{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T04:23:18Z","timestamp":1770783798180,"version":"3.50.0"},"reference-count":38,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7]]},"abstract":"\n Context.\u2014<\/jats:italic>\n The value of assessing CD5 expression in the differential diagnosis of small B-cell neoplasms is well established. Assessment is usually done qualitatively.\n <\/jats:p>\n \n Objectives.\u2014<\/jats:italic>\n To assess CD5 expression levels by quantitative flow cytometry immunophenotyping and to determine possible differences among various small B-cell neoplasms.\n <\/jats:p>\n \n Design.\u2014<\/jats:italic>\n We performed 4-color flow cytometry analysis on specimens of peripheral blood and bone marrow aspirate and quantified CD5 expression in various small B-cell lymphomas and leukemias. We also assessed CD5 levels in peripheral blood samples of healthy blood donors.\n <\/jats:p>\n \n Results.\u2014<\/jats:italic>\n Cases of chronic lymphocytic leukemia and mantle cell lymphoma had higher levels of CD5 compared with control B cells (\n P<\/jats:italic>\n < .001). Cases of marginal zone lymphoma and hairy cell leukemia had CD5 levels similar to control B cells (\n P<\/jats:italic>\n = .35 and\n P<\/jats:italic>\n = .14, respectively), whereas cases of follicular lymphoma and lymphoplasmacytic lymphoma had significantly lower CD5 levels than control B cells (\n P<\/jats:italic>\n < .001 and\n P<\/jats:italic>\n = .04, respectively). In B-cell neoplasms, a high level of CD5 expression was correlated with a homogeneous pattern of positive events, whereas lower CD5 levels were correlated with heterogeneous patterns of positive events.\n <\/jats:p>\n \n Conclusions.\u2014<\/jats:italic>\n Using flow cytometric immunophenotypic analysis to quantify CD5 levels can aid in diagnosis. CD5 expression levels are higher in patients with chronic lymphocytic leukemia and mantle cell lymphoma, and expression is observed in a homogeneous pattern, as compared with other B-cell neoplasms that are either negative for CD5 or express CD5 at lower levels with a heterogeneous pattern. However, there is some overlap in CD5 expression levels between a subset of atypical chronic lymphocytic leukemia and marginal zone lymphoma cases.\n <\/jats:p>","DOI":"10.5858\/arpa.2013-0367-oa","type":"journal-article","created":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T15:06:14Z","timestamp":1404140774000},"page":"903-909","source":"Crossref","is-referenced-by-count":12,"title":["Utility of Quantitative Flow Cytometry Immunophenotypic Analysis of CD5 Expression in Small B-Cell Neoplasms"],"prefix":"10.5858","volume":"138","author":[{"given":"Pramoda","family":"Challagundla","sequence":"first","affiliation":[{"name":"From the Departments of Hematopathology (Ms Challagundla, Mr Reyes, and Drs Jorgensen, Kanagal-Shamanna, Medeiros, and Miranda) and Leukemia (Dr Ferrajoli), University of Texas MD Anderson Cancer Center, Houston; the Department of Hematopathology, Genoptix Medical Laboratory, Carlsbad, California (Dr Gurevich); and the Department of Hematopathology, King's Daughters Medical Center, Ashland, Kentucky (Dr Pierson)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L.","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"From the Departments of Hematopathology (Ms Challagundla, Mr Reyes, and Drs Jorgensen, Kanagal-Shamanna, Medeiros, and Miranda) and Leukemia (Dr Ferrajoli), University of Texas MD Anderson Cancer Center, Houston; the Department of Hematopathology, Genoptix Medical Laboratory, Carlsbad, California (Dr Gurevich); and the Department of Hematopathology, King's Daughters Medical Center, Ashland, Kentucky (Dr