{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:59:52Z","timestamp":1789498792398,"version":"build-2803163510"},"reference-count":18,"publisher":"The Pediatric Pharmacy Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Sugammadex is a novel pharmacologic agent that is used to selectively reverse the effects of the neuromuscular blocking agents rocuronium and vecuronium. Various advantages have been reported when comparing its reversal of neuromuscular blockade to that achieved with acetylcholinesterase inhibitors (neostigmine). In heart transplant recipients, bradycardia may occur following the administration of acetylcholinesterase inhibitors, due to the denervation of the heart. Theoretically, the combination of rocuronium and sugammadex could be advantageous in this clinical scenario to avoid the potential bradycardia resulting from neostigmine administration. We present a 10-year-old male who developed profound bradycardia immediately following the administration of intravenous sugammadex. The options for reversal of neuromuscular blockade in heart transplant recipients is discussed, previous reports of bradycardia following sugammadex are presented, and the role of sugammadex in the bradycardia in our patient is reviewed.<\/jats:p>","DOI":"10.5863\/1551-6776-22.5.378","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T20:17:10Z","timestamp":1507839430000},"page":"378-381","source":"Crossref","is-referenced-by-count":6,"title":["Bradycardia in a Pediatric Heart Transplant Recipient: Is It the Sugammadex?"],"prefix":"10.5863","volume":"22","author":[{"given":"Adele","family":"King","sequence":"first","affiliation":[{"name":"Department of Anesthesiology & Pain Medicine (AK, AN, JDT), Nationwide Children's Hospital, Columbus, Ohio, Department of Anesthesiology & Pain Medicine (AN, JDT), The Ohio State University College of Medicine, Columbus, Ohio, and Department of Pediatrics (JDT), The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymen","family":"Naguib","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Pain Medicine (AK, AN, JDT), Nationwide Children's Hospital, Columbus, Ohio, Department of Anesthesiology & Pain Medicine (AN, JDT), The Ohio State University College of Medicine, Columbus, Ohio, and Department of Pediatrics (JDT), The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Tobias","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Pain Medicine (AK, AN, JDT), Nationwide Children's Hospital, Columbus, Ohio, Department of Anesthesiology & Pain Medicine (AN, JDT), The Ohio State University College of Medicine, Columbus, Ohio, and Department of Pediatrics (JDT), The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"issue":"7","key":"i1551-6776-22-5-378-b1","series-title":"Paediatr Anaesth","first-page":"591","article-title":"Neuromuscular block and current treatment strategies for its reversal in children","volume":"20","year":"2010","unstructured":"Meretoja\n              OA.\n            \n          \n          Neuromuscular block and current treatment strategies for its reversal in children. Paediatr Anaesth. 2010;20(7):591\u2013604."},{"issue":"2","key":"i1551-6776-22-5-378-b2","series-title":"Paediatr Anaesth","first-page":"118","article-title":"Current evidence for the use of sugammadex in children","volume":"27","year":"2017","unstructured":"Tobias\n              JD.\n            \n          \n          Current evidence for the use of sugammadex in children. Paediatr Anaesth. 2017;27(2):118\u2013125."},{"issue":"3","key":"i1551-6776-22-5-378-b3","series-title":"Anesth Analg","first-page":"575","article-title":"Sugammadex: another milestone in clinical neuromuscular pharmacology","volume":"104","year":"2007","unstructured":"Naguib\n              M.\n            \n          \n          Sugammadex: another milestone in clinical neuromuscular pharmacology. 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J Cardiothorac Vasc Anesth. 2016;30(2):462\u2013465."},{"issue":"2","key":"i1551-6776-22-5-378-b11","series-title":"Masui","first-page":"160","article-title":"Anesthetic management for endoscopic sinus surgery in a patient with transplanted heart--a case report [in Japanese]","volume":"64","year":"2015","unstructured":"Hashimoto\n              M\n            , SakaguchiH, SadanagaM.\n          Anesthetic management for endoscopic sinus surgery in a patient with transplanted heart--a case report [in Japanese]. Masui. 2015;64(2):160\u2013163."},{"key":"i1551-6776-22-5-378-b12","series-title":"Rev Esp Anestesiol Reanim","first-page":"611","article-title":"Sugammadex in a man with a transplanted kidney: a case report [in Spanish]","volume":"58","year":"2011","unstructured":"Cordero Escobar\n              I\n            , Rey Mart\u00ednezB, Company TeulerR, \n          et al. Sugammadex in a man with a transplanted kidney: a case report [in Spanish]. 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J Anesth. 2012;26(4):627\u2013628."},{"issue":"2","key":"i1551-6776-22-5-378-b15","series-title":"Anesthesiology","first-page":"188","article-title":"Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial","volume":"109","year":"2008","unstructured":"P\u00fchringer\n              FK\n            , RexC, Sielenk\u00e4mperAW, \n          et al. Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial. 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Pediatr Crit Care Med. 2003;4(2):203\u2013205."},{"issue":"2","key":"i1551-6776-22-5-378-b18","series-title":"Clin Pharmacol Ther","first-page":"239","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","year":"1981","unstructured":"Naranjo\n              CA\n            , BustoU, SellersEM, \n          et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239\u2013245."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/22\/5\/article-p378.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jppt\/article-pdf\/22\/5\/378\/1785304\/1551-6776-22_5_378.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/22\/5\/article-p378.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/22\/5\/article-p378.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:47:18Z","timestamp":1747356438000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/22\/5\/article-p378.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":18,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.5863\/1551-6776-22.5.378","relation":{},"ISSN":["1551-6776"],"issn-type":[{"value":"1551-6776","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}