{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:23:28Z","timestamp":1788326608908,"version":"build-2803163510"},"reference-count":25,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context.\u2014<\/jats:title>\n                    <jats:p>Nonuterine high-grade serous carcinomas (HGSCs) are believed to arise most often from precursors in the fallopian tube referred to as serous tubal intraepithelial carcinomas (STICs). A designation of tubal origin has been suggested for all cases of nonuterine HGSC if a STIC is identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective.\u2014<\/jats:title>\n                    <jats:p>To highlight that many different types of nongynecologic and gynecologic carcinomas, including HGSC, can metastasize to the tubal mucosa and mimic de novo STIC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources.\u2014<\/jats:title>\n                    <jats:p>A mini-review of several recently published studies that collectively examine STIC-like lesions of the fallopian tube.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.\u2014<\/jats:title>\n                    <jats:p>The fallopian tube mucosa can be a site of metastasis from carcinomas arising elsewhere, and pathologists should exercise caution in diagnosing STIC without first considering the possibility of metastasis. Routinely used immunohistochemical stains can often be used to determine if a STIC-like lesion is tubal or nongynecologic in origin. In the context of uterine and nonuterine HGSC, STIC may represent a metastasis rather than the site of origin, particularly when widespread disease is present.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5858\/arpa.2017-0231-ra","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T12:11:34Z","timestamp":1506946294000},"page":"1313-1315","source":"Crossref","is-referenced-by-count":25,"title":["Serous Tubal Intraepithelial Carcinoma or Not? Metastases to Fallopian Tube Mucosa Can Masquerade as In Situ Lesions"],"prefix":"10.5858","volume":"141","author":[{"given":"Reena","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","published-online":{"date-parts":[[2017,10,1]]},"reference":[{"issue":"5","key":"2020081222344811700_i1543-2165-141-10-1313-b01","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"issue":"4","key":"2020081222344811700_i1543-2165-141-10-1313-b02","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer","volume":"195","author":"Piek","year":"2001","journal-title":"J Pathol"},{"issue":"2","key":"2020081222344811700_i1543-2165-141-10-1313-b03","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/gyno.2000.6071","article-title":"Occult cancer of the fallopian tube in BRCA-1 germline mutation carriers at prophylactic oophorectomy: a case for recommending hysterectomy at surgical prophylaxis","volume":"80","author":"Paley","year":"2001","journal-title":"Gynecol Oncol"},{"issue":"2","key":"2020081222344811700_i1543-2165-141-10-1313-b04","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","article-title":"The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome","volume":"30","author":"Medeiros","year":"2006","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"2020081222344811700_i1543-2165-141-10-1313-b05","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/PAS.0000000000000353","article-title":"Incidental nonuterine high-grade serous carcinomas arise in the fallopian tube in most cases: further evidence for the tubal origin of high-grade serous carcinomas","volume":"39","author":"Gilks","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"2020081222344811700_i1543-2165-141-10-1313-b06","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/PAS.0000000000000352","article-title":"Incidental serous tubal intraepithelial carcinoma and early invasive serous carcinoma in the nonprophylactic setting: analysis of a case series","volume":"39","author":"Morrison","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"2020081222344811700_i1543-2165-141-10-1313-b07","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/PAS.0000000000000199","article-title":"Early detection of high-grade tubal serous carcinoma in women at low risk for hereditary breast and ovarian cancer syndrome by systematic examination of fallopian tubes incidentally removed during benign surgery","volume":"38","author":"Rabban","year":"2014","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"2020081222344811700_i1543-2165-141-10-1313-b08","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ygyno.2015.10.022","article-title":"Primary site assignment in tubo-ovarian high-grade serous carcinoma: Consensus statement on unifying practice worldwide","volume":"141","author":"Singh","year":"2016","journal-title":"Gynecol Oncol"},{"key":"2020081222344811700_i1543-2165-141-10-1313-b09","unstructured":"Kurman \n              RJ, \n            \n            \n              Carcanglu \n              ML, \n            \n            \n              Herrington \n              CS, \n            \n            \n              Young \n              RH, \n            \n          \n          International Agency for Research on Cancer. WHO Classification of Tumours of Female Reproductive Organs. 