{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:49:15Z","timestamp":1770814155460,"version":"3.50.1"},"reference-count":62,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2]]},"abstract":"\n Context.\u2014<\/jats:bold>\n Despite increased use of dilation and evacuation in the setting of fetuses with developmental anomalies, the pathology examination of fragmented specimens obtained by this technique has been understudied.\n <\/jats:p>\n \n Objectives.\u2014<\/jats:bold>\n To correlate pathologic findings in second-trimester fetal dilation and evacuation specimens with prenatal diagnoses established through ultrasound and\/or chromosome studies to determine the value of pathology examination for supplementing or correcting clinical diagnoses.\n <\/jats:p>\n \n Design.\u2014<\/jats:bold>\n In this retrospective study, clinical and pathology findings were correlated in 448 dilation and evacuation specimens performed for second-trimester termination of pregnancy for fetal anomalies discovered on ultrasound examination (278 cases) or chromosome analysis (170 cases).\n <\/jats:p>\n \n Results.\u2014<\/jats:bold>\n In 109 of the 170 cases with chromosomal abnormalities (64%), pathologists identified at least 1 congenital defect associated with the respective karyotype. In 278 cases with ultrasound-detected anomalies, pathologists confirmed the major congenital defect in 116 fetal specimens (42%). Evaluating for congenital central nervous system and body wall\/diaphragm pathologic findings proved challenging owing to tissue disruption. However, taking all categories into account, pathology studies corrected ultrasound diagnoses in 152 of 413 cases (37%) and yielded additional diagnostic findings in 137 cases (33%).\n <\/jats:p>\n \n Conclusions.\u2014<\/jats:bold>\n In a substantial number of cases, examination of fragmented fetuses corrected or refined prenatal diagnoses, demonstrating a role for detailed pathology examination of dilation and evacuation specimens in quality control of prenatal imaging studies and for potentially aiding subsequent genetic counseling.\n <\/jats:p>","DOI":"10.5858\/arpa.2016-0029-oa","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T13:16:38Z","timestamp":1476969398000},"page":"267-273","source":"Crossref","is-referenced-by-count":1,"title":["Correlation of Prenatal Diagnosis and Pathology Findings Following Dilation and Evacuation for Fetal Anomalies"],"prefix":"10.5858","volume":"141","author":[{"given":"Carolin A.","family":"Boecking","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor A.","family":"Drey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Kerns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter E.","family":"Finkbeiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"4","key":"i1543-2165-141-2-267-b01","series-title":"Obstet Gynecol","first-page":"788","article-title":"Second-trimester abortion for fetal anomalies or fetal death: labor induction compared with dilation and evacuation","volume":"117","author":"Bryant \n AG,","year":"2011","unstructured":"Bryant \n AG, \n \n \n Grimes \n DA, \n \n \n Garrett \n JM, \n \n \n Stuart \n GS. \n \n \n Second-trimester abortion for fetal anomalies or fetal death: labor induction compared with dilation and evacuation. Obstet Gynecol. 2011;117(4):788\u2013792."},{"issue":"4","key":"i1543-2165-141-2-267-b02","series-title":"Am J Obstet Gynecol","first-page":"386.e1","article-title":"Midtrimester dilation and evcuation versus prostaglandin induction: a comparison of composite outcomes","volume":"205","author":"Whitley \n KA,","year":"2011","unstructured":"Whitley \n KA, \n \n \n Trinchere \n K, \n \n \n Prutsman \n W, \n \n \n Qui\u00f1ones \n JN, \n \n \n Rochon \n ML. \n \n \n Midtrimester dilation and evcuation versus prostaglandin induction: a comparison of composite outcomes. 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Int J Gynaecol Obstet. 2012;116(3):244\u2013248."