{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:24:43Z","timestamp":1780547083566,"version":"3.54.1"},"reference-count":34,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context.\u2014<\/jats:title>\n                    <jats:p>Serous carcinoma of the gynecologic tract often involves the external bladder wall and can occasionally mimic primary urothelial carcinoma of the bladder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective.\u2014<\/jats:title>\n                    <jats:p>To define the spectrum of morphologic and immunohistochemical features that characterize serous carcinoma involving the bladder wall and its distinction from urothelial carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design.\u2014<\/jats:title>\n                    <jats:p>We reviewed all cases of serous carcinoma secondarily involving the bladder wall from the University of California San Diego and Polytechnic Institute for histopathologic and immunohistochemical features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.\u2014<\/jats:title>\n                    <jats:p>We identified 20 cases of M\u00fcllerian high-grade serous carcinoma involving the bladder wall. Five cases were clinical mimics of urothelial carcinoma, including 2 cases that presented as a large, transmural, primary bladder mass without precedent gynecologic history in women younger than 60 years, and 3 cases presumed to be new bladder carcinoma occurring distant to a serous carcinoma diagnosis. A subset of cases were morphologic mimics of urothelial carcinoma, which showed nested growth patterns (2 of 20; 10%), squamouslike foci (2 of 20; 10%), spindled\/sarcomatoid growth (2 of 20; 10%), basaloid morphology (3 of 20; 15%), and syncytial growth patterns (1 of 20; 5%). Immunohistochemical stains in 17 cases showed immunoreactivity for CK7 (17 of 17; 100%), WT1 (17 of 17; 100%), uroplakin (UP) II (1 of 17; 6%), p63 (2 of 17; 12%), GATA3 (2 of 17; 12%), and PAX8 (17 of 17; 100%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.\u2014<\/jats:title>\n                    <jats:p>A subset of serous carcinomas involving the bladder wall can mimic urothelial carcinoma. Awareness of this mimicker and use of an immunohistochemical panel that includes CK7, WT1, UPII, PAX8, p63, and GATA3 can be helpful in confirming the diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5858\/arpa.2017-0004-oa","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T09:40:16Z","timestamp":1502358016000},"page":"168-177","source":"Crossref","is-referenced-by-count":4,"title":["Serous Carcinoma Mimicking Primary Urothelial Carcinoma on Clinical Evaluation and Pathology: A Potential Diagnostic Pitfall"],"prefix":"10.5858","volume":"142","author":[{"given":"Leili","family":"Mirsadraei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Hodkoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karra","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Shabaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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High-grade serous carcinoma involving fallopian tube, ovary and peritoneum","volume":"4","author":"Al-Agha","year":"2011","journal-title":"Surg Pathol Clin"},{"key":"2020081219495369100_i1543-2165-142-2-168-b03","doi-asserted-by":"crossref","DOI":"10.1102\/1470-7330.2007.9015","article-title":"PET\/CT and cross sectional imaging of gynecologic malignancy","author":"Iyer","year":"2007","journal-title":"Cancer Imaging"},{"issue":"3","key":"2020081219495369100_i1543-2165-142-2-168-b04","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2217\/WHE.14.19","article-title":"Role of imaging in the pretreatment evaluation of common gynecological cancers","volume":"10","author":"Micc\u00f2","year":"2014","journal-title":"Womens Health (Lond)"},{"issue":"2","key":"2020081219495369100_i1543-2165-142-2-168-b05","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11604-015-0513-3","article-title":"Revised FIGO staging system for cancer of the ovary, fallopian tube, and peritoneum: important implications for radiologists","volume":"34","author":"Saida","year":"2016","journal-title":"Jpn J Radiol"},{"issue":"3","key":"2020081219495369100_i1543-2165-142-2-168-b06","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/(SICI)1097-0339(199903)20:3<156::AID-DC8>3.0.CO;2-6","article-title":"Cytologic diagnosis of metastatic ovarian adenocarcinoma in the urinary bladder: a case report and review of the literature","volume":"20","author":"Edgerton","year":"1999","journal-title":"Diagn Cytopathol"},{"issue":"3","key":"2020081219495369100_i1543-2165-142-2-168-b07","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00004347-198809000-00001","article-title":"Urothelial and ovarian carcinomas