Pierson)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Kanagal-Shamanna","sequence":"additional","affiliation":[{"name":"From the Departments of Hematopathology (Ms Challagundla, Mr Reyes, and Drs Jorgensen, Kanagal-Shamanna, Medeiros, and Miranda) and Leukemia (Dr Ferrajoli), University of Texas MD Anderson Cancer Center, Houston; the Department of Hematopathology, Genoptix Medical Laboratory, Carlsbad, California (Dr Gurevich); and the Department of Hematopathology, King's Daughters Medical Center, Ashland, Kentucky (Dr Pierson)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Gurevich","sequence":"additional","affiliation":[{"name":"From the Departments of Hematopathology (Ms Challagundla, Mr Reyes, and Drs Jorgensen, Kanagal-Shamanna, Medeiros, and Miranda) and Leukemia (Dr Ferrajoli), University of Texas MD Anderson Cancer Center, Houston; the Department of Hematopathology, Genoptix Medical Laboratory, Carlsbad, California (Dr Gurevich); and the Department of Hematopathology, King's Daughters Medical Center, Ashland, Kentucky (Dr Pierson)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane M.","family":"Pierson","sequence":"additional","affiliation":[{"name":"From the Departments of Hematopathology (Ms Challagundla, Mr Reyes, and Drs Jorgensen, Kanagal-Shamanna, Medeiros, and Miranda) and Leukemia (Dr Ferrajoli), University of Texas MD Anderson Cancer Center, Houston; the Department of Hematopathology, Genoptix Medical Laboratory, Carlsbad, California (Dr Gurevich); and the Department of Hematopathology, King's Daughters Medical Center, Ashland, Kentucky (Dr Pierson)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Ferrajoli","sequence":"additional","affiliation":[{"name":"From the Departments of Hematopathology (Ms Challagundla, Mr Reyes, and Drs Jorgensen, Kanagal-Shamanna, Medeiros, and Miranda) and Leukemia (Dr Ferrajoli), University of Texas MD Anderson Cancer Center, Houston; the Department of Hematopathology, Genoptix Medical Laboratory, Carlsbad, California (Dr Gurevich); and the Department of Hematopathology, King's Daughters Medical Center, Ashland, Kentucky (Dr Pierson)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Reyes","sequence":"additional","affiliation":[{"name":"From the Departments of Hematopathology (Ms Challagundla, Mr Reyes, and Drs Jorgensen, Kanagal-Shamanna, Medeiros, and Miranda) and Leukemia (Dr Ferrajoli), University of Texas MD Anderson Cancer Center, Houston; the Department of Hematopathology, Genoptix Medical Laboratory, Carlsbad, California (Dr Gurevich); and the Department of Hematopathology, King's Daughters Medical Center, Ashland, Kentucky (Dr Pierson)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"From the Departments of Hematopathology (Ms Challagundla, Mr Reyes, and Drs Jorgensen, Kanagal-Shamanna, Medeiros, and Miranda) and Leukemia (Dr Ferrajoli), University of Texas MD Anderson Cancer Center, Houston; the Department of Hematopathology, Genoptix Medical Laboratory, Carlsbad, California (Dr Gurevich); and the Department of Hematopathology, King's Daughters Medical Center, Ashland, Kentucky (Dr Pierson)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto N.","family":"Miranda","sequence":"additional","affiliation":[{"name":"From the Departments of Hematopathology (Ms Challagundla, Mr Reyes, and Drs Jorgensen, Kanagal-Shamanna, Medeiros, and Miranda) and Leukemia (Dr Ferrajoli), University of Texas MD Anderson Cancer Center, Houston; the Department of Hematopathology, Genoptix Medical Laboratory, Carlsbad, California (Dr Gurevich); and the Department of Hematopathology, King's Daughters Medical Center, Ashland, Kentucky (Dr Pierson)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-138-7-903-b01","series-title":"Semin Oncol","first-page":"6","article-title":"Clinical utility of flow cytometry in the chronic lymphoid leukemias","volume":"1","author":"DiGiuseppe\n JA,","year":"1998","unstructured":"DiGiuseppe\n JA, \n \n Borowitz\n MJ. \n \n Clinical utility of flow cytometry in the chronic lymphoid leukemias. Semin Oncol. 