{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:28:43Z","timestamp":1790389723481,"version":"4.1.0"},"reference-count":80,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"abstract":"\n Context.\u2014<\/jats:bold>\n Intraductal tubulopapillary neoplasm (ITPN) is a rare intraductal epithelial neoplasm of the pancreas recently recognized as a distinct entity by the World Health Organization classification in 2010. It is defined as an intraductal, grossly visible, tubule-forming epithelial neoplasm with high-grade dysplasia and ductal differentiation without overt production of mucin. The diagnosis can be challenging owing to morphologic overlap with other intraductal lesions and its rarity. While recent advances in molecular genetic studies of ITPN have provided new tools to facilitate clinical diagnosis, the limited number of cases has yielded limited follow-up data to guide management.\n <\/jats:p>\n \n Objective.\u2014<\/jats:bold>\n To provide a clinical, pathologic, and molecular update on ITPN with respect to clinical presentation, imaging findings, histopathologic features, differential diagnosis, biological behavior, molecular characteristics, and treatment options.\n <\/jats:p>\n \n Data Sources.\u2014<\/jats:bold>\n Analysis of the pertinent literature (PubMed) and authors' research and clinical practice experience based on institutional and consultation materials.\n <\/jats:p>\n \n Conclusions.\u2014<\/jats:bold>\n Clinical presentation, imaging findings, histopathology, immunohistochemistry studies, molecular characteristics, prognosis, and treatment options of ITPN are reviewed. Important differential diagnoses with other intraductal neoplasms of the pancreas\u2014especially intraductal papillary mucinous neoplasm\u2014using histopathologic, molecular, and immunohistochemical studies, are discussed. Despite the recent progress, more studies are necessary to assess the biology and genetics of ITPN for a better understanding of the prognostic factors and treatment options.\n <\/jats:p>","DOI":"10.5858\/arpa.2016-0207-ra","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T09:14:32Z","timestamp":1475140472000},"page":"1068-1073","source":"Crossref","is-referenced-by-count":30,"title":["Intraductal Tubulopapillary Neoplasm of the Pancreas: An Update From a Pathologist's Perspective"],"prefix":"10.5858","volume":"140","author":[{"given":"Sarah L.","family":"Rooney","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Shi","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-140-10-1068-b01","series-title":"Verh Dtsch Ges Pathol","first-page":"219","article-title":"WHO-classification 2000: exocrine pancreatic tumors","volume":"85","author":"Kloppel \n G,","year":"2001","unstructured":"Kloppel \n G, \n \n \n Luttges \n J. \n \n \n WHO-classification 2000: exocrine pancreatic tumors. Verh Dtsch Ges Pathol. 2001;85:219\u2013228."},{"issue":"5","key":"i1543-2165-140-10-1068-b02","series-title":"Am J Surg Pathol","first-page":"579","article-title":"Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions","volume":"25","author":"Hruban \n RH,","year":"2001","unstructured":"Hruban \n RH, \n \n \n Adsay \n NV, \n \n \n Albores-Saavedra \n J, \n \n et al. \n Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. 2001;25(5):579\u2013586."},{"issue":"3","key":"i1543-2165-140-10-1068-b03","series-title":"J Pathol","first-page":"335","article-title":"The discrete nature and distinguishing molecular features of pancreatic intraductal tubulopapillary neoplasms and intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant","volume":"231","author":"Yamaguchi \n H,","year":"2013","unstructured":"Yamaguchi \n H, \n \n \n Kuboki \n Y, \n \n \n Hatori \n T, \n \n et al. \n The discrete nature and distinguishing molecular features of pancreatic intraductal tubulopapillary neoplasms and intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant. J Pathol. 2013;231(3):335\u2013341."},{"issue":"8","key":"i1543-2165-140-10-1068-b04","series-title":"Int J Clin Exp Pathol","first-page":"9672","article-title":"Multifocal intraductal tubulopapillary neoplasm of the pancreas with total pancreatectomy: report of a case and review of literature","volume":"8","author":"Kolby \n D,","year":"2015","unstructured":"Kolby \n D, \n \n \n Thilen \n J, \n \n \n Andersson \n R, \n \n \n Sasor \n A, \n \n \n Ansari \n D. \n \n \n Multifocal intraductal tubulopapillary neoplasm of the pancreas with total pancreatectomy: report of a case and review of literature. Int J Clin Exp Pathol. 2015;8(8):9672\u20139680."