{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:45:35Z","timestamp":1770810335066,"version":"3.50.0"},"reference-count":62,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Frontotemporal lobar degenerations are clinically, genetically, and molecularly heterogeneous diseases characterized by mainly frontal and temporal atrophy and affecting behavioral, language, cognitive, and motor functions. The term\n                    <jats:italic>frontotemporal dementia<\/jats:italic>\n                    incorporates 3 distinct clinical syndromes seen in frontotemporal degenerations: behavioral variant of frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia. Progressive supranuclear palsy syndrome, corticobasal syndrome, and motor neuron disease syndrome are also associated with frontotemporal lobar degenerations. The neuropathologic hallmark of frontotemporal lobar degenerations is accumulation of abnormal proteins in the cytoplasm and nuclei of neurons and glial cells. Proteins involved in pathologic processes that represent the basis for frontotemporal lobar degeneration classification are tau protein, transactive response DNA-binding protein of 43 kDa, and \u201cfused in sarcoma\u201d protein. The aim of this review is to provide a summary of practical approaches for neuropathologic diagnostics of the rapidly evolving classifications of frontotemporal lobar degenerations.\n                  <\/jats:p>","DOI":"10.5858\/arpa.2012-0510-rs","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T17:14:49Z","timestamp":1388423689000},"page":"132-138","source":"Crossref","is-referenced-by-count":13,"title":["Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations: A Practical Approach"],"prefix":"10.5858","volume":"138","author":[{"given":"Zdenek","family":"Rohan","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Molecular Medicine, Thomayer Hospital, and the Department of Pathology, Third Faculty of Medicine, Charles University, Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radoslav","family":"Matej","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Molecular Medicine, Thomayer Hospital, and the Department of Pathology, Third Faculty of Medicine, Charles University, Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"suppl 5","key":"i1543-2165-138-1-132-b01","series-title":"Ann Neurol","first-page":"S29","article-title":"Epidemiology and genetics of frontotemporal dementia\/Pick's disease","volume":"54","author":"Bird\n              T,","year":"2003","unstructured":"Bird\n              T, \n            \n              Knopman\n              D, \n            \n              VanSwieten\n              J, \n            et al\n          . 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