{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:42:52Z","timestamp":1791420172634,"version":"4.3.3"},"reference-count":52,"publisher":"The Pediatric Pharmacy Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Invasive candidiasis accounts for approximately 10% of nosocomial infections in preterm infants, with an incidence of 1% to 4% among neonatal intensive care unit (NICU) admissions and a mortality as high as 20% to 30%. These outcomes warrant improved treatment and prevention strategies for infants at highest risk. The Infectious Diseases Society of America provides guidelines on antifungal medications for the prophylaxis and treatment of candidiasis in NICUs; however, there are still variations in practice on the use of fluconazole for prophylaxis and treatment of invasive candidiasis. This review provides specific information regarding fluconazole activity, pharmacokinetics, and a literature evaluation of dosing strategies and comparisons to other treatments in the neonatal population.<\/jats:p>","DOI":"10.5863\/1551-6776-26.2.115","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T21:16:52Z","timestamp":1613510212000},"page":"115-122","source":"Crossref","is-referenced-by-count":9,"title":["Review of Fluconazole Treatment and Prophylaxis for Invasive Candidiasis in Neonates"],"prefix":"10.5863","volume":"26","author":[{"given":"Chi D.","family":"Hornik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah S.","family":"Bondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Petrea","family":"Cober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnabas","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"issue":"19","key":"i1551-6776-26-2-115-b1","series-title":"JAMA","first-page":"2357","article-title":"Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection","volume":"292","year":"2004","unstructured":"Stoll\n              BJ,\n            \n            \n              Hansen\n              NI,\n            \n            \n              Adams-Chapman\n              I,\n            \n          \n          .\n\t\t\t\t\tNeurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal 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birth weight infant","volume":"107","year":"2001","unstructured":"Kicklighter\n              SD,\n            \n            \n              Springer\n              SC,\n            \n            \n              Cox\n              T,\n            \n          \n          .\n\t\t\t\t\tFluconazole for prophylaxis against candida rectal colonization in the very low birth weight infant.\n\t\t\t\t\tPediatrics.\n\t\t\t\t\t2001;\n\t\t\t\t\t107(\n\t\t\t\t\t2):\n\t\t\t\t\t293\u2013\n\t\t\t\t\t298."},{"issue":"23","key":"i1551-6776-26-2-115-b32","series-title":"N Engl J Med","first-page":"1660","article-title":"Fluconazole prophylaxis against fungal colonization and infection in preterm infants","volume":"345","year":"2001","unstructured":"Kaufman\n              D,\n            \n            \n              Boyle\n              R,\n            \n            \n              Hazen\n              KC,\n            \n          \n          .\n\t\t\t\t\tFluconazole prophylaxis against fungal colonization 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Prophylaxis.\n\t\t\t\t\tIn:SmithPB,BenitzB,eds.Infectious Disease and Pharmacology: Neonatology Questions and Controversies.\n\t\t\t\t\tNew York:\n\t\t\t\t\tElsevier;\n\t\t\t\t\t2018:\n\t\t\t\t\t63\u2013\n\t\t\t\t\t68."},{"issue":"4","key":"i1551-6776-26-2-115-b36","series-title":"Pediatrics","first-page":"703","article-title":"Fluconazole prophylaxis in extremely low birth weight neonates reduces invasive candidiasis mortality rates without emergence of fluconazole-resistant Candida species","volume":"121","year":"2008","unstructured":"Healy\n              CM,\n            \n            \n              Campbell\n              JR,\n            \n            \n              Zaccaria\n              E,\n            \n          \n          .\n\t\t\t\t\tFluconazole prophylaxis in extremely low birth weight neonates reduces invasive candidiasis mortality rates without emergence of fluconazole-resistant Candida 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Accessed January 9, 2021. http:\/\/online.lexi.com"},{"key":"i1551-6776-26-2-115-b47","article-title":"Amphotericin B (Conventional). Lexicomp","unstructured":"Amphotericin B (Conventional). Lexicomp.\n\t\t\t\t\tHudson, OH:\n\t\t\t\t\tWolters Kluwer Health, Inc.\n\t\t\t\t\tUpdated December 23, 2020. 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