},{"issue":"7","key":"i1543-2165-140-10-1068-b05","series-title":"Arch Pathol Lab Med","first-page":"848","article-title":"Difficult diagnostic problems in pancreatobiliary neoplasia","volume":"139","author":"Bledsoe \n JR,","year":"2015","unstructured":"Bledsoe \n JR, \n \n \n Shinagare \n SA, \n \n \n Deshpande \n V. \n \n \n Difficult diagnostic problems in pancreatobiliary neoplasia. Arch Pathol Lab Med. 2015;139(7):848\u2013857."},{"issue":"6","key":"i1543-2165-140-10-1068-b06","series-title":"Semin Diagn Pathol","first-page":"452","article-title":"Intraductal neoplasms of the pancreas","volume":"31","author":"Kloppel \n G,","year":"2014","unstructured":"Kloppel \n G, \n \n \n Basturk \n O, \n \n \n Schlitter \n AM, \n \n \n Konukiewitz \n B, \n \n \n Esposito \n I. \n \n \n Intraductal neoplasms of the pancreas. Semin Diagn Pathol. 2014;31(6):452\u2013466."},{"issue":"2","key":"i1543-2165-140-10-1068-b07","series-title":"Diagn Cytopathol","first-page":"156","article-title":"Intraductal tubulopapillary neoplasm of the pancreas on fine needle aspiration: case report with differential diagnosis","volume":"42","author":"Guan \n H,","year":"2014","unstructured":"Guan \n H, \n \n \n Gurda \n G, \n \n \n Lennon \n AM, \n \n \n Hruban \n RH, \n \n \n Erozan \n YS. \n \n \n Intraductal tubulopapillary neoplasm of the pancreas on fine needle aspiration: case report with differential diagnosis. Diagn Cytopathol. 2014;42(2):156\u2013160."},{"issue":"4","key":"i1543-2165-140-10-1068-b08","series-title":"Diagn Cytopathol","first-page":"314","article-title":"Intraductal tubulopapillary neoplasm with expansile invasive carcinoma of the pancreas diagnosed by endoscopic ultrasonography-guided fine needle aspiration: a case report","volume":"42","author":"Furuhata \n A,","year":"2014","unstructured":"Furuhata \n A, \n \n \n Minamiguchi \n S, \n \n \n Mikami \n Y, \n \n et al. \n Intraductal tubulopapillary neoplasm with expansile invasive carcinoma of the pancreas diagnosed by endoscopic ultrasonography-guided fine needle aspiration: a case report. Diagn Cytopathol. 2014;42(4):314\u2013320."},{"issue":"2","key":"i1543-2165-140-10-1068-b09","series-title":"Fam Cancer","first-page":"227","article-title":"Is intraductal tubulopapillary neoplasia a new entity in the spectrum of familial pancreatic cancer syndrome?","volume":"13","author":"Del Chiaro \n M,","year":"2014","unstructured":"Del Chiaro \n M, \n \n \n Mucelli \n RP, \n \n \n Blomberg \n J, \n \n \n Segersvard \n R, \n \n \n Verbeke \n C. \n \n \n Is intraductal tubulopapillary neoplasia a new entity in the spectrum of familial pancreatic cancer syndrome?\n Fam Cancer. 2014;13(2):227\u2013229."},{"issue":"3","key":"i1543-2165-140-10-1068-b10","series-title":"J Nippon Med Sch","first-page":"224","article-title":"Intraductal tubulopapillary neoplasms of the pancreas: case report and review of the literature","volume":"80","author":"Kasugai \n H,","year":"2013","unstructured":"Kasugai \n H, \n \n \n Tajiri \n T, \n \n \n Takehara \n Y, \n \n \n Mukai \n S, \n \n \n Tanaka \n J, \n \n \n Kudo \n SE. \n \n \n Intraductal tubulopapillary neoplasms of the pancreas: case report and review of the literature. J Nippon Med Sch. 2013;80(3):224\u2013229."},{"issue":"11","key":"i1543-2165-140-10-1068-b11","series-title":"Anticancer Res","first-page":"4435","article-title":"Intraductal tubular carcinoma of the pancreas: case report with review of literature","volume":"30","author":"Hioki \n M,","year":"2010","unstructured":"Hioki \n M, \n \n \n Nakagohri \n T, \n \n \n Ikumoto \n T, \n \n et al. \n Intraductal tubular carcinoma of the pancreas: case report with review of literature. Anticancer Res. 2010;30(11):4435\u20134441."},{"issue":"1","key":"i1543-2165-140-10-1068-b12","series-title":"Pancreas","first-page":"92","article-title":"Intraductal and cystic tubulopapillary adenocarcinoma of the pancreas\u2014a possible variant of intraductal tubular carcinoma","volume":"36","author":"Konigsrainer \n I,","year":"2008","unstructured":"Konigsrainer \n I, \n \n \n Glatzle \n J, \n \n \n Kloppel \n G, \n \n \n Konigsrainer \n A, \n \n \n Wehrmann \n M. \n \n \n Intraductal and cystic tubulopapillary adenocarcinoma of the pancreas\u2014a possible variant of intraductal tubular carcinoma. Pancreas. 2008;36(1):92\u201395."},{"issue":"8","key":"i1543-2165-140-10-1068-b13","series-title":"Am J Surg Pathol","first-page":"1164","article-title":"Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms","volume":"33","author":"Yamaguchi \n H,","year":"2009","unstructured":"Yamaguchi \n H, \n \n \n Shimizu \n M, \n \n \n Ban \n S, \n \n et al. \n Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2009;33(8):1164\u20131172."