{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:22:49Z","timestamp":1756902169555,"version":"3.44.0"},"reference-count":72,"publisher":"The Pediatric Pharmacy Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"abstract":"Lymphatic malformations in neonates often manifest as a chylothorax, and although rare, morbidity and mortality can be significant. First-line treatment with medium-chain triglyceride\u2013enriched formulas, or enteric rest with total parenteral nutrition, are not always successful. We describe the case of a premature neonate with trisomy 21 who presented with bilateral pleural effusions and a pericardial effusion that worsened with the initiation of enteral nutrition. Clinical improvement was not seen until the initiation of treatment with oral propranolol at a maximum dosage of 0.5 mg\/kg\/day divided every 8 hours with extubation 8 days after propranolol initiation. Two case reports have described the use of propranolol in similar patients receiving 2 mg\/kg\/day; however, our experience is the first to report treatment success at a much lower dose. A review of the literature for alternative medication treatments uncovered numerous case reports and series documenting variable results with incongruent definitions of treatment success in a diverse patient population. The rarity of this disease state makes accrual of patients difficult and more robust treatment data unlikely. Therefore, selection of the optimal adjunctive treatment must be based on individual patient and disease state characteristics as well as safety and efficacy profile of the medication.<\/jats:p>","DOI":"10.5863\/1551-6776-25.2.155","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T19:07:57Z","timestamp":1581016077000},"page":"155-162","source":"Crossref","is-referenced-by-count":4,"title":["Propranolol for the Treatment of Lymphatic Malformations in a Neonate \u2013 A Case Report and Review of Literature"],"prefix":"10.5863","volume":"25","author":[{"given":"Caren J.","family":"Liviskie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen C.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary A.","family":"Vesoulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"issue":"1","key":"i1551-6776-25-2-155-b1","series-title":"Eur J Pediatr","first-page":"2","article-title":"Chylothorax in the neonatal period","volume":"152","year":"1993","unstructured":"van Straaten\n HL\n , GerardsLJ, KredietTG.\n Chylothorax in the neonatal period. Eur J Pediatr. 1993;152(1):2\u20135."},{"issue":"1","key":"i1551-6776-25-2-155-b2","series-title":"Ann Thorac Surg","first-page":"90","article-title":"The management of chylothorax","volume":"39","year":"1985","unstructured":"Robinson\n CL.\n \n \n The management of chylothorax. Ann Thorac Surg. 1985;39(1):90\u201395."},{"issue":"3","key":"i1551-6776-25-2-155-b3","series-title":"Chest","first-page":"682","article-title":"Chylothorax in children: guidelines for diagnosis and management","volume":"116","year":"1999","unstructured":"Buttiker\n V\n , FanconiS, BurgerR.\n Chylothorax in children: guidelines for diagnosis and management. Chest. 1999;116(3):682\u2013687."},{"issue":"4","key":"i1551-6776-25-2-155-b4","series-title":"Pediatrics","first-page":"722","article-title":"Chylothorax in infants and children","volume":"133","year":"2014","unstructured":"Tutor\n JD.\n \n \n Chylothorax in infants and children. Pediatrics. 2014;133(4):722\u2013733."},{"issue":"12","key":"i1551-6776-25-2-155-b5","series-title":"J Paediatr Child Health","first-page":"716","article-title":"Post-operative chylothorax in children: an evidence-based management algorithm","volume":"44","year":"2008","unstructured":"Panthongviriyakul\n C\n , BinesJE.\n Post-operative chylothorax in children: an evidence-based management algorithm. J Paediatr Child Health. 2008;44(12):716\u2013721."},{"issue":"5","key":"i1551-6776-25-2-155-b6","series-title":"Pediatr Surg Int","first-page":"425","article-title":"Pediatric lymphatic malformations: evolving understanding and therapeutic options","volume":"32","year":"2016","unstructured":"Defnet\n AM\n , BagrodiaN, HernandezSL, \n et al. Pediatric lymphatic malformations: evolving understanding and therapeutic options. Pediatr Surg Int. 2016;32(5):425\u2013433."},{"issue":"3","key":"i1551-6776-25-2-155-b7","series-title":"J Pediatr Hematol Oncol","first-page":"232","article-title":"Treatment of childhood lymphangiomas with interferon-alpha","volume":"19","year":"1997","unstructured":"Reinhardt\n MA\n , NelsonSC, SencerSF, \n et al. Treatment of childhood lymphangiomas with interferon-alpha. J Pediatr Hematol Oncol. 