1998(1);25:6\u201310."},{"key":"i1543-2165-138-7-903-b02","series-title":"Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues. 4th ed","first-page":"270","article-title":"T-cell prolymphocytic leukaemia","author":"Catovsky\n D,","year":"2008","unstructured":"Catovsky\n D, \n \n Muller-Hermelink\n HK, \n \n Ralfkiaer\n E. \n \n T-cell prolymphocytic leukaemia. In: Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press;2008:270\u2013271. World Health Organization Classification of Tumours; vol 2."},{"key":"i1543-2165-138-7-903-b03","series-title":"Diagnostic Pathology: Lymph Nodes and Spleen With Extranodal Lymphomas. 1st ed","first-page":"12-24","article-title":"Metastatic Kaposi sarcoma","author":"Bueso-Ramos\n C.","year":"2011","unstructured":"Bueso-Ramos\n C. \n \n Metastatic Kaposi sarcoma. In: MedeirosLJ, ed. Diagnostic Pathology: Lymph Nodes and Spleen With Extranodal Lymphomas. 1st ed. Altona, Manitoba, Canada: Amirsys Inc;2011:12-24\u201312-29."},{"issue":"11","key":"i1543-2165-138-7-903-b04","series-title":"Int J Biochem Cell Biol","first-page":"2105","article-title":"The CD5+ B-cell","volume":"36","author":"Dono\n M,","year":"2004","unstructured":"Dono\n M, \n \n Cerruti\n G, \n \n Zupo\n S. \n \n The CD5+ B-cell. Int J Biochem Cell Biol. 2004;36(11):2105\u20132111."},{"issue":"4","key":"i1543-2165-138-7-903-b05","series-title":"Autoimmun Rev","first-page":"349","article-title":"CD5: a safeguard against autoimmunity and a shield for cancer cells","volume":"8","author":"Dalloul\n A.","year":"2009","unstructured":"Dalloul\n A. \n \n CD5: a safeguard against autoimmunity and a shield for cancer cells. Autoimmun Rev. 2009;8(4):349\u2013353."},{"key":"i1543-2165-138-7-903-b06","series-title":"Immunol Rev","first-page":"179","article-title":"Peripheral development of B cells in mouse and man","volume":"197","author":"Carsetti\n R,","year":"2004","unstructured":"Carsetti\n R, \n \n Rosado\n MM, \n \n Wardmann\n H. \n \n Peripheral development of B cells in mouse and man. Immunol Rev. 2004;197:179\u2013191."},{"key":"i1543-2165-138-7-903-b07","series-title":"Am J Surg Pathol","first-page":"201","article-title":"CD5+ low-grade marginal zone B-cell lymphomas with localized presentation","volume":"2","author":"Ballesteros\n E,","year":"1998","unstructured":"Ballesteros\n E, \n \n Osborne\n BM, \n \n Matsushima\n AY. \n \n CD5+ low-grade marginal zone B-cell lymphomas with localized presentation. Am J Surg Pathol. 1998(2);22:201\u2013207."},{"issue":"4","key":"i1543-2165-138-7-903-b08","series-title":"Haematologica","first-page":"604","article-title":"CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathological, cytogenetic and molecular study of 24 cases","volume":"95","author":"Baseggio\n L,","year":"2010","unstructured":"Baseggio\n L, \n \n Traverse-Glehen\n A, \n \n Petinataud\n F, \n et al\n . CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathological, cytogenetic and molecular study of 24 cases. Haematologica. 2010;95(4):604\u2013612."},{"issue":"9","key":"i1543-2165-138-7-903-b09","series-title":"Hum Pathol","first-page":"1436","article-title":"CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases","volume":"43","author":"Jaso\n J,","year":"2012","unstructured":"Jaso\n J, \n \n Chen\n L, \n \n Li\n S, \n et al\n . CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases. Hum Pathol. 2012;43(9):1436\u20131443."