theise\n ND,","year":"2000","unstructured":"Theise\n ND, \n \n Nimmakayalu\n M, \n \n Gardner\n R, \n et al\n . Liver from bone marrow in humans. Hepatology. 2000;32(1):11\u201316."},{"issue":"6","key":"i1543-2165-138-2-274-b12","series-title":"Liver Transpl","first-page":"552","article-title":"Extensive chimerism in liver transplants: vascular endothelium, bile duct epithelium, and hepatocytes","volume":"9","author":"Hove\n WR,","year":"2003","unstructured":"Hove\n WR, \n \n van Hoek\n B, \n \n Bajema\n IM, \n et al\n . Extensive chimerism in liver transplants: vascular endothelium, bile duct epithelium, and hepatocytes. Liver Transpl. 2003;9(6):552\u2013556."},{"issue":"suppl 2","key":"i1543-2165-138-2-274-b01","series-title":"Liver Transpl","first-page":"S90","article-title":"De novo malignancies following liver transplantation: impact and recommendations","volume":"15","author":"Herrero\n JI.","year":"2009","unstructured":"Herrero\n JI. \n \n De novo malignancies following liver transplantation: impact and recommendations. Liver Transpl. 2009;15(suppl 2):S90\u2013S94."},{"issue":"7","key":"i1543-2165-138-2-274-b02","series-title":"Am J Transplant","first-page":"1908","article-title":"Molecular and clinicopathological analysis of Epstein-Barr virus-associated posttransplant smooth muscle tumors","volume":"12","author":"Jonigk\n D,","year":"2012","unstructured":"Jonigk\n D, \n \n Laenger\n F, \n \n Maegel\n L, \n et al\n . Molecular and clinicopathological analysis of Epstein-Barr virus-associated posttransplant smooth muscle tumors. Am J Transplant. 2012;12(7):1908\u20131917."},{"issue":"2","key":"i1543-2165-138-2-274-b03","series-title":"Liver Transpl","first-page":"320","article-title":"De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report","volume":"10","author":"Chan\n SC,","year":"2004","unstructured":"Chan\n SC, \n \n Cheung\n ST, \n \n Leung\n SY, \n et al\n . De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report. Liver Transpl. 2004;10(2):320\u2013323."},{"issue":"2","key":"i1543-2165-138-2-274-b04","series-title":"Transplant Proc","first-page":"709","article-title":"De novo malignancies in liver transplantation","volume":"35","author":"Valero\n JM,","year":"2003","unstructured":"Valero\n JM, \n \n Rubio\n E, \n \n Moreno\n JM, \n et al\n . De novo malignancies in liver transplantation. Transplant Proc. 2003;35(2):709\u2013711."},{"issue":"1","key":"i1543-2165-138-2-274-b05","series-title":"Am J Surg Pathol","first-page":"75","article-title":"Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients","volume":"30","author":"Deyrup\n AT,","year":"2006","unstructured":"Deyrup\n AT, \n \n Lee\n VK, \n \n Hill\n CE, \n et al\n . Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol. 2006;30(1):75\u201382."},{"issue":"1","key":"i1543-2165-138-2-274-b06","series-title":"N Engl J Med","first-page":"19","article-title":"The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation","volume":"332","author":"Lee\n ES,","year":"1995","unstructured":"Lee\n ES, \n \n Locker\n J, \n \n Nalesnik\n M, \n et al\n . The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation. N Engl J Med. 1995;332(1):19\u201325."},{"issue":"11","key":"i1543-2165-138-2-274-b07","series-title":"J Heart Lung Transplant","first-page":"1217","article-title":"EBV-associated hepatic smooth muscle tumor after lung transplantation: report of a case and review of the literature","volume":"28","author":"Salamanca\n J,","year":"2009","unstructured":"Salamanca\n J, \n \n Massa\n DS. \n \n EBV-associated hepatic smooth muscle tumor after lung transplantation: report of a case and review of the literature. J Heart Lung Transplant. 2009;28(11):1217\u20131220."},{"issue":"3","key":"i1543-2165-138-2-274-b08","series-title":"Pathology","first-page":"245","article-title":"Epstein-Barr virus-associated smooth muscle tumour: a distinctive mesenchymal tumour of immunocompromised individuals","volume":"34","author":"Cheuk\n W,","year":"2002","unstructured":"Cheuk\n W, \n \n Li\n PC, \n \n Chan\n JK. \n \n Epstein-Barr virus-associated smooth muscle tumour: a distinctive mesenchymal tumour of immunocompromised individuals. Pathology. 2002;34(3):245\u2013249."},{"issue":"11","key":"i1543-2165-138-2-274-b09","series-title":"Oncogene","first-page":"1656","article-title":"Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13","volume":"26","author":"Matta\n H,","year":"2007","unstructured":"Matta\n H, \n \n Surabhi\n RM, \n \n Zhao\n J, \n et al\n . Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13. Oncogene. 2007;26(11):1656\u20131660."},{"issue":"5417","key":"i1543-2165-138-2-274-b10","series-title":"Science","first-page":"1168","article-title":"Bone marrow as a potential source of hepatic oval cells","volume":"284","author":"Petersen\n BE,","year":"1999","unstructured":"Petersen\n BE, \n \n Bowen\n WC, \n \n Patrene\n KD, \n et al\n . Bone marrow as a potential source of hepatic oval cells. Science. 1999;284(5417):1168\u20131170."},{"issue":"1","key":"i1543-2165-138-2-274-b11","series-title":"Hepatology","first-page":"11","article-title":"Liver from bone marrow in humans","volume":"32","author":"Theise\n ND,","year":"2000","unstructured":"Theise\n ND, \n \n Nimmakayalu\n M, \n \n Gardner\n R, \n et al\n . Liver from bone marrow in humans. Hepatology. 2000;32(1):11\u201316."},{"issue":"6","key":"i1543-2165-138-2-274-b12","series-title":"Liver Transpl","first-page":"552","article-title":"Extensive chimerism in liver transplants: vascular endothelium, bile duct epithelium, and hepatocytes","volume":"9","author":"Hove\n WR,","year":"2003","unstructured":"Hove\n WR, \n \n van Hoek\n B, \n \n Bajema\n IM, \n et al\n . Extensive chimerism in liver transplants: vascular endothelium, bile duct epithelium, and hepatocytes. Liver Transpl. 2003;9(6):552\u2013556."}],"container-title":["Archives of Pathology and Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/138\/2\/article-p274.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/138\/2\/274\/2271138\/arpa_2012-0480-cr.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/138\/2\/article-p274.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/138\/2\/article-p274.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:01:01Z","timestamp":1770771661000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/138\/2\/article-p274.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":24,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5858\/arpa.2012-0480-cr","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}