{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:24:43Z","timestamp":1783401883720,"version":"3.54.6"},"reference-count":42,"publisher":"The Pediatric Pharmacy Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To compare the efficacy and safety of dexmedetomidine and fentanyl for sedation in mechanically ventilated premature neonates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This was a retrospective, observational case-control study in a level III neonatal intensive care unit. Forty-eight premature neonates requiring mechanical ventilation were included. Patients received fentanyl (n=24) or dexmedetomidine (n=24) for pain or sedation. Each group also received fentanyl and lorazepam boluses as needed for agitation. The primary outcomes were efficacy and frequency of acute adverse events associated with each drug. Days on mechanical ventilation, stooling patterns, feeding tolerance, and neurologic outcomes were also evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There were no significant differences in baseline demographics between the dexmedetomidine and fentanyl patients. Patients in the dexmedetomidine group required less adjunctive sedation and had more days free of additional sedation in comparison to fentanyl (54.1% vs. 16.5%, p&amp;lt;0.0001). There were no differences in hemodynamic parameters between the 2 groups. Duration of mechanical ventilation was shorter in the dexmedetomidine group (14.4 vs. 28.4 days, p&amp;lt;0.001). Meconium passage (7.5 vs. 22.4 days, p&amp;lt;0.0002) and time from initiation to achievement of full enteral feeds (26.8 vs. 50.8 days, p&amp;lt;0.0001) were shorter in the dexmedetomidine group. Incidence of culture-positive sepsis was lower in the dexmedetomidine group (48% vs. 88%). The incidence of either severe intraventricular hemorrhage or periventricular leukomalacia was not statistically significantly reduced (2% vs. 7%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Dexmedetomidine was safe and effective for sedation in the premature neonates included in this study. Prospective randomized-controlled trials are needed before routine use of dexmedetomidine can be recommended.<\/jats:p>\n               <\/jats:sec>","DOI":"10.5863\/1551-6776-17.3.252","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T18:06:01Z","timestamp":1355853961000},"page":"252-262","source":"Crossref","is-referenced-by-count":31,"title":["Dexmedetomidine Versus Standard Therapy with Fentanyl for Sedation in Mechanically Ventilated Premature Neonates"],"prefix":"10.5863","volume":"17","author":[{"given":"Keliana","family":"O'Mara","sequence":"first","affiliation":[{"name":"Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gal","sequence":"additional","affiliation":[{"name":"Women's Hospital of Greensboro, Cone Health, Greensboro, North Carolina"},{"name":"Greensboro Area Health Education Center, Greensboro, North Carolina"},{"name":"University of North Carolina, Eschelman School of Pharmacy, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wimmer","sequence":"additional","affiliation":[{"name":"Women's Hospital of Greensboro, Cone Health, Greensboro, North Carolina"},{"name":"Piedmont Neonatology, PC, Greensboro, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Laurence","family":"Ransom","sequence":"additional","affiliation":[{"name":"Women's Hospital of Greensboro, Cone Health, Greensboro, North Carolina"},{"name":"Piedmont Neonatology, PC, Greensboro, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita Q.","family":"Carlos","sequence":"additional","affiliation":[{"name":"Women's Hospital of Greensboro, Cone Health, Greensboro, North Carolina"},{"name":"Piedmont Neonatology, PC, Greensboro, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann V.T.","family":"Dimaguila","sequence":"additional","affiliation":[{"name":"Women's Hospital of Greensboro, Cone Health, Greensboro, North Carolina"},{"name":"Piedmont Neonatology, PC, Greensboro, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie C.","family":"Davanzo","sequence":"additional","affiliation":[{"name":"Women's Hospital of Greensboro, Cone Health, Greensboro, North Carolina"},{"name":"Piedmont Neonatology, PC, Greensboro, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McCrae","family":"Smith","sequence":"additional","affiliation":[{"name":"Women's Hospital of Greensboro, Cone Health, Greensboro, North Carolina"},{"name":"Piedmont Neonatology, PC, Greensboro, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"issue":"6","key":"2020102715594911900_i1551-6776-17-3-252-b1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.clinthera.2005.06.019","article-title":"Analgesia and sedation during mechanical ventilation in neonates","volume":"27","author":"Aranda","year":"2005","journal-title":"Clin Ther"},{"issue":"4","key":"2020102715594911900_i1551-6776-17-3-252-b2","doi-asserted-by":"crossref","first-page":"F241","DOI":"10.1136\/adc.2008.150318","article-title":"Opioids for neonates receiving mechanical ventilation","volume":"95","author":"Bell\u00f9","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"1","key":"2020102715594911900_i1551-6776-17-3-252-b3","first-page":"CD002052","article-title":"Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit","author":"Ng","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"2020102715594911900_i1551-6776-17-3-252-b4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1159\/000297771","article-title":"Pulmonary and neurological follow-up of extremely pre-term infants","volume":"97","author":"Doyle","year":"2010","journal-title":"Neonatology"},{"issue":"4","key":"2020102715594911900_i1551-6776-17-3-252-b5","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/MPG.0b013e31818c5fc3","article-title":"Does the enteral feeding advancement affect short-term outcomes in very low birth weight infants?","volume":"48","author":"H\u00e4rtel","year":"2009","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"2020102715594911900_i1551-6776-17-3-252-b6","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1542\/peds.2004-1398","article-title":"Morphine, hypotension, and adverse outcomes among preterm neonates: who's to blame? 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