{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T06:47:07Z","timestamp":1794638827168,"version":"4.9.1"},"reference-count":30,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Anaplastic large cell lymphoma has histopathologic features that necessitate a broad differential diagnosis. Diagnostic considerations include carcinoma, melanoma, and hematopoietic malignancies, including diffuse large B-cell lymphoma, classical Hodgkin lymphoma, myeloid sarcoma, and peripheral T-cell lymphoma, not otherwise specified. Unusual features can include subtle sinusoidal involvement, histiocytic morphology, cytokeratin expression, CD15 expression, and variant patterns of anaplastic lymphoma kinase expression. Cases with unusual morphologic or immunohistochemical findings will be presented to highlight the complexity encountered in practice.<\/jats:p>","DOI":"10.5858\/arpa.2014-0295-cc","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T18:30:55Z","timestamp":1412101855000},"page":"1290-1294","source":"Crossref","is-referenced-by-count":32,"title":["Anaplastic Large Cell Lymphoma: Features Presenting Diagnostic Challenges"],"prefix":"10.5858","volume":"138","author":[{"given":"Maria A.","family":"Pletneva","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren B.","family":"Smith","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"issue":"3","key":"i1543-2165-138-10-1290-b01","series-title":"Mod Pathol","first-page":"219","article-title":"Anaplastic large cell lymphoma: the shifting sands of diagnostic hematopathology","volume":"14","author":"Jaffe\n              ES.","year":"2001","unstructured":"Jaffe\n              ES. \n          \n          Anaplastic large cell lymphoma: the shifting sands of diagnostic hematopathology. Mod Pathol. 2001;14(3):219\u2013228."},{"issue":"5","key":"i1543-2165-138-10-1290-b02","series-title":"Am J Clin Pathol","first-page":"707","article-title":"Anaplastic large cell lymphoma","volume":"127","author":"Medeiros\n              LJ,","year":"2007","unstructured":"Medeiros\n              LJ, \n            \n              Elenitoba-Johnson\n              KS. \n          \n          Anaplastic large cell lymphoma. Am J Clin Pathol. 2007;127(5):707\u2013722."},{"issue":"2","key":"i1543-2165-138-10-1290-b03","series-title":"Crit Rev Oncol Hematol","first-page":"206","article-title":"Anaplastic large cell lymphoma, ALK-negative","volume":"85","author":"Ferreri\n              AJ,","year":"2013","unstructured":"Ferreri\n              AJ, \n            \n              Govi\n              S, \n            \n              Pileri\n              SA, \n            \n              Savage\n              KJ. \n          \n          Anaplastic large cell lymphoma, ALK-negative. Crit Rev Oncol Hematol. 2013;85(2):206\u2013215."},{"issue":"2","key":"i1543-2165-138-10-1290-b04","series-title":"Crit Rev Oncol Hematol","first-page":"293","article-title":"Anaplastic large cell lymphoma, ALK-positive","volume":"83","author":"Ferreri\n              AJ,","year":"2012","unstructured":"Ferreri\n              AJ, \n            \n              Govi\n              S, \n            \n              Pileri\n              SA, \n            \n              Savage\n              KJ. \n          \n          Anaplastic large cell lymphoma, ALK-positive. Crit Rev Oncol Hematol. 2012;83(2):293\u2013302."},{"issue":"1","key":"i1543-2165-138-10-1290-b05","series-title":"Am J Pathol","first-page":"59","article-title":"Coexpression of epithelial membrane antigen (EMA), Ki-1 and interleukin-2 receptor by anaplastic large cell lymphomas: diagnostic value in so-called malignant histiocytosis","volume":"130","author":"Delsol\n              G,","year":"1988","unstructured":"Delsol\n              G, \n            \n              Al Saati\n              T, \n            \n              Gatter\n              K, \n            et al\n          . Coexpression of epithelial membrane antigen (EMA), Ki-1 and interleukin-2 receptor by anaplastic large cell lymphomas: diagnostic value in so-called malignant histiocytosis. Am J Pathol. 1988;130(1):59\u201370."},{"key":"i1543-2165-138-10-1290-b06","series-title":"WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues","first-page":"312","article-title":"Anaplastic large cell lymphoma (ALCL), ALK-positive","author":"Delsol\n              G,","year":"2008","unstructured":"Delsol\n              G, \n            \n              Falini\n              B, \n            \n              M\u00fcller-Hermelink\n              HK, \n            et al\n          . Anaplastic large cell lymphoma (ALCL), ALK-positive. In: SwerdlowSH, CampoE, HarrisNL, et al, eds. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2008:312\u2013316."},{"issue":"2","key":"i1543-2165-138-10-1290-b07","series-title":"Am J Clin Pathol","first-page":"205","article-title":"Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry","volume":"119","author":"Juco\n              J,","year":"2003","unstructured":"Juco\n              J, \n            \n              Holden\n              JT, \n            \n              Mann\n              KP, \n            \n              Kelley\n              LG, \n            \n              Li\n              S. \n          \n          Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry. Am J Clin Pathol. 