{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:34:35Z","timestamp":1794335675751,"version":"4.9.0"},"reference-count":30,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>In this article, we review prostatic lymphomas and discuss the differential diagnosis of high-grade malignant neoplasms of the prostate. We illustrate this with a case of a 46-year-old man seen with lower urinary tract obstruction who had diffuse involvement by a high-grade malignancy on prostate biopsy. Morphologic evaluation and immunohistochemistry were consistent with diffuse large B-cell lymphoma of the prostate. Workup with positron emission tomography-computed tomography demonstrated intensely hypermetabolic lymph nodes in the mediastinum, as well as widespread osseous involvement and involvement of the pancreatic tail, prostate, and urinary bladder, suggesting secondary prostatic involvement by a nodal lymphoma. Lymphomas of the prostate are uncommon in surgical pathology practice and usually represent secondary involvement from leukemia\/lymphoma at a more typical site. Chronic lymphocytic leukemia\/small lymphocytic lymphoma is the most common subtype.<\/jats:p>","DOI":"10.5858\/arpa.2014-0276-cc","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T18:30:55Z","timestamp":1412101855000},"page":"1286-1289","source":"Crossref","is-referenced-by-count":22,"title":["Diffuse Large B-Cell Lymphoma of the Prostate"],"prefix":"10.5858","volume":"138","author":[{"given":"Joshua I.","family":"Warrick","sequence":"first","affiliation":[{"name":"From the Department of Pathology (Drs Warrick, Owens, and Tomlins), Michigan Center for Translational Pathology (Dr Tomlins), Department of Urology (Dr Tomlins), and Comprehensive Cancer Center (Dr Tomlins), University of Michigan Medical School, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Owens","sequence":"additional","affiliation":[{"name":"From the Department of Pathology (Drs Warrick, Owens, and Tomlins), Michigan Center for Translational Pathology (Dr Tomlins), Department of Urology (Dr Tomlins), and Comprehensive Cancer Center (Dr Tomlins), University of Michigan Medical School, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Tomlins","sequence":"additional","affiliation":[{"name":"From the Department of Pathology (Drs Warrick, Owens, and Tomlins), Michigan Center for Translational Pathology (Dr Tomlins), Department of Urology (Dr Tomlins), and Comprehensive Cancer Center (Dr Tomlins), University of Michigan Medical School, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"issue":"4","key":"i1543-2165-138-10-1286-b01","series-title":"J Urol","first-page":"1457","article-title":"Hematolymphoid malignancies diagnosed at the time of radical prostatectomy","volume":"158","author":"Terris\n              MK,","year":"1997","unstructured":"Terris\n              MK, \n            \n              Hausdorff\n              J, \n            \n              Freiha\n              FS. \n          \n          Hematolymphoid malignancies diagnosed at the time of radical prostatectomy. J Urol. 1997;158(4):1457\u20131459."},{"issue":"5","key":"i1543-2165-138-10-1286-b02","series-title":"Am J Surg Pathol","first-page":"693","article-title":"Incidental and concurrent malignant lymphomas discovered at the time of prostatectomy and prostate biopsy: a study of 29 cases","volume":"29","author":"Chu\n              PG,","year":"2005","unstructured":"Chu\n              PG, \n            \n              Huang\n              Q, \n            \n              Weiss\n              LM. \n          \n          Incidental and concurrent malignant lymphomas discovered at the time of prostatectomy and prostate biopsy: a study of 29 cases. Am J Surg Pathol. 2005;29(5):693\u2013699."},{"issue":"12","key":"i1543-2165-138-10-1286-b03","series-title":"Cancer","first-page":"2932","article-title":"Malignant lymphomas involving the prostate: a study of 13 cases","volume":"56","author":"Bostwick\n              DG,","year":"1985","unstructured":"Bostwick\n              DG, \n            \n              Mann\n              RB. \n          \n          Malignant lymphomas involving the prostate: a study of 13 cases. Cancer. 1985;56(12):2932\u20132938."},{"issue":"4","key":"i1543-2165-138-10-1286-b04","series-title":"Cancer","first-page":"732","article-title":"Malignant lymphoma involving the prostate: report of 62 cases","volume":"83","author":"Bostwick\n              DG,","year":"1998","unstructured":"Bostwick\n              DG, \n            \n              Iczkowski\n              KA, \n            \n              Amin\n              MB, \n            \n              Discigil\n              G, \n            \n              Osborne\n              B. \n          \n          Malignant lymphoma involving the prostate: report of 62 cases. Cancer. 