{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T04:23:09Z","timestamp":1770783789396,"version":"3.50.0"},"reference-count":254,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3]]},"abstract":"\n Context.\u2014<\/jats:italic>\n Hematopathology is a dynamic field that has always been on the frontier of clinical research within the scope of pathology. Several recent developments in hematopathology will likely affect its practice clinically.\n <\/jats:p>\n \n Objective.\u2014<\/jats:italic>\n To review 5 important recent advances in hematopathology: (1) detection and prognostic implication of\n MYC<\/jats:italic>\n in diffuse large B-cell lymphomas, (2) determining origin and prognosis through immunoglobulin gene usage in mature B-cell neoplasms, (3)detecting minimal residual disease in multiple myeloma, (4) using genome-wide analysis in myelodysplastic syndromes, and (5) employing whole-genome sequencing in acute myeloid leukemias.\n <\/jats:p>\n \n Data Sources.\u2014<\/jats:italic>\n Literature review and the authors' experiences in an academic center.\n <\/jats:p>\n \n Conclusions.\u2014<\/jats:italic>\n These advances will bring hematopathology into a new molecular era and help us to better understand the molecular, pathologic mechanisms of lymphomas, leukemias, myelomas, and myelodysplastic syndromes. They will help us to identify diagnostic and prognostic markers and eventually provide new therapeutic targets and treatments for these diseases.\n <\/jats:p>","DOI":"10.5858\/arpa.2012-0645-ra","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T15:06:56Z","timestamp":1393513616000},"page":"410-419","source":"Crossref","is-referenced-by-count":4,"title":["Five Important Advances in Hematopathology"],"prefix":"10.5858","volume":"138","author":[{"given":"Min","family":"Shi","sequence":"first","affiliation":[{"name":"From the Department of Pathology, UMass Memorial Medical Center, Worcester, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruobing","family":"Xiao","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, UMass Memorial Medical Center, Worcester, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Woda","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, UMass Memorial Medical Center, Worcester, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Yu","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, UMass Memorial Medical Center, Worcester, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"24","key":"i1543-2165-138-3-410-b01","series-title":"Proc Natl Acad Sci. 982;","first-page":"7824","article-title":"Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells","volume":"79","author":"Dalla-Favera\n R,","unstructured":"Dalla-Favera\n R, \n \n Bregni\n M, \n \n Erikson\n J, \n \n Patterson\n D, \n \n Gallo\n RC, \n \n Croce\n CM. \n \n Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.Proc Natl Acad Sci. 982;79(24):7824\u20137827."},{"issue":"8","key":"i1543-2165-138-3-410-b02","series-title":"Nat Rev Mol Cell Biol","first-page":"635","article-title":"Transcriptional regulation and transformation by Myc proteins","volume":"6","author":"Adhikary\n S,","year":"2005","unstructured":"Adhikary\n S, \n \n Eilers\n M. \n \n Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol. 2005;6(8):635\u2013645."},{"issue":"4","key":"i1543-2165-138-3-410-b03","series-title":"Semin Cancer Biol","first-page":"253","article-title":"The c-Myc target gene network","volume":"16","author":"Dang\n CV,","year":"2006","unstructured":"Dang\n CV, \n \n O'Donnell\n KA, \n \n Zeller\n KI, \n \n Nguyen\n T, \n \n Osthus\n RC, \n \n Li\n F. \n \n The c-Myc target gene network. Semin Cancer Biol. 2006;16(4):253\u2013264."},{"issue":"4","key":"i1543-2165-138-3-410-b04","series-title":"Br J Haematol","first-page":"484","article-title":"Advances in the understanding of MYC-induced lymphomagenesis","volume":"149","author":"Klapproth\n K,","year":"2010","unstructured":"Klapproth\n K, \n \n Wirth\n T. \n \n Advances in the understanding of MYC-induced lymphomagenesis. Br J Haematol. 2010;149(4):484\u2013497."},{"issue":"7152","key":"i1543-2165-138-3-410-b05","series-title":"Nature","first-page":"445","article-title":"Non-transcriptional control of DNA replication by c-Myc","volume":"448","author":"Dominguez-Sola\n D,","year":"2007","unstructured":"Dominguez-Sola\n D, \n \n Ying\n CY, \n \n Grandori\n C, \n et al\n . Non-transcriptional control of DNA replication by c-Myc. Nature. 2007;448(7152):445\u2013451."},{"key":"i1543-2165-138-3-410-b06","series-title":"Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed","first-page":"233","article-title":"Diffuse large B-cell lymphoma, not otherwise specified","author":"Stein\n H,","year":"2008","unstructured":"Stein\n H, \n \n Warnke\n RA, \n \n Chan\n WC\n \n et al\n . Diffuse large B-cell lymphoma, not otherwise specified. In: Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press;2008:233\u2013237. World Health Organization Classification of Tumours; vol 2."},{"issue":"4","key":"i1543-2165-138-3-410-b07","series-title":"Blood Cells Mol Dis","first-page":"317","article-title":"The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma","volume":"45","author":"Smith\n SM,","year":"2010","unstructured":"Smith\n SM, \n \n Anastasi\n J, \n \n Cohen\n KS, \n \n Godley\n LA. \n \n The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma. Blood Cells Mol Dis. 2010;45(4):317\u2013323."},{"issue":"6769","key":"i1543-2165-138-3-410-b08","series-title":"Nature","first-page":"503","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh\n AA,","year":"2000","unstructured":"Alizadeh\n AA, \n \n Eisen\n MB, \n \n Davis\n RE, \n et al\n . Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403(6769):503\u2013511."