{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:39:00Z","timestamp":1774831140443,"version":"3.50.1"},"reference-count":156,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>\n                    <jats:italic>Context.\u2014<\/jats:italic>\n                    Endometrial carcinoma is a disease of older postmenopausal women, and is relatively uncommon in patients younger than 40 years. Endometrial carcinomas in this age group may be familial, associated with Lynch syndrome, or sporadic.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objectives.\u2014<\/jats:italic>\n                    To present our current knowledge of endometrial carcinomas in women younger than 40 years.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Data Sources.\u2014<\/jats:italic>\n                    The review is based on previously published articles on this topic.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions.\u2014<\/jats:italic>\n                    Most endometrial carcinomas that occur in this age group are associated with estrogen excess. They are usually low-grade endometrioid carcinomas that present at low stages and are associated with favorable clinical outcomes. Tumors associated with mismatch repair abnormalities and Lynch syndrome appear to be distinct, with worse prognostic factors and, possibly, clinical behavior. Conservative hormonal therapy and ovarian conservation are reasonable considerations in the management of these young patients, but carry the risk of tumor progression, recurrence, and an occult synchronous or metachronous ovarian carcinoma.\n                  <\/jats:p>","DOI":"10.5858\/arpa.2012-0654-ra","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T15:06:56Z","timestamp":1393513616000},"page":"335-342","source":"Crossref","is-referenced-by-count":61,"title":["Endometrial Carcinoma in Women Aged 40 Years and Younger"],"prefix":"10.5858","volume":"138","author":[{"given":"Karuna","family":"Garg","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of California San Francisco (Dr Garg); and the Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York (Dr Soslow)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Soslow","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of California San Francisco (Dr Garg); and the Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York (Dr Soslow)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"5","key":"i1543-2165-138-3-335-b01","series-title":"Eur J Gynaecol Oncol","first-page":"353","article-title":"Clinico-pathological profile of endometrial carcinoma in young women (under 40 years of age)","volume":"10","author":"Colafranceschi\n              M,","year":"1989","unstructured":"Colafranceschi\n              M, \n            \n              Taddei\n              GL, \n            \n              Scarselli\n              G, \n            \n              Branconi\n              F, \n            \n              Tinacci\n              G, \n            \n              Savino\n              L. \n          \n          Clinico-pathological profile of endometrial carcinoma in young women (under 40 years of age). Eur J Gynaecol Oncol. 1989;10(5):353\u2013356."},{"issue":"6","key":"i1543-2165-138-3-335-b02","series-title":"Obstet Gynecol","first-page":"699","article-title":"Endometrial carcinoma in women 40 years of age or younger","volume":"57","author":"Crissman\n              JD,","year":"1981","unstructured":"Crissman\n              JD, \n            \n              Azoury\n              RS, \n            \n              Barnes\n              AE, \n            \n              Schellhas\n              HF. \n          \n          Endometrial carcinoma in women 40 years of age or younger. Obstet Gynecol. 1981;57(6):699\u2013704."},{"issue":"2","key":"i1543-2165-138-3-335-b03","series-title":"Gynecol Oncol","first-page":"388","article-title":"Endometrial cancer in women 40 years old or younger","volume":"83","author":"Duska\n              LR,","year":"2001","unstructured":"Duska\n              LR, \n            \n              Garrett\n              A, \n            \n              Rueda\n              BR, \n            \n              Haas\n              J, \n            \n              Chang\n              Y, \n            \n              Fuller\n              AF. \n          \n          Endometrial cancer in women 40 years old or younger. Gynecol Oncol. 2001;83(2):388\u2013393."},{"issue":"3","key":"i1543-2165-138-3-335-b04","series-title":"Obstet Gynecol","first-page":"417","article-title":"Adenocarcinoma of the endometrium in women 40 years of age or younger","volume":"64","author":"Gallup\n              DG,","year":"1984","unstructured":"Gallup\n              DG, \n            \n              Stock\n              RJ. \n          \n          Adenocarcinoma of the endometrium in women 40 years of age or younger. Obstet Gynecol. 1984;64(3):417\u2013420."},{"issue":"4","key":"i1543-2165-138-3-335-b05","series-title":"Int J Gynecol Cancer","first-page":"657","article-title":"Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger","volume":"15","author":"Ota\n              T,","year":"2005","unstructured":"Ota\n              T, \n            \n              Yoshida\n              M, \n            \n              Kimura\n              M, \n            \n              Kinoshita\n              K. \n          \n          Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger. Int J Gynecol Cancer. 2005;15(4):657\u2013662."},{"issue":"33","key":"i1543-2165-138-3-335-b06","series-title":"J Clin Oncol","first-page":"5158","article-title":"Prospective determination of prevalence of Lynch syndrome in young women with endometrial cancer","volume":"25","author":"Lu\n              KH,","year":"2007","unstructured":"Lu\n              KH, \n            \n              Schorge\n              JO, \n            \n              Rodabaugh\n              KJ, \n            et al\n          . Prospective determination of prevalence of Lynch syndrome in young women with endometrial cancer. J Clin Oncol. 2007;25(33):5158\u20135164."},{"issue":"1","key":"i1543-2165-138-3-335-b07","series-title":"Gynecol Oncol","first-page":"88","article-title":"Clinicopathologic significance of DNA mismatch repair protein defects and endometrial cancer in women 40 years of age and younger","volume":"123","author":"Shih\n              KK,","year":"2011","unstructured":"Shih\n              KK, \n            \n              Garg\n              K, \n            \n              Levine\n              DA, \n            et al\n          . Clinicopathologic significance of DNA mismatch repair protein defects and endometrial cancer in women 40 years of age and younger. Gynecol Oncol. 2011;123(1):88\u201394."},{"issue":"12","key":"i1543-2165-138-3-335-b08","series-title":"Am J Surg Pathol","first-page":"1869","article-title":"Endometrial carcinomas in women aged 40 years and younger: tumors associated with loss of DNA mismatch repair proteins comprise a distinct clinicopathologic subset","volume":"33","author":"Garg\n              K,","year":"2009","unstructured":"Garg\n              K, \n            \n              Shih\n              K, \n            \n              Barakat\n              R, \n            \n              Zhou\n              Q, \n            \n              Iasonos\n              A, \n            \n              Soslow\n              RA. \n          \n          Endometrial carcinomas in women aged 40 years and younger: tumors associated with loss of DNA mismatch repair proteins comprise a distinct clinicopathologic subset. Am J Surg Pathol. 2009;33(12):1869\u20131877."},{"issue":"6","key":"i1543-2165-138-3-335-b09","series-title":"Clin Cancer Res","first-page":"1692","article-title":"Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients","volume":"14","author":"Walsh\n              MD,","year":"2008","unstructured":"Walsh\n              MD, \n            \n              Cummings\n              MC, \n            \n              Buchanan\n              DD, \n            et al\n          . Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients. Clin Cancer Res. 2008;14(6):1692\u20131700."},{"issue":"5","key":"i1543-2165-138-3-335-b10","series-title":"Obstet Gynecol","first-page":"1161","article-title":"Lynch syndrome in women less than 50 years of age with endometrial cancer","volume":"111","author":"Matthews\n              KS,","year":"2008","unstructured":"Matthews\n              KS, \n            \n              Estes\n              JM, \n            \n              Conner\n              MG, \n            et al\n          . Lynch syndrome in women less than 50 years of age with endometrial cancer. Obstet Gynecol. 2008;111(5):1161\u20131166."},{"issue":"3","key":"i1543-2165-138-3-335-b11","series-title":"Obstet Gynecol","first-page":"575","article-title":"Risk factors for young premenopausal women with endometrial cancer","volume":"105","author":"Soliman\n              PT,","year":"2005","unstructured":"Soliman\n              PT, \n            \n              Oh\n              JC, \n            \n              Schmeler\n              KM, \n            et al\n          . Risk factors for young premenopausal women with endometrial cancer. Obstet Gynecol. 2005;105(3):575\u2013580."},{"issue":"12","key":"i1543-2165-138-3-335-b12","series-title":"Cancer Causes Control","first-page":"2303","article-title":"Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study","volume":"21","author":"Fearnley\n              EJ,","year":"2010","unstructured":"Fearnley\n              EJ, \n            \n              Marquart\n              L, \n            \n              Spurdle\n              AB, \n            \n              Weinstein\n              P, \n            \n              Webb\n              PM. \n          \n          Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study. Cancer Causes Control. 2010;21(12):2303\u20132308."},{"issue":"3","key":"i1543-2165-138-3-335-b13","series-title":"Gynecol Oncol","first-page":"535","article-title":"Body mass index: relationship to clinical, pathologic and features of microsatellite instability in endometrial cancer","volume":"104","author":"McCourt\n              CK,","year":"2007","unstructured":"McCourt\n              CK, \n            \n              Mutch\n              DG, \n            \n              Gibb\n              RK, \n            et al\n          . Body mass index: relationship to clinical, pathologic and features of microsatellite instability in endometrial cancer. Gynecol Oncol. 2007;104(3):535\u2013539."},{"issue":"2","key":"i1543-2165-138-3-335-b14","series-title":"Gynecol Oncol","first-page":"388","article-title":"Endometrial cancer in young, normal-weight women","volume":"99","author":"Schmeler\n              KM,","year":"2005","unstructured":"Schmeler\n              KM, \n            \n              Soliman\n              PT, \n            \n              Sun\n              CC, \n            \n              Slomovitz\n              BM, \n            \n              Gershenson\n              DM, \n            \n              Lu\n              KH. \n          \n          Endometrial cancer in young, normal-weight women. Gynecol Oncol. 2005;99(2):388\u2013392."},{"issue":"1","key":"i1543-2165-138-3-335-b15","series-title":"Int J Gynecol Pathol","first-page":"52","article-title":"Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma?","volume":"25","author":"Silva\n              EG,","year":"2006","unstructured":"Silva\n              EG, \n            \n              Deavers\n              MT, \n            \n              Bodurka\n              DC, \n            \n              Malpica\n              A. \n          \n          Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma?\n          Int J Gynecol Pathol. 2006;25(1):52\u201358."},{"issue":"10","key":"i1543-2165-138-3-335-b16","series-title":"Am J Surg Pathol","first-page":"1316","article-title":"Undifferentiated carcinoma of the endometrium","volume":"29","author":"Altrabulsi\n              B,","year":"2005","unstructured":"Altrabulsi\n              B, \n            \n              Malpica\n              A, \n            \n              Deavers\n              MT, \n            \n              Bodurka\n              DC, \n            \n              Broaddus\n              R, \n            \n              Silva\n              EG. \n          \n          Undifferentiated carcinoma of the endometrium. Am J Surg Pathol. 2005;29(10):1316\u20131321."