},{"issue":"3","key":"i1543-2165-138-7-903-b10","series-title":"Am J Clin Pathol","first-page":"414","article-title":"Immunophenotypic profile of lymphoplasmacytic lymphoma\/Waldenstr\u00f6m macroglobulinemia","volume":"124","author":"Konoplev\n S,","year":"2005","unstructured":"Konoplev\n S, \n \n Medeiros\n LJ, \n \n Bueso-Ramos\n CE, \n \n Jorgensen\n JL, \n \n Lin\n P. \n \n Immunophenotypic profile of lymphoplasmacytic lymphoma\/Waldenstr\u00f6m macroglobulinemia. Am J Clin Pathol. 2005;124(3):414\u2013420."},{"issue":"2","key":"i1543-2165-138-7-903-b11","series-title":"Am J Clin Pathol","first-page":"218","article-title":"B-cell lymphomas with coexpression of CD5 and CD10","volume":"119","author":"Dong\n HY,","year":"2003","unstructured":"Dong\n HY, \n \n Gorczyca\n W, \n \n Liu\n Z, \n et al\n . B-cell lymphomas with coexpression of CD5 and CD10. Am J Clin Pathol. 2003;119 (2):218\u2013230."},{"issue":"1","key":"i1543-2165-138-7-903-b12","series-title":"Br J Haematol","first-page":"36","article-title":"Chronic lymphocytic leukaemia CD20 expression is dependent on the genetic subtype: a study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients","volume":"141","author":"Tam\n CS,","year":"2008","unstructured":"Tam\n CS, \n \n Otero-Palacios\n J, \n \n Abruzzo\n LV, \n et al\n . Chronic lymphocytic leukaemia CD20 expression is dependent on the genetic subtype: a study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients. Br J Haematol. 2008;141(1):36\u201340."},{"issue":"10","key":"i1543-2165-138-7-903-b13","series-title":"Leukemia","first-page":"1640","article-title":"The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL","volume":"8","author":"Matutes\n E,","year":"1994","unstructured":"Matutes\n E, \n \n Owusu-Ankomah\n K, \n \n Morilla\n R, \n et al\n . The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia. 1994;8(10):1640\u20131645."},{"key":"i1543-2165-138-7-903-b14","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed","author":"Swerdlow\n SH,","year":"2008","unstructured":"Swerdlow\n SH, \n \n Campo\n E, \n \n Harris\n NL, \n et al. eds\n . WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press;2008. World Health Organization Classification of Tumours; vol 2."},{"issue":"4","key":"i1543-2165-138-7-903-b15","series-title":"Am J Clin Pathol","first-page":"378","article-title":"Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b)","volume":"108","author":"Moreau\n EJ,","year":"1997","unstructured":"Moreau\n EJ, \n \n Matutes\n E, \n \n A'Hern\n RP, \n et al\n . Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b). 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Basel, Switzerland: S Karger AG; 2009."},{"issue":"4","key":"i1543-2165-138-7-903-b17","series-title":"Am J Hematol","first-page":"275","article-title":"Quantitative flow cytometry for the differential diagnosis of leukemic B-cell chronic lymphoproliferative disorders","volume":"64","author":"D'Arena\n G,","year":"2000","unstructured":"D'Arena\n G, \n \n Musto\n P, \n \n Cascavilla\n N, \n \n Dell'Olio\n M, \n \n Di Renzo\n N, \n \n Carotenuto\n M. \n \n Quantitative flow cytometry for the differential diagnosis of leukemic B-cell chronic lymphoproliferative disorders. Am J Hematol. 2000;64(4):275\u2013281."},{"issue":"2","key":"i1543-2165-138-7-903-b18","series-title":"Cytometry","first-page":"197","article-title":"Determination of CD4 antigen density on cells: role of antibody valency, avidity, clones, and conjugation","volume":"33","author":"Davis\n KA,","year":"1998","unstructured":"Davis\n KA, \n \n Abrams\n B, \n \n Iyer\n SB, \n \n Hoffman\n RA, \n \n Bishop\n JE. \n \n Determination of CD4 antigen density on cells: role of antibody valency, avidity, clones, and conjugation. Cytometry. 1998;33(2):197\u2013205."