},{"key":"i1543-2165-140-10-1068-b14","series-title":"BMJ Case Rep","article-title":"Intraductal tubulopapillary neoplasm of the pancreas as a radiation induced malignancy","author":"Bhuva \n N,","year":"2011","unstructured":"Bhuva \n N, \n \n \n Wasan \n H, \n \n \n Spalding \n D, \n \n \n Stamp \n G, \n \n \n Harrison \n M. \n \n \n Intraductal tubulopapillary neoplasm of the pancreas as a radiation induced malignancy. BMJ Case Rep. 2011;2011:bcr0920114777."},{"issue":"6","key":"i1543-2165-140-10-1068-b15","series-title":"J Dig Dis","first-page":"357","article-title":"Intraductal tubulopapillary neoplasm of the pancreatic branch duct showing atypical images","volume":"16","author":"Yoshida \n Y,","year":"2015","unstructured":"Yoshida \n Y, \n \n \n Matsubayashi \n H, \n \n \n Sasaki \n K, \n \n \n Kanemoto \n H, \n \n \n Uesaka \n K, \n \n \n Ono \n H. \n \n \n Intraductal tubulopapillary neoplasm of the pancreatic branch duct showing atypical images. J Dig Dis. 2015;16(6):357\u2013361."},{"issue":"6","key":"i1543-2165-140-10-1068-b16","series-title":"J Comput Assist Tomogr","first-page":"710","article-title":"Imaging studies of intraductal tubulopapillary neoplasms of the pancreas: 2-tone duct sign and cork-of-wine-bottle sign as indicators of intraductal tumor growth","volume":"36","author":"Motosugi \n U,","year":"2012","unstructured":"Motosugi \n U, \n \n \n Yamaguchi \n H, \n \n \n Furukawa \n T, \n \n et al. \n Imaging studies of intraductal tubulopapillary neoplasms of the pancreas: 2-tone duct sign and cork-of-wine-bottle sign as indicators of intraductal tumor growth. J Comput Assist Tomogr. 2012;36(6):710\u2013717."},{"issue":"9","key":"i1543-2165-140-10-1068-b17","series-title":"Pathol Int","first-page":"501","article-title":"A case of intraductal tubulopapillary neoplasm of pancreas with severe calcification, a potential pitfall in diagnostic imaging","volume":"65","author":"Takayama \n S,","year":"2015","unstructured":"Takayama \n S, \n \n \n Maeda \n T, \n \n \n Nishihara \n M, \n \n et al. \n A case of intraductal tubulopapillary neoplasm of pancreas with severe calcification, a potential pitfall in diagnostic imaging. Pathol Int. 2015;65(9):501\u2013506."},{"issue":"4","key":"i1543-2165-140-10-1068-b18","series-title":"Clin Nucl Med","first-page":"e277","article-title":"18F-FDG uptake in intraductal tubulopapillary neoplasm of the pancreas","volume":"39","author":"Someya \n Y,","year":"2014","unstructured":"Someya \n Y, \n \n \n Nakamoto \n Y, \n \n \n Nakatani \n K, \n \n \n Kawaguchi \n M, \n \n \n Minamiguchi \n S, \n \n \n Togashi \n K. \n \n \n 18F-FDG uptake in intraductal tubulopapillary neoplasm of the pancreas. Clin Nucl Med. 2014;39(4):e277\u2013e280."},{"key":"i1543-2165-140-10-1068-b19","series-title":"Diagn Pathol","first-page":"11","article-title":"Case report: intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype","volume":"9","author":"Ahls \n MG,","year":"2014","unstructured":"Ahls \n MG, \n \n \n Niedergethmann \n M, \n \n \n Dinter \n D, \n \n et al. \n Case report: intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype. Diagn Pathol. 2014;9:11."},{"issue":"5","key":"i1543-2165-140-10-1068-b20","series-title":"Pathol Int","first-page":"339","article-title":"Intraductal tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia; a case report","volume":"62","author":"Jokoji \n R,","year":"2012","unstructured":"Jokoji \n R, \n \n \n Tsuji \n H, \n \n \n Tsujimoto \n M, \n \n \n Shinno \n N, \n \n \n Tori \n M. \n \n \n Intraductal tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia; a case report. Pathol Int. 2012;62(5):339\u2013343."},{"issue":"4","key":"i1543-2165-140-10-1068-b21","series-title":"Am J Gastroenterol","first-page":"798","article-title":"Variant of intraductal carcinoma (with scant mucin production) is of main pancreatic duct origin: a clinicopathological study of four patients","volume":"91","author":"Suda \n K,","year":"1996","unstructured":"Suda \n K, \n \n \n Hirai \n S, \n \n \n Matsumoto \n Y, \n \n et al. \n Variant of intraductal carcinoma (with scant mucin production) is of main pancreatic duct origin: a clinicopathological study of four patients. Am J Gastroenterol. 1996;91(4):798\u2013800."},{"issue":"7","key":"i1543-2165-140-10-1068-b22","series-title":"Am J Surg Pathol","first-page":"1025","article-title":"Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas","volume":"34","author":"Ban \n D,","year":"2010","unstructured":"Ban \n D, \n \n \n Shimada \n K, \n \n \n Sekine \n S, \n \n et al. \n Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas. Am J Surg Pathol. 2010;34(7):1025\u20131036."