},{"issue":"25","key":"i1543-2165-138-3-410-b09","series-title":"N Engl J Med","first-page":"1937","article-title":"The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma","volume":"346","author":"Rosenwald\n A,","year":"2002","unstructured":"Rosenwald\n A, \n \n Wright\n G, \n \n Chan\n WC, \n et al\n . The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346(25):1937\u20131947."},{"issue":"1","key":"i1543-2165-138-3-410-b10","series-title":"Blood","first-page":"275","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans\n CP,","year":"2004","unstructured":"Hans\n CP, \n \n Weisenburger\n DD, \n \n Greiner\n TC, \n et al\n . Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103(1):275\u2013282."},{"issue":"3","key":"i1543-2165-138-3-410-b11","series-title":"Adv Anat Pathol","first-page":"219","article-title":"and aggressive B-cell lymphomas","volume":"18","author":"Slack\n GW,","year":"2011","unstructured":"Slack\n GW, \n \n Gascoyne\n RD. MYC\n \n \n and aggressive B-cell lymphomas. Adv Anat Pathol. 2011;18(3):219\u2013228."},{"issue":"17","key":"i1543-2165-138-3-410-b12","series-title":"Blood","first-page":"3533","article-title":"MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy","volume":"114","author":"Savage\n KJ,","year":"2009","unstructured":"Savage\n KJ, \n \n Johnson\n NA, \n \n Ben-Neriah\n S, \n et al\n . MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. Blood. 2009;114(17):3533\u20133537."},{"issue":"2","key":"i1543-2165-138-3-410-b13","series-title":"Cancer Sci","first-page":"233","article-title":"Clinical significance of 8q24\/c-MYC translocation in diffuse large B-cell lymphoma","volume":"100","author":"Nitsu\n N,","year":"2009","unstructured":"Nitsu\n N, \n \n Okamoto\n M, \n \n Miura\n I, \n \n Hirano\n M. \n \n Clinical significance of 8q24\/c-MYC translocation in diffuse large B-cell lymphoma. Cancer Sci. 2009;100(2):233\u2013237."},{"issue":"2","key":"i1543-2165-138-3-410-b14","series-title":"Leukemia","first-page":"323","article-title":"FAB\/LMB 96 International Study Committee. 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Leukemia. 2009;23(2):323\u2013331."},{"issue":"20","key":"i1543-2165-138-3-410-b15","series-title":"J Clin Oncol","first-page":"3360","article-title":"Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab","volume":"28","author":"Barrans\n S,","year":"2010","unstructured":"Barrans\n S, \n \n Crouch\n S, \n \n Smith\n A, \n et al\n . Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab. J Clin Oncol. 2010;28(20):3360\u20133365."},{"issue":"28","key":"i1543-2165-138-3-410-b16","series-title":"J Clin Oncol","first-page":"3452","article-title":"Concurrent Expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone","volume":"30","author":"Johnson\n NA,","year":"2012","unstructured":"Johnson\n NA, \n \n Slack\n GW, \n \n Savage\n KJ, \n et al\n . Concurrent Expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 2012; 30(28):3452\u20133459."},{"issue":"12","key":"i1543-2165-138-3-410-b17","series-title":"Leukemia","first-page":"2226","article-title":"German High-Grade Non-Hodgkin's Lymphoma Study Group. Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)","volume":"22","author":"Klapper\n W,","year":"2008","unstructured":"Klapper\n W, \n \n Stoecklein\n H, \n \n Zeynalova\n S, \n et al;\n \n German High-Grade Non-Hodgkin's Lymphoma Study Group. 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J Clin Oncol. 2009;27(33):5573\u20135579."},{"issue":"4","key":"i1543-2165-138-3-410-b19","series-title":"Am J Surg Pathol","first-page":"612","article-title":"High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma","volume":"36","author":"Green\n TM,","year":"2012","unstructured":"Green\n TM, \n \n Nielsen\n O, \n \n de Stricker\n K, \n \n Xu-Monette\n ZY, \n \n Young\n KH, \n \n Moller\n MB. \n \n High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma. Am J Surg Pathol. 2012;36(4):612\u2013619."},{"issue":"4","key":"i1543-2165-138-3-410-b20","series-title":"PLoS One","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033813","article-title":"Immunohistochemical detection of MYC-driven diffuse large B-cell lymphomas","volume":"7","author":"Kluk\n MJ,","year":"2012","unstructured":"Kluk\n MJ, \n \n Chapuy\n B, \n \n Sinha\n P, \n et al\n . 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Am J Surg Pathol. 2010;34(6):882\u2013891."},{"issue":"28","key":"i1543-2165-138-3-410-b22","series-title":"J Clin Oncol","first-page":"3460","article-title":"Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone","volume":"30","author":"Green\n TM,","year":"2012","unstructured":"Green\n TM, \n \n Young\n KH, \n \n Visco\n C, \n et al\n . Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 2012; 30(28):3460\u20133467."},{"key":"i1543-2165-138-3-410-b23","series-title":"Annu Rev Genet","first-page":"23","article-title":"Immunoglobulin gene diversification","volume":"39","author":"Maizels\n N.","year":"2005","unstructured":"Maizels\n N. \n \n Immunoglobulin gene diversification. Annu Rev Genet. 2005;39:23\u201346."},{"issue":"20","key":"i1543-2165-138-3-410-b24","series-title":"N Engl J Med","first-page":"1520","article-title":"Cellular origin of human B-cell lymphomas","volume":"341","author":"Kuppers\n R,","year":"1999","unstructured":"Kuppers\n R, \n \n Klein\n U, \n \n Hansmann\n ML, \n \n Rajewsky\n K. \n \n Cellular origin of human B-cell lymphomas. N Engl J Med. 1999;341(20):1520\u20131529."},{"issue":"1","key":"i1543-2165-138-3-410-b25","series-title":"Blood Rev","first-page":"25","article-title":"Prognostic markers in chronic lymphocytic leukemia: a comprehensive review","volume":"23","author":"Van Bockstaele\n F,","year":"2009","unstructured":"Van Bockstaele\n F, \n \n Verhasselt\n B, \n \n Philippe\n J. \n \n Prognostic markers in chronic lymphocytic leukemia: a comprehensive review. Blood Rev. 2009;23(1):25\u201347."