},{"issue":"6","key":"i1543-2165-138-3-335-b17","series-title":"Mod Pathol","first-page":"781","article-title":"Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasms","volume":"23","author":"Tafe\n              LJ,","year":"2010","unstructured":"Tafe\n              LJ, \n            \n              Garg\n              K, \n            \n              Chew\n              I, \n            \n              Tornos\n              C, \n            \n              Soslow\n              RA. \n          \n          Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasms. Mod Pathol. 2010;23(6):781\u2013789."},{"issue":"6","key":"i1543-2165-138-3-335-b18","series-title":"Am J Surg Pathol","first-page":"925","article-title":"Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities","volume":"33","author":"Garg\n              K,","year":"2009","unstructured":"Garg\n              K, \n            \n              Leitao\n              MM\n              Jr, \n            \n              Kauff\n              ND, \n            et al\n          . Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities. Am J Surg Pathol. 2009;33(6):925\u2013933."},{"issue":"1","key":"i1543-2165-138-3-335-b19","series-title":"Int J Surg Pathol","first-page":"21","article-title":"Lynch syndrome\u2014related endometrial carcinomas show a high frequency of nonendometrioid types and of high FIGO grade endometrioid types","volume":"18","author":"Carcangiu\n              ML,","year":"2010","unstructured":"Carcangiu\n              ML, \n            \n              Radice\n              P, \n            \n              Casalini\n              P, \n            \n              Bertario\n              L, \n            \n              Merola\n              M, \n            \n              Sala\n              P. \n          \n          Lynch syndrome\u2014related endometrial carcinomas show a high frequency of nonendometrioid types and of high FIGO grade endometrioid types. Int J Surg Pathol. 2010;18(1):21\u201326."},{"issue":"1","key":"i1543-2165-138-3-335-b20","series-title":"Cancer","first-page":"87","article-title":"Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma","volume":"106","author":"Broaddus\n              RR,","year":"2006","unstructured":"Broaddus\n              RR, \n            \n              Lynch\n              HT, \n            \n              Chen\n              LM, \n            et al\n          . Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma. Cancer. 2006;106(1):87\u201394."},{"issue":"4","key":"i1543-2165-138-3-335-b21","series-title":"Semin Diagn Pathol","first-page":"261","article-title":"Endometrial carcinomas with ambiguous features","volume":"27","author":"Soslow\n              RA.","year":"2010","unstructured":"Soslow\n              RA. \n          \n          Endometrial carcinomas with ambiguous features. Semin Diagn Pathol. 2010;27(4):261\u2013273."},{"issue":"36","key":"i1543-2165-138-3-335-b22","series-title":"J Clin Oncol","first-page":"5965","article-title":"Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome","volume":"26","author":"Westin\n              SN,","year":"2008","unstructured":"Westin\n              SN, \n            \n              Lacour\n              RA, \n            \n              Urbauer\n              DL, \n            et al\n          . Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome. J Clin Oncol. 2008;26(36):5965\u20135971."},{"issue":"1","key":"i1543-2165-138-3-335-b23","series-title":"Hum Pathol","first-page":"116","article-title":"Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer","volume":"39","author":"Shia\n              J,","year":"2008","unstructured":"Shia\n              J, \n            \n              Black\n              D, \n            \n              Hummer\n              AJ, \n            \n              Boyd\n              J, \n            \n              Soslow\n              RA. \n          \n          Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer. Hum Pathol. 2008;39(1):116\u2013125."},{"issue":"1","key":"i1543-2165-138-3-335-b24","series-title":"Am J Surg Pathol","first-page":"1","article-title":"Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus: a clinicopathologic study of 55 cases","volume":"20","author":"Longacre\n              TA,","year":"1996","unstructured":"Longacre\n              TA, \n            \n              Chung\n              MH, \n            \n              Rouse\n              RV, \n            \n              Hendrickson\n              MR. \n          \n          Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus: a clinicopathologic study of 55 cases. Am J Surg Pathol. 1996;20(1):1\u201320."},{"issue":"2","key":"i1543-2165-138-3-335-b25","series-title":"Am J Clin Pathol","first-page":"139","article-title":"Atypical polypoid adenomyoma of the uterus: a report of 27 cases","volume":"86","author":"Young\n              RH,","year":"1986","unstructured":"Young\n              RH, \n            \n              Treger\n              T, \n            \n              Scully\n              RE. \n          \n          Atypical polypoid adenomyoma of the uterus: a report of 27 cases. Am J Clin Pathol. 1986;86(2):139\u2013145."},{"issue":"6","key":"i1543-2165-138-3-335-b26","series-title":"Am J Surg Pathol","first-page":"706","article-title":"More differences between HNPCC-related and sporadic carcinomas from the endometrium as compared to the colon","volume":"28","author":"van den Bos\n              M,","year":"2004","unstructured":"van den Bos\n              M, \n            \n              van den Hoven\n              M, \n            \n              Jongejan\n              E, \n            et al\n          . More differences between HNPCC-related and sporadic carcinomas from the endometrium as compared to the colon. Am J Surg Pathol. 2004;28(6):706\u2013711."},{"issue":"6","key":"i1543-2165-138-3-335-b27","series-title":"Am J Surg Pathol","first-page":"846","article-title":"Microsatellite instability in endometrioid type endometrial adenocarcinoma is associated with poor prognostic indicators","volume":"31","author":"An\n              HJ,","year":"2007","unstructured":"An\n              HJ, \n            \n              Kim\n              KI, \n            \n              Kim\n              JY, \n            et al\n          . Microsatellite instability in endometrioid type endometrial adenocarcinoma is associated with poor prognostic indicators. Am J Surg Pathol. 2007;31(6):846\u2013853."},{"issue":"3","key":"i1543-2165-138-3-335-b28","series-title":"Gynecol Oncol","first-page":"408","article-title":"Clinical and pathologic features of young endometrial cancer patients with loss of mismatch repair expression","volume":"126","author":"Grzankowski\n              KS,","year":"2012","unstructured":"Grzankowski\n              KS, \n            \n              Shimizu\n              DM, \n            \n              Kimata\n              C, \n            \n              Black\n              M, \n            \n              Terada\n              KY. \n          \n          Clinical and pathologic features of young endometrial cancer patients with loss of mismatch repair expression. Gynecol Oncol. 2012;126(3):408\u2013412."},{"issue":"2","key":"i1543-2165-138-3-335-b29","series-title":"Gynecol Oncol","first-page":"234","article-title":"Mismatch repair status and outcomes after adjuvant therapy in patients with surgically staged endometrial cancer","volume":"117","author":"Resnick\n              KE,","year":"2010","unstructured":"Resnick\n              KE, \n            \n              Frankel\n              WL, \n            \n              Morrison\n              CD, \n            et al\n          . Mismatch repair status and outcomes after adjuvant therapy in patients with surgically staged endometrial cancer. Gynecol Oncol. 2010;117(2):234\u2013238."},{"issue":"11","key":"i1543-2165-138-3-335-b30","series-title":"J Clin Oncol","first-page":"1745","article-title":"Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma","volume":"24","author":"Black\n              D,","year":"2006","unstructured":"Black\n              D, \n            \n              Soslow\n              RA, \n            \n              Levine\n              DA, \n            et al\n          . Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma. J Clin Oncol. 2006;24(11):1745\u20131753."},{"issue":"9","key":"i1543-2165-138-3-335-b31","series-title":"Mod Pathol","first-page":"1262","article-title":"Biomarkers and microsatellite instability analysis of curettings can predict the behavior of FIGO stage I endometrial endometrioid adenocarcinoma","volume":"24","author":"Steinbakk\n              A,","year":"2011","unstructured":"Steinbakk\n              A, \n            \n              Malpica\n              A, \n            \n              Slewa\n              A, \n            et al\n          . Biomarkers and microsatellite instability analysis of curettings can predict the behavior of FIGO stage I endometrial endometrioid adenocarcinoma. Mod Pathol. 2011;24(9):1262\u20131271."},{"issue":"5","key":"i1543-2165-138-3-335-b32","series-title":"Am J Surg Pathol","first-page":"744","article-title":"Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma","volume":"31","author":"Modica\n              I,","year":"2007","unstructured":"Modica\n              I, \n            \n              Soslow\n              RA, \n            \n              Black\n              D, \n            \n              Tornos\n              C, \n            \n              Kauff\n              N, \n            \n              Shia\n              J. \n          \n          Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma. Am J Surg Pathol. 2007;31(5):744\u2013751."},{"issue":"15","key":"i1543-2165-138-3-335-b33","series-title":"Cancer Res","first-page":"7810","article-title":"Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients","volume":"66","author":"Hampel\n              H,","year":"2006","unstructured":"Hampel\n              H, \n            \n              Frankel\n              W, \n            \n              Panescu\n              J, \n            et al\n          . Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res. 2006;66(15):7810\u20137817."},{"issue":"12","key":"i1543-2165-138-3-335-b34","series-title":"Am J Surg Pathol","first-page":"1902","article-title":"\u201cNull pattern\u201d of immunoreactivity in a Lynch syndrome-associated colon cancer due to germline MSH2 mutation and somatic MLH1 hypermethylation","volume":"35","author":"Hagen\n              CE,","year":"2011","unstructured":"Hagen\n              CE, \n            \n              Lefferts\n              J, \n            \n              Hornick\n              JL, \n            \n              Srivastava\n              A. \n          \n          \u201cNull pattern\u201d of immunoreactivity in a Lynch syndrome-associated colon cancer due to germline MSH2 mutation and somatic MLH1 hypermethylation. Am J Surg Pathol. 2011;35(12):1902\u20131905."},{"issue":"5","key":"i1543-2165-138-3-335-b35","series-title":"Int J Cancer","first-page":"697","article-title":"MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers","volume":"99","author":"Whelan\n              AJ,","year":"2002","unstructured":"Whelan\n              AJ, \n            \n              Babb\n              S, \n            \n              Mutch\n              DG, \n            et al\n          . MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers. Int J Cancer. 2002;99(5):697\u2013704."},{"issue":"2","key":"i1543-2165-138-3-335-b36","series-title":"Clin Cancer Res","first-page":"481","article-title":"Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation","volume":"10","author":"Buttin\n              BM,","year":"2004","unstructured":"Buttin\n              BM, \n            \n              Powell\n              MA, \n            \n              Mutch\n              DG, \n            et al\n          . Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation. Clin Cancer Res. 2004;10(2):481\u2013490."},{"issue":"16","key":"i1543-2165-138-3-335-b37","series-title":"J Clin Oncol","first-page":"2247","article-title":"Testing women with endometrial cancer to detect Lynch syndrome","volume":"29","author":"Kwon\n              JS,","year":"2011","unstructured":"Kwon\n              JS, \n            \n              Scott\n              JL, \n            \n              Gilks\n              CB, \n            \n              Daniels\n              MS, \n            \n              Sun\n              CC, \n            \n              Lu\n              KH. \n          \n          Testing women with endometrial cancer to detect Lynch syndrome. J Clin Oncol. 