},{"issue":"12","key":"i1543-2165-140-10-1068-b23","series-title":"Pathol Res Pract","first-page":"1034","article-title":"A case of MUC5AC-positive intraductal neoplasm of the pancreas classified as an intraductal tubulopapillary neoplasm?","volume":"211","author":"Muraki \n T,","year":"2015","unstructured":"Muraki \n T, \n \n \n Uehara \n T, \n \n \n Sano \n K, \n \n et al. \n A case of MUC5AC-positive intraductal neoplasm of the pancreas classified as an intraductal tubulopapillary neoplasm?\n Pathol Res Pract. 2015;211(12):1034\u20131039."},{"issue":"3","key":"i1543-2165-140-10-1068-b24","series-title":"Pathol Int","first-page":"176","article-title":"BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens","volume":"63","author":"Hosoda \n W,","year":"2013","unstructured":"Hosoda \n W, \n \n \n Sasaki \n E, \n \n \n Murakami \n Y, \n \n \n Yamao \n K, \n \n \n Shimizu \n Y, \n \n \n Yatabe \n Y. \n \n \n BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens. Pathol Int. 2013;63(3):176\u2013182."},{"issue":"2","key":"i1543-2165-140-10-1068-b25","series-title":"Virchows Arch","first-page":"133","article-title":"The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia","volume":"454","author":"La Rosa \n S,","year":"2009","unstructured":"La Rosa \n S, \n \n \n Franzi \n F, \n \n \n Marchet \n S, \n \n et al. \n The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia. Virchows Arch. 2009;454(2):133\u2013142."},{"issue":"7","key":"i1543-2165-140-10-1068-b26","series-title":"Pathology","first-page":"662","article-title":"Cytological features of pancreatic intraductal tubulopapillary neoplasm and an unexpected immunohistochemical profile","volume":"46","author":"Zhao \n L,","year":"2014","unstructured":"Zhao \n L, \n \n \n Hart \n J, \n \n \n Xiao \n SY, \n \n \n Antic \n T. \n \n \n Cytological features of pancreatic intraductal tubulopapillary neoplasm and an unexpected immunohistochemical profile. Pathology. 2014;46(7):662\u2013665."},{"issue":"6","key":"i1543-2165-140-10-1068-b27","series-title":"Gastroenterology","first-page":"1501","article-title":"A combination of molecular markers and clinical features improve the classification of pancreatic cysts","volume":"149","author":"Springer \n S,","year":"2015","unstructured":"Springer \n S, \n \n \n Wang \n Y, \n \n \n Dal Molin \n M, \n \n et al. \n A combination of molecular markers and clinical features improve the classification of pancreatic cysts. Gastroenterology. 2015;149(6):1501\u20131510."},{"issue":"2","key":"i1543-2165-140-10-1068-b28","series-title":"Am J Clin Pathol","first-page":"168","article-title":"Molecular genetics of pancreatic neoplasms and their morphologic correlates: an update on recent advances and potential diagnostic applications","volume":"141","author":"Reid \n MD,","year":"2014","unstructured":"Reid \n MD, \n \n \n Saka \n B, \n \n \n Balci \n S, \n \n \n Goldblum \n AS, \n \n \n Adsay \n NV. \n \n \n Molecular genetics of pancreatic neoplasms and their morphologic correlates: an update on recent advances and potential diagnostic applications. Am J Clin Pathol. 2014;141(2):168\u2013180."},{"issue":"3","key":"i1543-2165-140-10-1068-b29","series-title":"J Pathol","first-page":"217","article-title":"Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas","volume":"233","author":"Amato \n E,","year":"2014","unstructured":"Amato \n E, \n \n \n Molin \n MD, \n \n \n Mafficini \n A, \n \n et al. \n Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas. J Pathol. 2014;233(3):217\u2013227."},{"issue":"24","key":"i1543-2165-140-10-1068-b30","series-title":"Clin Cancer Res","first-page":"6830","article-title":"Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas","volume":"19","author":"Garcia-Carracedo \n D,","year":"2013","unstructured":"Garcia-Carracedo \n D, \n \n \n Turk \n AT, \n \n \n Fine \n SA, \n \n et al. \n Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas. Clin Cancer Res. 2013;19(24):6830\u20136841."},{"issue":"3","key":"i1543-2165-140-10-1068-b31","series-title":"Am J Pathol","first-page":"755","article-title":"Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas","volume":"157","author":"Iacobuzio-Donahue \n CA,","year":"2000","unstructured":"Iacobuzio-Donahue \n CA, \n \n \n Klimstra \n DS, \n \n \n Adsay \n NV, \n \n et al. \n Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. Am J Pathol. 2000;157(3):755\u2013761."},{"issue":"6","key":"i1543-2165-140-10-1068-b32","series-title":"Clin Gastroenterol Hepatol","first-page":"719","article-title":"Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia","volume":"11","author":"Kanda \n M,","year":"2013","unstructured":"Kanda \n M, \n \n \n Sadakari \n Y, \n \n \n Borges \n M, \n \n et al. \n Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia. Clin Gastroenterol Hepatol. 2013;11(6):719\u2013730.e715."