},{"issue":"6","key":"i1543-2165-138-7-903-b19","series-title":"Br J Haematol","first-page":"1017","article-title":"Prognostic significance of CD38 and CD20 expression as assessed by quantitative flow cytometry in chronic lymphocytic leukaemia","volume":"120","author":"Hsi\n ED,","year":"2003","unstructured":"Hsi\n ED, \n \n Kopecky\n KJ, \n \n Appelbaum\n FR, \n et al\n . Prognostic significance of CD38 and CD20 expression as assessed by quantitative flow cytometry in chronic lymphocytic leukaemia. Br J Haematol. 2003;120(6):1017\u20131025."},{"key":"i1543-2165-138-7-903-b01","series-title":"Semin Oncol","first-page":"6","article-title":"Clinical utility of flow cytometry in the chronic lymphoid leukemias","volume":"1","author":"DiGiuseppe\n JA,","year":"1998","unstructured":"DiGiuseppe\n JA, \n \n Borowitz\n MJ. \n \n Clinical utility of flow cytometry in the chronic lymphoid leukemias. Semin Oncol. 1998(1);25:6\u201310."},{"key":"i1543-2165-138-7-903-b02","series-title":"Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues. 4th ed","first-page":"270","article-title":"T-cell prolymphocytic leukaemia","author":"Catovsky\n D,","year":"2008","unstructured":"Catovsky\n D, \n \n Muller-Hermelink\n HK, \n \n Ralfkiaer\n E. \n \n T-cell prolymphocytic leukaemia. In: Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press;2008:270\u2013271. World Health Organization Classification of Tumours; vol 2."},{"key":"i1543-2165-138-7-903-b03","series-title":"Diagnostic Pathology: Lymph Nodes and Spleen With Extranodal Lymphomas. 1st ed","first-page":"12-24","article-title":"Metastatic Kaposi sarcoma","author":"Bueso-Ramos\n C.","year":"2011","unstructured":"Bueso-Ramos\n C. \n \n Metastatic Kaposi sarcoma. In: MedeirosLJ, ed. Diagnostic Pathology: Lymph Nodes and Spleen With Extranodal Lymphomas. 1st ed. Altona, Manitoba, Canada: Amirsys Inc;2011:12-24\u201312-29."},{"issue":"11","key":"i1543-2165-138-7-903-b04","series-title":"Int J Biochem Cell Biol","first-page":"2105","article-title":"The CD5+ B-cell","volume":"36","author":"Dono\n M,","year":"2004","unstructured":"Dono\n M, \n \n Cerruti\n G, \n \n Zupo\n S. \n \n The CD5+ B-cell. Int J Biochem Cell Biol. 2004;36(11):2105\u20132111."},{"issue":"4","key":"i1543-2165-138-7-903-b05","series-title":"Autoimmun Rev","first-page":"349","article-title":"CD5: a safeguard against autoimmunity and a shield for cancer cells","volume":"8","author":"Dalloul\n A.","year":"2009","unstructured":"Dalloul\n A. \n \n CD5: a safeguard against autoimmunity and a shield for cancer cells. Autoimmun Rev. 2009;8(4):349\u2013353."},{"key":"i1543-2165-138-7-903-b06","series-title":"Immunol Rev","first-page":"179","article-title":"Peripheral development of B cells in mouse and man","volume":"197","author":"Carsetti\n R,","year":"2004","unstructured":"Carsetti\n R, \n \n Rosado\n MM, \n \n Wardmann\n H. \n \n Peripheral development of B cells in mouse and man. Immunol Rev. 2004;197:179\u2013191."},{"key":"i1543-2165-138-7-903-b07","series-title":"Am J Surg Pathol","first-page":"201","article-title":"CD5+ low-grade marginal zone B-cell lymphomas with localized presentation","volume":"2","author":"Ballesteros\n E,","year":"1998","unstructured":"Ballesteros\n E, \n \n Osborne\n BM, \n \n Matsushima\n AY. \n \n CD5+ low-grade marginal zone B-cell lymphomas with localized presentation. Am J Surg Pathol. 1998(2);22:201\u2013207."},{"issue":"4","key":"i1543-2165-138-7-903-b08","series-title":"Haematologica","first-page":"604","article-title":"CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathological, cytogenetic and molecular study of 24 cases","volume":"95","author":"Baseggio\n L,","year":"2010","unstructured":"Baseggio\n L, \n \n Traverse-Glehen\n A, \n \n Petinataud\n F, \n et al\n . CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathological, cytogenetic and molecular study of 24 cases. Haematologica. 