{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:39:29Z","timestamp":1768873169628,"version":"3.49.0"},"reference-count":34,"publisher":"The Pediatric Pharmacy Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:sec>\n          <jats:title>OBJECTIVE<\/jats:title>\n          <jats:p>Levetiracetam (LEV) efficacy for neonatal seizures is debated. We evaluated LEV as a first line anti-seizure medicine (ASM) in neonates following neonatal congenital heart defect (CHD) repair who did not require extracorporeal membrane oxygenation (ECMO) vs neonates who required ECMO.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>METHODS<\/jats:title>\n          <jats:p>A single center retrospective review of neonates with CHD from 2015 to 2020 was conducted. Neonates were included if seizures were present on continuous EEG after CHD repair either on or off ECMO, and they received LEV as a first line ASM. Primary outcomes were seizure resolution with LEV, adverse events and response to subsequent ASM.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>RESULTS<\/jats:title>\n          <jats:p>Eighteen total neonates were evaluated, 10 with seizures post-CHD repair who did not require ECMO and 8 who required ECMO. In the non-ECMO cohort, nine of ten were successfully treated with LEV monotherapy with no adverse events. In comparison, the eight neonates who required ECMO had a higher initial seizure burden (1.6% vs 17%, p=0.003), were more likely to have injury on neuroimaging (12.5 vs 75%, p= 0.04), and all neonates required multiple ASMs. Seizure burden did not decrease with LEV, but significantly decreased with phenobarbital and fosphenytoin (14.4% and 10.5%, p = 0.024).<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>CONCLUSIONS<\/jats:title>\n          <jats:p>Neonates with CHD and seizures on and off ECMO demonstrated divergent seizure characteristics including seizure burden and response to LEV. LEV may reduce neonatal seizure burden after uncomplicated CHD repair. However, in neonates requiring ECMO, multiple ASMs were required. A prospective evaluation of ASM efficacy and safety in this high-risk population is urgently needed.<\/jats:p>\n        <\/jats:sec>","DOI":"10.5863\/1551-6776-27.3.254","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T18:10:20Z","timestamp":1647886220000},"page":"254-262","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective Evaluation of First-line Levetiracetam use for Neonatal Seizures after Congenital Heart Defect repair with or without Extracorporeal Membrane Oxygenation"],"prefix":"10.5863","volume":"27","author":[{"given":"Jennifer C.","family":"Keene","sequence":"first","affiliation":[{"name":"University of Washington, Department of Neurology, Division of Child Neurology (JK, MW, LM, XB, NN), Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Wainwright","sequence":"additional","affiliation":[{"name":"University of Washington, Department of Neurology, Division of Child Neurology (JK, MW, LM, XB, NN), Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey A.","family":"Morgan","sequence":"additional","affiliation":[{"name":"University of Washington, Department of Neurology, Division of Child Neurology (JK, MW, LM, XB, NN), Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Mietzsch","sequence":"additional","affiliation":[{"name":"Division of Neonatology (UM), Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ndidi","family":"Musa","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine (NM), Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhua L.","family":"Bozarth","sequence":"additional","affiliation":[{"name":"University of Washington, Department of Neurology, Division of Child Neurology (JK, MW, LM, XB, NN), Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niranjana","family":"Natarajan","sequence":"additional","affiliation":[{"name":"University of Washington, Department of Neurology, Division of Child Neurology (JK, MW, LM, XB, NN), Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"issue":"4","key":"i2331-348X-27-3-254-b1","series-title":"Neurology","first-page":"724","article-title":"A population-based study of neonatal seizures in Fayette County, Kentucky","volume":"45","year":"1995","unstructured":"Lanska\n              MJ,\n            \n            \n              Lanska\n              DJ,\n            \n            \n              Baumann\n              RJ,\n            \n          \n          .\n\t\t\t\t\tA population-based study of neonatal seizures in Fayette County, Kentucky.\n\t\t\t\t\tNeurology.\n\t\t\t\t\t1995;\n\t\t\t\t\t45(\n\t\t\t\t\t4):\n\t\t\t\t\t724\u2013\n\t\t\t\t\t732."},{"issue":"1","key":"i2331-348X-27-3-254-b2","series-title":"J Thorac Cardiovasc Surg","first-page":"132","article-title":"Postoperative electroencephalographic seizures are associated with deficits in executive function and social behaviors at 4 years of age following cardiac surgery in infancy","volume":"146","year":"2013","unstructured":"Gaynor\n              JW,\n            \n            \n              Jarvik\n              GP,\n            \n            \n              Gerdes\n              M,\n            \n          \n          .