},{"issue":"1","key":"i1543-2165-140-10-1068-b33","series-title":"Gastroenterology","first-page":"365","article-title":"Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas","volume":"123","author":"Sato \n N,","year":"2002","unstructured":"Sato \n N, \n \n \n Ueki \n T, \n \n \n Fukushima \n N, \n \n et al. \n Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas. Gastroenterology. 2002;123(1):365\u2013372."},{"issue":"3","key":"i1543-2165-140-10-1068-b34","series-title":"Pancreatology","first-page":"343","article-title":"Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma","volume":"11","author":"Ryu \n JK,","year":"2011","unstructured":"Ryu \n JK, \n \n \n Matthaei \n H, \n \n \n Dal Molin \n M, \n \n et al. \n Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma. Pancreatology. 2011;11(3):343\u2013350."},{"issue":"12","key":"i1543-2165-140-10-1068-b35","series-title":"Am J Surg Pathol","first-page":"1812","article-title":"Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas","volume":"35","author":"Yamaguchi \n H,","year":"2011","unstructured":"Yamaguchi \n H, \n \n \n Kuboki \n Y, \n \n \n Hatori \n T, \n \n et al. \n Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. Am J Surg Pathol. 2011;35(12):1812\u20131817."},{"issue":"6","key":"i1543-2165-140-10-1068-b36","series-title":"Clin J Gastroenterol","first-page":"413","article-title":"Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation","volume":"5","author":"Urata \n T,","year":"2012","unstructured":"Urata \n T, \n \n \n Naito \n Y, \n \n \n Nagamine \n M, \n \n et al. \n Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation. Clin J Gastroenterol. 2012;5(6):413\u2013420."},{"issue":"2S","key":"i1543-2165-140-10-1068-b37","series-title":"Mod Pathol","first-page":"440A","article-title":"Molecular characteristics of the pancreatic intraductal tubulopapillary neoplasm","volume":"28","author":"Bhanot \n U,","year":"2015","unstructured":"Bhanot \n U, \n \n \n Basturk \n O, \n \n \n Berger \n M, \n \n et al. \n Molecular characteristics of the pancreatic intraductal tubulopapillary neoplasm. Mod Pathol. 2015;28(2S):440A."},{"issue":"5","key":"i1543-2165-140-10-1068-b38","series-title":"Virchows Arch","first-page":"447","article-title":"Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity?","volume":"444","author":"Esposito \n I,","year":"2004","unstructured":"Esposito \n I, \n \n \n Bauer \n A, \n \n \n Hoheisel \n JD, \n \n et al. \n Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity?\n Virchows Arch. 2004;444(5):447\u2013453."},{"issue":"52","key":"i1543-2165-140-10-1068-b39","series-title":"Proc Natl Acad Sci U S A","first-page":"21188","article-title":"Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways","volume":"108","author":"Wu \n J,","year":"2011","unstructured":"Wu \n J, \n \n \n Jiao \n Y, \n \n \n Dal Molin \n M, \n \n et al. \n Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. 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Am J Surg Pathol. 2001;25(5):579\u2013586."},{"issue":"3","key":"i1543-2165-140-10-1068-b03","series-title":"J Pathol","first-page":"335","article-title":"The discrete nature and distinguishing molecular features of pancreatic intraductal tubulopapillary neoplasms and intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant","volume":"231","author":"Yamaguchi \n H,","year":"2013","unstructured":"Yamaguchi \n H, \n \n \n Kuboki \n Y, \n \n \n Hatori \n T, \n \n et al. \n The discrete nature and distinguishing molecular features of pancreatic intraductal tubulopapillary neoplasms and intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant. J Pathol. 2013;231(3):335\u2013341."},{"issue":"8","key":"i1543-2165-140-10-1068-b04","series-title":"Int J Clin Exp Pathol","first-page":"9672","article-title":"Multifocal intraductal tubulopapillary neoplasm of the pancreas with total pancreatectomy: report of a case and review of literature","volume":"8","author":"Kolby \n D,","year":"2015","unstructured":"Kolby \n D, \n \n \n Thilen \n J, \n \n \n Andersson \n R, \n \n \n Sasor \n A, \n \n \n Ansari \n D. \n \n \n Multifocal intraductal tubulopapillary neoplasm of the pancreas with total pancreatectomy: report of a case and review of literature. 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Semin Diagn Pathol. 2014;31(6):452\u2013466."},{"issue":"2","key":"i1543-2165-140-10-1068-b07","series-title":"Diagn Cytopathol","first-page":"156","article-title":"Intraductal tubulopapillary neoplasm of the pancreas on fine needle aspiration: case report with differential diagnosis","volume":"42","author":"Guan \n H,","year":"2014","unstructured":"Guan \n H, \n \n \n Gurda \n G, \n \n \n Lennon \n AM, \n \n \n Hruban \n RH, \n \n \n Erozan \n YS. \n \n \n Intraductal tubulopapillary neoplasm of the pancreas on fine needle aspiration: case report with differential diagnosis. Diagn Cytopathol. 