{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:13:04Z","timestamp":1785928384298,"version":"3.56.0"},"reference-count":78,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"abstract":"\n Context.\u2014<\/jats:italic>\n BCL6<\/jats:italic>\n translocations are a frequent finding in B-cell lymphomas of diverse subtypes, including some cases of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). However, reliable analysis of\n BCL6<\/jats:italic>\n rearrangements using fluorescence in situ hybridization is difficult in NLPHL because of the relative paucity of neoplastic cells. Combined immunofluorescence microscopy and fluorescence in situ hybridization, or fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms (FICTION), permits targeted analysis of neoplastic cells.\n <\/jats:p>\n \n Objective.\u2014<\/jats:italic>\n To better define the spectrum of\n BCL6<\/jats:italic>\n abnormalities in NLPHL using FICTION analysis.\n <\/jats:p>\n \n Design.\u2014<\/jats:italic>\n We performed an optimized FICTION analysis of 24 lymph nodes, including 11 NLPHL, 5 follicular hyperplasia with prominent progressive transformation of germinal centers, and 8 follicular hyperplasia without progressive transformation of germinal centers.\n <\/jats:p>\n \n Results.\u2014<\/jats:italic>\n BCL6<\/jats:italic>\n rearrangement was identified in 5 of 11 cases of NLPHL (46%). In addition,\n BCL6<\/jats:italic>\n gene amplification, with large clusters of\n BCL6<\/jats:italic>\n signals in the absence of chromosome 3 aneuploidy, was detected in 3 of 11 cases of NLPHL (27%). One NLPHL showed extra copies of\n BCL6<\/jats:italic>\n present in conjunction with multiple copies of chromosome 3. Altogether, we detected\n BCL6<\/jats:italic>\n abnormalities in 9 of 11 cases of NLPHL (82%). None of the progressive transformation of germinal centers or follicular hyperplasia cases showed\n BCL6<\/jats:italic>\n abnormalities by FICTION.\n <\/jats:p>\n \n Conclusions.\u2014<\/jats:italic>\n To our knowledge, this is the first report of\n BCL6<\/jats:italic>\n gene amplification in NLPHL. Our optimized protocol for FICTION permits detection of cytogenetic abnormalities in most NLPHL cases and may represent a useful ancillary diagnostic technique.\n <\/jats:p>","DOI":"10.5858\/arpa.2012-0663-oa","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T21:18:38Z","timestamp":1396041518000},"page":"538-542","source":"Crossref","is-referenced-by-count":16,"title":["Fluorescence Immunophenotyping and Interphase Cytogenetics (FICTION) Detects BCL6 Abnormalities, Including Gene Amplification, in Most Cases of Nodular Lymphocyte-Predominant Hodgkin Lymphoma"],"prefix":"10.5858","volume":"138","author":[{"given":"Alexei G.","family":"Bakhirev","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque. Dr Reichard is now with the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Vasef","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque. Dr Reichard is now with the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque. Dr Reichard is now with the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaaren K.","family":"Reichard","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque. Dr Reichard is now with the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Czuchlewski","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque. Dr Reichard is now with the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"issue":"1","key":"i1543-2165-138-4-538-b01","series-title":"Br J Haematol","first-page":"3","article-title":"Ko Ferrigno P. The role of BCL6 in lymphomas and routes to therapy","volume":"152","author":"Wagner\n SD,","year":"2011","unstructured":"Wagner\n SD, \n \n Ahearne\n M, \n \n Ko Ferrigno P. The role of BCL6 in lymphomas and routes to therapy. Br J Haematol. 2011;152(1):3\u201312."},{"issue":"1\u20132","key":"i1543-2165-138-4-538-b02","series-title":"Leuk Lymphoma","first-page":"85","article-title":"BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma","volume":"20","author":"Offit\n K,","year":"1995","unstructured":"Offit\n K, \n \n Louie\n DC, \n \n Parsa\n NZ, \n et al\n . 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