{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:07:30Z","timestamp":1769191650865,"version":"3.49.0"},"reference-count":33,"publisher":"The Pediatric Pharmacy Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Rasburicase, used in the prevention and treatment of tumor lysis syndrome (TLS), may cause hemolytic anemia and methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Although routine screening for G6PD deficiency has been recommended, given the turnaround time for test results and the urgency to treat TLS, such screening may not be feasible. We report a case of rasburicase-induced hemolytic anemia without methemoglobinemia in an adolescent with T-cell lymphoblastic lymphoma, TLS, and previously unrecognized G6PD deficiency. Previous reports of hemolytic anemia with rasburicase are reviewed, mechanisms discussed, and preventative strategies presented.<\/jats:p>","DOI":"10.5863\/1551-6776-22.6.471","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T15:46:36Z","timestamp":1513698396000},"page":"471","source":"Crossref","is-referenced-by-count":5,"title":["Rasburicase-induced Hemolytic Anemia in an Adolescent With Unknown Glucose-6-Phosphate Dehydrogenase Deficiency"],"prefix":"10.5863","volume":"22","author":[{"given":"Manzilat","family":"Akande","sequence":"first","affiliation":[{"name":"Division of Pediatric Critical Care Medicine (MA), Nationwide Children's Hospital, Columbus, Ohio, Department of Pediatrics (MA, ANA), The Ohio State University College of Medicine, Columbus, Ohio, Division of Pediatric Hematology\/Oncology\/BMT (ANA), Nationwide Children's Hospital, Columbus Ohio, Department of Anesthesiology & Pain Medicine (JTD), Nationwide Children's Hospital, Columbus, Ohio, and Department of Anesthesiology & Pain Medicine (JTD), The Ohio State University College of Medicine..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony N.","family":"Audino","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine (MA), Nationwide Children's Hospital, Columbus, Ohio, Department of Pediatrics (MA, ANA), The Ohio State University College of Medicine, Columbus, Ohio, Division of Pediatric Hematology\/Oncology\/BMT (ANA), Nationwide Children's Hospital, Columbus Ohio, Department of Anesthesiology & Pain Medicine (JTD), Nationwide Children's Hospital, Columbus, Ohio, and Department of Anesthesiology & Pain Medicine (JTD), The Ohio State University College of Medicine..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Tobias","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine (MA), Nationwide Children's Hospital, Columbus, Ohio, Department of Pediatrics (MA, ANA), The Ohio State University College of Medicine, Columbus, Ohio, Division of Pediatric Hematology\/Oncology\/BMT (ANA), Nationwide Children's Hospital, Columbus Ohio, Department of Anesthesiology & Pain Medicine (JTD), Nationwide Children's Hospital, Columbus, Ohio, and Department of Anesthesiology & Pain Medicine (JTD), The Ohio State University College of Medicine..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"issue":"1","key":"i1551-6776-22-6-471-b1","series-title":"Br J Haematol","first-page":"3","article-title":"Tumour lysis syndrome: new therapeutic strategies and classification","volume":"127","year":"2004","unstructured":"Cairo\n              MS\n            , BishopM.\n          Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004;127(1):3\u201311."},{"issue":"1","key":"i1551-6776-22-6-471-b2","series-title":"Adv Chronic Kidney Dis","first-page":"18","article-title":"Tumor lysis syndrome: new challenges and recent advances","volume":"21","year":"2014","unstructured":"Wilson\n              FP\n            , BernsJS.\n          Tumor lysis syndrome: new challenges and recent advances. Adv Chronic Kidney Dis. 2014;21(1):18\u201326."},{"issue":"2","key":"i1551-6776-22-6-471-b3","series-title":"Leuk Lymphoma","first-page":"221","article-title":"Prognostic significance of acute renal injury in acute tumor lysis syndrome","volume":"51","year":"2010","unstructured":"Darmon\n              M\n            , GuichardI, VincentF, \n          et al. Prognostic significance of acute renal injury in acute tumor lysis syndrome. 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Oct2002;49(5):877\u2013891."},{"issue":"1","key":"i1551-6776-22-6-471-b22","series-title":"Am J Hematol","first-page":"7","article-title":"Concise review: methemoglobinemia","volume":"42","year":"1993","unstructured":"Mansouri\n              A\n            , LurieAA.\n          Concise review: methemoglobinemia. Am J Hematol. 1993;42(1):7\u201312."},{"issue":"2","key":"i1551-6776-22-6-471-b23","series-title":"Am J Hematol","first-page":"134","article-title":"Methemoglobin\u2014it's not just blue: a concise review","volume":"82","year":"2007","unstructured":"Umbreit\n              J.\n            \n          \n          Methemoglobin\u2014it's not just blue: a concise review. 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In: HoffmanR, ed.Hematology: Basic Principles and Practice. 4th ed.Philadelphia, PA: Churchill Livingstone; 2000:657\u2013660."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/22\/6\/article-p471-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jppt\/article-pdf\/22\/6\/471\/1785192\/1551-6776-22_6_471.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/22\/6\/article-p471-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/22\/6\/article-p471-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:47:49Z","timestamp":1747356469000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/22\/6\/article-p471-s.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":33,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.5863\/1551-6776-22.6.471","relation":{},"ISSN":["1551-6776"],"issn-type":[{"value":"1551-6776","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}