{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:21:18Z","timestamp":1782166878693,"version":"3.54.5"},"reference-count":10,"publisher":"The Pediatric Pharmacy Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>\n          <jats:bold>OBJECTIVE<\/jats:bold> Although acetaminophen has emerged as a therapeutic option for treating hemodynamically significant patent ductus arteriosus (PDA) in preterm infants, limited data exist on pharmacodynamics. The objective of this research is to report serum acetaminophen concentrations at steady state in infants treated with intravenous acetaminophen for PDA and to examine associations with clinical outcomes.<\/jats:p>\n        <jats:p>\n          <jats:bold>METHODS<\/jats:bold> This retrospective study evaluated all infants admitted during the study period who received intravenous acetaminophen for the treatment of PDA. Acetaminophen dosing was 15 mg\/kg every 6 hours. A serum acetaminophen concentration was obtained 4 hours after the eighth dose. Associations between serum concentrations and efficacy, assessed by ductal constriction on echocardiogram, and safety, assessed by serum creatinine and hepatic transaminases, were explored using simple linear regression.<\/jats:p>\n        <jats:p>\n          <jats:bold>RESULTS<\/jats:bold> A total of 36 infants were included, with a median birth weight of 720 g (IQR 585\u2013895 g) and a median gestational age of 25 weeks (IQR 24\u201326 weeks). The median acetaminophen concentration in the cohort was 12.3 mg\/L (IQR 6.7\u201316.5 mg\/L; range, 1.1\u201329.0 mg\/L). Serum acetaminophen concentrations did not correlate with infant demographics, hepatic transaminases during treatment, or duct size at treatment completion. We observed ductal closure across a wide range of serum acetaminophen concentrations.<\/jats:p>\n        <jats:p>\n          <jats:bold>CONCLUSIONS<\/jats:bold> We did not identify an association between acetaminophen serum concentrations following intravenous therapy and ductal response or hepatic toxicity.<\/jats:p>","DOI":"10.5863\/1551-6776-24.2.134","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T18:31:02Z","timestamp":1555957862000},"page":"134-137","source":"Crossref","is-referenced-by-count":6,"title":["Acetaminophen Serum Concentrations in Infants Treated Intravenously for Patent Ductus Arteriosus"],"prefix":"10.5863","volume":"24","author":[{"given":"Christopher","family":"McPherson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlyn M.","family":"Luecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren J.","family":"Liviskie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandy N.","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Vesoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"issue":"4","key":"i1551-6776-24-2-134-b1","series-title":"Cochrane Database Syst Rev","article-title":"Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants","year":"2018","unstructured":"Ohlsson\n              A\n            , ShahPS.\n          Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database Syst Rev. 2018;(4):CD010061."},{"key":"i1551-6776-24-2-134-b2","series-title":"J Pediatr","first-page":"304","article-title":"Paracetamol serum concentrations in neonates treated enterally for ductal closure: a pilot study","volume":"198","year":"2018","unstructured":"Bin-Nun\n              A\n            , FinkD, MimouniFB, \n          et al. Paracetamol serum concentrations in neonates treated enterally for ductal closure: a pilot study. J Pediatr. 2018;198:304\u2013307."},{"issue":"5","key":"i1551-6776-24-2-134-b3","series-title":"JPEN J Parenter Enteral Nutr","first-page":"689","article-title":"Osmolality, pH, and compatibility of selected oral liquid medications with an enteral nutrition product","volume":"37","year":"2013","unstructured":"Klang\n              M\n            , McLymontV, NgN.\n          Osmolality, pH, and compatibility of selected oral liquid medications with an enteral nutrition product. JPEN J Parenter Enteral Nutr. 2013;37(5):689\u2013694."},{"issue":"2","key":"i1551-6776-24-2-134-b4","series-title":"Ann Pharmacother","first-page":"241","article-title":"Acetaminophen for patent ductus arteriosus","volume":"49","year":"2015","unstructured":"Le\n              J\n            , GalesMA, GalesBJ.\n          Acetaminophen for patent ductus arteriosus. Ann Pharmacother. 2015;49(2):241\u2013246."},{"issue":"6","key":"i1551-6776-24-2-134-b5","series-title":"Arch Dis Child","first-page":"575","article-title":"The pharmacokinetics of intravenous paracetamol in neonates: size matters most","volume":"96","year":"2011","unstructured":"Allegaert\n              K\n            , PalmerGM, AndersonBJ.\n          The pharmacokinetics of intravenous paracetamol in neonates: size matters most. Arch Dis Child. 2011;96(6):575\u2013580."},{"issue":"6","key":"i1551-6776-24-2-134-b6","series-title":"J Pediatr Pharmacol Ther","first-page":"461","article-title":"Acetaminophen for patent ductus arteriosus in extremely low-birth-weight neonates","volume":"22","year":"2017","unstructured":"Luecke\n              CM\n            , LiviskieCJ, ZellerBN, \n          et al. Acetaminophen for patent ductus arteriosus in extremely low-birth-weight neonates. J Pediatr Pharmacol Ther. 2017;22(6):461\u2013466."},{"issue":"1","key":"i1551-6776-24-2-134-b7","series-title":"Clin Pharmacokinet","first-page":"107","article-title":"Population pharmacokinetics of intravenous paracetamol (acetaminophen) in preterm and term neonates: model development and external evaluation","volume":"55","year":"2016","unstructured":"Cook\n              SF\n            , RobertsJK, Samiee-ZafarghandyS, \n          et al. Population pharmacokinetics of intravenous paracetamol (acetaminophen) in preterm and term neonates: model development and external evaluation. Clin Pharmacokinet. 2016;55(1):107\u2013119."},{"issue":"2","key":"i1551-6776-24-2-134-b8","series-title":"Cochrane Database Syst Rev","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants","year":"2015","unstructured":"Ohlsson\n              A\n            , WaliaR, ShahSS.\n          Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. Cochrane Database Syst Rev. 2015;(2):CD003481."},{"issue":"2","key":"i1551-6776-24-2-134-b9","series-title":"Arch Dis Child Fetal Neonatal Ed","first-page":"F116","article-title":"Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm infants","volume":"97","year":"2012","unstructured":"Barzilay\n              B\n            , YoungsterI, BatashD, \n          et al. Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2012;97(2):F116\u2013F119."},{"key":"i1551-6776-24-2-134-b10","series-title":"J Pediatr","first-page":"10","article-title":"Acetaminophen in the neonatal intensive care unit: shotgun approach or silver bullet","volume":"198","year":"2018","unstructured":"van den Anker\n              JN\n            , AllegaertK.\n          Acetaminophen in the neonatal intensive care unit: shotgun approach or silver bullet. J Pediatr. 2018;198:10\u201311."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/24\/2\/article-p134.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jppt\/article-pdf\/24\/2\/134\/2466864\/1551-6776-24_2_134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/24\/2\/article-p134.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/24\/2\/article-p134.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:41:11Z","timestamp":1747356071000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/24\/2\/article-p134.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":10,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5863\/1551-6776-24.2.134","relation":{},"ISSN":["1551-6776"],"issn-type":[{"value":"1551-6776","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}