2014;42(2):156\u2013160."},{"issue":"4","key":"i1543-2165-140-10-1068-b08","series-title":"Diagn Cytopathol","first-page":"314","article-title":"Intraductal tubulopapillary neoplasm with expansile invasive carcinoma of the pancreas diagnosed by endoscopic ultrasonography-guided fine needle aspiration: a case report","volume":"42","author":"Furuhata \n A,","year":"2014","unstructured":"Furuhata \n A, \n \n \n Minamiguchi \n S, \n \n \n Mikami \n Y, \n \n et al. \n Intraductal tubulopapillary neoplasm with expansile invasive carcinoma of the pancreas diagnosed by endoscopic ultrasonography-guided fine needle aspiration: a case report. Diagn Cytopathol. 2014;42(4):314\u2013320."},{"issue":"2","key":"i1543-2165-140-10-1068-b09","series-title":"Fam Cancer","first-page":"227","article-title":"Is intraductal tubulopapillary neoplasia a new entity in the spectrum of familial pancreatic cancer syndrome?","volume":"13","author":"Del Chiaro \n M,","year":"2014","unstructured":"Del Chiaro \n M, \n \n \n Mucelli \n RP, \n \n \n Blomberg \n J, \n \n \n Segersvard \n R, \n \n \n Verbeke \n C. \n \n \n Is intraductal tubulopapillary neoplasia a new entity in the spectrum of familial pancreatic cancer syndrome?\n Fam Cancer. 2014;13(2):227\u2013229."},{"issue":"3","key":"i1543-2165-140-10-1068-b10","series-title":"J Nippon Med Sch","first-page":"224","article-title":"Intraductal tubulopapillary neoplasms of the pancreas: case report and review of the literature","volume":"80","author":"Kasugai \n H,","year":"2013","unstructured":"Kasugai \n H, \n \n \n Tajiri \n T, \n \n \n Takehara \n Y, \n \n \n Mukai \n S, \n \n \n Tanaka \n J, \n \n \n Kudo \n SE. \n \n \n Intraductal tubulopapillary neoplasms of the pancreas: case report and review of the literature. J Nippon Med Sch. 2013;80(3):224\u2013229."},{"issue":"11","key":"i1543-2165-140-10-1068-b11","series-title":"Anticancer Res","first-page":"4435","article-title":"Intraductal tubular carcinoma of the pancreas: case report with review of literature","volume":"30","author":"Hioki \n M,","year":"2010","unstructured":"Hioki \n M, \n \n \n Nakagohri \n T, \n \n \n Ikumoto \n T, \n \n et al. \n Intraductal tubular carcinoma of the pancreas: case report with review of literature. 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Pancreas. 2008;36(1):92\u201395."},{"issue":"8","key":"i1543-2165-140-10-1068-b13","series-title":"Am J Surg Pathol","first-page":"1164","article-title":"Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms","volume":"33","author":"Yamaguchi \n H,","year":"2009","unstructured":"Yamaguchi \n H, \n \n \n Shimizu \n M, \n \n \n Ban \n S, \n \n et al. \n Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2009;33(8):1164\u20131172."},{"key":"i1543-2165-140-10-1068-b14","series-title":"BMJ Case Rep","article-title":"Intraductal tubulopapillary neoplasm of the pancreas as a radiation induced malignancy","author":"Bhuva \n N,","year":"2011","unstructured":"Bhuva \n N, \n \n \n Wasan \n H, \n \n \n Spalding \n D, \n \n \n Stamp \n G, \n \n \n Harrison \n M. \n \n \n Intraductal tubulopapillary neoplasm of the pancreas as a radiation induced malignancy. BMJ Case Rep. 2011;2011:bcr0920114777."},{"issue":"6","key":"i1543-2165-140-10-1068-b15","series-title":"J Dig Dis","first-page":"357","article-title":"Intraductal tubulopapillary neoplasm of the pancreatic branch duct showing atypical images","volume":"16","author":"Yoshida \n Y,","year":"2015","unstructured":"Yoshida \n Y, \n \n \n Matsubayashi \n H, \n \n \n Sasaki \n K, \n \n \n Kanemoto \n H, \n \n \n Uesaka \n K, \n \n \n Ono \n H. \n \n \n Intraductal tubulopapillary neoplasm of the pancreatic branch duct showing atypical images. J Dig Dis. 2015;16(6):357\u2013361."},{"issue":"6","key":"i1543-2165-140-10-1068-b16","series-title":"J Comput Assist Tomogr","first-page":"710","article-title":"Imaging studies of intraductal tubulopapillary neoplasms of the pancreas: 2-tone duct sign and cork-of-wine-bottle sign as indicators of intraductal tumor growth","volume":"36","author":"Motosugi \n U,","year":"2012","unstructured":"Motosugi \n U, \n \n \n Yamaguchi \n H, \n \n \n Furukawa \n T, \n \n et al. \n Imaging studies of intraductal tubulopapillary neoplasms of the pancreas: 2-tone duct sign and cork-of-wine-bottle sign as indicators of intraductal tumor growth. J Comput Assist Tomogr. 2012;36(6):710\u2013717."