},{"issue":"1","key":"i1543-2165-138-3-410-b26","series-title":"Best Pract Res Clin Haematol","first-page":"97","article-title":"Clinical impact of molecular diagnostics in low-grade lymphoma","volume":"18","author":"Bahloul\n M,","year":"2005","unstructured":"Bahloul\n M, \n \n Asnafi\n V, \n \n Macintyre\n E. \n \n Clinical impact of molecular diagnostics in low-grade lymphoma. 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Br J Haematol. 2001;115(4):854\u2013861."},{"issue":"6","key":"i1543-2165-138-3-410-b30","series-title":"Blood","first-page":"1902","article-title":"CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia","volume":"97","author":"Matrai\n Z,","year":"2001","unstructured":"Matrai\n Z, \n \n Lin\n K, \n \n Dennis\n M, \n et al\n . CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia. Blood. 2001;97(6):1902\u20131903."},{"issue":"3","key":"i1543-2165-138-3-410-b31","series-title":"Blood","first-page":"1023","article-title":"CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease","volume":"99","author":"Hamblin\n TJ,","year":"2002","unstructured":"Hamblin\n TJ, \n \n Orchard\n JA, \n \n Ibbotson\n RE, \n et al\n . 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Blood. 2002;99(6):2262\u20132264."},{"issue":"4","key":"i1543-2165-138-3-410-b33","series-title":"Blood","first-page":"1262","article-title":"The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression","volume":"101","author":"Ghia\n P,","year":"2003","unstructured":"Ghia\n P, \n \n Guida\n G, \n \n Stella\n S, \n et al\n . The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood. 2003;101(4):1262\u20131269."},{"issue":"12","key":"i1543-2165-138-3-410-b34","series-title":"Blood","first-page":"4952","article-title":"Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted V\u03bb2\u201314 gene use and homologous CDR3s: implicating recognition of a common antigen epitope","volume":"101","author":"Tobin\n G,","year":"2003","unstructured":"Tobin\n G, \n \n Thunberg\n U, \n \n Johnson\n A, \n et al\n . 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J Clin Oncol. 2003;21(21):3928\u20133932."},{"issue":"6","key":"i1543-2165-138-3-410-b36","series-title":"Eur J Haematol","first-page":"407","article-title":"VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia","volume":"73","author":"Aleskog\n A,","year":"2004","unstructured":"Aleskog\n A, \n \n Tobin\n G, \n \n Laurell\n A, \n et al\n . VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia. Eur J Haematol. 2004;73(6):407\u2013411."},{"issue":"5","key":"i1543-2165-138-3-410-b37","series-title":"J Mol Diagn","first-page":"566","article-title":"Immunoglobulin mutational status detected through single-round amplification of partial V(H) region represents a good prognostic marker for clinical outcome in chronic lymphocytic leukemia","volume":"7","author":"Marasca\n R,","year":"2005","unstructured":"Marasca\n R, \n \n Maffei\n R, \n \n Morselli\n M, \n et al\n . 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Blood. 2006;107(7):2889\u20132894."},{"issue":"4","key":"i1543-2165-138-3-410-b39","series-title":"Haematologica","first-page":"465","article-title":"Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome","volume":"90","author":"Tobin\n G,","year":"2005","unstructured":"Tobin\n G, \n \n Thunberg\n U, \n \n Laurell\n A, \n et al\n . Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome. Haematologica. 2005;90(4):465\u2013469."},{"issue":"7","key":"i1543-2165-138-3-410-b40","series-title":"Blood","first-page":"2615","article-title":"B-chronic lymphocytic leukemia: a malignancy of anti-self B cells","volume":"87","author":"Caligaris-Cappio\n F.","year":"1996","unstructured":"Caligaris-Cappio\n F. \n \n B-chronic lymphocytic leukemia: a malignancy of anti-self B cells. 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Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research","volume":"124","author":"Bertoni\n F,","year":"2004","unstructured":"Bertoni\n F, \n \n Conconi\n A, \n \n Cogliatti\n SB, \n et al;\n \n Swiss Group for Clinical Cancer Research. Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research. Br J Haematol. 2004;124(3):289\u2013298."},{"issue":"8","key":"i1543-2165-138-3-410-b49","series-title":"Blood","first-page":"3003","article-title":"VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome","volume":"102","author":"Kienle\n D,","year":"2003","unstructured":"Kienle\n D, \n \n Krober\n A, \n \n Katzenberger\n T, \n et al\n . 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Br J Dermatol. 2010;162(3):611\u2013618."},{"issue":"11","key":"i1543-2165-138-3-410-b66","series-title":"Invest Ophthalmol Vis Sci","first-page":"2450","article-title":"Immunoglobulin heavy chain gene analysis of ocular adnexal extranodal marginal zone B-cell lymphoma","volume":"42","author":"Hara\n Y,","year":"2001","unstructured":"Hara\n Y, \n \n Nakamura\n N, \n \n Kuze\n T, \n et al\n . Immunoglobulin heavy chain gene analysis of ocular adnexal extranodal marginal zone B-cell lymphoma. 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New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. Blood. 2007;110(13):4385\u20134395."},{"issue":"8","key":"i1543-2165-138-3-410-b89","series-title":"Blood","first-page":"3412","article-title":"High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival","volume":"112","author":"Starczynowski\n DT,","year":"2008","unstructured":"Starczynowski\n DT, \n \n Vercauteren\n S, \n \n Telenius\n A, \n et al\n . High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood. 2008;112(8):3412\u20133424."