{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:21:30Z","timestamp":1756902090452,"version":"3.44.0"},"reference-count":10,"publisher":"The Pediatric Pharmacy Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Historically, prophylactic indomethacin (pINDO) has been used in some institutions for patent ductus arteriosus (PDA) in extremely low birthweight neonates while other institutions have used it as prophylaxis for intraventricular hemorrhage (IVH). The objective of this study was to evaluate the incidence of IVH and PDA with or without pINDO in premature neonates.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n This was a retrospective, single-center study comparing neonatal outcomes in neonates weighing 1250 grams or less who received pINDO (pINDO group) to those who did not (No pINDO group) after our institution discontinued its routine use.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n A total of 399 infants were included for analysis (pINDO, n = 141; No pINDO, n = 258). No difference was found between pINDO and No pINDO groups in incidence of any IVH (18% vs 14%, respectively) or severe IVH (7% vs 3%, respectively) when adjusting for gestational age and antenatal corticosteroids. Although the incidence of moderate-to-large PDA was lower in the pINDO group (13% vs 23%, respectively, adjusted p = 0.002), there was no significant difference for PDA requiring surgery (4% vs 3%, respectively). Results demonstrated a higher incidence of bronchopulmonary dysplasia (BPD) in the pINDO group (55% vs 41%, respectively, adjusted p = 0.014).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n No difference in the incidence of IVH, severe IVH, or PDA requiring surgery was observed between groups, whereas an increase in BPD was seen with use of pINDO. These data support our institutional practice change to discontinue routine use of pINDO in premature neonates. Further research is needed to guide clinical practice.<\/jats:p>\n <\/jats:sec>","DOI":"10.5863\/1551-6776-26.5.478","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T22:44:13Z","timestamp":1624920253000},"page":"478-483","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Neonatal Outcomes With and Without Prophylaxis With Indomethacin in Premature Neonates"],"prefix":"10.5863","volume":"26","author":[{"given":"Ingrid","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja A.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaideep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly Nelson","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah S.","family":"Bondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"issue":"4","key":"i1551-6776-26-5-478-b1","series-title":"Clin Perinatol","first-page":"737","article-title":"Intracranial hemorrhage in the preterm infant: understanding it, preventing it","volume":"36","year":"2009","unstructured":"Bassan\n H.\n \n \n Intracranial hemorrhage in the preterm infant: understanding it, preventing it.\n\t\t\t\t\tClin Perinatol.\n\t\t\t\t\t2009;\n\t\t\t\t\t36(\n\t\t\t\t\t4):\n\t\t\t\t\t737\u2013\n\t\t\t\t\t762."},{"issue":"6","key":"i1551-6776-26-5-478-b2","series-title":"J Pediatr","first-page":"937","article-title":"Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates","volume":"107","year":"1985","unstructured":"Ment\n LR,\n \n \n Duncan\n CC,\n \n \n Ehrenkranz\n RA,\n \n \n .\n\t\t\t\t\tRandomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates.\n\t\t\t\t\tJ Pediatr.\n\t\t\t\t\t1985;\n\t\t\t\t\t107(\n\t\t\t\t\t6):\n\t\t\t\t\t937\u2013\n\t\t\t\t\t943."},{"issue":"4","key":"i1551-6776-26-5-478-b3","series-title":"J Pediatr","first-page":"631","article-title":"Indomethacin reduces the risks of severe intraventricular hemorrhage","volume":"115","year":"1989","unstructured":"Bada\n HS,\n \n \n Green\n RS,\n \n \n Pourcyrous\n M,\n \n \n .\n\t\t\t\t\tIndomethacin reduces the risks of severe intraventricular hemorrhage.\n\t\t\t\t\tJ Pediatr.\n\t\t\t\t\t1989;\n\t\t\t\t\t115(\n\t\t\t\t\t4):\n\t\t\t\t\t631\u2013\n\t\t\t\t\t637."},{"issue":"4","key":"i1551-6776-26-5-478-b4","series-title":"Pediatrics","first-page":"543","article-title":"Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial","volume":"93","year":"1994","unstructured":"Ment\n LR,\n \n \n Oh\n W,\n \n \n Ehrenkranz\n RA,\n \n \n .