2011;29(16):2247\u20132252."},{"issue":"1","key":"i1543-2165-138-3-335-b38","series-title":"Gynecol Oncol","first-page":"43","article-title":"Conservative treatment of early endometrial cancer: preliminary results of a pilot study","volume":"120","author":"Laurelli\n              G,","year":"2011","unstructured":"Laurelli\n              G, \n            \n              Di Vagno\n              G, \n            \n              Scaffa\n              C, \n            \n              Losito\n              S, \n            \n              Del Giudice\n              M, \n            \n              Greggi\n              S. \n          \n          Conservative treatment of early endometrial cancer: preliminary results of a pilot study. Gynecol Oncol. 2011;120(1):43\u201346."},{"issue":"4","key":"i1543-2165-138-3-335-b39","series-title":"Am J Obstet Gynecol","first-page":"651","article-title":"Intrauterine progesterone treatment of early endometrial cancer","volume":"186","author":"Montz\n              FJ,","year":"2002","unstructured":"Montz\n              FJ, \n            \n              Bristow\n              RE, \n            \n              Bovicelli\n              A, \n            \n              Tomacruz\n              R, \n            \n              Kurman\n              RJ. \n          \n          Intrauterine progesterone treatment of early endometrial cancer. Am J Obstet Gynecol. 2002;186(4):651\u2013657."},{"issue":"2, pt 2","key":"i1543-2165-138-3-335-b40","series-title":"Obstet Gynecol","first-page":"423","article-title":"Progestin intrauterine device in an adolescent with grade 2 endometrial cancer","volume":"119","author":"Brown\n              AJ,","year":"2012","unstructured":"Brown\n              AJ, \n            \n              Westin\n              SN, \n            \n              Broaddus\n              RR, \n            \n              Schmeler\n              K. \n          \n          Progestin intrauterine device in an adolescent with grade 2 endometrial cancer. Obstet Gynecol. 2012;119(2, pt 2):423\u2013426."},{"issue":"2","key":"i1543-2165-138-3-335-b41","series-title":"Gynecol Oncol","first-page":"255","article-title":"Conservative treatment of endometrial cancer permitting subsequent triplet pregnancy","volume":"58","author":"Kimmig\n              R,","year":"1995","unstructured":"Kimmig\n              R, \n            \n              Strowitzki\n              T, \n            \n              Muller-Hocker\n              J, \n            \n              Kurzl\n              R, \n            \n              Korell\n              M, \n            \n              Hepp\n              H. \n          \n          Conservative treatment of endometrial cancer permitting subsequent triplet pregnancy. Gynecol Oncol. 1995;58(2):255\u2013257."},{"issue":"2","key":"i1543-2165-138-3-335-b42","series-title":"Cancer","first-page":"320","article-title":"Progestin alone as primary treatment of endometrial carcinoma in premenopausal women: report of seven cases and review of the literature","volume":"79","author":"Kim\n              YB,","year":"1997","unstructured":"Kim\n              YB, \n            \n              Holschneider\n              CH, \n            \n              Ghosh\n              K, \n            \n              Nieberg\n              RK, \n            \n              Montz\n              FJ. \n          \n          Progestin alone as primary treatment of endometrial carcinoma in premenopausal women: report of seven cases and review of the literature. Cancer. 1997;79(2):320\u2013327."},{"issue":"1","key":"i1543-2165-138-3-335-b43","series-title":"Cancer Lett","first-page":"39","article-title":"Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: central pathologic review and treatment outcome","volume":"167","author":"Kaku\n              T,","year":"2001","unstructured":"Kaku\n              T, \n            \n              Yoshikawa\n              H, \n            \n              Tsuda\n              H, \n            et al\n          . Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: central pathologic review and treatment outcome. Cancer Lett. 2001;167(1):39\u201348."},{"issue":"3","key":"i1543-2165-138-3-335-b44","series-title":"Obstet Gynecol","first-page":"434","article-title":"Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40","volume":"90","author":"Randall\n              TC,","year":"1997","unstructured":"Randall\n              TC, \n            \n              Kurman\n              RJ. \n          \n          Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40. Obstet Gynecol. 1997;90(3):434\u2013440."},{"issue":"7","key":"i1543-2165-138-3-335-b45","series-title":"Am J Surg Pathol","first-page":"988","article-title":"Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins","volume":"31","author":"Wheeler\n              DT,","year":"2007","unstructured":"Wheeler\n              DT, \n            \n              Bristow\n              RE, \n            \n              Kurman\n              RJ. \n          \n          Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am J Surg Pathol. 2007;31(7):988\u2013998."},{"issue":"8","key":"i1543-2165-138-3-335-b46","series-title":"Cancer","first-page":"2192","article-title":"Fertility-preserving treatment in young patients with endometrial adenocarcinoma","volume":"94","author":"Wang\n              CB,","year":"2002","unstructured":"Wang\n              CB, \n            \n              Wang\n              CJ, \n            \n              Huang\n              HJ, \n            et al\n          . Fertility-preserving treatment in young patients with endometrial adenocarcinoma. Cancer. 2002;94(8):2192\u20132198."},{"issue":"3","key":"i1543-2165-138-3-335-b47","series-title":"BJOG","first-page":"317","article-title":"Outcome of fertility-preserving treatment in young women with endometrial carcinomas","volume":"112","author":"Niwa\n              K,","year":"2005","unstructured":"Niwa\n              K, \n            \n              Tagami\n              K, \n            \n              Lian\n              Z, \n            \n              Onogi\n              K, \n            \n              Mori\n              H, \n            \n              Tamaya\n              T. \n          \n          Outcome of fertility-preserving treatment in young women with endometrial carcinomas. BJOG. 2005;112(3):317\u2013320."},{"issue":"19","key":"i1543-2165-138-3-335-b48","series-title":"J Clin Oncol","first-page":"2798","article-title":"Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women","volume":"25","author":"Ushijima\n              K,","year":"2007","unstructured":"Ushijima\n              K, \n            \n              Yahata\n              H, \n            \n              Yoshikawa\n              H, \n            et al\n          . Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol. 2007;25(19):2798\u20132803."},{"issue":"2 suppl","key":"i1543-2165-138-3-335-b49","series-title":"Gynecol Oncol","first-page":"S101","article-title":"Sparing fertility in young patients with endometrial cancer","volume":"111","author":"Chiva\n              L,","year":"2008","unstructured":"Chiva\n              L, \n            \n              Lapuente\n              F, \n            \n              Gonzalez-Cortijo\n              L, \n            et al\n          . Sparing fertility in young patients with endometrial cancer. Gynecol Oncol. 2008;111(2 suppl):S101\u2013S104."},{"issue":"6","key":"i1543-2165-138-3-335-b50","series-title":"Int J Gynecol Cancer","first-page":"1068","article-title":"Conservative treatment with progestin and pregnancy outcomes in endometrial cancer","volume":"19","author":"Hahn\n              HS,","year":"2009","unstructured":"Hahn\n              HS, \n            \n              Yoon\n              SG, \n            \n              Hong\n              JS, \n            et al\n          . Conservative treatment with progestin and pregnancy outcomes in endometrial cancer. Int J Gynecol Cancer. 2009;19(6):1068\u20131073."},{"issue":"3","key":"i1543-2165-138-3-335-b51","series-title":"Gynecol Oncol","first-page":"504","article-title":"A review of the challenges faced in the conservative treatment of young women with endometrial carcinoma and risk of ovarian cancer","volume":"115","author":"Zivanovic\n              O,","year":"2009","unstructured":"Zivanovic\n              O, \n            \n              Carter\n              J, \n            \n              Kauff\n              ND, \n            \n              Barakat\n              RR. \n          \n          A review of the challenges faced in the conservative treatment of young women with endometrial carcinoma and risk of ovarian cancer. Gynecol Oncol. 2009;115(3):504\u2013509."},{"issue":"3","key":"i1543-2165-138-3-335-b52","series-title":"Anticancer Res","first-page":"1037","article-title":"Progestin treatment of atypical hyperplasia and well-differentiated adenocarcinoma of the endometrium to preserve fertility","volume":"32","author":"Koskas\n              M,","year":"2012","unstructured":"Koskas\n              M, \n            \n              Azria\n              E, \n            \n              Walker\n              F, \n            \n              Luton\n              D, \n            \n              Madelenat\n              P, \n            \n              Yazbeck\n              C. \n          \n          Progestin treatment of atypical hyperplasia and well-differentiated adenocarcinoma of the endometrium to preserve fertility. Anticancer Res. 2012;32(3):1037\u20131043."},{"issue":"1","key":"i1543-2165-138-3-335-b53","series-title":"Gynecol Oncol","first-page":"215","article-title":"Progression of conservatively treated endometrial carcinoma after full term pregnancy: a case report","volume":"99","author":"Ferrandina\n              G,","year":"2005","unstructured":"Ferrandina\n              G, \n            \n              Zannoni\n              GF, \n            \n              Gallotta\n              V, \n            \n              Foti\n              E, \n            \n              Mancuso\n              S, \n            \n              Scambia\n              G. \n          \n          Progression of conservatively treated endometrial carcinoma after full term pregnancy: a case report. Gynecol Oncol. 2005;99(1):215\u2013217."},{"issue":"2","key":"i1543-2165-138-3-335-b54","series-title":"Gynecol Oncol","first-page":"472","article-title":"Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia","volume":"99","author":"Rubatt\n              JM,","year":"2005","unstructured":"Rubatt\n              JM, \n            \n              Slomovitz\n              BM, \n            \n              Burke\n              TW, \n            \n              Broaddus\n              RR. \n          \n          Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia. Gynecol Oncol. 2005;99(2):472\u2013476."},{"issue":"10","key":"i1543-2165-138-3-335-b55","series-title":"Endocrinology","first-page":"4863","article-title":"Estrogen up-regulates mismatch repair activity in normal and malignant endometrial glandular cells","volume":"147","author":"Miyamoto\n              T,","year":"2006","unstructured":"Miyamoto\n              T, \n            \n              Shiozawa\n              T, \n            \n              Kashima\n              H, \n            et al\n          . Estrogen up-regulates mismatch repair activity in normal and malignant endometrial glandular cells. Endocrinology. 2006;147(10):4863\u20134870."},{"issue":"1","key":"i1543-2165-138-3-335-b56","series-title":"Cancer Res","first-page":"126","article-title":"Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer","volume":"61","author":"Slattery\n              ML,","year":"2001","unstructured":"Slattery\n              ML, \n            \n              Potter\n              JD, \n            \n              Curtin\n              K, \n            et al\n          . Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer. Cancer Res. 2001;61(1):126\u2013130."},{"issue":"11","key":"i1543-2165-138-3-335-b57","series-title":"J Reprod Med","first-page":"869","article-title":"Absence of progesterone receptors in a failed case of fertility-sparing treatment in early endometrial cancer: a case report","volume":"53","author":"Hoekstra\n              AV,","year":"2008","unstructured":"Hoekstra\n              AV, \n            \n              Kim\n              JJ, \n            \n              Keh\n              P, \n            \n              Schink\n              JC. \n          \n          Absence of progesterone receptors in a failed case of fertility-sparing treatment in early endometrial cancer: a case report. J Reprod Med. 2008;53(11):869\u2013873."