{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:22:52Z","timestamp":1756902172517,"version":"3.44.0"},"reference-count":26,"publisher":"The Pediatric Pharmacy Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n          <jats:bold>OBJECTIVE<\/jats:bold> Although non-steroidal anti-inflammatory drugs (NSAIDs) are the current standard therapy for the treatment of patent ductus arteriosus (PDA), many neonates have contraindications to receiving or may fail NSAID therapy. To avoid surgical ligation, these patients may benefit from an alternative therapy. The objective of this research is to report the efficacy and safety of acetaminophen for the treatment of PDA in a cohort of premature neonates.<\/jats:p>\n        <jats:p>\n          <jats:bold>METHODS<\/jats:bold> Demographics and clinical course were retrospectively evaluated for all neonates admitted during the study period who received acetaminophen for the treatment of PDA. Initial acetaminophen dosing was 15 mg\/kg every 6 hours (88% intravenous). Efficacy was analyzed from ductal constriction on echocardiogram as well as need for further PDA treatment. Markers of hepatic and renal function as well as respiratory support and neonatal morbidities were evaluated to describe the safety of acetaminophen.<\/jats:p>\n        <jats:p>\n          <jats:bold>RESULTS<\/jats:bold> Forty-one neonates were identified with a median birth weight of 760 g (IQR 614\u2013948 g) and median gestational age of 25 weeks (IQR 24\u201327 weeks). Treatment was initiated at a median postnatal age of 15 days (IQR 8\u201319 days) for a median duration of 7 days (IQR 6\u201310 days). Twenty-seven neonates (66%) required no further PDA treatment, with echocardiographic PDA closure documented in 10 neonates (24%) and reduced ductal size in 15 neonates (37%). No clinically significant adverse effects attributable to acetaminophen therapy were detected.<\/jats:p>\n        <jats:p>\n          <jats:bold>CONCLUSIONS<\/jats:bold> Most patients in this study responded to acetaminophen treatment for PDA, indicating that this therapy may be an option for extremely low-birth-weight neonates in order to avoid surgical ligation.<\/jats:p>","DOI":"10.5863\/1551-6776-22.6.461","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T15:46:36Z","timestamp":1513698396000},"page":"461-466","source":"Crossref","is-referenced-by-count":3,"title":["Acetaminophen for Patent Ductus Arteriosus in Extremely Low-Birth-Weight Neonates"],"prefix":"10.5863","volume":"22","author":[{"given":"Caitlyn M.","family":"Luecke","sequence":"first","affiliation":[{"name":"Department of Pharmacy (CML, CJL, BNZ, CM), St. Louis Children's Hospital, St Louis, Missouri, Department of Pediatrics (ZAV, CM), Washington University School of Medicine, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caren J.","family":"Liviskie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (CML, CJL, BNZ, CM), St. Louis Children's Hospital, St Louis, Missouri, Department of Pediatrics (ZAV, CM), Washington University School of Medicine, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandy N.","family":"Zeller","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (CML, CJL, BNZ, CM), St. Louis Children's Hospital, St Louis, Missouri, Department of Pediatrics (ZAV, CM), Washington University School of Medicine, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary A.","family":"Vesoulis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (CML, CJL, BNZ, CM), St. Louis Children's Hospital, St Louis, Missouri, Department of Pediatrics (ZAV, CM), Washington University School of Medicine, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"McPherson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (CML, CJL, BNZ, CM), St. Louis Children's Hospital, St Louis, Missouri, Department of Pediatrics (ZAV, CM), Washington University School of Medicine, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"issue":"9","key":"i1551-6776-22-6-461-b1","series-title":"JAMA Pediatr","first-page":"863","article-title":"Diagnosis, evaluation, and management of patent ductus arteriosus in preterm neonates","volume":"169","year":"2015","unstructured":"Jain\n              A\n            , ShahPS.\n          Diagnosis, evaluation, and management of patent ductus arteriosus in preterm neonates. JAMA Pediatr. 2015;169(9):863\u2013872."},{"issue":"3","key":"i1551-6776-22-6-461-b2","series-title":"J Pediatr","first-page":"229","article-title":"Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms","volume":"150","year":"2007","unstructured":"Kabra\n              NS\n            , SchmidtB, RobertsRS, \n          et al. Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms. J Pediatr. 2007;150(3):229\u2013234."},{"issue":"4","key":"i1551-6776-22-6-461-b3","series-title":"Pediatrics","first-page":"e1024","article-title":"PDA ligation and health outcomes: a meta-analysis","volume":"133","year":"2014","unstructured":"Weisz\n              DE\n            , MoreK, McNamaraPJ, \n          et al. 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Clin Pharmacol Ther. 1981;30(2):239\u2013245."},{"issue":"3","key":"i1551-6776-22-6-461-b13","series-title":"Arch Intern Med","first-page":"380","article-title":"Acetaminophen overdose: 662 cases with evaluation of oral acetaminophen treatment","volume":"141","year":"1981","unstructured":"Rumack\n              BH\n            , PetersonRC, KochGG, \n          et al. Acetaminophen overdose: 662 cases with evaluation of oral acetaminophen treatment. Arch Intern Med. 1981;141(3):380\u2013385."},{"issue":"2","key":"i1551-6776-22-6-461-b14","series-title":"J Pediatr","first-page":"406","article-title":"Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus","volume":"163","year":"2013","unstructured":"Clyman\n              R\n            , WickremasingheA, JhaveriN, \n          et al. Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus. J Pediatr. 2013;163(2):406\u2013411."},{"issue":"6","key":"i1551-6776-22-6-461-b15","series-title":"Arch Dis Child","first-page":"462","article-title":"Paracetamol to induce ductus arteriosus closure: is it valid?","volume":"98","year":"2013","unstructured":"Allegaert\n              K\n            , AndersonB, SimonsS, \n          et al. Paracetamol to induce ductus arteriosus closure: is it valid?Arch Dis Child. 2013;98(6):462\u2013466."},{"issue":"2","key":"i1551-6776-22-6-461-b16","series-title":"Crit Care Med","first-page":"343","article-title":"Effect of age and birth weight on indomethacin pharmacodynamics in neonates treated for patent ductus arteriosus","volume":"30","year":"2002","unstructured":"Shaffer\n              CL\n            , GalP, RansomJL, \n          et al. Effect of age and birth weight on indomethacin pharmacodynamics in neonates treated for patent ductus arteriosus. Crit Care Med. 2002;30(2):343\u2013348."},{"issue":"11","key":"i1551-6776-22-6-461-b17","series-title":"Eur J Pediatr","first-page":"1433","article-title":"Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure","volume":"174","year":"2015","unstructured":"Roofthooft\n              DW\n            , van BeynumIM, de KlerkJC, \n          et al. Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. Eur J Pediatr. 2015;174(11):1433\u20131440."},{"issue":"3","key":"i1551-6776-22-6-461-b18","series-title":"Arch Dis Child Fetal Neonatal Ed","first-page":"F253","article-title":"Late medical therapy of patent ductus arteriosus using intravenous paracetamol","volume":"100","year":"2015","unstructured":"El-Khuffash\n              A\n            , JamesAT, ClearyA, \n          et al. Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Arch Dis Child Fetal Neonatal Ed. 2015;100(3):F253\u2013F256."},{"issue":"7","key":"i1551-6776-22-6-461-b19","series-title":"Eur J Pediatr","first-page":"953","article-title":"Intravenous paracetamol for PDA closure in the preterm: a single-center experience","volume":"175","year":"2016","unstructured":"Valerio\n              E\n            , ValenteMR, SalvadoriS, \n          et al. Intravenous paracetamol for PDA closure in the preterm: a single-center experience. Eur J Pediatr. 2016;175(7):953\u2013966."},{"issue":"6","key":"i1551-6776-22-6-461-b20","series-title":"J Matern Fetal Neonatal Med","first-page":"987","article-title":"Ductal closure with intravenous paracetamol: a new approach to patent ductus arteriosus treatment","volume":"29","year":"2016","unstructured":"Memisoglu\n              A\n            , Alp UnkarZ, CetinerN, \n          et al. Ductal closure with intravenous paracetamol: a new approach to patent ductus arteriosus treatment. J Matern Fetal Neonatal Med. 2016;29(6):987\u2013990."},{"issue":"8","key":"i1551-6776-22-6-461-b21","series-title":"J Perinatol","first-page":"649","article-title":"Acetaminophen to avoid surgical ligation in extremely low gestational age neonates with persistent hemodynamically significant patent ductus arteriosus","volume":"36","year":"2016","unstructured":"Weisz\n              DE\n            , MartinsFF, NieldLE, \n          et al. Acetaminophen to avoid surgical ligation in extremely low gestational age neonates with persistent hemodynamically significant patent ductus arteriosus. J Perinatol. 2016;36(8):649\u2013653."},{"issue":"1","key":"i1551-6776-22-6-461-b22","series-title":"J Matern Fetal Neonatal Med","first-page":"135","article-title":"Oral versus intravenous paracetamol: which is better in closure of patent ductus arteriosus in very low birth weight infants?","volume":"29","year":"2016","unstructured":"Sancak\n              S\n            , Gokmen YildirimT, \n          et al. Oral versus intravenous paracetamol: which is better in closure of patent ductus arteriosus in very low birth weight infants?J Matern Fetal Neonatal Med. 2016;29(1):135\u2013139."},{"issue":"2","key":"i1551-6776-22-6-461-b23","series-title":"Pediatr Cardiol","first-page":"276","article-title":"Paracetamol therapy for patent ductus arteriosus in premature infants: a chance before surgical ligation","volume":"35","year":"2014","unstructured":"Ozdemir\n              OM\n            , DoganM, KucuktasciK, \n          et al. Paracetamol therapy for patent ductus arteriosus in premature infants: a chance before surgical ligation. 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Cochrane Database Syst Rev. 2015;(2):CD003481."},{"issue":"4","key":"i1551-6776-22-6-461-b26","series-title":"Pediatrics","first-page":"1113","article-title":"Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less","volume":"117","year":"2006","unstructured":"Koch\n              J\n            , HensleyG, RoyL, \n          et al. Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less. Pediatrics. 2006;117(4):1113\u20131121."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/22\/6\/article-p461.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jppt\/article-pdf\/22\/6\/461\/1785246\/1551-6776-22_6_461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/22\/6\/article-p461.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/22\/6\/article-p461.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:47:37Z","timestamp":1747356457000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/22\/6\/article-p461.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":26,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.5863\/1551-6776-22.6.461","relation":{},"ISSN":["1551-6776"],"issn-type":[{"type":"print","value":"1551-6776"}],"subject":[],"published":{"date-parts":[[2017]]}}}