{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:21:42Z","timestamp":1756902102640,"version":"3.44.0"},"reference-count":12,"publisher":"The Pediatric Pharmacy Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>Non-steroidal anti-inflammatory drugs (NSAID) have been used to close the patent ductus arteriosus in neonates for over two decades. Ibuprofen lysine, a parenteral NSAID, is labeled for the treatment of patent ductus arteriosus in neonates who do not respond to conventional medical management. While sharing many of the same adverse effects as indomethacin, spontaneous bowel perforation has not been reported. We describe a premature infant that experienced isolated bowel perforations after treatment with ibuprofen lysine for symptomatic patent ductus arteriosus.<\/jats:p>","DOI":"10.5863\/1551-6776-13.3.166","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T20:11:04Z","timestamp":1603829464000},"page":"166-169","source":"Crossref","is-referenced-by-count":0,"title":["Repeated Bowel Perforations with Ibuprofen Lysine: A Case Report"],"prefix":"10.5863","volume":"13","author":[{"given":"Gregory J.","family":"Peitz","sequence":"first","affiliation":[{"name":"Creighton University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric B.","family":"Hoie","sequence":"additional","affiliation":[{"name":"Creighton University School of Pharmacy and Health Professions"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Hoy","sequence":"additional","affiliation":[{"name":"Creighton University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Anderson-Berry","sequence":"additional","affiliation":[{"name":"Joint Division of Newborn Medicine, University of Nebraska Medical Center College of Medicine\/Creighton University School of Medicine, Omaha, Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"article-title":"NeoProfen\u00ae (ibuprofen lysine) injection [package insert]","year":"2006","key":"i1551-6776-13-3-166-b1","unstructured":"NeoProfen\u00ae (ibuprofen lysine) injection [package insert]. Deerfield, IL: Ovation Pharmaceuticals;2006."},{"year":"2005","series-title":"Avery's Diseases of the Newborn","key":"i1551-6776-13-3-166-b2","unstructured":"Taeusch\n              HW\n            , BallardRA, GleasonCA.\n          Avery's Diseases of the Newborn. 8th ed. Philadelphia: Elsavier Saunders;2005."},{"key":"i1551-6776-13-3-166-b3","series-title":"Pediatr Pharm","first-page":"1","article-title":"Food and Drug Administration Update: Pediatric Highlights","volume":"13","year":"2007","unstructured":"Buck\n              ML.\n            \n          \n          Food and Drug Administration Update: Pediatric Highlights. Pediatr Pharm. 2007;13:1\u20134."},{"key":"i1551-6776-13-3-166-b4","series-title":"Proc (Bayl Univ Med Cent)","first-page":"83","article-title":"Ibuprofen lysine (NeoProfen\u00ae) for the treatment of patent ductus arteriosus","volume":"20","year":"2007","unstructured":"Poon\n              G.\n            \n          \n          Ibuprofen lysine (NeoProfen\u00ae) for the treatment of patent ductus arteriosus. Proc (Bayl Univ Med Cent). 2007;20:83\u201385."},{"key":"i1551-6776-13-3-166-b5","series-title":"J Am Coll Surg","first-page":"796","article-title":"Spontaneous localized intestinal perforation in very-low-birth-weight infants: A distinct clinical entity different from necrotizing enterocolitis","volume":"195","year":"2002","unstructured":"Pumberger\n              W\n            , MayrM, KohlhauserC, WenigerM.\n          Spontaneous localized intestinal perforation in very-low-birth-weight infants: A distinct clinical entity different from necrotizing enterocolitis. J Am Coll Surg2002;195:796\u2013803."},{"key":"i1551-6776-13-3-166-b6","series-title":"Pediatr International","first-page":"599","article-title":"Gastrointestinal perforation in very low-birth-weight infants","volume":"48","year":"2006","unstructured":"Kawase\n              Y\n            , IshiiT, AraiH, UgaN.\n          Gastrointestinal perforation in very low-birth-weight infants. Pediatr International2006;48:599\u2013603."},{"key":"i1551-6776-13-3-166-b7","series-title":"J Perinatol","first-page":"93","article-title":"New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure","volume":"26","year":"2006","unstructured":"Attridge\n              JT\n            , ClarkR, WalkerMW, GordonPV.\n          New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure. J Perinatol2006;26:93\u201399."},{"key":"i1551-6776-13-3-166-b8","series-title":"JPGN","first-page":"509","article-title":"A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin","volume":"45","year":"2007","unstructured":"Gordon\n              PV\n            , HermanAC, MarcinkiewiczM, et al. A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin. JPGN2007;45:509\u2013519."},{"key":"i1551-6776-13-3-166-b9","series-title":"Pediatrics","first-page":"164","article-title":"Prevention of Necrotizing Enterocolitis in Preterm Infants: A 20-Year Experience","volume":"119","year":"2006","unstructured":"Pietz\n              J\n            , AchantiB, LilienL, et al. Prevention of Necrotizing Enterocolitis in Preterm Infants: A 20-Year Experience. Pediatrics2006;119:164\u2013170."},{"key":"i1551-6776-13-3-166-b10","series-title":"J Pediatr Surg","first-page":"442","article-title":"Indomethacin associated bowel perforation: a study of possible risk factors","volume":"34","year":"1999","unstructured":"Shorter\n              NA\n            , LiuJY, MooneyDP, HarmonBJ.\n          Indomethacin associated bowel perforation: a study of possible risk factors. J Pediatr Surg1999;34:442\u2013444."},{"key":"i1551-6776-13-3-166-b11","unstructured":"Neish\n              SR.\n            \n          \n          \u201cPatent Ductus Arteriosus\u201d eMedicine from webMD. Jul 2006, Nov 2007. http:\/\/www.emedicine.com\/ped\/topic1747.htm Accessed on March 31, 2008.","article-title":"\u201cPatent Ductus Arteriosus\u201d eMedicine from webMD. Jul 2006, Nov 2007"},{"key":"i1551-6776-13-3-166-b12","series-title":"J Perinatol","first-page":"286","article-title":"Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus","volume":"23","year":"2003","unstructured":"O'Donovan\n              DJ\n            , BaetiongA, AdamsK, ChenA, SmithEO, AdamsJM\n          et.al. Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus. J Perinatol2003;23:286\u2013290."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/13\/3\/article-p166.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jppt\/article-pdf\/13\/3\/166\/1784885\/1551-6776-13_3_166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/13\/3\/article-p166.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/13\/3\/article-p166.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:47:01Z","timestamp":1747356421000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/13\/3\/article-p166.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":12,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5863\/1551-6776-13.3.166","relation":{},"ISSN":["1551-6776"],"issn-type":[{"type":"print","value":"1551-6776"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}