{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:46:11Z","timestamp":1760985971289,"version":"3.44.0"},"reference-count":47,"publisher":"The Pediatric Pharmacy Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Providing parenteral nutrition to pediatric patients requiring various other intravenous products can be challenging. Evaluation of compatibility is essential; however, information is limited and sometimes conflicting. We strove to critically evaluate and present the available published data as a comprehensive and practical reference. To accomplish this, we weighed the strength of evidence supporting compatibility versus incompatibility and provided specific conditions affecting compatibility, where appropriate. Many commonly used medications in pediatric patients have consistently demonstrated Y-site compatibility with parenteral nutrition and may be safely administered simultaneously. Exceptions must be noted and these medications should preferentially be administered through a separate line, if available, or the same line may be used only after stopping the parenteral nutrition infusion and flushing the line before and after drug administration.<\/jats:p>","DOI":"10.5863\/1551-6776-12.1.53","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T20:10:29Z","timestamp":1603829429000},"page":"53-59","source":"Crossref","is-referenced-by-count":3,"title":["Y-Site Compatibility of Medications with Parenteral Nutrition"],"prefix":"10.5863","volume":"12","author":[{"given":"Christine A.","family":"Robinson","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey and Department of Pharmacy and Clinical Services, Hackensack University Medical Center, Hackensack, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey and Department of Pharmacy and Clinical Services, Hackensack University Medical Center, Hackensack, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"year":"2005","series-title":"Handbook on Injectable Drugs","key":"i1551-6776-12-1-53-b1","unstructured":"Trissel\n              LA\n            \n          , Handbook on Injectable Drugs, 13th ed, Bethesda, MD: American Society of Health-System Pharmacists, Inc, 2005."},{"key":"i1551-6776-12-1-53-b2","series-title":"Am J Health-Syst Pharm","first-page":"2611","article-title":"Compatibility of neonatal parenteral nutrient solutions with selected intravenous drugs","volume":"53","year":"1996","unstructured":"Veltri\n              M\n            , LeeCKK.\n          Compatibility of neonatal parenteral nutrient solutions with selected intravenous drugs. 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DCIP;1990;24: 232\u2013235."},{"key":"i1551-6776-12-1-53-b26","series-title":"Am J Health Sys Pharm","first-page":"1194","article-title":"Visual compatibility of fentanyl citrate with parenteral nutrient solutions [Letters]","volume":"55","year":"1998","unstructured":"Moshfeghi\n              M\n            , CiuffoJ.\n          Visual compatibility of fentanyl citrate with parenteral nutrient solutions [Letters]. Am J Health Sys Pharm1998;55:1194\u20131197."},{"key":"i1551-6776-12-1-53-b27","series-title":"Am J Hosp Pharm","first-page":"1459","article-title":"Stability of fluconazole and amino acids in parenteral nutrient solutions","volume":"49","year":"1992","unstructured":"Couch\n              P\n            , JacobsonP, JohnsonCE.\n          Stability of fluconazole and amino acids in parenteral nutrient solutions. Am J Hosp Pharm1992;49:1459\u20131462."},{"key":"i1551-6776-12-1-53-b28","series-title":"Am J Hosp Pharm","first-page":"2075","article-title":"Visual compatibility of foscarnet with other injectable drugs during simulated Y-site administration","volume":"47","year":"1990","unstructured":"Baltz\n              JK\n            , KennedyP, MinorJR, GallelliJ.\n          Visual compatibility of foscarnet with other injectable drugs during simulated Y-site administration. Am J Hosp Pharm1990;47:2075\u20132077."},{"key":"i1551-6776-12-1-53-b29","series-title":"Am J Hosp Pharm","first-page":"1538","article-title":"Visual compatibility of ganciclovir sodium and parenteral nutrient solution during simulated Y-site injection","volume":"48","year":"1991","unstructured":"Outman\n              WR\n            , MitranoFP, BaptistaRJ.\n          Visual compatibility of ganciclovir sodium and parenteral nutrient solution during simulated Y-site injection. 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J Am Pharm Assoc2000;40:515\u2013519."},{"key":"i1551-6776-12-1-53-b41","series-title":"Am J Hosp Pharm","first-page":"123","article-title":"Visual compatibility of morphine sulfate and meperidine hydrochloride with other injectable drugs during simulated Y-site injection","volume":"48","year":"1991","unstructured":"Pugh\n              CB\n            , PabisDJ, RodriguezC.\n          Visual compatibility of morphine sulfate and meperidine hydrochloride with other injectable drugs during simulated Y-site injection. Am J Hosp Pharm1991;48:123\u2013125."},{"key":"i1551-6776-12-1-53-b42","series-title":"Am J Hosp Pharm","first-page":"285","article-title":"Stability of midazolam hydrochloride in parenteral nutrient solutions","volume":"50","year":"1993","unstructured":"Bhatt-Mehta\n              V\n            , RosenDA, KingRS, MaksymCJ.\n          Stability of midazolam hydrochloride in parenteral nutrient solutions. Am J Hosp Pharm1993;50:285\u2013288."},{"key":"i1551-6776-12-1-53-b43","series-title":"Am J Health-Syst Pharm","first-page":"63","article-title":"Stability of milrinone lactate in the presence of 29 critical care drugs and 4 i.v. solutions","volume":"56","year":"1999","unstructured":"Akkerman\n              SR\n            , ZhangH, MullinsRE, YaughnK.\n          Stability of milrinone lactate in the presence of 29 critical care drugs and 4 i.v. solutions. Am J Health-Syst Pharm1999;56:63\u201368."},{"key":"i1551-6776-12-1-53-b44","series-title":"Am J Health-Syst Pharm","first-page":"452","article-title":"Physical compatibility of milrinone lactate injection with intravenous drugs commonly used in the pediatric intensive care unit","volume":"59","year":"2002","unstructured":"Veltri\n              MA\n            , ConnerKG.\n          Physical compatibility of milrinone lactate injection with intravenous drugs commonly used in the pediatric intensive care unit. Am J Health-Syst Pharm2002;59:452\u2013454."},{"key":"i1551-6776-12-1-53-b45","series-title":"Am J Health-Syst Pharm","first-page":"192","article-title":"Stability of propofol with parenteral nutrient solutions during simulated Y-site injection","volume":"52","year":"1995","unstructured":"Bhatt-Mehta\n              V\n            , PagliaRE, RosenDA.\n          Stability of propofol with parenteral nutrient solutions during simulated Y-site injection. Am J Health-Syst Pharm1995;52:192\u2013196."},{"key":"i1551-6776-12-1-53-b46","series-title":"Am J Hosp Pharm","first-page":"402","article-title":"Visual compatibility of sargramostim with selected antineoplastic agents, anti-infectives, or other drugs during simulated Y-site injection","volume":"49","year":"1992","unstructured":"Trissel\n              LA\n            , BreadyBB, KwanJW, SantiagoNM.\n          Visual compatibility of sargramostim with selected antineoplastic agents, anti-infectives, or other drugs during simulated Y-site injection. 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