of identical cell types: problems in interpretation: a report of three cases and review of the literature","volume":"7","author":"Young","year":"1988","journal-title":"Int J Gynecol Pathol"},{"issue":"6","key":"2020081219495369100_i1543-2165-142-2-168-b08","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.pathol.2016.05.008","article-title":"A combination of p40, GATA-3 and uroplakin II shows utility in the diagnosis and prognosis of muscle-invasive urothelial carcinoma","volume":"48","author":"Leivo","year":"2016","journal-title":"Pathology"},{"issue":"7","key":"2020081219495369100_i1543-2165-142-2-168-b09","doi-asserted-by":"crossref","first-page":"943","DOI":"10.5858\/arpa.2013-0221-OA","article-title":"A newly developed uroplakin II antibody with increased sensitivity in urothelial carcinoma of the bladder","volume":"138","author":"Hoang","year":"2014","journal-title":"Arch Pathol Lab Med"},{"issue":"10","key":"2020081219495369100_i1543-2165-142-2-168-b10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/PAI.0000000000000143","article-title":"(UPII), GATA3, and p40 are highly sensitive markers for the differential diagnosis of invasive urothelial carcinoma","volume":"23","author":"Hoang","year":"2015","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"2020081219495369100_i1543-2165-142-2-168-b11","unstructured":"Kurman \n              RJ.\n            \n            \n              Carcangiu \n              ML.\n            \n            \n              Herrington \n              CS.\n            \n            \n              Young \n              RH.\n            \n          \n          eds. WHO Classification of Tumours of Female Reproductive Organs. 4th ed. Lyon, France: IARC Press;2014. World Health Organization Classification of Tumours; vol 6."},{"issue":"suppl 10","key":"2020081219495369100_i1543-2165-142-2-168-b12","doi-asserted-by":"crossref","first-page":"x16","DOI":"10.1093\/annonc\/mdt463","article-title":"Origin and molecular pathogenesis of ovarian high-grade serous carcinoma","volume":"24","author":"Kurman","year":"2013","journal-title":"Ann Oncol"},{"issue":"5","key":"2020081219495369100_i1543-2165-142-2-168-b13","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0090-4295(85)90468-6","article-title":"Unusual behavior of low-grade, low-stage transitional cell carcinoma of bladder","volume":"25","author":"Andriole","year":"1985","journal-title":"Urology"},{"issue":"1","key":"2020081219495369100_i1543-2165-142-2-168-b14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/003655998750014774","article-title":"Metastatic transitional cell carcinoma of the ovary from superficial bladder tumour","volume":"32","author":"Kardar","year":"1998","journal-title":"Scand J Urol Nephrol"},{"issue":"1","key":"2020081219495369100_i1543-2165-142-2-168-b15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3802\/jgo.2010.21.1.59","article-title":"Metastasis to the ovaries from transitional cell carcinoma of the bladder and renal pelvis: a report of two cases","volume":"21","author":"Lee","year":"2010","journal-title":"J Gynecol Oncol"},{"issue":"1","key":"2020081219495369100_i1543-2165-142-2-168-b16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/GRF.0000000000000082","article-title":"Pathology of the adnexal mass","volume":"58","author":"Bennett","year":"2015","journal-title":"Clin Obstet Gynecol"},{"issue":"5","key":"2020081219495369100_i1543-2165-142-2-168-b17","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0002-9440(10)63708-X","article-title":"Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis","volume":"164","author":"Shih Ie","year":"2004","journal-title":"Am J Pathol"},{"issue":"3","key":"2020081219495369100_i1543-2165-142-2-168-b18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1028-4559(10)60079-4","article-title":"Transitional cell carcinomas in the bladder and ovary: unusual primary association or metastatic lesions?","volume":"49","author":"Kadiri","year":"2010","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"2","key":"2020081219495369100_i1543-2165-142-2-168-b19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/PAI.0b013e31818637c5","article-title":"Problems arising in the diagnosis of primary ovarian transitional cell carcinoma after the occurrence of a transitional cell carcinoma of the bladder: a report of a difficult case and a critical review of literature","volume":"17","author":"Raspollini","year":"2009","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"2","key":"2020081219495369100_i1543-2165-142-2-168-b20","first-page":"161","article-title":"Histologic subtypes of ovarian carcinoma: an overview","volume":"27","author":"Soslow","year":"2008","journal-title":"Int J Gynecol