2010;95(4):604\u2013612."},{"issue":"9","key":"i1543-2165-138-7-903-b09","series-title":"Hum Pathol","first-page":"1436","article-title":"CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases","volume":"43","author":"Jaso\n J,","year":"2012","unstructured":"Jaso\n J, \n \n Chen\n L, \n \n Li\n S, \n et al\n . CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases. Hum Pathol. 2012;43(9):1436\u20131443."},{"issue":"3","key":"i1543-2165-138-7-903-b10","series-title":"Am J Clin Pathol","first-page":"414","article-title":"Immunophenotypic profile of lymphoplasmacytic lymphoma\/Waldenstr\u00f6m macroglobulinemia","volume":"124","author":"Konoplev\n S,","year":"2005","unstructured":"Konoplev\n S, \n \n Medeiros\n LJ, \n \n Bueso-Ramos\n CE, \n \n Jorgensen\n JL, \n \n Lin\n P. \n \n Immunophenotypic profile of lymphoplasmacytic lymphoma\/Waldenstr\u00f6m macroglobulinemia. Am J Clin Pathol. 2005;124(3):414\u2013420."},{"issue":"2","key":"i1543-2165-138-7-903-b11","series-title":"Am J Clin Pathol","first-page":"218","article-title":"B-cell lymphomas with coexpression of CD5 and CD10","volume":"119","author":"Dong\n HY,","year":"2003","unstructured":"Dong\n HY, \n \n Gorczyca\n W, \n \n Liu\n Z, \n et al\n . B-cell lymphomas with coexpression of CD5 and CD10. 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Br J Haematol. 2008;141(1):36\u201340."},{"issue":"10","key":"i1543-2165-138-7-903-b13","series-title":"Leukemia","first-page":"1640","article-title":"The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL","volume":"8","author":"Matutes\n E,","year":"1994","unstructured":"Matutes\n E, \n \n Owusu-Ankomah\n K, \n \n Morilla\n R, \n et al\n . The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia. 1994;8(10):1640\u20131645."},{"key":"i1543-2165-138-7-903-b14","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed","author":"Swerdlow\n SH,","year":"2008","unstructured":"Swerdlow\n SH, \n \n Campo\n E, \n \n Harris\n NL, \n et al. eds\n . WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press;2008. World Health Organization Classification of Tumours; vol 2."},{"issue":"4","key":"i1543-2165-138-7-903-b15","series-title":"Am J Clin Pathol","first-page":"378","article-title":"Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b)","volume":"108","author":"Moreau\n EJ,","year":"1997","unstructured":"Moreau\n EJ, \n \n Matutes\n E, \n \n A'Hern\n RP, \n et al\n . Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b). Am J Clin Pathol. 1997;108(4):378\u2013382."},{"key":"i1543-2165-138-7-903-b16","series-title":"ISCN 2009: An International System for Human Cytogenetic Nomenclature (2009)\u2014Recommendations of the International Standing Committee on Human Cytogenetic Nomenclature","author":"Shaffer\n LG,","year":"2009","unstructured":"Shaffer\n LG, \n \n Slovak\n ML, \n \n Campbell\n LJ, \n \n eds. ISCN 2009: An International System for Human Cytogenetic Nomenclature (2009)\u2014Recommendations of the International Standing Committee on Human Cytogenetic Nomenclature. Basel, Switzerland: S Karger AG; 2009."},{"issue":"4","key":"i1543-2165-138-7-903-b17","series-title":"Am J Hematol","first-page":"275","article-title":"Quantitative flow cytometry for the differential diagnosis of leukemic B-cell chronic lymphoproliferative disorders","volume":"64","author":"D'Arena\n G,","year":"2000","unstructured":"D'Arena\n G, \n \n Musto\n P, \n \n Cascavilla\n N, \n \n Dell'Olio\n M, \n \n Di Renzo\n N, \n \n Carotenuto\n M. \n \n Quantitative flow cytometry for the differential diagnosis of leukemic B-cell chronic lymphoproliferative disorders. 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