},{"key":"i1543-2165-138-3-410-b90","series-title":"Mol Cytogenet","first-page":"23","article-title":"Assessing karyotype precision by microarray-based comparative genomic hybridization in the myelodysplastic\/myeloproliferative syndromes","volume":"3","author":"Slovak\n ML,","year":"2010","unstructured":"Slovak\n ML, \n \n Smith\n DD, \n \n Bedell\n V, \n et al\n . Assessing karyotype precision by microarray-based comparative genomic hybridization in the myelodysplastic\/myeloproliferative syndromes. Mol Cytogenet. 2010;3:23."},{"issue":"1","key":"i1543-2165-138-3-410-b91","series-title":"Am J Clin Pathol","first-page":"119","article-title":"Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities","volume":"134","author":"Vercauteren\n SM,","year":"2010","unstructured":"Vercauteren\n SM, \n \n Sung\n S, \n \n Starczynowski\n DT, \n et al\n . Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. Am J Clin Pathol. 2010;134(1):119\u2013126."},{"issue":"2","key":"i1543-2165-138-3-410-b92","series-title":"Exp Hematol","first-page":"240","article-title":"High-resolution genomic arrays facilitate detection of novel cryptic chromosomal lesions in myelodysplastic syndromes","volume":"35","author":"O'Keefe\n CL,","year":"2007","unstructured":"O'Keefe\n CL, \n \n Tiu\n R, \n \n Gondek\n LP, \n et al\n . High-resolution genomic arrays facilitate detection of novel cryptic chromosomal lesions in myelodysplastic syndromes. 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Blood. 2008;111(3):1534\u20131542."},{"issue":"22","key":"i1543-2165-138-3-410-b94","series-title":"Curr Med Chem","first-page":"3739","article-title":"Significance of genome-wide analysis of copy number alterations and UPD in myelodysplastic syndromes using combined CGH \u2013 SNP Arrays","volume":"19","author":"Ahmad\n A,","year":"2012","unstructured":"Ahmad\n A, \n \n Iqbal\n MA. \n \n Significance of genome-wide analysis of copy number alterations and UPD in myelodysplastic syndromes using combined CGH \u2013 SNP Arrays. Curr Med Chem. 2012;19(22):3739\u20133747."},{"issue":"1","key":"i1543-2165-138-3-410-b95","series-title":"Semin Oncol","first-page":"109","article-title":"Clinical applications of epigenetic markers and epigenetic profiling in myeloid malignancies","volume":"39","author":"McDevitt\n MA.","year":"2012","unstructured":"McDevitt\n MA. \n \n Clinical applications of epigenetic markers and epigenetic profiling in myeloid malignancies. 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A high occurrence of acquisition and\/or expansion of C-CBL mutant clones in the progression of high-risk myelodysplastic syndrome to acute myeloid leukemia. Neoplasia. 2011;13(11):1035\u20131042."},{"issue":"11","key":"i1543-2165-138-3-410-b104","series-title":"Leuk Res","first-page":"1539","article-title":"Clonal selection of 11q CN-LOH and CBL gene mutation in a serially studied patient during MDS progression to AML","volume":"34","author":"Barresi\n V,","year":"2010","unstructured":"Barresi\n V, \n \n Palumbo\n GA, \n \n Musso\n N, \n et al\n . Clonal selection of 11q CN-LOH and CBL gene mutation in a serially studied patient during MDS progression to AML. 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Blood. 2010;116(19):3923\u20133932."},{"issue":"15","key":"i1543-2165-138-3-410-b106","series-title":"Blood","first-page":"3285","article-title":"TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)","volume":"114","author":"Kosmider\n O,","year":"2009","unstructured":"Kosmider\n O, \n \n Gelsi-Boyer\n V, \n \n Cheok\n M, \n et al\n . TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood. 2009;114(15):3285\u20133291."},{"issue":"8","key":"i1543-2165-138-3-410-b107","series-title":"Nat Genet","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/ng.621","article-title":"Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders","volume":"42","author":"Ernst\n T,","year":"2010","unstructured":"Ernst\n T, \n \n Chase\n AJ, \n \n Score\n J, \n et al\n . Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. 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Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients. Leukemia. 2012;26(1):101\u2013105."},{"issue":"2","key":"i1543-2165-138-3-410-b113","series-title":"Hematol Oncol Clin North Am","first-page":"317","article-title":"Epigenetic changes in the myelodysplastic syndrome","volume":"24","author":"Issa\n JP.","year":"2010","unstructured":"Issa\n JP. \n \n Epigenetic changes in the myelodysplastic syndrome. Hematol Oncol Clin North Am. 2010;24(2):317\u2013330."},{"issue":"6","key":"i1543-2165-138-3-410-b114","series-title":"Br J Haematol","first-page":"1062","article-title":"Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations","volume":"120","author":"Au\n WY,","year":"2003","unstructured":"Au\n WY, \n \n Fung\n A, \n \n Man\n C, \n et al\n . 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Br J Haematol. 2001;112(1):148\u2013154."},{"issue":"9","key":"i1543-2165-138-3-410-b116","series-title":"Leukemia","first-page":"1813","article-title":"Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia","volume":"17","author":"Christiansen\n DH,","year":"2003","unstructured":"Christiansen\n DH, \n \n Andersen\n MK, \n \n Pedersen-Bjergaard\n J. \n \n Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia. Leukemia. 2003;17(9):1813\u20131819."},{"issue":"4","key":"i1543-2165-138-3-410-b117","series-title":"J Clin Oncol","first-page":"605","article-title":"DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes","volume":"28","author":"Shen\n L,","year":"2010","unstructured":"Shen\n L, \n \n Kantarjian\n H, \n \n Guo\n Y, \n et al\n . DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol. 2010;28(4):605\u2013613."