},{"issue":"1","key":"i1543-2165-141-2-267-b06","series-title":"Contraception","first-page":"63","article-title":"Characteristics of women who undergo second-trimester abortion in the setting of a fetal anomaly","volume":"85","author":"Kerns \n JL,","year":"2012","unstructured":"Kerns \n JL, \n \n \n Swanson \n M, \n \n \n Pena \n S, \n \n et al. \n Characteristics of women who undergo second-trimester abortion in the setting of a fetal anomaly. Contraception. 2012;85(1):63\u201368."},{"issue":"3","key":"i1543-2165-141-2-267-b07","series-title":"Arch Pathol Lab Med","first-page":"326","article-title":"Pathologic examination of fetal and placental tissue obtained by dilation and evacuation","volume":"137","author":"Ernst \n LM,","year":"2013","unstructured":"Ernst \n LM, \n \n \n Gawron \n L, \n \n \n Fritsch \n MK. \n \n \n Pathologic examination of fetal and placental tissue obtained by dilation and evacuation. 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Obstet Gynecol. 1990;75(6):1037\u20131040."},{"issue":"2","key":"i1543-2165-141-2-267-b10","series-title":"Pediatr Dev Pathol","first-page":"131","article-title":"Correlation of prenatal US diagnosis and pathologic findings in fetal anomalies","volume":"2","author":"Sun \n CC,","year":"1999","unstructured":"Sun \n CC, \n \n \n Grumbach \n K, \n \n \n DeCosta \n DT, \n \n \n Meyers \n CM, \n \n \n Dungan \n JS. \n \n \n Correlation of prenatal US diagnosis and pathologic findings in fetal anomalies. Pediatr Dev Pathol. 1999;2(2):131\u2013142."},{"issue":"8","key":"i1543-2165-141-2-267-b11","series-title":"Arch Pathol Lab Med","first-page":"1083","article-title":"Perinatal pathologic examination of nonintact, second-trimester fetal demise specimens: the value of standardization","volume":"137","author":"Gawron \n LM,","year":"2013","unstructured":"Gawron \n LM, \n \n \n Hammond \n C, \n \n \n Ernst \n LM. \n \n \n Perinatal pathologic examination of nonintact, second-trimester fetal demise specimens: the value of standardization. Arch Pathol Lab Med. 2013;137(8):1083\u20131087."},{"issue":"31 suppl","key":"i1543-2165-141-2-267-b12","series-title":"Reprod Health Matters","first-page":"151","article-title":"Surgical abortion in the second trimester","volume":"16","author":"Lohr \n PA.","year":"2008","unstructured":"Lohr \n PA. \n \n \n Surgical abortion in the second trimester. Reprod Health Matters. 2008;16(31 suppl):151\u2013161."},{"issue":"10","key":"i1543-2165-141-2-267-b13","series-title":"MMWR Surveill Summ","first-page":"1","article-title":"Abortion surveillance\u2014United States, 2012","volume":"64","author":"Pazol \n K,","year":"2015","unstructured":"Pazol \n K, \n \n \n Creanga \n AA, \n \n \n Jamieson \n DJ. \n \n \n Abortion surveillance\u2014United States, 2012. MMWR Surveill Summ. 2015;64(10):1\u201340."},{"issue":"2","key":"i1543-2165-141-2-267-b14","series-title":"Clin Obstet Gynecol","first-page":"179","article-title":"Second-trimester surgical abortion","volume":"52","author":"Prager \n SW,","year":"2009","unstructured":"Prager \n SW, \n \n \n Oyer \n D. \n \n \n Second-trimester surgical abortion. Clin Obstet Gynecol. 2009;52(2):179\u2013187."},{"issue":"2, pt 1","key":"i1543-2165-141-2-267-b15","series-title":"Obstet Gynecol","first-page":"307","article-title":"Uterine evacuation for second-trimester fetal death and maternal morbidity","volume":"117","author":"Edlow \n AG,","year":"2011","unstructured":"Edlow \n AG, \n \n \n Hou \n MY, \n \n \n Maurer \n R, \n \n \n Benson \n C, \n \n \n Delli-Bovi \n L, \n \n \n Goldberg \n AB. \n \n \n Uterine evacuation for second-trimester fetal death and maternal morbidity. Obstet Gynecol. 2011;117(2, pt 1):307\u2013316."},{"issue":"6720","key":"i1543-2165-141-2-267-b16","series-title":"BMJ","first-page":"295","article-title":"Examination of fetuses after induced abortion for fetal abnormality","volume":"300","author":"Clayton-Smith \n J,","year":"1990","unstructured":"Clayton-Smith \n J, \n \n \n Farndon \n PA, \n \n \n McKeown \n C, \n \n \n Donnai \n D. \n \n \n Examination of fetuses after induced abortion for fetal abnormality. BMJ. 1990;300(6720):295\u2013297."