Pathol"},{"issue":"12","key":"2020081219495369100_i1543-2165-142-2-168-b21","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1097\/00000478-199412000-00005","article-title":"Micropapillary variant of transitional cell carcinoma of the urinary bladder. Histologic pattern resembling ovarian papillary serous carcinoma","volume":"18","author":"Amin","year":"1994","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"2020081219495369100_i1543-2165-142-2-168-b22","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.humpath.2014.02.024","article-title":"Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder","volume":"45","author":"Paner","year":"2014","journal-title":"Hum Pathol"},{"issue":"7","key":"2020081219495369100_i1543-2165-142-2-168-b23","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/PAS.0b013e3181962dcd","article-title":"Immunohistochemical panel to identify the primary site of invasive micropapillary carcinoma","volume":"33","author":"Lotan","year":"2009","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"2020081219495369100_i1543-2165-142-2-168-b24","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/PGP.0b013e3181a071b5","article-title":"Morphologic changes in ovarian carcinoma after neoadjuvant chemotherapy: report of a case showing extensive clear cell changes mimicking clear cell carcinoma","volume":"28","author":"Chew","year":"2009","journal-title":"Int J Gynecol Pathol"},{"issue":"5","key":"2020081219495369100_i1543-2165-142-2-168-b25","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1136\/jcp.2007.053793","article-title":"An immunohistochemical and morphological analysis of post-chemotherapy ovarian carcinoma","volume":"61","author":"Miller","year":"2008","journal-title":"J Clin Pathol"},{"issue":"10","key":"2020081219495369100_i1543-2165-142-2-168-b26","first-page":"2121","article-title":"Cytologic changes of ovarian epithelial cancer induced by neoadjuvant chemotherapy","volume":"6","author":"Wang","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"issue":"6","key":"2020081219495369100_i1543-2165-142-2-168-b27","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/PAS.0b013e318216c112","article-title":"A comprehensive analysis of PAX8 expression in human epithelial tumors","volume":"35","author":"Laury","year":"2011","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"2020081219495369100_i1543-2165-142-2-168-b28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/PAI.0b013e3182025f66","article-title":"Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study","volume":"19","author":"Tacha","year":"2011","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"8","key":"2020081219495369100_i1543-2165-142-2-168-b29","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1097\/PAS.0b013e31802f5d33","article-title":"Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma","volume":"31","author":"Chuang","year":"2007","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"2020081219495369100_i1543-2165-142-2-168-b30","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1111\/jog.12447","article-title":"Expression of glucose transporter protein 1 and p63 in serous ovarian tumor","volume":"40","author":"Cai","year":"2014","journal-title":"J Obstet Gynaecol Res"},{"issue":"1","key":"2020081219495369100_i1543-2165-142-2-168-b31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1525-1438.2006.00290.x","article-title":"p63 expression in epithelial ovarian tumors","volume":"16","author":"Poli Neto OB, Candido Dos Reis FJ, Zambelli Ramalho LN, Nogueira AA, de Andrade JM","year":"2006","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"2020081219495369100_i1543-2165-142-2-168-b32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1309\/AJCP8H2VBDSCIOBF","article-title":"Semiquantitative GATA-3 immunoreactivity in breast, bladder, gynecologic tract, and other cytokeratin 7-positive carcinomas","volume":"142","author":"Clark","year":"2014","journal-title":"Am J Clin Pathol"},{"issue":"7","key":"2020081219495369100_i1543-2165-142-2-168-b33","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.humpath.2014.02.023","article-title":"Differential expression of GATA-3 in urothelial carcinoma variants","volume":"45","author":"Liang","year":"2014","journal-title":"Hum Pathol"},{"issue":"3","key":"2020081219495369100_i1543-2165-142-2-168-b34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/PGP.0000000000000155","article-title":"Simultaneous carcinomas of the breast and ovary: utility of Pax-8, WT-1, and GATA3 for distinguishing independent primary tumors from metastases","volume":"34","author":"Espinosa","year":"2015","journal-title":"Int J Gynecol Pathol"}],"container-title":["Archives of Pathology &amp; 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