2003;119(2):205\u2013212."},{"issue":"6","key":"i1543-2165-138-10-1290-b08","series-title":"Am J Pathol","first-page":"1413","article-title":"Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas","volume":"138","author":"Gustmann\n              C,","year":"1991","unstructured":"Gustmann\n              C, \n            \n              Altmannsberger\n              M, \n            \n              Osborn\n              M, \n            \n              Griesser\n              H, \n            \n              Feller\n              AC. \n          \n          Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas. Am J Pathol. 1991;138(6):1413\u20131422."},{"issue":"4","key":"i1543-2165-138-10-1290-b09","series-title":"Int J Clin Exp Pathol","first-page":"798","article-title":"Cytokeratin positivity in anaplastic large cell lymphoma: a potential diagnostic pitfall in misdiagnosis of metastatic carcinoma","volume":"6","author":"Zhang\n              Q,","year":"2013","unstructured":"Zhang\n              Q, \n            \n              Ming\n              J, \n            \n              Zhang\n              S, \n            \n              Li\n              B, \n            \n              Han\n              X, \n            \n              Qiu\n              X. \n          \n          Cytokeratin positivity in anaplastic large cell lymphoma: a potential diagnostic pitfall in misdiagnosis of metastatic carcinoma. Int J Clin Exp Pathol. 2013;6(4):798\u2013801."},{"issue":"33","key":"i1543-2165-138-10-1290-b10","series-title":"J Clin Oncol","first-page":"443","article-title":"Anaplastic large cell lymphoma with aberrant expression of multiple cytokeratins masquerading as metastatic carcinoma of unknown primary","volume":"31","author":"Nguyen\n              TT,","year":"2013","unstructured":"Nguyen\n              TT, \n            \n              Kreisel\n              FH, \n            \n              Frater\n              JL, \n            \n              Bartlett\n              NL. \n          \n          Anaplastic large cell lymphoma with aberrant expression of multiple cytokeratins masquerading as metastatic carcinoma of unknown primary. J Clin Oncol. 2013;31(33):443\u2013445."},{"issue":"2","key":"i1543-2165-138-10-1290-b11","series-title":"Appl Immunohistochem Mol Morphol","first-page":"165","article-title":"The selective expression of CD43 in adenoid cystic carcinoma","volume":"16","author":"Seethala\n              RR,","year":"2008","unstructured":"Seethala\n              RR, \n            \n              Pasha\n              TL, \n            \n              Raqhunath\n              PN, \n            \n              Livolsi\n              VA, \n            \n              Zhang\n              PJ. \n          \n          The selective expression of CD43 in adenoid cystic carcinoma. Appl Immunohistochem Mol Morphol. 2008;16(2):165\u2013172."},{"issue":"12","key":"i1543-2165-138-10-1290-b12","series-title":"Am J Surg Pathol","first-page":"1513","article-title":"Peripheral T-cell lymphomas expressing CD30 and CD15","volume":"27","author":"Barry\n              TS,","year":"2003","unstructured":"Barry\n              TS, \n            \n              Jaffe\n              ES, \n            \n              Sorbara\n              L, \n            \n              Raffeld\n              M, \n            \n              Pittaluga\n              S. \n          \n          Peripheral T-cell lymphomas expressing CD30 and CD15. Am J Surg Pathol. 2003;27(12):1513\u20131522."},{"issue":"4","key":"i1543-2165-138-10-1290-b13","series-title":"Mod Pathol","first-page":"593","article-title":"PAX5-positive T-cell anaplastic large cell lymphomas associated with extra copies of the PAX5 gene locus","volume":"23","author":"Feldman\n              AL,","year":"2010","unstructured":"Feldman\n              AL, \n            \n              Law\n              ME, \n            \n              Inwards\n              DJ, \n            \n              Dogan\n              A, \n            \n              McClure\n              RF, \n            \n              Macon\n              WR. \n          \n          PAX5-positive T-cell anaplastic large cell lymphomas associated with extra copies of the PAX5 gene locus. Mod Pathol. 2010;23(4):593\u2013602."},{"issue":"10","key":"i1543-2165-138-10-1290-b14","series-title":"Nat Rev Cancer","first-page":"685","article-title":"Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology","volume":"13","author":"Hallberg\n              B,","year":"2013","unstructured":"Hallberg\n              B, \n            \n              Palmer\n              RH. \n          \n          Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Nat Rev Cancer. 2013;13(10):685\u2013700."