},{"issue":"16","key":"i1543-2165-138-3-410-b118","series-title":"Blood","first-page":"3448","article-title":"MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation","volume":"114","author":"Figueroa\n ME,","year":"2009","unstructured":"Figueroa\n ME, \n \n Skrabanek\n L, \n \n Li\n Y, \n et al\n . MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. 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Blood. 2008;111(5):2776\u20132784."},{"issue":"6","key":"i1543-2165-138-3-410-b120","series-title":"Mod Pathol","first-page":"795","article-title":"Targeted next generation sequencing of clinically significant gene mutations and translocations in leukemia","volume":"25","author":"Duncavage\n EJ,","year":"2012","unstructured":"Duncavage\n EJ, \n \n Abel\n HJ, \n \n Szankasi\n P, \n \n Kelley\n TW, \n \n Pfeifer\n JD. \n \n Targeted next generation sequencing of clinically significant gene mutations and translocations in leukemia. Mod Pathol. 2012;25(6):795\u2013804."},{"issue":"7218","key":"i1543-2165-138-3-410-b121","series-title":"Nature","first-page":"66","article-title":"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome","volume":"456","author":"Ley\n TJ,","year":"2008","unstructured":"Ley\n TJ, \n \n Mardis\n ER, \n \n Ding\n L, \n et al\n . DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. 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N Engl J Med. 2009;361(11):1058\u20131066."},{"issue":"7382","key":"i1543-2165-138-3-410-b126","series-title":"Nature","first-page":"506","article-title":"Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing","volume":"481","author":"Ding\n L,","year":"2012","unstructured":"Ding\n L, \n \n Ley\n TJ, \n \n Larson\n DE, \n et al\n . Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012;481(7382):506\u2013510."},{"issue":"12","key":"i1543-2165-138-3-410-b127","series-title":"N Engl J Med","first-page":"1090","article-title":"Clonal architecture of secondary acute myeloid leukemia","volume":"366","author":"Walter\n MJ,","year":"2012","unstructured":"Walter\n MJ, \n \n Shen\n D, \n \n Ding\n L, \n et al\n . Clonal architecture of secondary acute myeloid leukemia. N Engl J Med. 2012;366(12):1090\u20131098."},{"issue":"24","key":"i1543-2165-138-3-410-b01","series-title":"Proc Natl Acad Sci. 982;","first-page":"7824","article-title":"Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells","volume":"79","author":"Dalla-Favera\n R,","unstructured":"Dalla-Favera\n R, \n \n Bregni\n M, \n \n Erikson\n J, \n \n Patterson\n D, \n \n Gallo\n RC, \n \n Croce\n CM. \n \n Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.Proc Natl Acad Sci. 982;79(24):7824\u20137827."},{"issue":"8","key":"i1543-2165-138-3-410-b02","series-title":"Nat Rev Mol Cell Biol","first-page":"635","article-title":"Transcriptional regulation and transformation by Myc proteins","volume":"6","author":"Adhikary\n S,","year":"2005","unstructured":"Adhikary\n S, \n \n Eilers\n M. \n \n Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol. 2005;6(8):635\u2013645."},{"issue":"4","key":"i1543-2165-138-3-410-b03","series-title":"Semin Cancer Biol","first-page":"253","article-title":"The c-Myc target gene network","volume":"16","author":"Dang\n CV,","year":"2006","unstructured":"Dang\n CV, \n \n O'Donnell\n KA, \n \n Zeller\n KI, \n \n Nguyen\n T, \n \n Osthus\n RC, \n \n Li\n F. \n \n The c-Myc target gene network. Semin Cancer Biol. 2006;16(4):253\u2013264."},{"issue":"4","key":"i1543-2165-138-3-410-b04","series-title":"Br J Haematol","first-page":"484","article-title":"Advances in the understanding of MYC-induced lymphomagenesis","volume":"149","author":"Klapproth\n K,","year":"2010","unstructured":"Klapproth\n K, \n \n Wirth\n T. \n \n Advances in the understanding of MYC-induced lymphomagenesis. Br J Haematol. 2010;149(4):484\u2013497."},{"issue":"7152","key":"i1543-2165-138-3-410-b05","series-title":"Nature","first-page":"445","article-title":"Non-transcriptional control of DNA replication by c-Myc","volume":"448","author":"Dominguez-Sola\n D,","year":"2007","unstructured":"Dominguez-Sola\n D, \n \n Ying\n CY, \n \n Grandori\n C, \n et al\n . Non-transcriptional control of DNA replication by c-Myc. Nature. 2007;448(7152):445\u2013451."},{"key":"i1543-2165-138-3-410-b06","series-title":"Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed","first-page":"233","article-title":"Diffuse large B-cell lymphoma, not otherwise specified","author":"Stein\n H,","year":"2008","unstructured":"Stein\n H, \n \n Warnke\n RA, \n \n Chan\n WC\n \n et al\n . Diffuse large B-cell lymphoma, not otherwise specified. In: Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press;2008:233\u2013237. World Health Organization Classification of Tumours; vol 2."},{"issue":"4","key":"i1543-2165-138-3-410-b07","series-title":"Blood Cells Mol Dis","first-page":"317","article-title":"The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma","volume":"45","author":"Smith\n SM,","year":"2010","unstructured":"Smith\n SM, \n \n Anastasi\n J, \n \n Cohen\n KS, \n \n Godley\n LA. \n \n The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma. Blood Cells Mol Dis. 2010;45(4):317\u2013323."},{"issue":"6769","key":"i1543-2165-138-3-410-b08","series-title":"Nature","first-page":"503","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh\n AA,","year":"2000","unstructured":"Alizadeh\n AA, \n \n Eisen\n MB, \n \n Davis\n RE, \n et al\n . 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Adv Anat Pathol. 2011;18(3):219\u2013228."},{"issue":"17","key":"i1543-2165-138-3-410-b12","series-title":"Blood","first-page":"3533","article-title":"MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy","volume":"114","author":"Savage\n KJ,","year":"2009","unstructured":"Savage\n KJ, \n \n Johnson\n NA, \n \n Ben-Neriah\n S, \n et al\n . MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. Blood. 