},{"issue":"9","key":"i1543-2165-140-10-1068-b17","series-title":"Pathol Int","first-page":"501","article-title":"A case of intraductal tubulopapillary neoplasm of pancreas with severe calcification, a potential pitfall in diagnostic imaging","volume":"65","author":"Takayama \n S,","year":"2015","unstructured":"Takayama \n S, \n \n \n Maeda \n T, \n \n \n Nishihara \n M, \n \n et al. \n A case of intraductal tubulopapillary neoplasm of pancreas with severe calcification, a potential pitfall in diagnostic imaging. Pathol Int. 2015;65(9):501\u2013506."},{"issue":"4","key":"i1543-2165-140-10-1068-b18","series-title":"Clin Nucl Med","first-page":"e277","article-title":"18F-FDG uptake in intraductal tubulopapillary neoplasm of the pancreas","volume":"39","author":"Someya \n Y,","year":"2014","unstructured":"Someya \n Y, \n \n \n Nakamoto \n Y, \n \n \n Nakatani \n K, \n \n \n Kawaguchi \n M, \n \n \n Minamiguchi \n S, \n \n \n Togashi \n K. \n \n \n 18F-FDG uptake in intraductal tubulopapillary neoplasm of the pancreas. Clin Nucl Med. 2014;39(4):e277\u2013e280."},{"key":"i1543-2165-140-10-1068-b19","series-title":"Diagn Pathol","first-page":"11","article-title":"Case report: intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype","volume":"9","author":"Ahls \n MG,","year":"2014","unstructured":"Ahls \n MG, \n \n \n Niedergethmann \n M, \n \n \n Dinter \n D, \n \n et al. \n Case report: intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype. Diagn Pathol. 2014;9:11."},{"issue":"5","key":"i1543-2165-140-10-1068-b20","series-title":"Pathol Int","first-page":"339","article-title":"Intraductal tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia; a case report","volume":"62","author":"Jokoji \n R,","year":"2012","unstructured":"Jokoji \n R, \n \n \n Tsuji \n H, \n \n \n Tsujimoto \n M, \n \n \n Shinno \n N, \n \n \n Tori \n M. \n \n \n Intraductal tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia; a case report. Pathol Int. 2012;62(5):339\u2013343."},{"issue":"4","key":"i1543-2165-140-10-1068-b21","series-title":"Am J Gastroenterol","first-page":"798","article-title":"Variant of intraductal carcinoma (with scant mucin production) is of main pancreatic duct origin: a clinicopathological study of four patients","volume":"91","author":"Suda \n K,","year":"1996","unstructured":"Suda \n K, \n \n \n Hirai \n S, \n \n \n Matsumoto \n Y, \n \n et al. \n Variant of intraductal carcinoma (with scant mucin production) is of main pancreatic duct origin: a clinicopathological study of four patients. Am J Gastroenterol. 1996;91(4):798\u2013800."},{"issue":"7","key":"i1543-2165-140-10-1068-b22","series-title":"Am J Surg Pathol","first-page":"1025","article-title":"Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas","volume":"34","author":"Ban \n D,","year":"2010","unstructured":"Ban \n D, \n \n \n Shimada \n K, \n \n \n Sekine \n S, \n \n et al. \n Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas. Am J Surg Pathol. 2010;34(7):1025\u20131036."},{"issue":"12","key":"i1543-2165-140-10-1068-b23","series-title":"Pathol Res Pract","first-page":"1034","article-title":"A case of MUC5AC-positive intraductal neoplasm of the pancreas classified as an intraductal tubulopapillary neoplasm?","volume":"211","author":"Muraki \n T,","year":"2015","unstructured":"Muraki \n T, \n \n \n Uehara \n T, \n \n \n Sano \n K, \n \n et al. \n A case of MUC5AC-positive intraductal neoplasm of the pancreas classified as an intraductal tubulopapillary neoplasm?\n Pathol Res Pract. 2015;211(12):1034\u20131039."},{"issue":"3","key":"i1543-2165-140-10-1068-b24","series-title":"Pathol Int","first-page":"176","article-title":"BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens","volume":"63","author":"Hosoda \n W,","year":"2013","unstructured":"Hosoda \n W, \n \n \n Sasaki \n E, \n \n \n Murakami \n Y, \n \n \n Yamao \n K, \n \n \n Shimizu \n Y, \n \n \n Yatabe \n Y. \n \n \n BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens. Pathol Int. 2013;63(3):176\u2013182."},{"issue":"2","key":"i1543-2165-140-10-1068-b25","series-title":"Virchows Arch","first-page":"133","article-title":"The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia","volume":"454","author":"La Rosa \n S,","year":"2009","unstructured":"La Rosa \n S, \n \n \n Franzi \n F, \n \n \n Marchet \n S, \n \n et al. \n The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia. Virchows Arch. 2009;454(2):133\u2013142."},{"issue":"7","key":"i1543-2165-140-10-1068-b26","series-title":"Pathology","first-page":"662","article-title":"Cytological features of pancreatic intraductal tubulopapillary neoplasm and an unexpected immunohistochemical profile","volume":"46","author":"Zhao \n L,","year":"2014","unstructured":"Zhao \n L, \n \n \n Hart \n J, \n \n \n Xiao \n SY, \n \n \n Antic \n T. \n \n \n Cytological features of pancreatic intraductal tubulopapillary neoplasm and an unexpected immunohistochemical profile. Pathology. 