},{"issue":"10","key":"i1543-2165-138-10-1290-b15","series-title":"Blood","first-page":"3509","article-title":"Lymphomas expressing ALK fusion protein(s) other than NPM-ALK","volume":"94","author":"Falini\n              B,","year":"1999","unstructured":"Falini\n              B, \n            \n              Pulford\n              K, \n            \n              Pucciarini\n              A, \n            et al\n          . Lymphomas expressing ALK fusion protein(s) other than NPM-ALK. Blood. 1999;94(10):3509\u20133515."},{"issue":"3","key":"i1543-2165-138-10-1290-b01","series-title":"Mod Pathol","first-page":"219","article-title":"Anaplastic large cell lymphoma: the shifting sands of diagnostic hematopathology","volume":"14","author":"Jaffe\n              ES.","year":"2001","unstructured":"Jaffe\n              ES. \n          \n          Anaplastic large cell lymphoma: the shifting sands of diagnostic hematopathology. Mod Pathol. 2001;14(3):219\u2013228."},{"issue":"5","key":"i1543-2165-138-10-1290-b02","series-title":"Am J Clin Pathol","first-page":"707","article-title":"Anaplastic large cell lymphoma","volume":"127","author":"Medeiros\n              LJ,","year":"2007","unstructured":"Medeiros\n              LJ, \n            \n              Elenitoba-Johnson\n              KS. \n          \n          Anaplastic large cell lymphoma. Am J Clin Pathol. 2007;127(5):707\u2013722."},{"issue":"2","key":"i1543-2165-138-10-1290-b03","series-title":"Crit Rev Oncol Hematol","first-page":"206","article-title":"Anaplastic large cell lymphoma, ALK-negative","volume":"85","author":"Ferreri\n              AJ,","year":"2013","unstructured":"Ferreri\n              AJ, \n            \n              Govi\n              S, \n            \n              Pileri\n              SA, \n            \n              Savage\n              KJ. \n          \n          Anaplastic large cell lymphoma, ALK-negative. Crit Rev Oncol Hematol. 2013;85(2):206\u2013215."},{"issue":"2","key":"i1543-2165-138-10-1290-b04","series-title":"Crit Rev Oncol Hematol","first-page":"293","article-title":"Anaplastic large cell lymphoma, ALK-positive","volume":"83","author":"Ferreri\n              AJ,","year":"2012","unstructured":"Ferreri\n              AJ, \n            \n              Govi\n              S, \n            \n              Pileri\n              SA, \n            \n              Savage\n              KJ. \n          \n          Anaplastic large cell lymphoma, ALK-positive. Crit Rev Oncol Hematol. 2012;83(2):293\u2013302."},{"issue":"1","key":"i1543-2165-138-10-1290-b05","series-title":"Am J Pathol","first-page":"59","article-title":"Coexpression of epithelial membrane antigen (EMA), Ki-1 and interleukin-2 receptor by anaplastic large cell lymphomas: diagnostic value in so-called malignant histiocytosis","volume":"130","author":"Delsol\n              G,","year":"1988","unstructured":"Delsol\n              G, \n            \n              Al Saati\n              T, \n            \n              Gatter\n              K, \n            et al\n          . Coexpression of epithelial membrane antigen (EMA), Ki-1 and interleukin-2 receptor by anaplastic large cell lymphomas: diagnostic value in so-called malignant histiocytosis. Am J Pathol. 1988;130(1):59\u201370."},{"key":"i1543-2165-138-10-1290-b06","series-title":"WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues","first-page":"312","article-title":"Anaplastic large cell lymphoma (ALCL), ALK-positive","author":"Delsol\n              G,","year":"2008","unstructured":"Delsol\n              G, \n            \n              Falini\n              B, \n            \n              M\u00fcller-Hermelink\n              HK, \n            et al\n          . Anaplastic large cell lymphoma (ALCL), ALK-positive. In: SwerdlowSH, CampoE, HarrisNL, et al, eds. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2008:312\u2013316."},{"issue":"2","key":"i1543-2165-138-10-1290-b07","series-title":"Am J Clin Pathol","first-page":"205","article-title":"Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry","volume":"119","author":"Juco\n              J,","year":"2003","unstructured":"Juco\n              J, \n            \n              Holden\n              JT, \n            \n              Mann\n              KP, \n            \n              Kelley\n              LG, \n            \n              Li\n              S. \n          \n          Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry. Am J Clin Pathol. 2003;119(2):205\u2013212."},{"issue":"6","key":"i1543-2165-138-10-1290-b08","series-title":"Am J Pathol","first-page":"1413","article-title":"Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas","volume":"138","author":"Gustmann\n              C,","year":"1991","unstructured":"Gustmann\n              C, \n            \n              Altmannsberger\n              M, \n            \n              Osborn\n              M, \n            \n              Griesser\n              H, \n            \n              Feller\n              AC. \n          \n          Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas. Am J Pathol. 1991;138(6):1413\u20131422."