{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:45:13Z","timestamp":1764791113304,"version":"3.46.0"},"reference-count":17,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context.\u2014<\/jats:title>\n                    <jats:p>The cause of pancreatic acinar metaplasia (PAM) at the distal esophagus\/esophagogastric junction is still controversial. Whereas some authors believe it is congenital, others believe it is acquired because of inflammation of the gastric cardia, and more recently it was proposed to be due to chronic proton pump inhibitor use based on a study in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective.\u2014<\/jats:title>\n                    <jats:p>To determine whether there is correlation between chronic proton pump inhibitor use and PAM in humans. We also investigated the correlation between several clinical and pathologic factors and PAM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design.\u2014<\/jats:title>\n                    <jats:p>Four hundred forty-four consecutive biopsies from the distal esophagus\/esophagogastric junction were reviewed for the presence of PAM, which was then correlated with several clinical and pathologic findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.\u2014<\/jats:title>\n                    <jats:p>Pancreatic acinar metaplasia was found in 71 patients (16%). Pancreatic acinar metaplasia was significantly associated with patient age younger than 51 years (P &amp;lt; .001), chronic carditis (P = .01), and chronic proton pump inhibitor use (P = .008). Surprisingly, we also found significant association between PAM and chronic nonsteroidal anti-inflammatory drug use (P &amp;lt; .001). These associations, including that with chronic nonsteroidal anti-inflammatory drug use, remained significant in multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.\u2014<\/jats:title>\n                    <jats:p>Our findings confirm the previous reports of significant association between PAM and chronic carditis and the findings from animal studies of association with chronic proton pump inhibitor use. The strong association with chronic nonsteroidal anti-inflammatory drug use has not been previously reported and warrants further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5858\/arpa.2018-0152-oa","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T16:35:49Z","timestamp":1544459749000},"page":"510-512","source":"Crossref","is-referenced-by-count":4,"title":["Pancreatic Acinar Metaplasia in Distal Esophageal Biopsies Is Associated With Chronic Nonsteroidal Anti-inflammatory Drug Use"],"prefix":"10.5858","volume":"143","author":[{"given":"Suhair","family":"Al Salihi","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and Memorial Hermann Hospital\u2013TMC, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanya","family":"Jaitly","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and Memorial Hermann Hospital\u2013TMC, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Saulino","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and Memorial Hermann Hospital\u2013TMC, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W.","family":"DuPont","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and Memorial Hermann Hospital\u2013TMC, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atilla","family":"Ertan","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and Memorial Hermann Hospital\u2013TMC, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie M.","family":"Everett","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and Memorial Hermann Hospital\u2013TMC, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoun","family":"Younes","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and Memorial Hermann Hospital\u2013TMC, Houston, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"issue":"11","key":"2020081203352583000_i1543-2165-143-4-510-b01","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1097\/00000478-199311000-00006","article-title":"Pancreatic (acinar) metaplasia of the gastric mucosa: histology, ultrastructure, immunocytochemistry, and clinicopathologic correlations of 101 cases","volume":"17","author":"Doglioni","year":"1993","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"2020081203352583000_i1543-2165-143-4-510-b02","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1097\/00000478-199612000-00010","article-title":"Prevalence and significance of pancreatic acinar metaplasia at the gastroesophageal junction","volume":"20","author":"Wang","year":"1996","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"2020081203352583000_i1543-2165-143-4-510-b03","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1097\/00000478-199510000-00007","article-title":"Pancreatic metaplasia in Barrett's esophagus: an immunohistochemical study","volume":"19","author":"Krishnamurthy","year":"1995","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"2020081203352583000_i1543-2165-143-4-510-b04","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1080\/00365520510015692","article-title":"Prevalence of precancerous and other