{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:53:37Z","timestamp":1764172417194,"version":"3.44.0"},"reference-count":11,"publisher":"The Pediatric Pharmacy Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n          <jats:bold>OBJECTIVES:<\/jats:bold> The objective was to describe antifungal drug use by using the number of defined daily doses (DDD)\/1000 patient-days per antifungal, the number of days of therapy (DOT)\/1000 patient-days per antifungal, and the mean dose in mg\/kg\/day per antifungal during a 10-year period.<\/jats:p>\n        <jats:p>\n          <jats:bold>METHODS:<\/jats:bold> Retrospective, cross-sectional, descriptive study, in a mother-child university hospital center, with 400 pediatric beds and 100 obstetrics-gynecology beds. All inpatients who received 1 of the 7 authorized antifungals on the institution\u2019s local formulary in 2000\u20132001, 2005\u20132006, or 2010\u20132011 were included. Prescriptions for emergency department and outpatient clinics were excluded. The data were extracted from the patients\u2019 computerized medication profiles linked to patient admission, discharge, and transfer data. The DDD, DOT, and the mean dose in mg\/kg\/day were calculated for each antifungal and overall.<\/jats:p>\n        <jats:p>\n          <jats:bold>RESULTS:<\/jats:bold> There was a 2.97-fold increase in the overall number of DDD\/1000 patient-days, from 14.8 in 2000\u20132001 to 37.5 in 2005\u20132006 and 43.9 in 2010\u20132011. There was a 2.97-fold increase in the overall number of DOT\/1000 patient-days, from 22.8 in 2000\u20132001 to 50.3 in 2005\u20132006 and 67.8 in 2010\u20132011.<\/jats:p>\n        <jats:p>\n          <jats:bold>CONCLUSIONS:<\/jats:bold> It can be difficult to compare the use of antifungal drugs among institutions, owing to numerous factors, but it gives an idea about the consumption outside the studied center. Moreover, these ratios help to evaluate the use of antifungals within a same institution. These data could be correlated among others, with resistance patterns, in order to improve our daily practice concerning antifungal prescription.<\/jats:p>","DOI":"10.5863\/1551-6776-19.3.196","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T20:14:32Z","timestamp":1603829672000},"page":"196-201","source":"Crossref","is-referenced-by-count":4,"title":["Usefulness of Defined Daily Dose and Days of Therapy in Pediatrics and Obstetrics-Gynecology: A Comparative Analysis of Antifungal Drugs (2000\u20132001, 2005\u20132006, and 2010\u20132011)"],"prefix":"10.5863","volume":"19","author":[{"given":"Justine","family":"Guillot","sequence":"first","affiliation":[{"name":"1Pharmacy Practice Research Unit, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Lebel","sequence":"additional","affiliation":[{"name":"1Pharmacy Practice Research Unit, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"2Pharmacy Department, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Roy","sequence":"additional","affiliation":[{"name":"1Pharmacy Practice Research Unit, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"2Pharmacy Department, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Ovetchkine","sequence":"additional","affiliation":[{"name":"3Pediatrics Department, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Bussi\u00e8res","sequence":"additional","affiliation":[{"name":"1Pharmacy Practice Research Unit, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"2Pharmacy Department, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"4Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"issue":"5","key":"i1551-6776-19-3-196-b1","series-title":"Clin Infect Dis","first-page":"743","article-title":"Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole","volume":"39","year":"2004","unstructured":"Imhof\n              A\n            , BalajeeSA, FredricksDN, et al. Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole. Clin Infect Dis. 2004;39(5):743\u2013746."},{"article-title":"Guidelines for ATC classification and DDD assignment 2013","year":"2012","key":"i1551-6776-19-3-196-b2","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology\n          Guidelines for ATC classification and DDD assignment 2013. Oslo, Norway; 2012. http:\/\/www.whocc.no\/filearchive\/publications\/1_2013guidelines.pdf. Accessed April 24, 2014."},{"issue":"6","key":"i1551-6776-19-3-196-b3","series-title":"Rev Chilena Infectol","first-page":"419","article-title":"Intravenous antimicrobial use among different hospital in Chile during 2005 [in Spanish]","volume":"25","year":"2008","unstructured":"Fica\n              CA\n            , CabelloMA, JulietLC, et al. Intravenous antimicrobial use among different hospital in Chile during 2005 [in Spanish]. Rev Chilena Infectol. 