},{"issue":"7","key":"i1543-2165-138-3-335-b58","series-title":"Hum Reprod","first-page":"1953","article-title":"Fertility-preserving treatment with progestin, and pathological criteria to predict responses, in young women with endometrial cancer","volume":"22","author":"Yamazawa\n              K,","year":"2007","unstructured":"Yamazawa\n              K, \n            \n              Hirai\n              M, \n            \n              Fujito\n              A, \n            et al\n          . Fertility-preserving treatment with progestin, and pathological criteria to predict responses, in young women with endometrial cancer. Hum Reprod. 2007;22(7):1953\u20131958."},{"issue":"5","key":"i1543-2165-138-3-335-b59","series-title":"Int J Gynecol Cancer","first-page":"964","article-title":"Hormone therapy in advanced and recurrent endometrial cancer: a systematic review","volume":"17","author":"Decruze\n              SB,","year":"2007","unstructured":"Decruze\n              SB, \n            \n              Green\n              JA. \n          \n          Hormone therapy in advanced and recurrent endometrial cancer: a systematic review. Int J Gynecol Cancer. 2007;17(5):964\u2013978."},{"issue":"1","key":"i1543-2165-138-3-335-b60","series-title":"Int J Radiat Oncol Biol Phys","first-page":"21","article-title":"The predictive value of progesterone receptor levels in endometrial cancer","volume":"17","author":"Ingram\n              SS,","year":"1989","unstructured":"Ingram\n              SS, \n            \n              Rosenman\n              J, \n            \n              Heath\n              R, \n            \n              Morgan\n              TM, \n            \n              Moore\n              D, \n            \n              Varia\n              M. \n          \n          The predictive value of progesterone receptor levels in endometrial cancer. Int J Radiat Oncol Biol Phys. 1989;17(1):21\u201327."},{"issue":"4","key":"i1543-2165-138-3-335-b61","series-title":"Am J Obstet Gynecol","first-page":"796","article-title":"Steroid receptors and clinical outcome in patients with adenocarcinoma of the endometrium","volume":"158","author":"Ehrlich\n              CE,","year":"1988","unstructured":"Ehrlich\n              CE, \n            \n              Young\n              PC, \n            \n              Stehman\n              FB, \n            \n              Sutton\n              GP, \n            \n              Alford\n              WM. \n          \n          Steroid receptors and clinical outcome in patients with adenocarcinoma of the endometrium. Am J Obstet Gynecol. 1988;158(4):796\u2013807."},{"issue":"6","key":"i1543-2165-138-3-335-b62","series-title":"J Clin Oncol","first-page":"1736","article-title":"Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group","volume":"17","author":"Thigpen\n              JT,","year":"1999","unstructured":"Thigpen\n              JT, \n            \n              Brady\n              MF, \n            \n              Alvarez\n              RD, \n            et al\n          . Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J Clin Oncol. 1999;17(6):1736\u20131744."},{"issue":"3","key":"i1543-2165-138-3-335-b63","series-title":"Gynecol Oncol","first-page":"314","article-title":"Endometrial carcinoma: steroid receptors and response to medroxyprogesterone acetate","volume":"21","author":"Quinn\n              MA,","year":"1985","unstructured":"Quinn\n              MA, \n            \n              Cauchi\n              M, \n            \n              Fortune\n              D. \n          \n          Endometrial carcinoma: steroid receptors and response to medroxyprogesterone acetate. Gynecol Oncol. 1985;21(3):314\u2013319."},{"issue":"4","key":"i1543-2165-138-3-335-b64","series-title":"Obstet Gynecol","first-page":"693","article-title":"Coexisting ovarian malignancy in young women with endometrial cancer","volume":"106","author":"Walsh\n              C,","year":"2005","unstructured":"Walsh\n              C, \n            \n              Holschneider\n              C, \n            \n              Hoang\n              Y, \n            \n              Tieu\n              K, \n            \n              Karlan\n              B, \n            \n              Cass\n              I. \n          \n          Coexisting ovarian malignancy in young women with endometrial cancer. Obstet Gynecol. 2005;106(4):693\u2013699."},{"issue":"2","key":"i1543-2165-138-3-335-b65","series-title":"Gynecol Oncol","first-page":"456","article-title":"Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases","volume":"94","author":"Soliman\n              PT,","year":"2004","unstructured":"Soliman\n              PT, \n            \n              Slomovitz\n              BM, \n            \n              Broaddus\n              RR, \n            et al\n          . Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases. Gynecol Oncol. 2004;94(2):456\u2013462."},{"issue":"3","key":"i1543-2165-138-3-335-b66","series-title":"Obstet Gynecol","first-page":"349","article-title":"Profile of women 45 years of age and younger with endometrial cancer","volume":"91","author":"Evans-Metcalf\n              ER,","year":"1998","unstructured":"Evans-Metcalf\n              ER, \n            \n              Brooks\n              SE, \n            \n              Reale\n              FR, \n            \n              Baker\n              SP. \n          \n          Profile of women 45 years of age and younger with endometrial cancer. Obstet Gynecol. 1998;91(3):349\u2013354."},{"issue":"1","key":"i1543-2165-138-3-335-b67","series-title":"Gynecol Oncol","first-page":"109","article-title":"Incidence and factors associated with synchronous ovarian and endometrial cancer: a population-based case-control study","volume":"125","author":"AlHilli\n              MM,","year":"2012","unstructured":"AlHilli\n              MM, \n            \n              Dowdy\n              SC, \n            \n              Weaver\n              AL, \n            et al\n          . Incidence and factors associated with synchronous ovarian and endometrial cancer: a population-based case-control study. Gynecol Oncol. 2012;125(1):109\u2013113."},{"issue":"3","key":"i1543-2165-138-3-335-b68","series-title":"Gynecol Oncol","first-page":"757","article-title":"Young patients with endometrial carcinoma selected for conservative treatment: a need for vigilance for synchronous ovarian carcinomas, case report and literature review","volume":"104","author":"Shamshirsaz\n              AA,","year":"2007","unstructured":"Shamshirsaz\n              AA, \n            \n              Withiam-Leitch\n              M, \n            \n              Odunsi\n              K, \n            \n              Baker\n              T, \n            \n              Frederick\n              PJ, \n            \n              Lele\n              S. \n          \n          Young patients with endometrial carcinoma selected for conservative treatment: a need for vigilance for synchronous ovarian carcinomas, case report and literature review. Gynecol Oncol. 2007;104(3):757\u2013760."},{"issue":"2","key":"i1543-2165-138-3-335-b69","series-title":"Gynecol Oncol","first-page":"355","article-title":"Simultaneously detected endometrial and ovarian carcinomas\u2014a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study","volume":"83","author":"Zaino\n              R,","year":"2001","unstructured":"Zaino\n              R, \n            \n              Whitney\n              C, \n            \n              Brady\n              MF, \n            \n              DeGeest\n              K, \n            \n              Burger\n              RA, \n            \n              Buller\n              RE. \n          \n          Simultaneously detected endometrial and ovarian carcinomas\u2014a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol. 2001;83(2):355\u2013362."},{"issue":"1","key":"i1543-2165-138-3-335-b70","series-title":"Hum Pathol","first-page":"28","article-title":"Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases","volume":"16","author":"Ulbright\n              TM,","year":"1985","unstructured":"Ulbright\n              TM, \n            \n              Roth\n              LM. \n          \n          Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases. Hum Pathol. 1985;16(1):28\u201334."},{"issue":"6","key":"i1543-2165-138-3-335-b71","series-title":"Hum Pathol","first-page":"605","article-title":"Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis","volume":"36","author":"Irving\n              JA,","year":"2005","unstructured":"Irving\n              JA, \n            \n              Catasus\n              L, \n            \n              Gallardo\n              A, \n            et al\n          . Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis. Hum Pathol. 2005;36(6):605\u2013619."},{"issue":"2","key":"i1543-2165-138-3-335-b72","series-title":"Gynecol Oncol","first-page":"223","article-title":"The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer","volume":"82","author":"Watson\n              P,","year":"2001","unstructured":"Watson\n              P, \n            \n              Butzow\n              R, \n            \n              Lynch\n              HT, \n            et al\n          . The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. Gynecol Oncol. 2001;82(2):223\u2013228."},{"issue":"2","key":"i1543-2165-138-3-335-b73","series-title":"Am J Surg Pathol","first-page":"163","article-title":"Ovarian endometrioid adenocarcinoma: incidence and clinical significance of the morphologic and immunohistochemical markers of mismatch repair protein defects and tumor microsatellite instability","volume":"36","author":"Aysal\n              A,","year":"2012","unstructured":"Aysal\n              A, \n            \n              Karnezis\n              A, \n            \n              Medhi\n              I, \n            \n              Grenert\n              JP, \n            \n              Zaloudek\n              CJ, \n            \n              Rabban\n              JT. \n          \n          Ovarian endometrioid adenocarcinoma: incidence and clinical significance of the morphologic and immunohistochemical markers of mismatch repair protein defects and tumor microsatellite instability. Am J Surg Pathol. 2012;36(2):163\u2013172."},{"issue":"4","key":"i1543-2165-138-3-335-b74","series-title":"Clin Cancer Res","first-page":"1387","article-title":"Incidence of microsatellite instability in synchronous tumors of the ovary and endometrium","volume":"9","author":"Shannon\n              C,","year":"2003","unstructured":"Shannon\n              C, \n            \n              Kirk\n              J, \n            \n              Barnetson\n              R, \n            et al\n          . Incidence of microsatellite instability in synchronous tumors of the ovary and endometrium. Clin Cancer Res. 2003;9(4):1387\u20131392."},{"issue":"36","key":"i1543-2165-138-3-335-b75","series-title":"J Clin Oncol","first-page":"9344","article-title":"Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?","volume":"23","author":"Soliman\n              PT,","year":"2005","unstructured":"Soliman\n              PT, \n            \n              Broaddus\n              RR, \n            \n              Schmeler\n              KM, \n            et al\n          . Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?J Clin Oncol. 2005;23(36):9344\u20139350."},{"issue":"3","key":"i1543-2165-138-3-335-b76","series-title":"Gynecol Oncol","first-page":"462","article-title":"Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors","volume":"121","author":"Ketabi\n              Z,","year":"2011","unstructured":"Ketabi\n              Z, \n            \n              Bartuma\n              K, \n            \n              Bernstein\n              I, \n            et al\n          . Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors. Gynecol Oncol. 2011;121(3):462\u2013465."},{"issue":"7","key":"i1543-2165-138-3-335-b77","series-title":"Am J Surg Pathol","first-page":"1029","article-title":"Microsatellite instability and mismatch repair protein defects in ovarian epithelial neoplasms in patients 50 years of age and younger","volume":"32","author":"Jensen\n              KC,","year":"2008","unstructured":"Jensen\n              KC, \n            \n              Mariappan\n              MR, \n            \n              Putcha\n              GV, \n            et al\n          . Microsatellite instability and mismatch repair protein defects in ovarian epithelial neoplasms in patients 50 years of age and younger. Am J Surg Pathol. 