2009;114(17):3533\u20133537."},{"issue":"2","key":"i1543-2165-138-3-410-b13","series-title":"Cancer Sci","first-page":"233","article-title":"Clinical significance of 8q24\/c-MYC translocation in diffuse large B-cell lymphoma","volume":"100","author":"Nitsu\n N,","year":"2009","unstructured":"Nitsu\n N, \n \n Okamoto\n M, \n \n Miura\n I, \n \n Hirano\n M. \n \n Clinical significance of 8q24\/c-MYC translocation in diffuse large B-cell lymphoma. Cancer Sci. 2009;100(2):233\u2013237."},{"issue":"2","key":"i1543-2165-138-3-410-b14","series-title":"Leukemia","first-page":"323","article-title":"FAB\/LMB 96 International Study Committee. Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB\/LMB 96 international study","volume":"23","author":"Poirel\n HA,","year":"2009","unstructured":"Poirel\n HA, \n \n Cairo\n MS, \n \n Heerema\n NA, \n et al;\n \n FAB\/LMB 96 International Study Committee. Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB\/LMB 96 international study. Leukemia. 2009;23(2):323\u2013331."},{"issue":"20","key":"i1543-2165-138-3-410-b15","series-title":"J Clin Oncol","first-page":"3360","article-title":"Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab","volume":"28","author":"Barrans\n S,","year":"2010","unstructured":"Barrans\n S, \n \n Crouch\n S, \n \n Smith\n A, \n et al\n . Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab. J Clin Oncol. 2010;28(20):3360\u20133365."},{"issue":"28","key":"i1543-2165-138-3-410-b16","series-title":"J Clin Oncol","first-page":"3452","article-title":"Concurrent Expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone","volume":"30","author":"Johnson\n NA,","year":"2012","unstructured":"Johnson\n NA, \n \n Slack\n GW, \n \n Savage\n KJ, \n et al\n . 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J Clin Oncol. 2009;27(33):5573\u20135579."},{"issue":"4","key":"i1543-2165-138-3-410-b19","series-title":"Am J Surg Pathol","first-page":"612","article-title":"High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma","volume":"36","author":"Green\n TM,","year":"2012","unstructured":"Green\n TM, \n \n Nielsen\n O, \n \n de Stricker\n K, \n \n Xu-Monette\n ZY, \n \n Young\n KH, \n \n Moller\n MB. \n \n High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma. Am J Surg Pathol. 2012;36(4):612\u2013619."},{"issue":"4","key":"i1543-2165-138-3-410-b20","series-title":"PLoS One","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033813","article-title":"Immunohistochemical detection of MYC-driven diffuse large B-cell lymphomas","volume":"7","author":"Kluk\n MJ,","year":"2012","unstructured":"Kluk\n MJ, \n \n Chapuy\n B, \n \n Sinha\n P, \n et al\n . 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Am J Surg Pathol. 2010;34(6):882\u2013891."},{"issue":"28","key":"i1543-2165-138-3-410-b22","series-title":"J Clin Oncol","first-page":"3460","article-title":"Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone","volume":"30","author":"Green\n TM,","year":"2012","unstructured":"Green\n TM, \n \n Young\n KH, \n \n Visco\n C, \n et al\n . Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 2012; 30(28):3460\u20133467."},{"key":"i1543-2165-138-3-410-b23","series-title":"Annu Rev Genet","first-page":"23","article-title":"Immunoglobulin gene diversification","volume":"39","author":"Maizels\n N.","year":"2005","unstructured":"Maizels\n N. \n \n Immunoglobulin gene diversification. Annu Rev Genet. 2005;39:23\u201346."},{"issue":"20","key":"i1543-2165-138-3-410-b24","series-title":"N Engl J Med","first-page":"1520","article-title":"Cellular origin of human B-cell lymphomas","volume":"341","author":"Kuppers\n R,","year":"1999","unstructured":"Kuppers\n R, \n \n Klein\n U, \n \n Hansmann\n ML, \n \n Rajewsky\n K. \n \n Cellular origin of human B-cell lymphomas. 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Br J Haematol. 2001;115(4):854\u2013861."},{"issue":"6","key":"i1543-2165-138-3-410-b30","series-title":"Blood","first-page":"1902","article-title":"CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia","volume":"97","author":"Matrai\n Z,","year":"2001","unstructured":"Matrai\n Z, \n \n Lin\n K, \n \n Dennis\n M, \n et al\n . CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia. Blood. 2001;97(6):1902\u20131903."},{"issue":"3","key":"i1543-2165-138-3-410-b31","series-title":"Blood","first-page":"1023","article-title":"CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease","volume":"99","author":"Hamblin\n TJ,","year":"2002","unstructured":"Hamblin\n TJ, \n \n Orchard\n JA, \n \n Ibbotson\n RE, \n et al\n . 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Blood. 2002;99(6):2262\u20132264."},{"issue":"4","key":"i1543-2165-138-3-410-b33","series-title":"Blood","first-page":"1262","article-title":"The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression","volume":"101","author":"Ghia\n P,","year":"2003","unstructured":"Ghia\n P, \n \n Guida\n G, \n \n Stella\n S, \n et al\n . The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood. 2003;101(4):1262\u20131269."},{"issue":"12","key":"i1543-2165-138-3-410-b34","series-title":"Blood","first-page":"4952","article-title":"Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted V\u03bb2\u201314 gene use and homologous CDR3s: implicating recognition of a common antigen epitope","volume":"101","author":"Tobin\n G,","year":"2003","unstructured":"Tobin\n G, \n \n Thunberg\n U, \n \n Johnson\n A, \n et al\n . 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J Clin Oncol. 2003;21(21):3928\u20133932."