{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:21:06Z","timestamp":1791825666266,"version":"4.3.4"},"reference-count":38,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    <jats:bold>Context.\u2014<\/jats:bold>\n                    Knowing the subtype of vulvar cancer histology is important for estimating human papillomavirus\u2013related cancer etiology. Surveillance of human papillomavirus\u2013related vulvar cancers informs public health decisions related to vaccination against human papillomavirus.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective.\u2014<\/jats:bold>\n                    To assess the accuracy of registry classifications of vulvar cancer and determine the histologic classification of cases reported as not otherwise specified.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design.\u2014<\/jats:bold>\n                    Pathology specimens were collected from Florida, Iowa, and Hawaii cancer registries. Registry diagnosis was compared with the pathology report from the medical record and a single expert study histology review of a representative histologic section from each case.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.\u2014<\/jats:bold>\n                    The study included 60 invasive vulvar squamous cell carcinoma (SCC) cases, 6 Paget disease cases, 2 basal cell carcinoma cases, and 53 in situ cases. Comparing subtypes of invasive vulvar SCC, the registry agreed with the pathology report classification in 49 of 60 cases (81.7%). Study histology review identified the same SCC subtype as the registry in 9 of 60 cases (15.0%) and the same SCC subtype as the pathology report in 11 of 60 cases (18.3%). Whereas the registry and pathology reports classified 37 and 34 cases, respectively, as being SCC not otherwise specified, the study histology review identified a more specific subtype in all cases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions.\u2014<\/jats:bold>\n                    Subtypes of vulvar cancer were frequently recorded as not otherwise specified in the cancer registry primarily because the pathology report often did not specify the histologic subtype. Vulvar cancer registry data are useful for tracking broad diagnostic categories, but are less reliable for vulvar cancer subtypes.\n                  <\/jats:p>","DOI":"10.5858\/arpa.2015-0422-oa","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T13:14:47Z","timestamp":1476969287000},"page":"139-143","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of the Vulvar Cancer Histology Code Reported by Central Cancer Registries: Importance in Epidemiology"],"prefix":"10.5858","volume":"141","author":[{"given":"David A.","family":"Siegel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia W.","family":"Gargano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Y.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc T.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Saraiya","sequence":"additional","affiliation":[{"name":"From the Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia (Dr Siegel); the Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion (Dr Saraiya and Mss Wilson and Watson), the Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (Drs Gargano and Unger)..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-141-1-139-b01","series-title":"US Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute","article-title":"United States Cancer Statistics: 1999\u20132012 incidence and mortality web-based report. Atlanta, GA","year":"2015","unstructured":"US Cancer Statistics Working Group. United States Cancer Statistics: 1999\u20132012 incidence and mortality web-based report. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute; 2015. www.cdc.gov\/uscs. Accessed September 7, 2015."},{"issue":"10","key":"i1543-2165-141-1-139-b02","series-title":"Cancer","first-page":"2865","article-title":"Incidence of in situ and invasive vulvar cancer in the US, 1998\u20132003","volume":"113","author":"Saraiya \n              M,","year":"2008","unstructured":"Saraiya \n              M, \n            \n            \n              Watson \n              M, \n            \n            \n              Wu \n              XC, \n            \n            et al. \n          Incidence of in situ and invasive vulvar cancer in the US, 1998\u20132003. Cancer. 2008;113(10):2865\u20132872."},{"issue":"4","key":"i1543-2165-141-1-139-b03","series-title":"Obstet Gynecol","first-page":"917","article-title":"Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors","volume":"113","author":"Smith \n              JS,","year":"2009","unstructured":"Smith \n              JS, \n            \n            \n              Backes \n              DM, \n            \n            \n              Hoots \n              BE, \n            \n            \n              Kurman \n              RJ, \n            \n            \n              Pimenta \n              JM. \n            \n          \n          Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors. Obstet Gynecol. 