2008;25(6):419\u2013427."},{"issue":"2","key":"i1551-6776-19-3-196-b4","series-title":"Med Mal Infect","first-page":"103","article-title":"Use of 27 parenteral antimicrobial agents in north of France hospitals","volume":"37","year":"2007","unstructured":"Alfandari\n              S\n            , BonenfantC, DepretereL, et al. Use of 27 parenteral antimicrobial agents in north of France hospitals. Med Mal Infect. 2007;37(2):103\u2013107."},{"issue":"3","key":"i1551-6776-19-3-196-b5","series-title":"Med Mycol","first-page":"296","article-title":"The relationship between antifungal usage and antifungal susceptibility in clinical isolates of Candida: a multicenter Korean study","volume":"47","year":"2009","unstructured":"Kim\n              SH\n            , ShinJH, KimEC, et al. The relationship between antifungal usage and antifungal susceptibility in clinical isolates of Candida: a multicenter Korean study. Med Mycol. 2009;47(3):296\u2013304."},{"issue":"5","key":"i1551-6776-19-3-196-b6","series-title":"J Antimicrob Chemother","first-page":"853","article-title":"Reduction in broad-spectrum antimicrobial use associated with no improvement in hospital antibiogram","volume":"53","year":"2004","unstructured":"Cook\n              PP\n            , CatrouPG, ChristieJD, et al. Reduction in broad-spectrum antimicrobial use associated with no improvement in hospital antibiogram. J Antimicrob Chemother. 2004;53(5):853\u2013859."},{"issue":"4","key":"i1551-6776-19-3-196-b7","series-title":"Int J Antimicrob Agents","first-page":"349","article-title":"Association between incidence of candidaemia and consumption of antifungal agents at a medical centre in Taiwan","volume":"40","year":"2012","unstructured":"Lai\n              CC\n            , ChuCC, WangCY, et al. Association between incidence of candidaemia and consumption of antifungal agents at a medical centre in Taiwan. Int J Antimicrob Agents. 2012;40(4):349\u2013353."},{"issue":"6","key":"i1551-6776-19-3-196-b8","series-title":"Med Mycol","first-page":"581","article-title":"Seven-year trend analysis of nosocomial candidemia and antifungal (fluconazole and caspofungin) use in Intensive Care Units at a Brazilian University Hospital","volume":"46","year":"2008","unstructured":"Gir\u00e3o\n              E\n            , LevinAS, BassoM, et al. Seven-year trend analysis of nosocomial candidemia and antifungal (fluconazole and caspofungin) use in Intensive Care Units at a Brazilian University Hospital. Med Mycol. 2008;46(6):581\u2013588."},{"issue":"suppl 3","key":"i1551-6776-19-3-196-b9","series-title":"Enferm Infecc Microbiol Clin","first-page":"43","article-title":"Antibiotic consumption at 46 VINCat hospitals from 2007 to 2009, stratified by hospital size and clinical services","volume":"30","year":"2012","unstructured":"Grau\n              S\n            , FondevillaE, MojalS, et al. Antibiotic consumption at 46 VINCat hospitals from 2007 to 2009, stratified by hospital size and clinical services. Enferm Infecc Microbiol Clin. 2012;30(suppl 3):43\u201351."},{"key":"i1551-6776-19-3-196-b10","series-title":"BMC Infect Dis","first-page":"80","article-title":"Candidaemia and antifungal therapy in a French University Hospital: rough trends over a decade and possible links","volume":"6","year":"2006","unstructured":"Sendid\n              B\n            , CotteauA, Fran\u00e7oisN, et al. Candidaemia and antifungal therapy in a French University Hospital: rough trends over a decade and possible links. BMC Infect Dis. 2006;6:80."},{"year":"2010","series-title":"Surveillance of antimicrobial consumption in Europe","key":"i1551-6776-19-3-196-b11","unstructured":"European Centre for Disease Prevention and Control. Surveillance of antimicrobial consumption in Europe. Stockholm, Sweden; 2010. http:\/\/www.ecdc.europa.eu\/en\/publications\/Publications\/antimicrobial-antibiotic-consumption-ESAC-report-2010-data.pdf. Accessed April 29, 2014."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/19\/3\/article-p196.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jppt\/article-pdf\/19\/3\/196\/1784420\/1551-6776-19_3_196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/19\/3\/article-p196.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/19\/3\/article-p196.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:42:10Z","timestamp":1747356130000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/19\/3\/article-p196.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":11,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5863\/1551-6776-19.3.196","relation":{},"ISSN":["1551-6776"],"issn-type":[{"type":"print","value":"1551-6776"}],"subject":[],"published":{"date-parts":[[2014]]}}}