},{"issue":"6","key":"i1543-2165-138-3-410-b36","series-title":"Eur J Haematol","first-page":"407","article-title":"VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia","volume":"73","author":"Aleskog\n A,","year":"2004","unstructured":"Aleskog\n A, \n \n Tobin\n G, \n \n Laurell\n A, \n et al\n . VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia. Eur J Haematol. 2004;73(6):407\u2013411."},{"issue":"5","key":"i1543-2165-138-3-410-b37","series-title":"J Mol Diagn","first-page":"566","article-title":"Immunoglobulin mutational status detected through single-round amplification of partial V(H) region represents a good prognostic marker for clinical outcome in chronic lymphocytic leukemia","volume":"7","author":"Marasca\n R,","year":"2005","unstructured":"Marasca\n R, \n \n Maffei\n R, \n \n Morselli\n M, \n et al\n . 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Blood. 2006;107(7):2889\u20132894."},{"issue":"4","key":"i1543-2165-138-3-410-b39","series-title":"Haematologica","first-page":"465","article-title":"Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome","volume":"90","author":"Tobin\n G,","year":"2005","unstructured":"Tobin\n G, \n \n Thunberg\n U, \n \n Laurell\n A, \n et al\n . Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome. Haematologica. 2005;90(4):465\u2013469."},{"issue":"7","key":"i1543-2165-138-3-410-b40","series-title":"Blood","first-page":"2615","article-title":"B-chronic lymphocytic leukemia: a malignancy of anti-self B cells","volume":"87","author":"Caligaris-Cappio\n F.","year":"1996","unstructured":"Caligaris-Cappio\n F. \n \n B-chronic lymphocytic leukemia: a malignancy of anti-self B cells. 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Blood. 1997;89(11):4153\u20134160."},{"issue":"6","key":"i1543-2165-138-3-410-b45","series-title":"Blood","first-page":"1848","article-title":"Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin\n TJ,","year":"1999","unstructured":"Hamblin\n TJ, \n \n Davis\n Z, \n \n Gardiner\n A, \n \n Oscier\n DG, \n \n Stevenson\n FK. \n \n Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6):1848\u20131854."},{"issue":"4","key":"i1543-2165-138-3-410-b46","series-title":"Blood","first-page":"1410","article-title":"V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia","volume":"100","author":"Krober\n A,","year":"2002","unstructured":"Krober\n A, \n \n Seiler\n T, \n \n Benner\n A, \n et al\n . 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Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research","volume":"124","author":"Bertoni\n F,","year":"2004","unstructured":"Bertoni\n F, \n \n Conconi\n A, \n \n Cogliatti\n SB, \n et al;\n \n Swiss Group for Clinical Cancer Research. Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research. Br J Haematol. 2004;124(3):289\u2013298."},{"issue":"8","key":"i1543-2165-138-3-410-b49","series-title":"Blood","first-page":"3003","article-title":"VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome","volume":"102","author":"Kienle\n D,","year":"2003","unstructured":"Kienle\n D, \n \n Krober\n A, \n \n Katzenberger\n T, \n et al\n . 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Br J Dermatol. 2010;162(3):611\u2013618."},{"issue":"11","key":"i1543-2165-138-3-410-b66","series-title":"Invest Ophthalmol Vis Sci","first-page":"2450","article-title":"Immunoglobulin heavy chain gene analysis of ocular adnexal extranodal marginal zone B-cell lymphoma","volume":"42","author":"Hara\n Y,","year":"2001","unstructured":"Hara\n Y, \n \n Nakamura\n N, \n \n Kuze\n T, \n et al\n . Immunoglobulin heavy chain gene analysis of ocular adnexal extranodal marginal zone B-cell lymphoma. 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Blood. 2010;116(19):3923\u20133932."},{"issue":"15","key":"i1543-2165-138-3-410-b106","series-title":"Blood","first-page":"3285","article-title":"TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)","volume":"114","author":"Kosmider\n O,","year":"2009","unstructured":"Kosmider\n O, \n \n Gelsi-Boyer\n V, \n \n Cheok\n M, \n et al\n . TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood. 2009;114(15):3285\u20133291."},{"issue":"8","key":"i1543-2165-138-3-410-b107","series-title":"Nat Genet","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/ng.621","article-title":"Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders","volume":"42","author":"Ernst\n T,","year":"2010","unstructured":"Ernst\n T, \n \n Chase\n AJ, \n \n Score\n J, \n et al\n . Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. 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J Clin Oncol. 2011;29(18):2499\u20132506."},{"issue":"10","key":"i1543-2165-138-3-410-b111","series-title":"Haematologica","first-page":"1668","article-title":"IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis","volume":"95","author":"Thol\n F,","year":"2010","unstructured":"Thol\n F, \n \n Weissinger\n EM, \n \n Krauter\n J, \n et al\n . IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis. Haematologica. 2010;95(10):1668\u20131674."},{"issue":"1","key":"i1543-2165-138-3-410-b112","series-title":"Leukemia","first-page":"101","article-title":"Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients","volume":"26","author":"Patnaik\n MM,","year":"2012","unstructured":"Patnaik\n MM, \n \n Hanson\n CA, \n \n Hodnefield\n JM, \n et al\n . Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients. Leukemia. 2012;26(1):101\u2013105."},{"issue":"2","key":"i1543-2165-138-3-410-b113","series-title":"Hematol Oncol Clin North Am","first-page":"317","article-title":"Epigenetic changes in the myelodysplastic syndrome","volume":"24","author":"Issa\n JP.","year":"2010","unstructured":"Issa\n JP. \n \n Epigenetic changes in the myelodysplastic syndrome. Hematol Oncol Clin North Am. 2010;24(2):317\u2013330."