2008;32(7):1029\u20131037."},{"issue":"5","key":"i1543-2165-138-3-335-b78","series-title":"Hum Pathol","first-page":"552","article-title":"Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma","volume":"35","author":"Cai\n              KQ,","year":"2004","unstructured":"Cai\n              KQ, \n            \n              Albarracin\n              C, \n            \n              Rosen\n              D, \n            et al\n          . Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma. Hum Pathol. 2004;35(5):552\u2013559."},{"issue":"5","key":"i1543-2165-138-3-335-b01","series-title":"Eur J Gynaecol Oncol","first-page":"353","article-title":"Clinico-pathological profile of endometrial carcinoma in young women (under 40 years of age)","volume":"10","author":"Colafranceschi\n              M,","year":"1989","unstructured":"Colafranceschi\n              M, \n            \n              Taddei\n              GL, \n            \n              Scarselli\n              G, \n            \n              Branconi\n              F, \n            \n              Tinacci\n              G, \n            \n              Savino\n              L. \n          \n          Clinico-pathological profile of endometrial carcinoma in young women (under 40 years of age). Eur J Gynaecol Oncol. 1989;10(5):353\u2013356."},{"issue":"6","key":"i1543-2165-138-3-335-b02","series-title":"Obstet Gynecol","first-page":"699","article-title":"Endometrial carcinoma in women 40 years of age or younger","volume":"57","author":"Crissman\n              JD,","year":"1981","unstructured":"Crissman\n              JD, \n            \n              Azoury\n              RS, \n            \n              Barnes\n              AE, \n            \n              Schellhas\n              HF. \n          \n          Endometrial carcinoma in women 40 years of age or younger. Obstet Gynecol. 1981;57(6):699\u2013704."},{"issue":"2","key":"i1543-2165-138-3-335-b03","series-title":"Gynecol Oncol","first-page":"388","article-title":"Endometrial cancer in women 40 years old or younger","volume":"83","author":"Duska\n              LR,","year":"2001","unstructured":"Duska\n              LR, \n            \n              Garrett\n              A, \n            \n              Rueda\n              BR, \n            \n              Haas\n              J, \n            \n              Chang\n              Y, \n            \n              Fuller\n              AF. \n          \n          Endometrial cancer in women 40 years old or younger. Gynecol Oncol. 2001;83(2):388\u2013393."},{"issue":"3","key":"i1543-2165-138-3-335-b04","series-title":"Obstet Gynecol","first-page":"417","article-title":"Adenocarcinoma of the endometrium in women 40 years of age or younger","volume":"64","author":"Gallup\n              DG,","year":"1984","unstructured":"Gallup\n              DG, \n            \n              Stock\n              RJ. \n          \n          Adenocarcinoma of the endometrium in women 40 years of age or younger. Obstet Gynecol. 1984;64(3):417\u2013420."},{"issue":"4","key":"i1543-2165-138-3-335-b05","series-title":"Int J Gynecol Cancer","first-page":"657","article-title":"Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger","volume":"15","author":"Ota\n              T,","year":"2005","unstructured":"Ota\n              T, \n            \n              Yoshida\n              M, \n            \n              Kimura\n              M, \n            \n              Kinoshita\n              K. \n          \n          Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger. Int J Gynecol Cancer. 2005;15(4):657\u2013662."},{"issue":"33","key":"i1543-2165-138-3-335-b06","series-title":"J Clin Oncol","first-page":"5158","article-title":"Prospective determination of prevalence of Lynch syndrome in young women with endometrial cancer","volume":"25","author":"Lu\n              KH,","year":"2007","unstructured":"Lu\n              KH, \n            \n              Schorge\n              JO, \n            \n              Rodabaugh\n              KJ, \n            et al\n          . Prospective determination of prevalence of Lynch syndrome in young women with endometrial cancer. J Clin Oncol. 2007;25(33):5158\u20135164."},{"issue":"1","key":"i1543-2165-138-3-335-b07","series-title":"Gynecol Oncol","first-page":"88","article-title":"Clinicopathologic significance of DNA mismatch repair protein defects and endometrial cancer in women 40 years of age and younger","volume":"123","author":"Shih\n              KK,","year":"2011","unstructured":"Shih\n              KK, \n            \n              Garg\n              K, \n            \n              Levine\n              DA, \n            et al\n          . Clinicopathologic significance of DNA mismatch repair protein defects and endometrial cancer in women 40 years of age and younger. Gynecol Oncol. 2011;123(1):88\u201394."},{"issue":"12","key":"i1543-2165-138-3-335-b08","series-title":"Am J Surg Pathol","first-page":"1869","article-title":"Endometrial carcinomas in women aged 40 years and younger: tumors associated with loss of DNA mismatch repair proteins comprise a distinct clinicopathologic subset","volume":"33","author":"Garg\n              K,","year":"2009","unstructured":"Garg\n              K, \n            \n              Shih\n              K, \n            \n              Barakat\n              R, \n            \n              Zhou\n              Q, \n            \n              Iasonos\n              A, \n            \n              Soslow\n              RA. \n          \n          Endometrial carcinomas in women aged 40 years and younger: tumors associated with loss of DNA mismatch repair proteins comprise a distinct clinicopathologic subset. Am J Surg Pathol. 2009;33(12):1869\u20131877."},{"issue":"6","key":"i1543-2165-138-3-335-b09","series-title":"Clin Cancer Res","first-page":"1692","article-title":"Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients","volume":"14","author":"Walsh\n              MD,","year":"2008","unstructured":"Walsh\n              MD, \n            \n              Cummings\n              MC, \n            \n              Buchanan\n              DD, \n            et al\n          . Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients. Clin Cancer Res. 2008;14(6):1692\u20131700."},{"issue":"5","key":"i1543-2165-138-3-335-b10","series-title":"Obstet Gynecol","first-page":"1161","article-title":"Lynch syndrome in women less than 50 years of age with endometrial cancer","volume":"111","author":"Matthews\n              KS,","year":"2008","unstructured":"Matthews\n              KS, \n            \n              Estes\n              JM, \n            \n              Conner\n              MG, \n            et al\n          . Lynch syndrome in women less than 50 years of age with endometrial cancer. Obstet Gynecol. 2008;111(5):1161\u20131166."},{"issue":"3","key":"i1543-2165-138-3-335-b11","series-title":"Obstet Gynecol","first-page":"575","article-title":"Risk factors for young premenopausal women with endometrial cancer","volume":"105","author":"Soliman\n              PT,","year":"2005","unstructured":"Soliman\n              PT, \n            \n              Oh\n              JC, \n            \n              Schmeler\n              KM, \n            et al\n          . Risk factors for young premenopausal women with endometrial cancer. Obstet Gynecol. 2005;105(3):575\u2013580."},{"issue":"12","key":"i1543-2165-138-3-335-b12","series-title":"Cancer Causes Control","first-page":"2303","article-title":"Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study","volume":"21","author":"Fearnley\n              EJ,","year":"2010","unstructured":"Fearnley\n              EJ, \n            \n              Marquart\n              L, \n            \n              Spurdle\n              AB, \n            \n              Weinstein\n              P, \n            \n              Webb\n              PM. \n          \n          Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study. Cancer Causes Control. 2010;21(12):2303\u20132308."},{"issue":"3","key":"i1543-2165-138-3-335-b13","series-title":"Gynecol Oncol","first-page":"535","article-title":"Body mass index: relationship to clinical, pathologic and features of microsatellite instability in endometrial cancer","volume":"104","author":"McCourt\n              CK,","year":"2007","unstructured":"McCourt\n              CK, \n            \n              Mutch\n              DG, \n            \n              Gibb\n              RK, \n            et al\n          . Body mass index: relationship to clinical, pathologic and features of microsatellite instability in endometrial cancer. Gynecol Oncol. 2007;104(3):535\u2013539."},{"issue":"2","key":"i1543-2165-138-3-335-b14","series-title":"Gynecol Oncol","first-page":"388","article-title":"Endometrial cancer in young, normal-weight women","volume":"99","author":"Schmeler\n              KM,","year":"2005","unstructured":"Schmeler\n              KM, \n            \n              Soliman\n              PT, \n            \n              Sun\n              CC, \n            \n              Slomovitz\n              BM, \n            \n              Gershenson\n              DM, \n            \n              Lu\n              KH. \n          \n          Endometrial cancer in young, normal-weight women. Gynecol Oncol. 2005;99(2):388\u2013392."},{"issue":"1","key":"i1543-2165-138-3-335-b15","series-title":"Int J Gynecol Pathol","first-page":"52","article-title":"Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma?","volume":"25","author":"Silva\n              EG,","year":"2006","unstructured":"Silva\n              EG, \n            \n              Deavers\n              MT, \n            \n              Bodurka\n              DC, \n            \n              Malpica\n              A. \n          \n          Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma?\n          Int J Gynecol Pathol. 2006;25(1):52\u201358."},{"issue":"10","key":"i1543-2165-138-3-335-b16","series-title":"Am J Surg Pathol","first-page":"1316","article-title":"Undifferentiated carcinoma of the endometrium","volume":"29","author":"Altrabulsi\n              B,","year":"2005","unstructured":"Altrabulsi\n              B, \n            \n              Malpica\n              A, \n            \n              Deavers\n              MT, \n            \n              Bodurka\n              DC, \n            \n              Broaddus\n              R, \n            \n              Silva\n              EG. \n          \n          Undifferentiated carcinoma of the endometrium. Am J Surg Pathol. 2005;29(10):1316\u20131321."},{"issue":"6","key":"i1543-2165-138-3-335-b17","series-title":"Mod Pathol","first-page":"781","article-title":"Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasms","volume":"23","author":"Tafe\n              LJ,","year":"2010","unstructured":"Tafe\n              LJ, \n            \n              Garg\n              K, \n            \n              Chew\n              I, \n            \n              Tornos\n              C, \n            \n              Soslow\n              RA. \n          \n          Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasms. Mod Pathol. 2010;23(6):781\u2013789."},{"issue":"6","key":"i1543-2165-138-3-335-b18","series-title":"Am J Surg Pathol","first-page":"925","article-title":"Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities","volume":"33","author":"Garg\n              K,","year":"2009","unstructured":"Garg\n              K, \n            \n              Leitao\n              MM\n              Jr, \n            \n              Kauff\n              ND, \n            et al\n          . Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities. Am J Surg Pathol. 2009;33(6):925\u2013933."},{"issue":"1","key":"i1543-2165-138-3-335-b19","series-title":"Int J Surg Pathol","first-page":"21","article-title":"Lynch syndrome\u2014related endometrial carcinomas show a high frequency of nonendometrioid types and of high FIGO grade endometrioid types","volume":"18","author":"Carcangiu\n              ML,","year":"2010","unstructured":"Carcangiu\n              ML, \n            \n              Radice\n              P, \n            \n              Casalini\n              P, \n            \n              Bertario\n              L, \n            \n              Merola\n              M, \n            \n              Sala\n              P. \n          \n          Lynch syndrome\u2014related endometrial carcinomas show a high frequency of nonendometrioid types and of high FIGO grade endometrioid types. Int J Surg Pathol. 