1998;83(4):732\u2013738."},{"issue":"8","key":"i1543-2165-138-10-1286-b05","series-title":"Am J Surg Pathol","first-page":"1246","article-title":"Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma","volume":"31","author":"Chuang\n              AY,","year":"2007","unstructured":"Chuang\n              AY, \n            \n              DeMarzo\n              AM, \n            \n              Veltri\n              RW, \n            \n              Sharma\n              RB, \n            \n              Bieberich\n              CJ, \n            \n              Epstein\n              JI. \n          \n          Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma. Am J Surg Pathol. 2007;31(8):1246\u20131255."},{"issue":"5","key":"i1543-2165-138-10-1286-b06","series-title":"Am J Clin Pathol","first-page":"675","article-title":"Prostate-specific antigen, high-molecular-weight cytokeratin (clone 34\u03b2E12), and\/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma","volume":"125","author":"Kunju\n              LP,","year":"2006","unstructured":"Kunju\n              LP, \n            \n              Mehra\n              R, \n            \n              Snyder\n              M, \n            \n              Shah\n              RB. \n          \n          Prostate-specific antigen, high-molecular-weight cytokeratin (clone 34\u03b2E12), and\/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma. Am J Clin Pathol. 2006;125(5):675\u2013681."},{"issue":"10","key":"i1543-2165-138-10-1286-b07","series-title":"Am J Surg Pathol","first-page":"1472","article-title":"Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung","volume":"36","author":"Chang\n              A,","year":"2012","unstructured":"Chang\n              A, \n            \n              Amin\n              A, \n            \n              Gabrielson\n              E, \n            et al\n          . Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. Am J Surg Pathol. 2012;36(10):1472\u20131476."},{"issue":"1","key":"i1543-2165-138-10-1286-b08","series-title":"Hum Pathol","first-page":"11","article-title":"TMPRSS2-ERG gene fusion in small cell carcinoma of the prostate","volume":"42","author":"Guo\n              CC,","year":"2011","unstructured":"Guo\n              CC, \n            \n              Dancer\n              JY, \n            \n              Wang\n              Y, \n            et al\n          . TMPRSS2-ERG gene fusion in small cell carcinoma of the prostate. Hum Pathol. 2011;42(1):11\u201317."},{"issue":"6","key":"i1543-2165-138-10-1286-b09","series-title":"Mod Pathol","first-page":"820","article-title":"ERG gene rearrangements are common in prostatic small cell carcinomas","volume":"24","author":"Lotan\n              TL,","year":"2011","unstructured":"Lotan\n              TL, \n            \n              Gupta\n              NS, \n            \n              Wang\n              W, \n            et al\n          . 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Hum Pathol. 2013;44(10):2227\u20132233."},{"issue":"1","key":"i1543-2165-138-10-1286-b12","series-title":"Am J Surg Pathol","first-page":"65","article-title":"Small cell carcinoma of the prostate: a morphologic and immunohistochemical study of 95 cases","volume":"32","author":"Wang\n              W,","year":"2008","unstructured":"Wang\n              W, \n            \n              Epstein\n              JI. \n          \n          Small cell carcinoma of the prostate: a morphologic and immunohistochemical study of 95 cases. 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Am J Surg Pathol. 2005;29(5):693\u2013699."},{"issue":"12","key":"i1543-2165-138-10-1286-b03","series-title":"Cancer","first-page":"2932","article-title":"Malignant lymphomas involving the prostate: a study of 13 cases","volume":"56","author":"Bostwick\n              DG,","year":"1985","unstructured":"Bostwick\n              DG, \n            \n              Mann\n              RB. \n          \n          Malignant lymphomas involving the prostate: a study of 13 cases. 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Cancer. 1998;83(4):732\u2013738."