{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:42:10Z","timestamp":1764790930896,"version":"3.46.0"},"reference-count":27,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context.\u2014<\/jats:title>\n                    <jats:p>Patients with anti\u2013aminoacyl-tRNA synthetase syndrome (ARS), a subset of idiopathic inflammatory myopathy, have a high prevalence of lung involvement. Autoantibodies directed against alanyl-tRNA synthetase (anti\u2013PL-12 Abs) represent 1 of the 8 autoantibodies currently described under the rubric of ARS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective.\u2014<\/jats:title>\n                    <jats:p>To describe the clinical, radiographic, and pulmonary histopathologic findings in patients possessing anti\u2013PL-12 autoantibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design.\u2014<\/jats:title>\n                    <jats:p>Patients with anti\u2013PL-12 ARS were identified in the University of Pittsburgh Idiopathic Inflammatory Myopathy registry. Lung biopsies from 10 patients and lung explants from 2 patients with anti\u2013PL-12 ARS were reviewed, together with chest computed tomography and clinical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.\u2014<\/jats:title>\n                    <jats:p>Patients primarily presented with dyspnea and variable combinations of cough, fever, mechanic's hands, Raynaud phenomenon, and skin and muscle involvement. Chest computed tomography most commonly showed lower lung zone-predominant reticular infiltrates and traction bronchiectasis, with or without honeycomb change. Surgical lung biopsies and pneumonectomies for lung transplantation revealed usual interstitial pneumonia in 8 of 12 cases (67%), nonspecific interstitial pneumonia in 2 of 12 cases (17%), and organizing pneumonia in 2 of 12 cases (17%). Lymphoplasmacytic interstitial inflammation with lymphoid aggregates was common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.\u2014<\/jats:title>\n                    <jats:p>Lung disease is often the first manifestation of anti\u2013PL-12 ARS. There are no pathognomonic histopathologic features to distinguish anti\u2013PL-12 ARS-related lung disease from idiopathic variants of diffuse interstitial lung disease. Increased inflammation, lymphoid aggregates, and nonspecific interstitial pneumonia\u2013like areas in a biopsy, as well as clinical features of mechanic's hands, Raynaud phenomenon, arthritis, and fever, should prompt pathologists to suggest involvement by ARS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5858\/arpa.2017-0010-oa","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T09:58:54Z","timestamp":1506938334000},"page":"191-197","source":"Crossref","is-referenced-by-count":9,"title":["Pulmonary Pathologic Manifestations of Anti-Alanyl-tRNA Synthetase (Anti\u2013PL-12)\u2013Related Inflammatory Myopathy"],"prefix":"10.5858","volume":"142","author":[{"given":"Frank","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel A.","family":"Yousem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chester V.","family":"Oddis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","published-online":{"date-parts":[[2017,10,2]]},"reference":[{"issue":"6","key":"2020081219484963200_i1543-2165-142-2-191-b01","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/BOR.0b013e3282f01a8c","article-title":"Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significance","volume":"19","author":"Mimori","year":"2007","journal-title":"Curr Opin Rheumatol"},{"issue":"5","key":"2020081219484963200_i1543-2165-142-2-191-b02","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1440-1843.2007.01140.x","article-title":"Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis","volume":"12","author":"Takahashi","year":"2007","journal-title":"Respirology"},{"issue":"1","key":"2020081219484963200_i1543-2165-142-2-191-b03","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0049-0172(96)80026-6","article-title":"Interstitial lung disease with autoantibodies against aminoacyl-tRNA synthetases in the absence of clinically apparent myositis","volume":"26","author":"Friedman","year":"1996","journal-title":"Semin Arthritis Rheum"},{"issue":"3","key":"2020081219484963200_i1543-2165-142-2-191-b04","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0002-9343(90)90149-8","article-title":"Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase)","volume":"88","author":"Targoff","year":"1990","journal-title":"Am J Med"},{"issue":"6","key":"2020081219484963200_i1543-2165-142-2-191-b05","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1378\/chest.08-2233","article-title":"Clinical profile of anti-PL-12 autoantibody. 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