2010;18(1):21\u201326."},{"issue":"1","key":"i1543-2165-138-3-335-b20","series-title":"Cancer","first-page":"87","article-title":"Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma","volume":"106","author":"Broaddus\n              RR,","year":"2006","unstructured":"Broaddus\n              RR, \n            \n              Lynch\n              HT, \n            \n              Chen\n              LM, \n            et al\n          . Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma. Cancer. 2006;106(1):87\u201394."},{"issue":"4","key":"i1543-2165-138-3-335-b21","series-title":"Semin Diagn Pathol","first-page":"261","article-title":"Endometrial carcinomas with ambiguous features","volume":"27","author":"Soslow\n              RA.","year":"2010","unstructured":"Soslow\n              RA. \n          \n          Endometrial carcinomas with ambiguous features. Semin Diagn Pathol. 2010;27(4):261\u2013273."},{"issue":"36","key":"i1543-2165-138-3-335-b22","series-title":"J Clin Oncol","first-page":"5965","article-title":"Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome","volume":"26","author":"Westin\n              SN,","year":"2008","unstructured":"Westin\n              SN, \n            \n              Lacour\n              RA, \n            \n              Urbauer\n              DL, \n            et al\n          . Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome. J Clin Oncol. 2008;26(36):5965\u20135971."},{"issue":"1","key":"i1543-2165-138-3-335-b23","series-title":"Hum Pathol","first-page":"116","article-title":"Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer","volume":"39","author":"Shia\n              J,","year":"2008","unstructured":"Shia\n              J, \n            \n              Black\n              D, \n            \n              Hummer\n              AJ, \n            \n              Boyd\n              J, \n            \n              Soslow\n              RA. \n          \n          Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer. Hum Pathol. 2008;39(1):116\u2013125."},{"issue":"1","key":"i1543-2165-138-3-335-b24","series-title":"Am J Surg Pathol","first-page":"1","article-title":"Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus: a clinicopathologic study of 55 cases","volume":"20","author":"Longacre\n              TA,","year":"1996","unstructured":"Longacre\n              TA, \n            \n              Chung\n              MH, \n            \n              Rouse\n              RV, \n            \n              Hendrickson\n              MR. \n          \n          Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus: a clinicopathologic study of 55 cases. Am J Surg Pathol. 1996;20(1):1\u201320."},{"issue":"2","key":"i1543-2165-138-3-335-b25","series-title":"Am J Clin Pathol","first-page":"139","article-title":"Atypical polypoid adenomyoma of the uterus: a report of 27 cases","volume":"86","author":"Young\n              RH,","year":"1986","unstructured":"Young\n              RH, \n            \n              Treger\n              T, \n            \n              Scully\n              RE. \n          \n          Atypical polypoid adenomyoma of the uterus: a report of 27 cases. Am J Clin Pathol. 1986;86(2):139\u2013145."},{"issue":"6","key":"i1543-2165-138-3-335-b26","series-title":"Am J Surg Pathol","first-page":"706","article-title":"More differences between HNPCC-related and sporadic carcinomas from the endometrium as compared to the colon","volume":"28","author":"van den Bos\n              M,","year":"2004","unstructured":"van den Bos\n              M, \n            \n              van den Hoven\n              M, \n            \n              Jongejan\n              E, \n            et al\n          . More differences between HNPCC-related and sporadic carcinomas from the endometrium as compared to the colon. Am J Surg Pathol. 2004;28(6):706\u2013711."},{"issue":"6","key":"i1543-2165-138-3-335-b27","series-title":"Am J Surg Pathol","first-page":"846","article-title":"Microsatellite instability in endometrioid type endometrial adenocarcinoma is associated with poor prognostic indicators","volume":"31","author":"An\n              HJ,","year":"2007","unstructured":"An\n              HJ, \n            \n              Kim\n              KI, \n            \n              Kim\n              JY, \n            et al\n          . Microsatellite instability in endometrioid type endometrial adenocarcinoma is associated with poor prognostic indicators. Am J Surg Pathol. 2007;31(6):846\u2013853."},{"issue":"3","key":"i1543-2165-138-3-335-b28","series-title":"Gynecol Oncol","first-page":"408","article-title":"Clinical and pathologic features of young endometrial cancer patients with loss of mismatch repair expression","volume":"126","author":"Grzankowski\n              KS,","year":"2012","unstructured":"Grzankowski\n              KS, \n            \n              Shimizu\n              DM, \n            \n              Kimata\n              C, \n            \n              Black\n              M, \n            \n              Terada\n              KY. \n          \n          Clinical and pathologic features of young endometrial cancer patients with loss of mismatch repair expression. Gynecol Oncol. 2012;126(3):408\u2013412."},{"issue":"2","key":"i1543-2165-138-3-335-b29","series-title":"Gynecol Oncol","first-page":"234","article-title":"Mismatch repair status and outcomes after adjuvant therapy in patients with surgically staged endometrial cancer","volume":"117","author":"Resnick\n              KE,","year":"2010","unstructured":"Resnick\n              KE, \n            \n              Frankel\n              WL, \n            \n              Morrison\n              CD, \n            et al\n          . Mismatch repair status and outcomes after adjuvant therapy in patients with surgically staged endometrial cancer. Gynecol Oncol. 2010;117(2):234\u2013238."},{"issue":"11","key":"i1543-2165-138-3-335-b30","series-title":"J Clin Oncol","first-page":"1745","article-title":"Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma","volume":"24","author":"Black\n              D,","year":"2006","unstructured":"Black\n              D, \n            \n              Soslow\n              RA, \n            \n              Levine\n              DA, \n            et al\n          . Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma. J Clin Oncol. 2006;24(11):1745\u20131753."},{"issue":"9","key":"i1543-2165-138-3-335-b31","series-title":"Mod Pathol","first-page":"1262","article-title":"Biomarkers and microsatellite instability analysis of curettings can predict the behavior of FIGO stage I endometrial endometrioid adenocarcinoma","volume":"24","author":"Steinbakk\n              A,","year":"2011","unstructured":"Steinbakk\n              A, \n            \n              Malpica\n              A, \n            \n              Slewa\n              A, \n            et al\n          . Biomarkers and microsatellite instability analysis of curettings can predict the behavior of FIGO stage I endometrial endometrioid adenocarcinoma. Mod Pathol. 2011;24(9):1262\u20131271."},{"issue":"5","key":"i1543-2165-138-3-335-b32","series-title":"Am J Surg Pathol","first-page":"744","article-title":"Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma","volume":"31","author":"Modica\n              I,","year":"2007","unstructured":"Modica\n              I, \n            \n              Soslow\n              RA, \n            \n              Black\n              D, \n            \n              Tornos\n              C, \n            \n              Kauff\n              N, \n            \n              Shia\n              J. \n          \n          Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma. Am J Surg Pathol. 2007;31(5):744\u2013751."},{"issue":"15","key":"i1543-2165-138-3-335-b33","series-title":"Cancer Res","first-page":"7810","article-title":"Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients","volume":"66","author":"Hampel\n              H,","year":"2006","unstructured":"Hampel\n              H, \n            \n              Frankel\n              W, \n            \n              Panescu\n              J, \n            et al\n          . Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res. 2006;66(15):7810\u20137817."},{"issue":"12","key":"i1543-2165-138-3-335-b34","series-title":"Am J Surg Pathol","first-page":"1902","article-title":"\u201cNull pattern\u201d of immunoreactivity in a Lynch syndrome-associated colon cancer due to germline MSH2 mutation and somatic MLH1 hypermethylation","volume":"35","author":"Hagen\n              CE,","year":"2011","unstructured":"Hagen\n              CE, \n            \n              Lefferts\n              J, \n            \n              Hornick\n              JL, \n            \n              Srivastava\n              A. \n          \n          \u201cNull pattern\u201d of immunoreactivity in a Lynch syndrome-associated colon cancer due to germline MSH2 mutation and somatic MLH1 hypermethylation. Am J Surg Pathol. 2011;35(12):1902\u20131905."},{"issue":"5","key":"i1543-2165-138-3-335-b35","series-title":"Int J Cancer","first-page":"697","article-title":"MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers","volume":"99","author":"Whelan\n              AJ,","year":"2002","unstructured":"Whelan\n              AJ, \n            \n              Babb\n              S, \n            \n              Mutch\n              DG, \n            et al\n          . MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers. Int J Cancer. 2002;99(5):697\u2013704."},{"issue":"2","key":"i1543-2165-138-3-335-b36","series-title":"Clin Cancer Res","first-page":"481","article-title":"Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation","volume":"10","author":"Buttin\n              BM,","year":"2004","unstructured":"Buttin\n              BM, \n            \n              Powell\n              MA, \n            \n              Mutch\n              DG, \n            et al\n          . Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation. Clin Cancer Res. 2004;10(2):481\u2013490."},{"issue":"16","key":"i1543-2165-138-3-335-b37","series-title":"J Clin Oncol","first-page":"2247","article-title":"Testing women with endometrial cancer to detect Lynch syndrome","volume":"29","author":"Kwon\n              JS,","year":"2011","unstructured":"Kwon\n              JS, \n            \n              Scott\n              JL, \n            \n              Gilks\n              CB, \n            \n              Daniels\n              MS, \n            \n              Sun\n              CC, \n            \n              Lu\n              KH. \n          \n          Testing women with endometrial cancer to detect Lynch syndrome. J Clin Oncol. 2011;29(16):2247\u20132252."},{"issue":"1","key":"i1543-2165-138-3-335-b38","series-title":"Gynecol Oncol","first-page":"43","article-title":"Conservative treatment of early endometrial cancer: preliminary results of a pilot study","volume":"120","author":"Laurelli\n              G,","year":"2011","unstructured":"Laurelli\n              G, \n            \n              Di Vagno\n              G, \n            \n              Scaffa\n              C, \n            \n              Losito\n              S, \n            \n              Del Giudice\n              M, \n            \n              Greggi\n              S. \n          \n          Conservative treatment of early endometrial cancer: preliminary results of a pilot study. Gynecol Oncol. 2011;120(1):43\u201346."},{"issue":"4","key":"i1543-2165-138-3-335-b39","series-title":"Am J Obstet Gynecol","first-page":"651","article-title":"Intrauterine progesterone treatment of early endometrial cancer","volume":"186","author":"Montz\n              FJ,","year":"2002","unstructured":"Montz\n              FJ, \n            \n              Bristow\n              RE, \n            \n              Bovicelli\n              A, \n            \n              Tomacruz\n              R, \n            \n              Kurman\n              RJ. \n          \n          Intrauterine progesterone treatment of early endometrial cancer. Am J Obstet Gynecol. 2002;186(4):651\u2013657."