1997;19(3):232\u2013236."},{"issue":"6","key":"i1551-6776-25-2-155-b8","series-title":"J Pediatr Surg","first-page":"1209","article-title":"Is octreotide a risk factor in necrotizing enterocolitis?","volume":"43","year":"2008","unstructured":"Reck-Burneo\n CA\n , ParekhA, VelcekFT.\n Is octreotide a risk factor in necrotizing enterocolitis?\n J Pediatr Surg. 2008;43(6):1209\u20131210."},{"issue":"2","key":"i1551-6776-25-2-155-b9","series-title":"Pediatrics","article-title":"Efficacy and safety of sirolimus in the treatment of complicated vascular anomalies","volume":"137","year":"2016","unstructured":"Adams\n DM\n , TrenorCC3rd, HammillAM, \n et al. Efficacy and safety of sirolimus in the treatment of complicated vascular anomalies. Pediatrics. 2016;137(2):e20153257. doi: 10.1542\/peds.2015-3257."},{"key":"i1551-6776-25-2-155-b10","series-title":"Case Rep Pediatr","article-title":"Neonatal chylothoraces: a 10-year experience in a tertiary neonatal referral centre","volume":"2019","year":"2019","unstructured":"White\n MK\n , BhatR, GreenoughA.\n Neonatal chylothoraces: a 10-year experience in a tertiary neonatal referral centre. Case Rep Pediatr. 2019;2019:3903598. doi: 10.1155\/2019\/3903598."},{"issue":"5","key":"i1551-6776-25-2-155-b11","series-title":"Ann Thorac Surg","first-page":"1864","article-title":"Postoperative chylothorax after cardiothoracic surgery in children","volume":"80","year":"2005","unstructured":"Chan\n EH\n , RussellJL, WilliamsWG, \n et al. Postoperative chylothorax after cardiothoracic surgery in children. Ann Thorac Surg. 2005;80(5):1864\u20131870."},{"issue":"4 pt 1","key":"i1551-6776-25-2-155-b12","series-title":"J Card Surg","first-page":"302","article-title":"The management of chylothorax\/chylopericardium following pediatric cardiac surgery: a 10-year experience","volume":"10","year":"1995","unstructured":"Nguyen\n DM\n , Shum-TimD, DobellAR, \n et al. The management of chylothorax\/chylopericardium following pediatric cardiac surgery: a 10-year experience. J Card Surg. 1995;10(4 pt 1):302\u2013308."},{"key":"i1551-6776-25-2-155-b13","series-title":"J Cardiothorac Surg","first-page":"127","article-title":"Chylothorax after surgery on congenital heart disease in newborns and infants-risk factors and efficacy of MCT-diet","volume":"5","year":"2010","unstructured":"Biewer\n ES\n , ZurnC, ArnoldR, \n et al. Chylothorax after surgery on congenital heart disease in newborns and infants-risk factors and efficacy of MCT-diet. J Cardiothorac Surg. 2010;5:127. doi: 10.1186\/1749-8090-5-127."},{"issue":"5","key":"i1551-6776-25-2-155-b14","series-title":"Nutr Clin Pract","first-page":"529","article-title":"Chyle leaks: consensus on management?","volume":"23","year":"2008","unstructured":"Smoke\n A\n , DeleggeMH.\n Chyle leaks: consensus on management?\n Nutr Clin Pract. 2008;23(5):529\u2013532."},{"issue":"10","key":"i1551-6776-25-2-155-b15","series-title":"J Pediatr Surg","first-page":"1169","article-title":"Management of nutritional and infectious complications of postoperative chylothorax in children","volume":"26","year":"1991","unstructured":"Allen\n EM\n , van HeeckerenDW, SpectorML, \n et al. Management of nutritional and infectious complications of postoperative chylothorax in children. 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J Paediatr Child Health. 2018;54(8):840\u2013847."},{"issue":"5","key":"i1551-6776-25-2-155-b21","series-title":"J Perinatol","first-page":"384","article-title":"Congenital chylothorax treated with oral sildenafil: a case report and review of the literature","volume":"35","year":"2015","unstructured":"Malleske\n DT\n , YoderBA.\n Congenital chylothorax treated with oral sildenafil: a case report and review of the literature. J Perinatol. 2015;35(5):384\u2013386."},{"issue":"5","key":"i1551-6776-25-2-155-b22","series-title":"Pediatr Neonatol","first-page":"297","article-title":"Congenital chylothorax in a late preterm infant and successful treatment with octreotide","volume":"52","year":"2011","unstructured":"Foo\n NH\n , HwangYS, LinCC, \n et al. Congenital chylothorax in a late preterm infant and successful treatment with octreotide. 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J Paediatr Child Health. 2006;42(1\u20132):65\u201367."},{"issue":"6","key":"i1551-6776-25-2-155-b31","series-title":"Ann Thorac Surg","first-page":"2213","article-title":"Management of newborn lymphangiectasia and chylothorax after cardiac surgery with octreotide infusion","volume":"77","year":"2004","unstructured":"Tibballs\n J\n , SotoR, BharuchaT.\n Management of newborn lymphangiectasia and chylothorax after cardiac surgery with octreotide infusion. Ann Thorac Surg. 2004;77(6):2213\u20132215."