{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:42:01Z","timestamp":1764790921469,"version":"3.46.0"},"reference-count":23,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context.\u2014<\/jats:title>\n                    <jats:p>Persistent infection with high-risk human papillomavirus (hrHPV) is the major cause of cervical cancer. The effect of HPV infection patterns on cytologic detection of cervical lesions is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective.\u2014<\/jats:title>\n                    <jats:p>To determine the effect of HPV infection patterns on the sensitivity of cytologic detection of high-grade cervical lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design.\u2014<\/jats:title>\n                    <jats:p>Papanicolaou tests from 257 women with biopsy-confirmed, high-grade squamous intraepithelial lesions were analyzed with respect to HPV infection patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.\u2014<\/jats:title>\n                    <jats:p>Among 257 biopsy-confirmed, high-grade squamous intraepithelial lesion cases, the preceding cytology showed 20 cases (8%) were benign; 166 cases (65%) were low-grade cervical lesions, including atypical squamous cell of undetermined significance and low-grade squamous intraepithelial lesions; and 71 cases (28%) were high-grade cervical lesions, including atypical squamous cells cannot rule out high-grade squamous intraepithelial lesion (atypical squamous cell\u2013high), atypical glandular cells, and high-grade squamous intraepithelial lesions. In 236 cases tested for HPV, those exhibiting low-grade cervical lesions on cytology were often associated with coinfections of mixed hrHPV genotypes (31 of 40; 78%) or non-16\/18 hrHPV (75\/103; 73%), compared with single-genotype infections of HPV-16 (33 of 62; 53%) or HPV-18 (2 of 6; 33%) (P = .001). In contrast, high-grade cervical lesion cytomorphology tended to associate with the single-genotype infection of HPV-16 (20 of 62; 32%) or HPV-18 (3 of 6; 50%), compared with non-16\/18 hrHPV (25 of 103; 24%) or multigenotype infection (8 of 40; 20%) (P = .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.\u2014<\/jats:title>\n                    <jats:p>Our findings suggest that multigenotypic or non-16\/18 hrHPV infections often produce deceptive lower-grade cytomorphology, which could result in underdiagnosis and delay of treatment. The HPV infection patterns may offer unrecognized benefit beyond HPV genotyping and should be considered during clinical risk evaluation of women with lower-grade cytology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5858\/arpa.2016-0478-oa","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T11:56:02Z","timestamp":1511265362000},"page":"347-352","source":"Crossref","is-referenced-by-count":11,"title":["Do Infection Patterns of Human Papillomavirus Affect the Cytologic Detection of High-Grade Cervical Lesions on Papanicolaou Tests?"],"prefix":"10.5858","volume":"142","author":[{"given":"Siavash Azadmanesh","family":"Samimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxanne R.","family":"Mody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Luna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Armylagos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary R.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina R.","family":"Mody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Ge","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas (Drs Azadmanesh Samimi, D. Mody, Goodman, Schwartz, and Ge; Mr Luna; and Ms Armylagos); the School of Medicine, University of Texas Health Science Center, Houston (Dr R. Mody); the BioReference Laboratories, Houston (Mr Luna and Ms Armylagos); and the Department of Pathology and Genomic Medicine, Wei"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"2020081220050916500_i1543-2165-142-3-347-b01","unstructured":"Gerberding, \n              JL.\n            \n          \n          Department of Health and Human Resources, eds. Centers for Disease Control(CDC): Prevention of Genital Human Papillomavirus Infection. http:\/\/www.cdc.gov\/std\/hpv\/2004hpv-report.pdf. Published January 2004. Accessed June 2016."},{"issue":"1","key":"2020081220050916500_i1543-2165-142-3-347-b02","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.bjc.6600688","article-title":"Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis","volume":"88","author":"Clifford","year":"2003","journal-title":"Br J Cancer"},{"issue":"20","key":"2020081220050916500_i1543-2165-142-3-347-b03","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1056\/NEJMp058171","article-title":"The promise of global cervical-cancer prevention","volume":"353","author":"Schiffman","year":"2005","journal-title":"N Engl J Med"},{"issue":"6","key":"2020081220050916500_i1543-2165-142-3-347-b04","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/jnci\/92.6.464","article-title":"Population-based study of human papillomavirus infection and cervical neoplasia in rural Costa Rica","volume":"92","author":"Herrero","year":"2000","journal-title":"J Natl Cancer Inst"},{"issue":"14","key":"2020081220050916500_i1543-2165-142-3-347-b05","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/jnci\/dji187","article-title":"The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice","volume":"97","author":"Khan","year":"2005","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"2020081220050916500_i1543-2165-142-3-347-b06","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1309\/AJCPTGD94EVRSJCG","article-title":"American Cancer Society; American Society for Colposcopy and Cervical Pathology; American Society for Clinical Pathology. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer","volume":"137","author":"Saslow","year":"2012","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"2020081220050916500_i1543-2165-142-3-347-b07","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0002-9378(74)90013-1","article-title":"Estimation of the screening error rate from the observed detection rates in repeated cervical cytology","volume":"119","author":"Coppleson","year":"1974","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"2020081220050916500_i1543-2165-142-3-347-b08","doi-asserted-by":"crossref","first-page":"880","DOI":"10.7326\/0003-4819-156-12-201206190-00424","article-title":"US Preventive Services Task Force. Screening for cervical cancer: U.S. Preventive Services Task Force recommendation statement","volume":"156","author":"Moyer","year":"2013","journal-title":"Ann Intern Med"},{"issue":"5","key":"2020081220050916500_i1543-2165-142-3-347-b09","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/cncy.21687","article-title":"Clinical performance of the Food and Drug Administration\u2013Approved high-risk HPV test for the detection of high-grade cervicovaginal lesions","volume":"124","author":"Zhou","year":"2016","journal-title":"Cancer Cytopathol"},{"author":"American Society for Colposcopy and Cervical Pathology","key":"2020081220050916500_i1543-2165-142-3-347-b10","article-title":"Algorithms: Updated Consensus Guidelines for Managing Abnormal Cervical Cancer Screening Tests and Cancer Precursors"},{"issue":"5","key":"2020081220050916500_i1543-2165-142-3-347-b11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1159\/000442512","article-title":"Multiple human papilloma virus infections and their impact on the development of high-risk cervical lesions","volume":"59","author":"Salazar","year":"2015","journal-title":"Acta Cytol"},{"issue":"4","key":"2020081220050916500_i1543-2165-142-3-347-b12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1001\/jama.1991.03460040048027","article-title":"Genital human papillomavirus infection in female university students as determined by a PCR-based method","volume":"265","author":"Bauer","year":"1991","journal-title":"JAMA"},{"issue":"8","key":"2020081220050916500_i1543-2165-142-3-347-b13","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1002\/ijc.28514","article-title":"Interlaboratory variation in the performance of liquid-based cytology: insights from the ATHENA trial","volume":"134","author":"Wright","year":"2014","journal-title":"Int J Cancer"},{"issue":"7","key":"2020081220050916500_i1543-2165-142-3-347-b14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/cncy.21549","article-title":"Non-16\/18 high-risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL","volume":"123","author":"Lyons","year":"2015","journal-title":"Cancer Cytopathol"},{"issue":"1","key":"2020081220050916500_i1543-2165-142-3-347-b15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jasc.2013.06.001","article-title":"Genotype-specific prevalence and distribution of human papillomavirus genotypes in underserved Latino women with abnormal Papanicolaou tests","volume":"3","author":"Zhou","year":"2014","journal-title":"J Am Soc Cytopathol"},{"issue":"7","key":"2020081220050916500_i1543-2165-142-3-347-b16","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/infdis\/jiq139","article-title":"CVT Group. 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A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion","volume":"195","author":"Plummer","year":"2007","journal-title":"J Infect Dis"},{"issue":"pt 11","key":"2020081220050916500_i1543-2165-142-3-347-b19","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1099\/0022-1317-80-11-2931","article-title":"Serological evidence for protection by human papillomavirus (HPV) type 6 infection against HPV type 16 cervical carcinogenesis","volume":"80","author":"Silins","year":"1999","journal-title":"J Gen Virol"},{"key":"2020081220050916500_i1543-2165-142-3-347-b20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1750-9378-9-26","article-title":"Co-infection with HPV types from the same species provides natural cross-protection from progression to cervical cancer","volume":"9","author":"Sobota","year":"2014","journal-title":"Infect Agent Cancer"},{"issue":"6","key":"2020081220050916500_i1543-2165-142-3-347-b21","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<818::AID-IJC4>3.0.CO;2-T","article-title":"No excess risk of cervical carcinoma among women seropositive for both HPV16 and HPV6\/11","volume":"80","author":"Luostarinen","year":"1999","journal-title":"Int J Cancer"},{"issue":"11","key":"2020081220050916500_i1543-2165-142-3-347-b22","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1128\/JCM.05552-11","article-title":"Clinical validation of the Cobas 4800 HPV test for cervical screening purposes","volume":"49","author":"Heideman","year":"2011","journal-title":"J Clin Microbiol"},{"issue":"7","key":"2020081220050916500_i1543-2165-142-3-347-b23","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1128\/JCM.00337-12","article-title":"Comparison of the Abbott RealTime high-risk human papillomavirus (HPV), Roche Cobas HPV, and Hybrid Capture 2 assays to direct sequencing and genotyping of HPV DNA","volume":"50","author":"Park","year":"2012","journal-title":"J Clin Microbiol"}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/142\/3\/347\/1448261\/arpa_2016-0478-oa.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/142\/3\/347\/1448261\/arpa_2016-0478-oa.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:34:40Z","timestamp":1764790480000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/142\/3\/article-p347.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,21]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,11,21]]},"published-print":{"date-parts":[[2018,3,1]]}},"URL":"https:\/\/doi.org\/10.5858\/arpa.2016-0478-oa","relation":{},"ISSN":["0003-9985","1543-2165"],"issn-type":[{"type":"print","value":"0003-9985"},{"type":"electronic","value":"1543-2165"}],"subject":[],"published":{"date-parts":[[2017,11,21]]}}}