{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:22:16Z","timestamp":1756902136569,"version":"3.44.0"},"reference-count":23,"publisher":"The Pediatric Pharmacy Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Outbreaks of measles have been reported over the past 5 years, particularly affecting children between the ages of 1 and 5 years. Most of these children are younger than the age recommended by the Advisory Committee on Immunization Practices for the second dose of measles-mumps-rubella (MMR) vaccine. Question may arise as to whether strict adherence to the scheduled second dose is required or whether there is opportunity for earlier immunization under special circumstances (e.g., traveling abroad, poor response as evidenced by titer levels). The history of measles, its characteristics, and its evolving past and current immunization policies will be reviewed, focusing on the original intent of the recommended schedule and presenting a case in which deviating from current practice could be justified.<\/jats:p>","DOI":"10.5863\/1551-6776-20.2.144","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T19:53:43Z","timestamp":1603828423000},"page":"144-148","source":"Crossref","is-referenced-by-count":0,"title":["MMR Vaccine: When Is the Right Time for the Second Dose?"],"prefix":"10.5863","volume":"20","author":[{"given":"Oscar R.","family":"Herrera","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy"},{"name":"State of Tennessee Center of Excellence in Pediatric Pharmacokinetics and Therapeutics, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrika A.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Helms","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy"},{"name":"Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee"},{"name":"State of Tennessee Center of Excellence in Pediatric Pharmacokinetics and Therapeutics, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan L.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"issue":"12","key":"i1551-6776-20-2-144-b1","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"222","article-title":"Two measles outbreaks after importation\u2014Utah, March\u2013June 2011","volume":"62","year":"2013","unstructured":"CDC. Two measles outbreaks after importation\u2014Utah, March\u2013June 2011. MMWR Morb Mortal Wkly Rep. 2013;62(12):222\u2013225."},{"key":"i1551-6776-20-2-144-b2","series-title":"Vaccines","first-page":"353","article-title":"Measles vaccine","year":"2008","unstructured":"Strebel\n              P, \n            \n              Papania\n              MJ, \n            \n              Dayan\n              GH, \n          \n          et al. Measles vaccine. In: PlotkinSA, OrensteinWA, OffitPA, eds.Vaccines. 5th ed.Philadelphia, PA: WB Saunders; 2008:353\u2013398."},{"key":"i1551-6776-20-2-144-b3","series-title":"Epidemiology and Prevention of Vaccine-Preventable Diseases","first-page":"173","article-title":"Measles","year":"2012","unstructured":"Measles. In: AtkinsonW, WolfeC, HamborskyJ, eds.Epidemiology and Prevention of Vaccine-Preventable Diseases. 12th ed.Atlanta, GA: Centers for Disease Control and Prevention; 2012:173\u2013191."},{"issue":"6","key":"i1551-6776-20-2-144-b4","series-title":"Calif Med","first-page":"452","article-title":"Immune response with particular reference to the use of multiple antigens","volume":"109","year":"1968","unstructured":"Wehrle\n              PF.\n            \n          \n          Immune response with particular reference to the use of multiple antigens. Calif Med. 1968;109(6):452\u2013457."},{"key":"i1551-6776-20-2-144-b5","series-title":"Dev Biol Stand","first-page":"13","article-title":"Appropriate age for measles vaccination in the United States","volume":"65","year":"1986","unstructured":"Orenstein\n              WA, \n            \n              Markowitz\n              L, \n            \n              Preblud\n              SR, \n          \n          et al. 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Pediatrics. 1989;84(6):1110\u20131113."},{"issue":"13","key":"i1551-6776-20-2-144-b14","series-title":"N Engl J Med","first-page":"771","article-title":"Measles outbreak in a fully immunized secondary-school population","volume":"316","year":"1987","unstructured":"Gustafson\n              TL, \n            \n              Lievens\n              AW, \n            \n              Brunell\n              PA, \n          \n          et al. Measles outbreak in a fully immunized secondary-school population. 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