metaplasia in the distal oesophagus and gastro-oesophageal junction","volume":"40","author":"Johansson","year":"2005","journal-title":"Scand J Gastroenterol"},{"issue":"7","key":"2020081203352583000_i1543-2165-143-4-510-b05","doi-asserted-by":"crossref","first-page":"854","DOI":"10.5858\/2003-127-854-PACMIA","article-title":"Pancreatic acinar cell metaplasia in autoimmune gastritis","volume":"127","author":"Jhala","year":"2003","journal-title":"Arch Pathol Lab Med"},{"issue":"8","key":"2020081203352583000_i1543-2165-143-4-510-b06","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.5858\/2000-124-1165-PAPOPA","article-title":"Prevalence and pathogenesis of pancreatic acinar tissue at the gastroesophageal junction in children and young adults","volume":"124","author":"Popiolek","year":"2000","journal-title":"Arch Pathol Lab Med"},{"issue":"5","key":"2020081203352583000_i1543-2165-143-4-510-b07","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00428-013-1471-8","article-title":"Pancreatic acinar cells\u2014a normal finding at the gastroesophageal junction?: data from a prospective central European multicenter study","volume":"463","author":"Schneider","year":"2013","journal-title":"Virchows Arch"},{"key":"2020081203352583000_i1543-2165-143-4-510-b08","doi-asserted-by":"crossref","first-page":"e112862","DOI":"10.1371\/journal.pone.0112862","article-title":"Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic acinar cell metaplasia development: an experimental in vivo study","volume":"9","author":"Dall'Olmo","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"2020081203352583000_i1543-2165-143-4-510-b09","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1572-0241.2000.01833.x","article-title":"Intestinal and pancreatic metaplasia at the esophagogastric junction in patients without Barrett's esophagus","volume":"95","author":"Polkowski","year":"2000","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"2020081203352583000_i1543-2165-143-4-510-b10","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1097\/00000478-200209000-00011","article-title":"Histopathology of the gastroesophageal junction: a study on 36 operation specimens","volume":"26","author":"Sarbia","year":"2002","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"2020081203352583000_i1543-2165-143-4-510-b11","first-page":"A1325","article-title":"Prevalence of pancreatic acinar metaplasia at the esophagogastric junction","volume":"118","author":"Wolf","year":"2000","journal-title":"Gastroenterology"},{"issue":"1","key":"2020081203352583000_i1543-2165-143-4-510-b12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00428-004-1157-3","article-title":"Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia","volume":"446","author":"Faller","year":"2005","journal-title":"Virchows Arch"},{"issue":"5","key":"2020081203352583000_i1543-2165-143-4-510-b13","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s10620-006-9253-7","article-title":"Development of pancreatic acinar cell metaplasia after successful administration of omeprazole for 6 months in rats","volume":"52","author":"Hagiwara","year":"2007","journal-title":"Dig Dis Sci"},{"issue":"21","key":"2020081203352583000_i1543-2165-143-4-510-b14","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/jnci\/90.21.1609","article-title":"Cyclooxygenase-2 inhibitors in tumorigenesis (part II)","volume":"90","author":"Taketo","year":"1998","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"2020081203352583000_i1543-2165-143-4-510-b15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/ijc.1518","article-title":"Is COX-2 inhibition a panacea for cancer prevention?","volume":"94","author":"Vainio","year":"2001","journal-title":"Int J Cancer"},{"issue":"4","key":"2020081203352583000_i1543-2165-143-4-510-b16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00280-002-0485-8","article-title":"Superior effectiveness of ibuprofen compared with other NSAIDs for reducing the survival of human prostate cancer cells","volume":"50","author":"Andrews","year":"2002","journal-title":"Cancer Chemother Pharmacol"},{"issue":"2","key":"2020081203352583000_i1543-2165-143-4-510-b17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/bph.13867","article-title":"Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation","volume":"175","author":"Bombardo","year":"2018","journal-title":"Br J Pharmacol"}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/143\/4\/510\/2368815\/arpa_2018-0152-oa.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/143\/4\/510\/2368815\/arpa_2018-0152-oa.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:36:20Z","timestamp":1764790580000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/143\/4\/article-p510.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,10]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,12,10]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.5858\/arpa.2018-0152-oa","relation":{},"ISSN":["0003-9985","1543-2165"],"issn-type":[{"type":"print","value":"0003-9985"},{"type":"electronic","value":"1543-2165"}],"subject":[],"published":{"date-parts":[[2018,12,10]]}}}