},{"issue":"11","key":"i1551-6776-25-2-155-b32","series-title":"Indian J Pediatr","first-page":"1412","article-title":"Successful treatment of neonatal chylothorax with octreotide","volume":"78","year":"2011","unstructured":"Khatami\n SF\n , ParvareshP.\n Successful treatment of neonatal chylothorax with octreotide. Indian J Pediatr. 2011;78(11):1412\u20131414."},{"issue":"2","key":"i1551-6776-25-2-155-b33","series-title":"Turk J Pediatr","first-page":"195","article-title":"Report of a case of neonatal chylothorax that responded to long-term octreotide treatment, and review of the literature","volume":"57","year":"2015","unstructured":"Cakir\n U\n , KahveciogluD, YildizD, \n et al. Report of a case of neonatal chylothorax that responded to long-term octreotide treatment, and review of the literature. Turk J Pediatr. 2015;57(2):195\u2013197."},{"issue":"29","key":"i1551-6776-25-2-155-b34","series-title":"Medicine (Baltimore)","article-title":"Effects of somatostatin\/octreotide treatment in neonates with congenital chylothorax","volume":"96","year":"2017","unstructured":"Yin\n R\n , ZhangR, WangJ, \n et al. Effects of somatostatin\/octreotide treatment in neonates with congenital chylothorax. Medicine (Baltimore). 2017;96(29):e7594. doi: 10.1097\/MD.0000000000007594."},{"issue":"2","key":"i1551-6776-25-2-155-b35","series-title":"Arch Dis Child Fetal Neonatal Ed","first-page":"F169","article-title":"Congenital chylothorax: a prospective nationwide epidemiological study in Germany","volume":"100","year":"2015","unstructured":"Bialkowski\n A\n , PoetsCF, FranzAR, \n et al. Congenital chylothorax: a prospective nationwide epidemiological study in Germany. Arch Dis Child Fetal Neonatal Ed. 2015;100(2):F169\u2013F172."},{"issue":"7","key":"i1551-6776-25-2-155-b36","series-title":"Early Hum Dev","first-page":"387","article-title":"Safety of octreotide in hospitalized infants","volume":"91","year":"2015","unstructured":"Testoni\n D\n , HornikCP, NeelyML, \n et al. Safety of octreotide in hospitalized infants. Early Hum Dev. 2015;91(7):387\u2013392."},{"issue":"4","key":"i1551-6776-25-2-155-b37","series-title":"Pediatr Crit Care Med","first-page":"356","article-title":"Somatostatin analog (octreotide) in management of neonatal postoperative chylothorax: is it safe?","volume":"5","year":"2004","unstructured":"Mohseni-Bod\n H\n , MacraeD, SlavikZ.\n Somatostatin analog (octreotide) in management of neonatal postoperative chylothorax: is it safe?\n Pediatr Crit Care Med. 2004;5(4):356\u2013357."},{"issue":"9\u201310","key":"i1551-6776-25-2-155-b38","series-title":"J Paediatr Child Health","first-page":"585","article-title":"Octreotide in the treatment of congenital chylothorax","volume":"40","year":"2004","unstructured":"Rasiah\n SV\n , OeiJ, LuiK.\n Octreotide in the treatment of congenital chylothorax. J Paediatr Child Health. 2004;40(9\u201310):585\u2013588."},{"issue":"10","key":"i1551-6776-25-2-155-b39","series-title":"Indian J Pediatr","first-page":"885","article-title":"Congenital chylothorax treated with octreotide","volume":"72","year":"2005","unstructured":"Sahin\n Y\n , AydinD.\n Congenital chylothorax treated with octreotide. Indian J Pediatr. 2005;72(10):885\u2013888."},{"issue":"2","key":"i1551-6776-25-2-155-b40","series-title":"Pediatr Diabetes","first-page":"142","article-title":"Necrotizing enterocolitis in neonates receiving octreotide for the management of congenital hyperinsulinism","volume":"11","year":"2010","unstructured":"Laje\n P\n , HalabyL, AdzickNS, \n et al. Necrotizing enterocolitis in neonates receiving octreotide for the management of congenital hyperinsulinism. 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Am J Perinatol. 2005;22(8):401\u2013404."},{"issue":"7","key":"i1551-6776-25-2-155-b45","series-title":"Eur J Pediatr","first-page":"550","article-title":"Cholelithiasis in a newborn following treatment with the somatostatin analogue octreotide","volume":"159","year":"2000","unstructured":"Radetti\n G\n , GentiliL, PaganiniC, \n et al. Cholelithiasis in a newborn following treatment with the somatostatin analogue octreotide. Eur J Pediatr. 2000;159(7):550."},{"issue":"6","key":"i1551-6776-25-2-155-b46","series-title":"Pediatr Blood Cancer","first-page":"1018","article-title":"Sirolimus for the treatment of complicated vascular anomalies in children","volume":"57","year":"2011","unstructured":"Hammill\n AM\n , WentzelM, GuptaA, \n et al. Sirolimus for the treatment of complicated vascular anomalies in children. 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