{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:43:17Z","timestamp":1775688197442,"version":"3.50.1"},"reference-count":20,"publisher":"The Pediatric Pharmacy Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>This report describes the feasibility of high-dose magnesium sulfate infusion in pediatric patients with status asthmaticus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Retrospective chart review over a 3-year period of all patients younger than 18 years of age with status asthmaticus who underwent a high-dose magnesium sulfate infusion for 4 hours. All patients were breathing spontaneously but were refractory to conventional therapy. The magnesium sulfate infusion regimen was 50 mg\/kg (for patients weighing &amp;gt;30 kg) or 75 mg\/kg (for those weighing \u226430 kg) over a period of 30 to 45 minutes, followed by a continuous infusion of 40 mg\/kg\/hr for 4 hours. Information regarding vital and clinical respiratory signs, serum magnesium (SrMg), ionized magnesium (iMg), electrocardiograms, and cardiac troponin levels were retrieved. We analyzed the relationship between SrMg and iMg by using linear regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Nineteen patients were included. At the end of the infusion, SrMg levels were 4.4 \u00b1 0.8 mg\/dL, and iMg levels were 0.95 \u00b1 0.2 mmol\/L. SrMg levels only moderately predicted iMg (r2 = 0.541). There were no reports of hypotension, respiratory failure, neurological problems, or nausea. Discomfort at the site of infusion was reported in three cases. Troponin levels (n = 12) and electrocardiograms (n = 12), when available, were noted at the end of the infusion and were normal in all patients p=0.01.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In this case series, short-term high-dose administration of magnesium sulfate in the context of status asthmaticus was feasible, and we did not observe clinical complications with its use. Total SrMg was inadequate to reflect the active form of magnesium, iMg. The dose used achieved theoretical therapeutic levels of iMg.<\/jats:p>\n               <\/jats:sec>","DOI":"10.5863\/1551-6776-17.2.150","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T21:46:21Z","timestamp":1349819181000},"page":"150-154","source":"Crossref","is-referenced-by-count":4,"title":["Feasibility of Short-Term Infusion of Magnesium Sulfate in Pediatric Patients With Status Asthmaticus"],"prefix":"10.5863","volume":"17","author":[{"given":"Jose","family":"Irazuzta","sequence":"first","affiliation":[{"name":"Wolfson Children's Hospital\/Baptist Health, Jacksonville, Florida"},{"name":"University of Florida College of Medicine, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tosha","family":"Egelund","sequence":"additional","affiliation":[{"name":"Wolfson Children's Hospital\/Baptist Health, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah K.","family":"Wassil","sequence":"additional","affiliation":[{"name":"Wolfson Children's Hospital\/Baptist Health, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hampp","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"issue":"2","key":"2020102715545743600_i1551-6776-17-2-150-b01","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0735-6757(00)90024-X","article-title":"Efficacy of magnesium sulfate in acute adult-asthma: a meta-analysis of randomized trials","volume":"18","author":"Rodrigo","year":"2000","journal-title":"Am J Emerg Med"},{"issue":"1","key":"2020102715545743600_i1551-6776-17-2-150-b02","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1136\/adc.2004.050005","article-title":"A meta-analysis on intravenous magnesium sulphate for treating acute asthma","volume":"90","author":"Cheuk","year":"2005","journal-title":"Arch Dis Child"},{"issue":"10","key":"2020102715545743600_i1551-6776-17-2-150-b03","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1172\/JCI103726","article-title":"Some effects of magnesium loading upon renal excretion of magnesium and certain other electrolytes","volume":"37","author":"Chesley","year":"1985","journal-title":"J Clin Invest"},{"issue":"2","key":"2020102715545743600_i1551-6776-17-2-150-b04","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1447-0756.2007.00508.x","article-title":"Ionized and total magnesium concentration in patients with severe preeclampsia-eclampsia undergoing magnesium sulfate therapy","volume":"33","author":"Aali","year":"2007","journal-title":"J Obstet Gynaecol Res"},{"issue":"3","key":"2020102715545743600_i1551-6776-17-2-150-b05","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/tropej\/fmm101","article-title":"Intravenous magnesium sulphate vs. inhaled nitric oxide for moderate, persistent pulmonary hypertension of the newborn. A multicentre, retrospective study","volume":"54","author":"Raimondi","year":"2008","journal-title":"J Trop Pediatr"},{"issue":"1","key":"2020102715545743600_i1551-6776-17-2-150-b06","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.pcc.0000256620.55512.5f","article-title":"Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury","volume":"8","author":"Natale","year":"2007","journal-title":"Pediatr Crit Care Med"},{"issue":"5","key":"2020102715545743600_i1551-6776-17-2-150-b07","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3109\/02699051003610516","article-title":"Magnesium sulphate in the management of patients with aneurysmal subarachnoid haemorrhage: a meta-analysis of prospective controlled trials","volume":"24","author":"Ma","year":"2010","journal-title":"Brain Inj"},{"issue":"1","key":"2020102715545743600_i1551-6776-17-2-150-b08","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/BTER:115:1:13","article-title":"Weak relationship between ionized and total magnesium in serum of patients requiring magnesium status","volume":"115","author":"Johansson","year":"2007","journal-title":"Biol Trace Elem Res"},{"issue":"8","key":"2020102715545743600_i1551-6776-17-2-150-b09","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1080\/00365510500333825","article-title":"Ionized magnesium levels and the ratio of ionized calcium to magnesium in asthma patients before and after treatment with magnesium","volume":"65","author":"Sinert","year":"2005","journal-title":"Scand J Clin Lab Invest"},{"issue":"2","key":"2020102715545743600_i1551-6776-17-2-150-b10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1378\/chest.122.2.489","article-title":"Acute asthma\/magnesium study group. IV magnesium sulfate in the treatment of acute severe asthma: a multicenter randomized controlled trial","volume":"122","author":"Silverman","year":"2002","journal-title":"Chest"},{"issue":"2","key":"2020102715545743600_i1551-6776-17-2-150-b11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1197\/aemj.9.2.99","article-title":"Validation of the pulmonary score: an asthma severity score for children","volume":"9","author":"Smith","year":"2002","journal-title":"Acad Emerg Med"},{"key":"2020102715545743600_i1551-6776-17-2-150-b12","article-title":"MgSO4 kinetics in children","author":"DeNicola","year":"1995","journal-title":"Pediatric Science Day"},{"key":"2020102715545743600_i1551-6776-17-2-150-b13","unstructured":"Cunningham\n              FG, \n            \n              Leveno\n              KJ, \n            \n              Bloom\n              SL, \n            et al\n          . Williams Obstetrics, 22nd ed. 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