\n\t\t\t\t\tLow-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial.\n\t\t\t\t\tPediatrics.\n\t\t\t\t\t1994;\n\t\t\t\t\t93(\n\t\t\t\t\t4):\n\t\t\t\t\t543\u2013\n\t\t\t\t\t550."},{"issue":"26","key":"i1551-6776-26-5-478-b5","series-title":"N Engl J Med","first-page":"1966","article-title":"Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants","volume":"344","year":"2001","unstructured":"Schmidt\n B,\n \n \n Davis\n P,\n \n \n Moddemann\n D,\n \n \n .\n\t\t\t\t\tLong-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.\n\t\t\t\t\tN Engl J Med.\n\t\t\t\t\t2001;\n\t\t\t\t\t344(\n\t\t\t\t\t26):\n\t\t\t\t\t1966\u2013\n\t\t\t\t\t1972."},{"issue":"2","key":"i1551-6776-26-5-478-b6","series-title":"Cochrane Database Syst Rev","doi-asserted-by":"publisher","first-page":"CD000174","DOI":"10.1002\/14651858.CD000174.pub2","article-title":"Intravenous indomethacin for preventing mortality and morbidity in very low birth weight infants","year":"2000","unstructured":"Fowlie\n PW.\n \n \n Intravenous indomethacin for preventing mortality and morbidity in very low birth weight infants.\n\t\t\t\t\tCochrane Database Syst Rev.\n\t\t\t\t\t2000; (\n\t\t\t\t\t2):\n\t\t\t\t\tCD000174.\n\t\t\t\t\tdoi:10.1002\/14651858.CD000174.pub2."},{"issue":"2","key":"i1551-6776-26-5-478-b7","series-title":"Arch Dis Child Fetal Neonatal Ed","first-page":"F99","article-title":"A randomised placebo-controlled trial of early treatment of the patent ductus arteriosus","volume":"99","year":"2014","unstructured":"Kluckow\n M,\n \n \n Jeffery\n M,\n \n \n Gill\n A,\n \n \n Evans\n N.\n \n \n A randomised placebo-controlled trial of early treatment of the patent ductus arteriosus.\n\t\t\t\t\tArch Dis Child Fetal Neonatal Ed.\n\t\t\t\t\t2014;\n\t\t\t\t\t99(\n\t\t\t\t\t2):\n\t\t\t\t\tF99\u2013\n\t\t\t\t\tF104."},{"key":"i1551-6776-26-5-478-b8","series-title":"J Pediatr","first-page":"119","article-title":"Prophylactic indomethacin compared with delayed conservative management of the patent ductus arteriosus in extremely preterm infants: effects on neonatal outcomes","volume":"187","year":"2017","unstructured":"Liebowitz\n M,\n \n \n Clyman\n RI.\n \n \n Prophylactic indomethacin compared with delayed conservative management of the patent ductus arteriosus in extremely preterm infants: effects on neonatal outcomes.\n\t\t\t\t\tJ Pediatr.\n\t\t\t\t\t2017;\n\t\t\t\t\t187:\n\t\t\t\t\t119\u2013\n\t\t\t\t\t126.\n\t\t\t\t\te1."},{"issue":"4","key":"i1551-6776-26-5-478-b9","series-title":"J Pediatr","first-page":"605","article-title":"Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease","volume":"126","year":"1995","unstructured":"Rojas\n MA,\n \n \n Gonzalez\n A,\n \n \n Bancalari\n E,\n \n \n .\n\t\t\t\t\tChanging trends in the epidemiology and pathogenesis of neonatal chronic lung disease.\n\t\t\t\t\tJ Pediatr.\n\t\t\t\t\t1995;\n\t\t\t\t\t126(\n\t\t\t\t\t4):\n\t\t\t\t\t605\u2013\n\t\t\t\t\t610."},{"issue":"6","key":"i1551-6776-26-5-478-b10","series-title":"J Pediatr","first-page":"730","article-title":"Indomethacin prophylaxis, patent ductus arteriosus, and the risk of bronchopulmonary dysplasia: further analyses from the Trial of Indomethacin Prophylaxis in Preterms (TIPP)","volume":"148","year":"2006","unstructured":"Schmidt\n B,\n \n \n Roberts\n RS,\n \n \n Fanaroff\n A,\n \n \n .\n\t\t\t\t\tIndomethacin prophylaxis, patent ductus arteriosus, and the risk of bronchopulmonary dysplasia: further analyses from the Trial of Indomethacin Prophylaxis in Preterms (TIPP).\n\t\t\t\t\tJ Pediatr.\n\t\t\t\t\t2006;\n\t\t\t\t\t148(\n\t\t\t\t\t6):\n\t\t\t\t\t730\u2013\n\t\t\t\t\t734."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/26\/5\/article-p478.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jppt\/article-pdf\/26\/5\/478\/2855317\/i1551-6776-26-5-478.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/26\/5\/article-p478.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/26\/5\/article-p478.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:45:38Z","timestamp":1747356338000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/26\/5\/article-p478.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":10,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.5863\/1551-6776-26.5.478","relation":{},"ISSN":["1551-6776"],"issn-type":[{"type":"print","value":"1551-6776"}],"subject":[],"published":{"date-parts":[[2021]]}}}