},{"issue":"4","key":"i1543-2165-138-10-1290-b09","series-title":"Int J Clin Exp Pathol","first-page":"798","article-title":"Cytokeratin positivity in anaplastic large cell lymphoma: a potential diagnostic pitfall in misdiagnosis of metastatic carcinoma","volume":"6","author":"Zhang\n              Q,","year":"2013","unstructured":"Zhang\n              Q, \n            \n              Ming\n              J, \n            \n              Zhang\n              S, \n            \n              Li\n              B, \n            \n              Han\n              X, \n            \n              Qiu\n              X. \n          \n          Cytokeratin positivity in anaplastic large cell lymphoma: a potential diagnostic pitfall in misdiagnosis of metastatic carcinoma. Int J Clin Exp Pathol. 2013;6(4):798\u2013801."},{"issue":"33","key":"i1543-2165-138-10-1290-b10","series-title":"J Clin Oncol","first-page":"443","article-title":"Anaplastic large cell lymphoma with aberrant expression of multiple cytokeratins masquerading as metastatic carcinoma of unknown primary","volume":"31","author":"Nguyen\n              TT,","year":"2013","unstructured":"Nguyen\n              TT, \n            \n              Kreisel\n              FH, \n            \n              Frater\n              JL, \n            \n              Bartlett\n              NL. \n          \n          Anaplastic large cell lymphoma with aberrant expression of multiple cytokeratins masquerading as metastatic carcinoma of unknown primary. J Clin Oncol. 2013;31(33):443\u2013445."},{"issue":"2","key":"i1543-2165-138-10-1290-b11","series-title":"Appl Immunohistochem Mol Morphol","first-page":"165","article-title":"The selective expression of CD43 in adenoid cystic carcinoma","volume":"16","author":"Seethala\n              RR,","year":"2008","unstructured":"Seethala\n              RR, \n            \n              Pasha\n              TL, \n            \n              Raqhunath\n              PN, \n            \n              Livolsi\n              VA, \n            \n              Zhang\n              PJ. \n          \n          The selective expression of CD43 in adenoid cystic carcinoma. Appl Immunohistochem Mol Morphol. 2008;16(2):165\u2013172."},{"issue":"12","key":"i1543-2165-138-10-1290-b12","series-title":"Am J Surg Pathol","first-page":"1513","article-title":"Peripheral T-cell lymphomas expressing CD30 and CD15","volume":"27","author":"Barry\n              TS,","year":"2003","unstructured":"Barry\n              TS, \n            \n              Jaffe\n              ES, \n            \n              Sorbara\n              L, \n            \n              Raffeld\n              M, \n            \n              Pittaluga\n              S. \n          \n          Peripheral T-cell lymphomas expressing CD30 and CD15. Am J Surg Pathol. 2003;27(12):1513\u20131522."},{"issue":"4","key":"i1543-2165-138-10-1290-b13","series-title":"Mod Pathol","first-page":"593","article-title":"PAX5-positive T-cell anaplastic large cell lymphomas associated with extra copies of the PAX5 gene locus","volume":"23","author":"Feldman\n              AL,","year":"2010","unstructured":"Feldman\n              AL, \n            \n              Law\n              ME, \n            \n              Inwards\n              DJ, \n            \n              Dogan\n              A, \n            \n              McClure\n              RF, \n            \n              Macon\n              WR. \n          \n          PAX5-positive T-cell anaplastic large cell lymphomas associated with extra copies of the PAX5 gene locus. Mod Pathol. 2010;23(4):593\u2013602."},{"issue":"10","key":"i1543-2165-138-10-1290-b14","series-title":"Nat Rev Cancer","first-page":"685","article-title":"Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology","volume":"13","author":"Hallberg\n              B,","year":"2013","unstructured":"Hallberg\n              B, \n            \n              Palmer\n              RH. \n          \n          Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Nat Rev Cancer. 2013;13(10):685\u2013700."},{"issue":"10","key":"i1543-2165-138-10-1290-b15","series-title":"Blood","first-page":"3509","article-title":"Lymphomas expressing ALK fusion protein(s) other than NPM-ALK","volume":"94","author":"Falini\n              B,","year":"1999","unstructured":"Falini\n              B, \n            \n              Pulford\n              K, \n            \n              Pucciarini\n              A, \n            et al\n          . Lymphomas expressing ALK fusion protein(s) other than NPM-ALK. Blood. 1999;94(10):3509\u20133515."}],"container-title":["Archives of Pathology and Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/138\/10\/article-p1290.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/138\/10\/1290\/1614371\/arpa_2014-0295-cc.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/138\/10\/article-p1290.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/138\/10\/article-p1290.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:00:20Z","timestamp":1770771620000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/138\/10\/article-p1290.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":30,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.5858\/arpa.2014-0295-cc","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}