},{"issue":"10","key":"i1543-2165-141-2-267-b17","series-title":"Acta Obstet Gynecol Scand","first-page":"1208","article-title":"Comparison of ultrasound and autopsy findings in pregnancies terminated due to fetal anomalies","volume":"85","author":"Amini \n H,","year":"2006","unstructured":"Amini \n H, \n \n \n Antonsson \n P, \n \n \n Papadogiannakis \n N, \n \n et al. \n Comparison of ultrasound and autopsy findings in pregnancies terminated due to fetal anomalies. Acta Obstet Gynecol Scand. 2006;85(10):1208\u20131216."},{"issue":"6","key":"i1543-2165-141-2-267-b18","series-title":"J Ultrasound Med","first-page":"451","article-title":"A comparative study of prenatal diagnosis and perinatal autopsy","volume":"13","author":"Chescheir \n NC,","year":"1994","unstructured":"Chescheir \n NC, \n \n \n Reitnauer \n PJ. \n \n \n A comparative study of prenatal diagnosis and perinatal autopsy. 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Acta Obstet Gynecol Scand. 2012;91(3):386\u2013390."},{"issue":"5","key":"i1543-2165-141-2-267-b20","series-title":"Prenat Diagn","first-page":"339","article-title":"A comparative study of prenatal ultrasound findings and post-mortem examination in a tertiary referral centre","volume":"24","author":"Johns \n N,","year":"2004","unstructured":"Johns \n N, \n \n \n Al-Salti \n W, \n \n \n Cox \n P, \n \n \n Kilby \n MD. \n \n \n A comparative study of prenatal ultrasound findings and post-mortem examination in a tertiary referral centre. Prenat Diagn. 2004;24(5):339\u2013346."},{"issue":"7","key":"i1543-2165-141-2-267-b21","series-title":"Ultrasound Obstet Gynecol","first-page":"925","article-title":"Correlation between prenatal ultrasound and autopsy findings: a study of second-trimester abortions","volume":"28","author":"Kaasen \n A,","year":"2006","unstructured":"Kaasen \n A, \n \n \n Tuveng \n J, \n \n \n Heiberg \n A, \n \n \n Scott \n H, \n \n \n Haugen \n G. \n \n \n Correlation between prenatal ultrasound and autopsy findings: a study of second-trimester abortions. 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Ultrasound Obstet Gynecol. 1999;13(2):117\u2013126."},{"issue":"1","key":"i1543-2165-141-2-267-b29","series-title":"J Ultrasound Med","first-page":"61","article-title":"Correlation of prenatal sonographic diagnosis and morphologic findings of fetal autopsy in fetuses with trisomy 21","volume":"26","author":"Szigeti \n Z,","year":"2007","unstructured":"Szigeti \n Z, \n \n \n Csaba \n A, \n \n \n Pete \n B, \n \n \n Hajd\u00fa \n J, \n \n \n Papp \n Z, \n \n \n Papp \n C. \n \n \n Correlation of prenatal sonographic diagnosis and morphologic findings of fetal autopsy in fetuses with trisomy 21. J Ultrasound Med. 2007;26(1):61\u201368."},{"issue":"3","key":"i1543-2165-141-2-267-b30","series-title":"Arch Dis Child Fetal Neonatal Ed","first-page":"F256","article-title":"Holswilder-Olde Scholtenhuis MA, Bouman K, van Baren R, Bilardo CM, Bos AF. 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Int J Gynaecol Obstet. 2012;116(3):244\u2013248."},{"issue":"1","key":"i1543-2165-141-2-267-b06","series-title":"Contraception","first-page":"63","article-title":"Characteristics of women who undergo second-trimester abortion in the setting of a fetal anomaly","volume":"85","author":"Kerns \n JL,","year":"2012","unstructured":"Kerns \n JL, \n \n \n Swanson \n M, \n \n \n Pena \n S, \n \n et al. \n Characteristics of women who undergo second-trimester abortion in the setting of a fetal anomaly. Contraception. 2012;85(1):63\u201368."},{"issue":"3","key":"i1543-2165-141-2-267-b07","series-title":"Arch Pathol Lab Med","first-page":"326","article-title":"Pathologic examination of fetal and placental tissue obtained by dilation and evacuation","volume":"137","author":"Ernst \n LM,","year":"2013","unstructured":"Ernst \n LM, \n \n \n Gawron \n L, \n \n \n Fritsch \n MK. \n \n \n Pathologic examination of fetal and placental tissue obtained by dilation and evacuation. 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