2014;46(7):662\u2013665."},{"issue":"6","key":"i1543-2165-140-10-1068-b27","series-title":"Gastroenterology","first-page":"1501","article-title":"A combination of molecular markers and clinical features improve the classification of pancreatic cysts","volume":"149","author":"Springer \n S,","year":"2015","unstructured":"Springer \n S, \n \n \n Wang \n Y, \n \n \n Dal Molin \n M, \n \n et al. \n A combination of molecular markers and clinical features improve the classification of pancreatic cysts. Gastroenterology. 2015;149(6):1501\u20131510."},{"issue":"2","key":"i1543-2165-140-10-1068-b28","series-title":"Am J Clin Pathol","first-page":"168","article-title":"Molecular genetics of pancreatic neoplasms and their morphologic correlates: an update on recent advances and potential diagnostic applications","volume":"141","author":"Reid \n MD,","year":"2014","unstructured":"Reid \n MD, \n \n \n Saka \n B, \n \n \n Balci \n S, \n \n \n Goldblum \n AS, \n \n \n Adsay \n NV. \n \n \n Molecular genetics of pancreatic neoplasms and their morphologic correlates: an update on recent advances and potential diagnostic applications. Am J Clin Pathol. 2014;141(2):168\u2013180."},{"issue":"3","key":"i1543-2165-140-10-1068-b29","series-title":"J Pathol","first-page":"217","article-title":"Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas","volume":"233","author":"Amato \n E,","year":"2014","unstructured":"Amato \n E, \n \n \n Molin \n MD, \n \n \n Mafficini \n A, \n \n et al. \n Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas. J Pathol. 2014;233(3):217\u2013227."},{"issue":"24","key":"i1543-2165-140-10-1068-b30","series-title":"Clin Cancer Res","first-page":"6830","article-title":"Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas","volume":"19","author":"Garcia-Carracedo \n D,","year":"2013","unstructured":"Garcia-Carracedo \n D, \n \n \n Turk \n AT, \n \n \n Fine \n SA, \n \n et al. \n Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas. Clin Cancer Res. 2013;19(24):6830\u20136841."},{"issue":"3","key":"i1543-2165-140-10-1068-b31","series-title":"Am J Pathol","first-page":"755","article-title":"Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas","volume":"157","author":"Iacobuzio-Donahue \n CA,","year":"2000","unstructured":"Iacobuzio-Donahue \n CA, \n \n \n Klimstra \n DS, \n \n \n Adsay \n NV, \n \n et al. \n Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. Am J Pathol. 2000;157(3):755\u2013761."},{"issue":"6","key":"i1543-2165-140-10-1068-b32","series-title":"Clin Gastroenterol Hepatol","first-page":"719","article-title":"Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia","volume":"11","author":"Kanda \n M,","year":"2013","unstructured":"Kanda \n M, \n \n \n Sadakari \n Y, \n \n \n Borges \n M, \n \n et al. \n Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia. Clin Gastroenterol Hepatol. 2013;11(6):719\u2013730.e715."},{"issue":"1","key":"i1543-2165-140-10-1068-b33","series-title":"Gastroenterology","first-page":"365","article-title":"Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas","volume":"123","author":"Sato \n N,","year":"2002","unstructured":"Sato \n N, \n \n \n Ueki \n T, \n \n \n Fukushima \n N, \n \n et al. \n Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas. Gastroenterology. 2002;123(1):365\u2013372."},{"issue":"3","key":"i1543-2165-140-10-1068-b34","series-title":"Pancreatology","first-page":"343","article-title":"Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma","volume":"11","author":"Ryu \n JK,","year":"2011","unstructured":"Ryu \n JK, \n \n \n Matthaei \n H, \n \n \n Dal Molin \n M, \n \n et al. \n Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma. Pancreatology. 2011;11(3):343\u2013350."},{"issue":"12","key":"i1543-2165-140-10-1068-b35","series-title":"Am J Surg Pathol","first-page":"1812","article-title":"Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas","volume":"35","author":"Yamaguchi \n H,","year":"2011","unstructured":"Yamaguchi \n H, \n \n \n Kuboki \n Y, \n \n \n Hatori \n T, \n \n et al. \n Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. Am J Surg Pathol. 2011;35(12):1812\u20131817."},{"issue":"6","key":"i1543-2165-140-10-1068-b36","series-title":"Clin J Gastroenterol","first-page":"413","article-title":"Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation","volume":"5","author":"Urata \n T,","year":"2012","unstructured":"Urata \n T, \n \n \n Naito \n Y, \n \n \n Nagamine \n M, \n \n et al. \n Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation. 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