},{"issue":"6","key":"i1543-2165-138-3-410-b114","series-title":"Br J Haematol","first-page":"1062","article-title":"Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations","volume":"120","author":"Au\n WY,","year":"2003","unstructured":"Au\n WY, \n \n Fung\n A, \n \n Man\n C, \n et al\n . Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations. Br J Haematol. 2003;120(6):1062\u20131065."},{"issue":"1","key":"i1543-2165-138-3-410-b115","series-title":"Br J Haematol","first-page":"148","article-title":"Methylation of the p15INK4B gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation","volume":"112","author":"Tien\n HF,","year":"2001","unstructured":"Tien\n HF, \n \n Tang\n JH, \n \n Tsay\n W, \n et al\n . Methylation of the p15INK4B gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation. Br J Haematol. 2001;112(1):148\u2013154."},{"issue":"9","key":"i1543-2165-138-3-410-b116","series-title":"Leukemia","first-page":"1813","article-title":"Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia","volume":"17","author":"Christiansen\n DH,","year":"2003","unstructured":"Christiansen\n DH, \n \n Andersen\n MK, \n \n Pedersen-Bjergaard\n J. \n \n Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia. Leukemia. 2003;17(9):1813\u20131819."},{"issue":"4","key":"i1543-2165-138-3-410-b117","series-title":"J Clin Oncol","first-page":"605","article-title":"DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes","volume":"28","author":"Shen\n L,","year":"2010","unstructured":"Shen\n L, \n \n Kantarjian\n H, \n \n Guo\n Y, \n et al\n . DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol. 2010;28(4):605\u2013613."},{"issue":"16","key":"i1543-2165-138-3-410-b118","series-title":"Blood","first-page":"3448","article-title":"MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation","volume":"114","author":"Figueroa\n ME,","year":"2009","unstructured":"Figueroa\n ME, \n \n Skrabanek\n L, \n \n Li\n Y, \n et al\n . MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood. 2009;114(16):3448\u20133458."},{"issue":"5","key":"i1543-2165-138-3-410-b119","series-title":"Blood","first-page":"2776","article-title":"Medical Research Council Adult Leukaemia Working Party. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia","volume":"111","author":"Gale\n RE,","year":"2008","unstructured":"Gale\n RE, \n \n Green\n C, \n \n Allen\n C, \n et al;\n \n Medical Research Council Adult Leukaemia Working Party. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood. 2008;111(5):2776\u20132784."},{"issue":"6","key":"i1543-2165-138-3-410-b120","series-title":"Mod Pathol","first-page":"795","article-title":"Targeted next generation sequencing of clinically significant gene mutations and translocations in leukemia","volume":"25","author":"Duncavage\n EJ,","year":"2012","unstructured":"Duncavage\n EJ, \n \n Abel\n HJ, \n \n Szankasi\n P, \n \n Kelley\n TW, \n \n Pfeifer\n JD. \n \n Targeted next generation sequencing of clinically significant gene mutations and translocations in leukemia. Mod Pathol. 2012;25(6):795\u2013804."},{"issue":"7218","key":"i1543-2165-138-3-410-b121","series-title":"Nature","first-page":"66","article-title":"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome","volume":"456","author":"Ley\n TJ,","year":"2008","unstructured":"Ley\n TJ, \n \n Mardis\n ER, \n \n Ding\n L, \n et al\n . DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature. 2008;456(7218):66\u201372."},{"issue":"25","key":"i1543-2165-138-3-410-b122","series-title":"N Engl J Med","first-page":"2424","article-title":"DNMT3A mutations in acute myeloid leukemia","volume":"363","author":"Ley\n TJ,","year":"2010","unstructured":"Ley\n TJ, \n \n Ding\n L, \n \n Walter\n MJ, \n et al\n . DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363(25):2424\u20132433."},{"issue":"4","key":"i1543-2165-138-3-410-b123","series-title":"Nat Genet","first-page":"309","article-title":"Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia","volume":"43","author":"Yan\n XJ,","year":"2011","unstructured":"Yan\n XJ, \n \n Xu\n J, \n \n Gu\n ZH, \n et al\n . Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43(4):309\u2013315."},{"issue":"25","key":"i1543-2165-138-3-410-b124","series-title":"Oncogene","first-page":"3723","article-title":"Array-based genomic resequencing of human leukemia","volume":"29","author":"Yamashita\n Y,","year":"2010","unstructured":"Yamashita\n Y, \n \n Yuan\n J, \n \n Suetake\n I, \n et al\n . Array-based genomic resequencing of human leukemia. Oncogene. 2010;29(25):3723\u20133731."},{"issue":"11","key":"i1543-2165-138-3-410-b125","series-title":"N Engl J Med","first-page":"1058","article-title":"Recurring mutations found by sequencing an acute myeloid leukemia genome","volume":"361","author":"Mardis\n ER,","year":"2009","unstructured":"Mardis\n ER, \n \n Ding\n L, \n \n Dooling\n DJ, \n et al\n . Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009;361(11):1058\u20131066."},{"issue":"7382","key":"i1543-2165-138-3-410-b126","series-title":"Nature","first-page":"506","article-title":"Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing","volume":"481","author":"Ding\n L,","year":"2012","unstructured":"Ding\n L, \n \n Ley\n TJ, \n \n Larson\n DE, \n et al\n . Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012;481(7382):506\u2013510."},{"issue":"12","key":"i1543-2165-138-3-410-b127","series-title":"N Engl J Med","first-page":"1090","article-title":"Clonal architecture of secondary acute myeloid leukemia","volume":"366","author":"Walter\n MJ,","year":"2012","unstructured":"Walter\n MJ, \n \n Shen\n D, \n \n Ding\n L, \n et al\n . Clonal architecture of secondary acute myeloid leukemia. 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