},{"issue":"2, pt 2","key":"i1543-2165-138-3-335-b40","series-title":"Obstet Gynecol","first-page":"423","article-title":"Progestin intrauterine device in an adolescent with grade 2 endometrial cancer","volume":"119","author":"Brown\n              AJ,","year":"2012","unstructured":"Brown\n              AJ, \n            \n              Westin\n              SN, \n            \n              Broaddus\n              RR, \n            \n              Schmeler\n              K. \n          \n          Progestin intrauterine device in an adolescent with grade 2 endometrial cancer. Obstet Gynecol. 2012;119(2, pt 2):423\u2013426."},{"issue":"2","key":"i1543-2165-138-3-335-b41","series-title":"Gynecol Oncol","first-page":"255","article-title":"Conservative treatment of endometrial cancer permitting subsequent triplet pregnancy","volume":"58","author":"Kimmig\n              R,","year":"1995","unstructured":"Kimmig\n              R, \n            \n              Strowitzki\n              T, \n            \n              Muller-Hocker\n              J, \n            \n              Kurzl\n              R, \n            \n              Korell\n              M, \n            \n              Hepp\n              H. \n          \n          Conservative treatment of endometrial cancer permitting subsequent triplet pregnancy. Gynecol Oncol. 1995;58(2):255\u2013257."},{"issue":"2","key":"i1543-2165-138-3-335-b42","series-title":"Cancer","first-page":"320","article-title":"Progestin alone as primary treatment of endometrial carcinoma in premenopausal women: report of seven cases and review of the literature","volume":"79","author":"Kim\n              YB,","year":"1997","unstructured":"Kim\n              YB, \n            \n              Holschneider\n              CH, \n            \n              Ghosh\n              K, \n            \n              Nieberg\n              RK, \n            \n              Montz\n              FJ. \n          \n          Progestin alone as primary treatment of endometrial carcinoma in premenopausal women: report of seven cases and review of the literature. Cancer. 1997;79(2):320\u2013327."},{"issue":"1","key":"i1543-2165-138-3-335-b43","series-title":"Cancer Lett","first-page":"39","article-title":"Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: central pathologic review and treatment outcome","volume":"167","author":"Kaku\n              T,","year":"2001","unstructured":"Kaku\n              T, \n            \n              Yoshikawa\n              H, \n            \n              Tsuda\n              H, \n            et al\n          . Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: central pathologic review and treatment outcome. Cancer Lett. 2001;167(1):39\u201348."},{"issue":"3","key":"i1543-2165-138-3-335-b44","series-title":"Obstet Gynecol","first-page":"434","article-title":"Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40","volume":"90","author":"Randall\n              TC,","year":"1997","unstructured":"Randall\n              TC, \n            \n              Kurman\n              RJ. \n          \n          Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40. Obstet Gynecol. 1997;90(3):434\u2013440."},{"issue":"7","key":"i1543-2165-138-3-335-b45","series-title":"Am J Surg Pathol","first-page":"988","article-title":"Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins","volume":"31","author":"Wheeler\n              DT,","year":"2007","unstructured":"Wheeler\n              DT, \n            \n              Bristow\n              RE, \n            \n              Kurman\n              RJ. \n          \n          Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am J Surg Pathol. 2007;31(7):988\u2013998."},{"issue":"8","key":"i1543-2165-138-3-335-b46","series-title":"Cancer","first-page":"2192","article-title":"Fertility-preserving treatment in young patients with endometrial adenocarcinoma","volume":"94","author":"Wang\n              CB,","year":"2002","unstructured":"Wang\n              CB, \n            \n              Wang\n              CJ, \n            \n              Huang\n              HJ, \n            et al\n          . Fertility-preserving treatment in young patients with endometrial adenocarcinoma. Cancer. 2002;94(8):2192\u20132198."},{"issue":"3","key":"i1543-2165-138-3-335-b47","series-title":"BJOG","first-page":"317","article-title":"Outcome of fertility-preserving treatment in young women with endometrial carcinomas","volume":"112","author":"Niwa\n              K,","year":"2005","unstructured":"Niwa\n              K, \n            \n              Tagami\n              K, \n            \n              Lian\n              Z, \n            \n              Onogi\n              K, \n            \n              Mori\n              H, \n            \n              Tamaya\n              T. \n          \n          Outcome of fertility-preserving treatment in young women with endometrial carcinomas. BJOG. 2005;112(3):317\u2013320."},{"issue":"19","key":"i1543-2165-138-3-335-b48","series-title":"J Clin Oncol","first-page":"2798","article-title":"Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women","volume":"25","author":"Ushijima\n              K,","year":"2007","unstructured":"Ushijima\n              K, \n            \n              Yahata\n              H, \n            \n              Yoshikawa\n              H, \n            et al\n          . Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol. 2007;25(19):2798\u20132803."},{"issue":"2 suppl","key":"i1543-2165-138-3-335-b49","series-title":"Gynecol Oncol","first-page":"S101","article-title":"Sparing fertility in young patients with endometrial cancer","volume":"111","author":"Chiva\n              L,","year":"2008","unstructured":"Chiva\n              L, \n            \n              Lapuente\n              F, \n            \n              Gonzalez-Cortijo\n              L, \n            et al\n          . Sparing fertility in young patients with endometrial cancer. Gynecol Oncol. 2008;111(2 suppl):S101\u2013S104."},{"issue":"6","key":"i1543-2165-138-3-335-b50","series-title":"Int J Gynecol Cancer","first-page":"1068","article-title":"Conservative treatment with progestin and pregnancy outcomes in endometrial cancer","volume":"19","author":"Hahn\n              HS,","year":"2009","unstructured":"Hahn\n              HS, \n            \n              Yoon\n              SG, \n            \n              Hong\n              JS, \n            et al\n          . Conservative treatment with progestin and pregnancy outcomes in endometrial cancer. Int J Gynecol Cancer. 2009;19(6):1068\u20131073."},{"issue":"3","key":"i1543-2165-138-3-335-b51","series-title":"Gynecol Oncol","first-page":"504","article-title":"A review of the challenges faced in the conservative treatment of young women with endometrial carcinoma and risk of ovarian cancer","volume":"115","author":"Zivanovic\n              O,","year":"2009","unstructured":"Zivanovic\n              O, \n            \n              Carter\n              J, \n            \n              Kauff\n              ND, \n            \n              Barakat\n              RR. \n          \n          A review of the challenges faced in the conservative treatment of young women with endometrial carcinoma and risk of ovarian cancer. Gynecol Oncol. 2009;115(3):504\u2013509."},{"issue":"3","key":"i1543-2165-138-3-335-b52","series-title":"Anticancer Res","first-page":"1037","article-title":"Progestin treatment of atypical hyperplasia and well-differentiated adenocarcinoma of the endometrium to preserve fertility","volume":"32","author":"Koskas\n              M,","year":"2012","unstructured":"Koskas\n              M, \n            \n              Azria\n              E, \n            \n              Walker\n              F, \n            \n              Luton\n              D, \n            \n              Madelenat\n              P, \n            \n              Yazbeck\n              C. \n          \n          Progestin treatment of atypical hyperplasia and well-differentiated adenocarcinoma of the endometrium to preserve fertility. Anticancer Res. 2012;32(3):1037\u20131043."},{"issue":"1","key":"i1543-2165-138-3-335-b53","series-title":"Gynecol Oncol","first-page":"215","article-title":"Progression of conservatively treated endometrial carcinoma after full term pregnancy: a case report","volume":"99","author":"Ferrandina\n              G,","year":"2005","unstructured":"Ferrandina\n              G, \n            \n              Zannoni\n              GF, \n            \n              Gallotta\n              V, \n            \n              Foti\n              E, \n            \n              Mancuso\n              S, \n            \n              Scambia\n              G. \n          \n          Progression of conservatively treated endometrial carcinoma after full term pregnancy: a case report. Gynecol Oncol. 2005;99(1):215\u2013217."},{"issue":"2","key":"i1543-2165-138-3-335-b54","series-title":"Gynecol Oncol","first-page":"472","article-title":"Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia","volume":"99","author":"Rubatt\n              JM,","year":"2005","unstructured":"Rubatt\n              JM, \n            \n              Slomovitz\n              BM, \n            \n              Burke\n              TW, \n            \n              Broaddus\n              RR. \n          \n          Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia. Gynecol Oncol. 2005;99(2):472\u2013476."},{"issue":"10","key":"i1543-2165-138-3-335-b55","series-title":"Endocrinology","first-page":"4863","article-title":"Estrogen up-regulates mismatch repair activity in normal and malignant endometrial glandular cells","volume":"147","author":"Miyamoto\n              T,","year":"2006","unstructured":"Miyamoto\n              T, \n            \n              Shiozawa\n              T, \n            \n              Kashima\n              H, \n            et al\n          . Estrogen up-regulates mismatch repair activity in normal and malignant endometrial glandular cells. Endocrinology. 2006;147(10):4863\u20134870."},{"issue":"1","key":"i1543-2165-138-3-335-b56","series-title":"Cancer Res","first-page":"126","article-title":"Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer","volume":"61","author":"Slattery\n              ML,","year":"2001","unstructured":"Slattery\n              ML, \n            \n              Potter\n              JD, \n            \n              Curtin\n              K, \n            et al\n          . Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer. Cancer Res. 2001;61(1):126\u2013130."},{"issue":"11","key":"i1543-2165-138-3-335-b57","series-title":"J Reprod Med","first-page":"869","article-title":"Absence of progesterone receptors in a failed case of fertility-sparing treatment in early endometrial cancer: a case report","volume":"53","author":"Hoekstra\n              AV,","year":"2008","unstructured":"Hoekstra\n              AV, \n            \n              Kim\n              JJ, \n            \n              Keh\n              P, \n            \n              Schink\n              JC. \n          \n          Absence of progesterone receptors in a failed case of fertility-sparing treatment in early endometrial cancer: a case report. J Reprod Med. 2008;53(11):869\u2013873."},{"issue":"7","key":"i1543-2165-138-3-335-b58","series-title":"Hum Reprod","first-page":"1953","article-title":"Fertility-preserving treatment with progestin, and pathological criteria to predict responses, in young women with endometrial cancer","volume":"22","author":"Yamazawa\n              K,","year":"2007","unstructured":"Yamazawa\n              K, \n            \n              Hirai\n              M, \n            \n              Fujito\n              A, \n            et al\n          . Fertility-preserving treatment with progestin, and pathological criteria to predict responses, in young women with endometrial cancer. Hum Reprod. 2007;22(7):1953\u20131958."},{"issue":"5","key":"i1543-2165-138-3-335-b59","series-title":"Int J Gynecol Cancer","first-page":"964","article-title":"Hormone therapy in advanced and recurrent endometrial cancer: a systematic review","volume":"17","author":"Decruze\n              SB,","year":"2007","unstructured":"Decruze\n              SB, \n            \n              Green\n              JA. \n          \n          Hormone therapy in advanced and recurrent endometrial cancer: a systematic review. Int J Gynecol Cancer. 2007;17(5):964\u2013978."