{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:00:17Z","timestamp":1770786017130,"version":"3.50.0"},"reference-count":74,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10]]},"abstract":"\n Clear cell melanoma is a rare clear cell malignancy. Accurate diagnosis of clear cell melanoma requires integration of immunohistochemical and morphologic findings, with molecular studies to rule out clear cell sarcoma. The differential diagnosis includes melanoma, carcinoma, perivascular epithelioid cell tumor, and epidermotropic clear cell sarcoma. We use a case of a lesion on the helix of an 86-year-old man as an example. Histologic examination revealed an ulcerated clear cell malignant tumor. Tumor cell cytoplasm contained periodic acid-Schiff\u2013positive, diastase-sensitive glycogen. Tumor cells showed positive labeling for S100, HMB-45, and Melan-A, and negative labeling for cytokeratins, p63, and smooth muscle actin. Molecular studies demonstrated\n BRAF<\/jats:italic>\n V600E mutation, copy gains at the 6p25 (\n RREB1<\/jats:italic>\n ) and 11q13 (\n CCND1<\/jats:italic>\n ) loci, and absence of\n EWSR1-ATF1<\/jats:italic>\n fusion. These findings supported a diagnosis of clear cell melanoma. The rare pure clear cell morphology occurs due to accumulation of intracytoplasmic glycogen. We review the differential diagnosis of clear cell melanoma and describe the utility of immunohistochemical and molecular studies in confirming this diagnosis.\n <\/jats:p>","DOI":"10.5858\/arpa.2014-0307-cc","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T18:30:55Z","timestamp":1412101855000},"page":"1328-1336","source":"Crossref","is-referenced-by-count":20,"title":["Clear Cell Melanoma: A Cutaneous Clear Cell Malignancy"],"prefix":"10.5858","volume":"138","author":[{"given":"Maria A.","family":"Pletneva","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (Drs Pletneva, Andea, Palanisamy, Betz, Wang, Patel, Fullen, and Harms, and Ms Carskadon) and Dermatology (Drs Andea Patel, Fullen, and Harms), and the Michigan Center for Translational Pathology (Drs Palanisamy and Harms, and Ms Carskadon), University of Michigan Medical Center, Ann Arbor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleodor","family":"Andea","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Pletneva, Andea, Palanisamy, Betz, Wang, Patel, Fullen, and Harms, and Ms Carskadon) and Dermatology (Drs Andea Patel, Fullen, and Harms), and the Michigan Center for Translational Pathology (Drs Palanisamy and Harms, and Ms Carskadon), University of Michigan Medical Center, Ann Arbor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nallasivam","family":"Palanisamy","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Pletneva, Andea, Palanisamy, Betz, Wang, Patel, Fullen, and Harms, and Ms Carskadon) and Dermatology (Drs Andea Patel, Fullen, and Harms), and the Michigan Center for Translational Pathology (Drs Palanisamy and Harms, and Ms Carskadon), University of Michigan Medical Center, Ann Arbor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan L.","family":"Betz","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Pletneva, Andea, Palanisamy, Betz, Wang, Patel, Fullen, and Harms, and Ms Carskadon) and Dermatology (Drs Andea Patel, Fullen, and Harms), and the Michigan Center for Translational Pathology (Drs Palanisamy and Harms, and Ms Carskadon), University of Michigan Medical Center, Ann Arbor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Carskadon","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Pletneva, Andea, Palanisamy, Betz, Wang, Patel, Fullen, and Harms, and Ms Carskadon) and Dermatology (Drs Andea Patel, Fullen, and Harms), and the Michigan Center for Translational Pathology (Drs Palanisamy and Harms, and Ms Carskadon), University of Michigan Medical Center, Ann Arbor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Pletneva, Andea, Palanisamy, Betz, Wang, Patel, Fullen, and Harms, and Ms Carskadon) and Dermatology (Drs Andea Patel, Fullen, and Harms), and the Michigan Center for Translational Pathology (Drs Palanisamy and Harms, and Ms Carskadon), University of Michigan Medical Center, Ann Arbor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv M.","family":"Patel","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Pletneva, Andea, Palanisamy, Betz, Wang, Patel, Fullen, and Harms, and Ms Carskadon) and Dermatology (Drs Andea Patel, Fullen, and Harms), and the Michigan Center for Translational Pathology (Drs Palanisamy and Harms, and Ms Carskadon), University of Michigan Medical Center, Ann Arbor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Fullen","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Pletneva, Andea, Palanisamy, Betz, Wang, Patel, Fullen, and Harms, and Ms Carskadon) and Dermatology (Drs Andea Patel, Fullen, and Harms), and the Michigan Center for Translational Pathology (Drs Palanisamy and Harms, and Ms Carskadon), University of Michigan Medical Center, Ann Arbor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Harms","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Pletneva, Andea, Palanisamy, Betz, Wang, Patel, Fullen, and Harms, and Ms Carskadon) and Dermatology (Drs Andea Patel, Fullen, and Harms), and the Michigan Center for Translational Pathology (Drs Palanisamy and Harms, and Ms Carskadon), University of Michigan Medical Center, Ann Arbor."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-138-10-1328-b01","series-title":"Dermatol Res Pract","first-page":"984096","article-title":"Clear cell sarcoma (malignant melanoma) of soft parts: a clinicopathologic study of 52 cases","volume":"2012","author":"Hocar\n O,","year":"2012","unstructured":"Hocar\n O, \n \n Le Cesne\n A, \n \n Berissi\n S, \n et al\n . 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Semin Diagn Pathol. 2009;26(3):123\u2013130."},{"issue":"2","key":"i1543-2165-138-10-1328-b32","series-title":"J Cancer Res Ther","first-page":"305","article-title":"Pigmented perivascular epithelioid cell tumor of the liver: report of a rare case with brief review of literature","volume":"9","author":"Patra\n S,","year":"2013","unstructured":"Patra\n S, \n \n Vij\n M, \n \n Kota\n V, \n et al\n . Pigmented perivascular epithelioid cell tumor of the liver: report of a rare case with brief review of literature. J Cancer Res Ther. 2013;9(2):305\u2013307."},{"issue":"5","key":"i1543-2165-138-10-1328-b33","series-title":"Korean J Pathol","first-page":"499","article-title":"Pigmented perivascular epithelioid cell tumor (PEComa) of the kidney: a case report and review of the literature","volume":"46","author":"Chang\n H,","year":"2012","unstructured":"Chang\n H, \n \n Jung\n W, \n \n Kang\n Y, \n et al\n . 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