4th ed. Lyon, France: International Agency for Research on Cancer;2014. World Health Organization Classification of Tumours; vol 6."},{"issue":"12","key":"2020081222344811700_i1543-2165-141-10-1313-b10","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1097\/PAS.0b013e31822f58bc","article-title":"Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study","volume":"35","author":"Visvanathan","year":"2011","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"2020081222344811700_i1543-2165-141-10-1313-b11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship","volume":"31","author":"Kindelberger","year":"2007","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"2020081222344811700_i1543-2165-141-10-1313-b12","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1097\/PAS.0b013e3181ef7b16","article-title":"Are all pelvic (nonuterine) serous carcinomas of tubal origin?","volume":"34","author":"Przybycin","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"2020081222344811700_i1543-2165-141-10-1313-b13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/path.3023","article-title":"TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma\u2014evidence supporting the clonal relationship of the two lesions","volume":"226","author":"Kuhn","year":"2012","journal-title":"J Pathol"},{"issue":"17","key":"2020081222344811700_i1543-2165-141-10-1313-b14","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1158\/1078-0432.CCR-04-2509","article-title":"Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon","volume":"11","author":"Marquez","year":"2005","journal-title":"Clin Cancer Res"},{"issue":"3","key":"2020081222344811700_i1543-2165-141-10-1313-b15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","article-title":"Shih IeM. The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory","volume":"34","author":"Kurman","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"2020081222344811700_i1543-2165-141-10-1313-b16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ccr.2013.10.013","article-title":"Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in brca;tp53;pten models","volume":"24","author":"Perets","year":"2013","journal-title":"Cancer Cell"},{"issue":"10","key":"2020081222344811700_i1543-2165-141-10-1313-b17","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1073\/pnas.1117135109","article-title":"High-grade serous ovarian cancer arises from fallopian tube in a mouse model","volume":"109","author":"Kim","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"2020081222344811700_i1543-2165-141-10-1313-b18","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1001\/jamaoncol.2015.1618","article-title":"Next-generation sequencing of tubal intraepithelial carcinomas","volume":"1","author":"McDaniel","year":"2015","journal-title":"JAMA Oncol"},{"issue":"8","key":"2020081222344811700_i1543-2165-141-10-1313-b19","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1242\/dmm.015974","article-title":"Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?","volume":"7","author":"Grove","year":"2014","journal-title":"Dis Model Mech"},{"issue":"1","key":"2020081222344811700_i1543-2165-141-10-1313-b20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/emph\/eov006","article-title":"Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites","volume":"2015","author":"Cunningham","year":"2015","journal-title":"Evol Med Public Health"},{"issue":"12","key":"2020081222344811700_i1543-2165-141-10-1313-b21","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1158\/2159-8290.CD-16-0607","article-title":"Genomics of ovarian cancer progression reveals diverse metastatic trajectories including intraepithelial metastasis to the fallopian tube","volume":"6","author":"Eckert","year":"2016","journal-title":"Cancer Discov"},{"issue":"1","key":"2020081222344811700_i1543-2165-141-10-1313-b22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/PAS.0000000000000293","article-title":"Nongynecologic metastases to fallopian tube mucosa: a potential mimic of tubal high-grade serous carcinoma and benign tubal mucinous metaplasia or nonmucinous hyperplasia","volume":"39","author":"Rabban","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"2020081222344811700_i1543-2165-141-10-1313-b23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/PGP.0000000000000206","article-title":"Secondary involvement of the adnexa and uterine corpus by carcinomas of the uterine cervix: a detailed morphologic description","volume":"34","author":"Reyes","year":"2015","journal-title":"Int J Gynecol Pathol"},{"issue":"3","key":"2020081222344811700_i1543-2165-141-10-1313-b24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/01.pgp.0000235065.31301.3e","article-title":"Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma","volume":"26","author":"Chiesa-Vottero","year":"2007","journal-title":"Int J Gynecol Pathol"},{"issue":"2","key":"2020081222344811700_i1543-2165-141-10-1313-b25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/PAS.0000000000000757","article-title":"Uterine serous carcinomas frequently metastasize to the fallopian tube and can mimic serous tubal intraepithelial carcinoma","volume":"41","author":"Kommoss","year":"2016","journal-title":"Am J Surg Pathol"}],"container-title":["Archives of Pathology &amp; 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