2009;113(4):917\u2013924."},{"issue":"4","key":"i1543-2165-141-1-139-b04","series-title":"J Low Genit Tract Dis","first-page":"471","article-title":"Prevalence of human papillomavirus (HPV) types in vulvar cancers and VIN3 in the United States before vaccine introductions","volume":"16","author":"Gargano \n              JW,","year":"2012","unstructured":"Gargano \n              JW, \n            \n            \n              Wilkinson \n              EJ, \n            \n            \n              Unger \n              ER, \n            \n            et al. \n          Prevalence of human papillomavirus (HPV) types in vulvar cancers and VIN3 in the United States before vaccine introductions. J Low Genit Tract Dis. 2012;16(4):471\u2013479."},{"issue":"16","key":"i1543-2165-141-1-139-b05","series-title":"Eur J Cancer","first-page":"3450","article-title":"Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva","volume":"49","author":"de Sanjos\u00e9 \n              S,","year":"2013","unstructured":"de Sanjos\u00e9 \n              S, \n            \n            \n              Alemany \n              L, \n            \n            \n              Ordi \n              J, \n            \n            et al. \n          Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva. Eur J Cancer. 2013;49(16):3450\u20133461."},{"issue":"5","key":"i1543-2165-141-1-139-b06","series-title":"Am J Public Health","first-page":"695","article-title":"The potential and limitations of data from population-based state cancer registries","volume":"90","author":"Izquierdo \n              JN,","year":"2000","unstructured":"Izquierdo \n              JN, \n            \n            \n              Schoenbach \n              VJ. \n            \n          \n          The potential and limitations of data from population-based state cancer registries. 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Cancer. 2008;113(10):2865\u20132872."},{"issue":"4","key":"i1543-2165-141-1-139-b03","series-title":"Obstet Gynecol","first-page":"917","article-title":"Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors","volume":"113","author":"Smith \n              JS,","year":"2009","unstructured":"Smith \n              JS, \n            \n            \n              Backes \n              DM, \n            \n            \n              Hoots \n              BE, \n            \n            \n              Kurman \n              RJ, \n            \n            \n              Pimenta \n              JM. \n            \n          \n          Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors. Obstet Gynecol. 2009;113(4):917\u2013924."},{"issue":"4","key":"i1543-2165-141-1-139-b04","series-title":"J Low Genit Tract Dis","first-page":"471","article-title":"Prevalence of human papillomavirus (HPV) types in vulvar cancers and VIN3 in the United States before vaccine introductions","volume":"16","author":"Gargano \n              JW,","year":"2012","unstructured":"Gargano \n              JW, \n            \n            \n              Wilkinson \n              EJ, \n            \n            \n              Unger \n              ER, \n            \n            et al. \n          Prevalence of human papillomavirus (HPV) types in vulvar cancers and VIN3 in the United States before vaccine introductions. 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Lyon, France: IARC;2014:232\u2013241."},{"key":"i1543-2165-141-1-139-b18","series-title":"Tumors of the Cervix, Vagina, and Vulva","author":"Kurman \n              RJ,","year":"2010","unstructured":"Kurman \n              RJ, \n            \n            \n              Ronnett \n              BM, \n            \n            \n              Sherman \n              ME, \n            \n            \n              Wilkinson \n              EJ. \n            \n          \n          Tumors of the Cervix, Vagina, and Vulva. Washington, DC: ARP Press;2010. AFIP Atlas of Tumor Pathology; series 4."},{"issue":"2","key":"i1543-2165-141-1-139-b19","series-title":"J Registry Manag","first-page":"75","article-title":"Quality of cancer registry data: findings from CDC-NPCR's breast and prostate cancer data quality and patterns of care study","volume":"38","author":"German \n              RR,","year":"2011","unstructured":"German \n              RR, \n            \n            \n              Wike \n              JM, \n            \n            \n              Bauer \n              KR, \n            \n            et al. \n          Quality of cancer registry data: findings from CDC-NPCR's breast and prostate cancer data quality and patterns of care study. 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