},{"issue":"8","key":"i1543-2165-138-10-1286-b05","series-title":"Am J Surg Pathol","first-page":"1246","article-title":"Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma","volume":"31","author":"Chuang\n              AY,","year":"2007","unstructured":"Chuang\n              AY, \n            \n              DeMarzo\n              AM, \n            \n              Veltri\n              RW, \n            \n              Sharma\n              RB, \n            \n              Bieberich\n              CJ, \n            \n              Epstein\n              JI. \n          \n          Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma. Am J Surg Pathol. 2007;31(8):1246\u20131255."},{"issue":"5","key":"i1543-2165-138-10-1286-b06","series-title":"Am J Clin Pathol","first-page":"675","article-title":"Prostate-specific antigen, high-molecular-weight cytokeratin (clone 34\u03b2E12), and\/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma","volume":"125","author":"Kunju\n              LP,","year":"2006","unstructured":"Kunju\n              LP, \n            \n              Mehra\n              R, \n            \n              Snyder\n              M, \n            \n              Shah\n              RB. \n          \n          Prostate-specific antigen, high-molecular-weight cytokeratin (clone 34\u03b2E12), and\/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma. Am J Clin Pathol. 2006;125(5):675\u2013681."},{"issue":"10","key":"i1543-2165-138-10-1286-b07","series-title":"Am J Surg Pathol","first-page":"1472","article-title":"Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung","volume":"36","author":"Chang\n              A,","year":"2012","unstructured":"Chang\n              A, \n            \n              Amin\n              A, \n            \n              Gabrielson\n              E, \n            et al\n          . Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. Am J Surg Pathol. 2012;36(10):1472\u20131476."},{"issue":"1","key":"i1543-2165-138-10-1286-b08","series-title":"Hum Pathol","first-page":"11","article-title":"TMPRSS2-ERG gene fusion in small cell carcinoma of the prostate","volume":"42","author":"Guo\n              CC,","year":"2011","unstructured":"Guo\n              CC, \n            \n              Dancer\n              JY, \n            \n              Wang\n              Y, \n            et al\n          . TMPRSS2-ERG gene fusion in small cell carcinoma of the prostate. Hum Pathol. 2011;42(1):11\u201317."},{"issue":"6","key":"i1543-2165-138-10-1286-b09","series-title":"Mod Pathol","first-page":"820","article-title":"ERG gene rearrangements are common in prostatic small cell carcinomas","volume":"24","author":"Lotan\n              TL,","year":"2011","unstructured":"Lotan\n              TL, \n            \n              Gupta\n              NS, \n            \n              Wang\n              W, \n            et al\n          . ERG gene rearrangements are common in prostatic small cell carcinomas. Mod Pathol. 2011;24(6):820\u2013828."},{"issue":"7","key":"i1543-2165-138-10-1286-b10","series-title":"Histopathology","first-page":"937","article-title":"ERG rearrangement in small cell prostatic and lung cancer","volume":"56","author":"Scheble\n              VJ,","year":"2010","unstructured":"Scheble\n              VJ, \n            \n              Braun\n              M, \n            \n              Wilbertz\n              T, \n            et al\n          . ERG rearrangement in small cell prostatic and lung cancer. 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Hum Pathol. 2013;44(10):2227\u20132233."},{"issue":"1","key":"i1543-2165-138-10-1286-b12","series-title":"Am J Surg Pathol","first-page":"65","article-title":"Small cell carcinoma of the prostate: a morphologic and immunohistochemical study of 95 cases","volume":"32","author":"Wang\n              W,","year":"2008","unstructured":"Wang\n              W, \n            \n              Epstein\n              JI. \n          \n          Small cell carcinoma of the prostate: a morphologic and immunohistochemical study of 95 cases. Am J Surg Pathol. 2008;32(1):65\u201371."},{"issue":"7","key":"i1543-2165-138-10-1286-b13","series-title":"Arch Pathol Lab Med","first-page":"724","article-title":"Granulomatous prostatitis on needle biopsy","volume":"121","author":"Oppenheimer\n              JR,","year":"1997","unstructured":"Oppenheimer\n              JR, \n            \n              Kahane\n              H, \n            \n              Epstein\n              JI. \n          \n          Granulomatous prostatitis on needle biopsy. 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