{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:05:49Z","timestamp":1773083149598,"version":"3.50.1"},"reference-count":31,"publisher":"The Pediatric Pharmacy Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"\n OBJECTIVES:<\/jats:bold> To determine the proportion of infections caused by extended-spectrum \u00df-lactamase (ESBL)\u2013producing Klebsiella<\/jats:italic> or Escherichia coli<\/jats:italic> Gram-negative organisms in the pediatric intensive care unit (PICU), and to identify risk factors for these infections.<\/jats:p>\n \n METHODS:<\/jats:bold> A retrospective, single-center chart review of patients admitted to a PICU in a 5-year period with infections caused by Klebsiella<\/jats:italic> species or E coli<\/jats:italic> was completed.<\/jats:p>\n Data collected include demographics, length of stay, outcome, and relevant risk factors previously defined in the literature.<\/jats:p>\n \n RESULTS:<\/jats:bold> A total of 110 isolates were cultured from 94 patients. A total of 53% of the isolates were E coli<\/jats:italic>, and the remainder were Klebsiella<\/jats:italic> subspecies. Of the 110 isolates, 13 isolates (11.8%) in 7 patients were ESBL positive. The ESBL-producing isolates were equally distributed amongE coli<\/jats:italic> and Klebsiella<\/jats:italic> and were primarily cultured from tracheal aspirates. Most of the ESBL-positive isolates (9 of 13; 69%) were cultured from patients who received ceftazidime and\/or cefotaxime in the preceding 30 days. Patients infected with E coli<\/jats:italic> had higher PRISM 1 scores and were more likely to have a Foley catheter, whereas infections with Klebsiella<\/jats:italic> were more common in mechanically ventilated males. Although not statistically significant, 80% of patients who were infected with non\u2013ESBL-producing organisms survived to hospital discharge versus 57% of those infected with ESBL-producing E coli<\/jats:italic> and Klebsiella<\/jats:italic>.<\/jats:p>\n \n CONCLUSIONS:<\/jats:bold> Almost 12% of E coli<\/jats:italic> and Klebsiella<\/jats:italic> isolates in this patient population tested positive for ESBL production. ESBL production was equally distributed between E coli<\/jats:italic> and Klebsiella<\/jats:italic> species. These organisms were cultured from 7% of the study patients. As reported in previous studies, patients infected with ESBL-producing organisms most often had received prior cephalosporins and had a longer length of stay in the PICU.<\/jats:p>","DOI":"10.5863\/1551-6776-19.2.83","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T17:56:50Z","timestamp":1404755810000},"page":"83-90","source":"Crossref","is-referenced-by-count":8,"title":["Epidemiology of Infections Due to Extended-Spectrum Beta-Lactamase\u2013Producing Bacteria in a Pediatric Intensive Care Unit"],"prefix":"10.5863","volume":"19","author":[{"given":"Kim W.","family":"Benner","sequence":"first","affiliation":[{"name":"Samford University McWhorter School of Pharmacy, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Prabhakaran","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Autumn S.","family":"Lowros","sequence":"additional","affiliation":[{"name":"Samford University McWhorter School of Pharmacy, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"issue":"4","key":"i1551-6776-19-2-83-b1","series-title":"Pediatrics","first-page":"e39","article-title":"Nosocomial infections in pediatric intensive care units in the United States","volume":"103","year":"1999","unstructured":"Richards\n MJ\n , EdwardsJR, CulverDH, et al. 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