},{"issue":"1","key":"i1543-2165-138-3-335-b60","series-title":"Int J Radiat Oncol Biol Phys","first-page":"21","article-title":"The predictive value of progesterone receptor levels in endometrial cancer","volume":"17","author":"Ingram\n              SS,","year":"1989","unstructured":"Ingram\n              SS, \n            \n              Rosenman\n              J, \n            \n              Heath\n              R, \n            \n              Morgan\n              TM, \n            \n              Moore\n              D, \n            \n              Varia\n              M. \n          \n          The predictive value of progesterone receptor levels in endometrial cancer. Int J Radiat Oncol Biol Phys. 1989;17(1):21\u201327."},{"issue":"4","key":"i1543-2165-138-3-335-b61","series-title":"Am J Obstet Gynecol","first-page":"796","article-title":"Steroid receptors and clinical outcome in patients with adenocarcinoma of the endometrium","volume":"158","author":"Ehrlich\n              CE,","year":"1988","unstructured":"Ehrlich\n              CE, \n            \n              Young\n              PC, \n            \n              Stehman\n              FB, \n            \n              Sutton\n              GP, \n            \n              Alford\n              WM. \n          \n          Steroid receptors and clinical outcome in patients with adenocarcinoma of the endometrium. Am J Obstet Gynecol. 1988;158(4):796\u2013807."},{"issue":"6","key":"i1543-2165-138-3-335-b62","series-title":"J Clin Oncol","first-page":"1736","article-title":"Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group","volume":"17","author":"Thigpen\n              JT,","year":"1999","unstructured":"Thigpen\n              JT, \n            \n              Brady\n              MF, \n            \n              Alvarez\n              RD, \n            et al\n          . Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J Clin Oncol. 1999;17(6):1736\u20131744."},{"issue":"3","key":"i1543-2165-138-3-335-b63","series-title":"Gynecol Oncol","first-page":"314","article-title":"Endometrial carcinoma: steroid receptors and response to medroxyprogesterone acetate","volume":"21","author":"Quinn\n              MA,","year":"1985","unstructured":"Quinn\n              MA, \n            \n              Cauchi\n              M, \n            \n              Fortune\n              D. \n          \n          Endometrial carcinoma: steroid receptors and response to medroxyprogesterone acetate. Gynecol Oncol. 1985;21(3):314\u2013319."},{"issue":"4","key":"i1543-2165-138-3-335-b64","series-title":"Obstet Gynecol","first-page":"693","article-title":"Coexisting ovarian malignancy in young women with endometrial cancer","volume":"106","author":"Walsh\n              C,","year":"2005","unstructured":"Walsh\n              C, \n            \n              Holschneider\n              C, \n            \n              Hoang\n              Y, \n            \n              Tieu\n              K, \n            \n              Karlan\n              B, \n            \n              Cass\n              I. \n          \n          Coexisting ovarian malignancy in young women with endometrial cancer. Obstet Gynecol. 2005;106(4):693\u2013699."},{"issue":"2","key":"i1543-2165-138-3-335-b65","series-title":"Gynecol Oncol","first-page":"456","article-title":"Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases","volume":"94","author":"Soliman\n              PT,","year":"2004","unstructured":"Soliman\n              PT, \n            \n              Slomovitz\n              BM, \n            \n              Broaddus\n              RR, \n            et al\n          . Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases. Gynecol Oncol. 2004;94(2):456\u2013462."},{"issue":"3","key":"i1543-2165-138-3-335-b66","series-title":"Obstet Gynecol","first-page":"349","article-title":"Profile of women 45 years of age and younger with endometrial cancer","volume":"91","author":"Evans-Metcalf\n              ER,","year":"1998","unstructured":"Evans-Metcalf\n              ER, \n            \n              Brooks\n              SE, \n            \n              Reale\n              FR, \n            \n              Baker\n              SP. \n          \n          Profile of women 45 years of age and younger with endometrial cancer. Obstet Gynecol. 1998;91(3):349\u2013354."},{"issue":"1","key":"i1543-2165-138-3-335-b67","series-title":"Gynecol Oncol","first-page":"109","article-title":"Incidence and factors associated with synchronous ovarian and endometrial cancer: a population-based case-control study","volume":"125","author":"AlHilli\n              MM,","year":"2012","unstructured":"AlHilli\n              MM, \n            \n              Dowdy\n              SC, \n            \n              Weaver\n              AL, \n            et al\n          . Incidence and factors associated with synchronous ovarian and endometrial cancer: a population-based case-control study. Gynecol Oncol. 2012;125(1):109\u2013113."},{"issue":"3","key":"i1543-2165-138-3-335-b68","series-title":"Gynecol Oncol","first-page":"757","article-title":"Young patients with endometrial carcinoma selected for conservative treatment: a need for vigilance for synchronous ovarian carcinomas, case report and literature review","volume":"104","author":"Shamshirsaz\n              AA,","year":"2007","unstructured":"Shamshirsaz\n              AA, \n            \n              Withiam-Leitch\n              M, \n            \n              Odunsi\n              K, \n            \n              Baker\n              T, \n            \n              Frederick\n              PJ, \n            \n              Lele\n              S. \n          \n          Young patients with endometrial carcinoma selected for conservative treatment: a need for vigilance for synchronous ovarian carcinomas, case report and literature review. Gynecol Oncol. 2007;104(3):757\u2013760."},{"issue":"2","key":"i1543-2165-138-3-335-b69","series-title":"Gynecol Oncol","first-page":"355","article-title":"Simultaneously detected endometrial and ovarian carcinomas\u2014a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study","volume":"83","author":"Zaino\n              R,","year":"2001","unstructured":"Zaino\n              R, \n            \n              Whitney\n              C, \n            \n              Brady\n              MF, \n            \n              DeGeest\n              K, \n            \n              Burger\n              RA, \n            \n              Buller\n              RE. \n          \n          Simultaneously detected endometrial and ovarian carcinomas\u2014a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol. 2001;83(2):355\u2013362."},{"issue":"1","key":"i1543-2165-138-3-335-b70","series-title":"Hum Pathol","first-page":"28","article-title":"Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases","volume":"16","author":"Ulbright\n              TM,","year":"1985","unstructured":"Ulbright\n              TM, \n            \n              Roth\n              LM. \n          \n          Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases. Hum Pathol. 1985;16(1):28\u201334."},{"issue":"6","key":"i1543-2165-138-3-335-b71","series-title":"Hum Pathol","first-page":"605","article-title":"Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis","volume":"36","author":"Irving\n              JA,","year":"2005","unstructured":"Irving\n              JA, \n            \n              Catasus\n              L, \n            \n              Gallardo\n              A, \n            et al\n          . Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis. Hum Pathol. 2005;36(6):605\u2013619."},{"issue":"2","key":"i1543-2165-138-3-335-b72","series-title":"Gynecol Oncol","first-page":"223","article-title":"The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer","volume":"82","author":"Watson\n              P,","year":"2001","unstructured":"Watson\n              P, \n            \n              Butzow\n              R, \n            \n              Lynch\n              HT, \n            et al\n          . The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. Gynecol Oncol. 2001;82(2):223\u2013228."},{"issue":"2","key":"i1543-2165-138-3-335-b73","series-title":"Am J Surg Pathol","first-page":"163","article-title":"Ovarian endometrioid adenocarcinoma: incidence and clinical significance of the morphologic and immunohistochemical markers of mismatch repair protein defects and tumor microsatellite instability","volume":"36","author":"Aysal\n              A,","year":"2012","unstructured":"Aysal\n              A, \n            \n              Karnezis\n              A, \n            \n              Medhi\n              I, \n            \n              Grenert\n              JP, \n            \n              Zaloudek\n              CJ, \n            \n              Rabban\n              JT. \n          \n          Ovarian endometrioid adenocarcinoma: incidence and clinical significance of the morphologic and immunohistochemical markers of mismatch repair protein defects and tumor microsatellite instability. Am J Surg Pathol. 2012;36(2):163\u2013172."},{"issue":"4","key":"i1543-2165-138-3-335-b74","series-title":"Clin Cancer Res","first-page":"1387","article-title":"Incidence of microsatellite instability in synchronous tumors of the ovary and endometrium","volume":"9","author":"Shannon\n              C,","year":"2003","unstructured":"Shannon\n              C, \n            \n              Kirk\n              J, \n            \n              Barnetson\n              R, \n            et al\n          . Incidence of microsatellite instability in synchronous tumors of the ovary and endometrium. Clin Cancer Res. 2003;9(4):1387\u20131392."},{"issue":"36","key":"i1543-2165-138-3-335-b75","series-title":"J Clin Oncol","first-page":"9344","article-title":"Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?","volume":"23","author":"Soliman\n              PT,","year":"2005","unstructured":"Soliman\n              PT, \n            \n              Broaddus\n              RR, \n            \n              Schmeler\n              KM, \n            et al\n          . Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?J Clin Oncol. 2005;23(36):9344\u20139350."},{"issue":"3","key":"i1543-2165-138-3-335-b76","series-title":"Gynecol Oncol","first-page":"462","article-title":"Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors","volume":"121","author":"Ketabi\n              Z,","year":"2011","unstructured":"Ketabi\n              Z, \n            \n              Bartuma\n              K, \n            \n              Bernstein\n              I, \n            et al\n          . Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors. Gynecol Oncol. 2011;121(3):462\u2013465."},{"issue":"7","key":"i1543-2165-138-3-335-b77","series-title":"Am J Surg Pathol","first-page":"1029","article-title":"Microsatellite instability and mismatch repair protein defects in ovarian epithelial neoplasms in patients 50 years of age and younger","volume":"32","author":"Jensen\n              KC,","year":"2008","unstructured":"Jensen\n              KC, \n            \n              Mariappan\n              MR, \n            \n              Putcha\n              GV, \n            et al\n          . Microsatellite instability and mismatch repair protein defects in ovarian epithelial neoplasms in patients 50 years of age and younger. Am J Surg Pathol. 2008;32(7):1029\u20131037."},{"issue":"5","key":"i1543-2165-138-3-335-b78","series-title":"Hum Pathol","first-page":"552","article-title":"Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma","volume":"35","author":"Cai\n              KQ,","year":"2004","unstructured":"Cai\n              KQ, \n            \n              Albarracin\n              C, \n            \n              Rosen\n              D, \n            et al\n          . Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma. Hum Pathol. 2004;35(5):552\u2013559."}],"container-title":["Archives of Pathology and Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/138\/3\/article-p335.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/138\/3\/335\/1613001\/arpa_2012-0654-ra.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/138\/3\/article-p335.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/138\/3\/article-p335.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:01:34Z","timestamp":1770771694000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/138\/3\/article-p335.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":156,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5858\/arpa.2012-0654-ra","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}