\n\t\t\t\t\tPostoperative electroencephalographic seizures are associated with deficits in executive function and social behaviors at 4 years of age following cardiac surgery in infancy.\n\t\t\t\t\tJ Thorac Cardiovasc Surg.\n\t\t\t\t\t2013;\n\t\t\t\t\t146(\n\t\t\t\t\t1):\n\t\t\t\t\t132\u2013\n\t\t\t\t\t139."},{"issue":"5","key":"i2331-348X-27-3-254-b3","series-title":"J Thorac Cardiovasc Surg","first-page":"1278","article-title":"Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures","volume":"130","year":"2005","unstructured":"Gaynor\n              JW,\n            \n            \n              Nicolson\n              SC,\n            \n            \n              Jarvik\n              GP,\n            \n          \n          .\n\t\t\t\t\tIncreasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures.\n\t\t\t\t\tJ Thorac Cardiovasc Surg.\n\t\t\t\t\t2005;\n\t\t\t\t\t130(\n\t\t\t\t\t5):\n\t\t\t\t\t1278\u2013\n\t\t\t\t\t1286."},{"issue":"1","key":"i2331-348X-27-3-254-b4","series-title":"J Thorac Cardiovasc Surg","first-page":"169","article-title":"Subclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery","volume":"150","year":"2015","unstructured":"Naim\n              MY,\n            \n            \n              Gaynor\n              JW,\n            \n            \n              Chen\n              J,\n            \n          \n          .\n\t\t\t\t\tSubclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery.\n\t\t\t\t\tJ Thorac Cardiovasc Surg.\n\t\t\t\t\t2015;\n\t\t\t\t\t150(\n\t\t\t\t\t1):\n\t\t\t\t\t169\u2013\n\t\t\t\t\t180."},{"issue":"1","key":"i2331-348X-27-3-254-b5","series-title":"Epilepsia","first-page":"84","article-title":"Electrographic neonatal seizures after infant heart surgery","volume":"46","year":"2005","unstructured":"Clancy\n              RR,\n            \n            \n              Sharif\n              U,\n            \n            \n              Ichord\n              R,\n            \n          \n          .\n\t\t\t\t\tElectrographic neonatal seizures after infant heart surgery.\n\t\t\t\t\tEpilepsia.\n\t\t\t\t\t2005;\n\t\t\t\t\t46(\n\t\t\t\t\t1):\n\t\t\t\t\t84\u2013\n\t\t\t\t\t90."},{"key":"i2331-348X-27-3-254-b6","series-title":"Pediatr Neurol","first-page":"77","article-title":"Electro-graphic seizures and brain injury in children requiring extracorporeal membrane oxygenation","volume":"108","year":"2020","unstructured":"Cook\n              RJ,\n            \n            \n              Rau\n              SM,\n            \n            \n              Lester-Pelham\n              SG,\n            \n          \n          .\n\t\t\t\t\tElectro-graphic seizures and brain injury in children requiring extracorporeal membrane oxygenation.\n\t\t\t\t\tPediatr Neurol.\n\t\t\t\t\t2020;\n\t\t\t\t\t108:\n\t\t\t\t\t77\u2013\n\t\t\t\t\t85."},{"issue":"6","key":"i2331-348X-27-3-254-b7","series-title":"Pediatr Crit Care Med","first-page":"601","article-title":"Nonconvulsive seizures are common in children treated with extracorporeal cardiac life support","volume":"14","year":"2013","unstructured":"Piantino\n              JA,\n            \n            \n              Wainwright\n              MS,\n            \n            \n              Grimason\n              M,\n            \n          \n          .\n\t\t\t\t\tNonconvulsive seizures are common in children treated with extracorporeal cardiac life support.\n\t\t\t\t\tPediatr Crit Care Med.\n\t\t\t\t\t2013;\n\t\t\t\t\t14(\n\t\t\t\t\t6):\n\t\t\t\t\t601\u2013\n\t\t\t\t\t609."},{"issue":"5","key":"i2331-348X-27-3-254-b8","series-title":"Brain","first-page":"1429","article-title":"Seizure burden is independently associated with short term outcome in critically ill children","volume":"137","year":"2014","unstructured":"Payne\n              ET,\n            \n            \n              Zhao\n              XY,\n            \n            \n              Frndova\n              H,\n            \n          \n          .\n\t\t\t\t\tSeizure burden is independently associated with short term outcome in critically ill children.\n\t\t\t\t\tBrain.\n\t\t\t\t\t2014;\n\t\t\t\t\t137(\n\t\t\t\t\t5):\n\t\t\t\t\t1429\u2013\n\t\t\t\t\t1438."},{"issue":"12","key":"i2331-348X-27-3-254-b9","series-title":"Dev Med Child Neurol","first-page":"1242","article-title":"Seizure burden and neurodevelopmental outcome in neonates with hypoxic\u2013ischemic encephalopathy","volume":"58","year":"2016","unstructured":"Kharoshankaya\n              L,\n            \n            \n              Stevenson\n              NJ,\n            \n            \n              Livingstone\n              V,\n            \n          \n          .\n\t\t\t\t\tSeizure burden and neurodevelopmental outcome in neonates with hypoxic\u2013ischemic encephalopathy.\n\t\t\t\t\tDev Med Child Neurol.\n\t\t\t\t\t2016;\n\t\t\t\t\t58(\n\t\t\t\t\t12):\n\t\t\t\t\t1242\u2013\n\t\t\t\t\t1248."},{"issue":"3","key":"i2331-348X-27-3-254-b10","series-title":"Cochrane Database Syst Rev","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004218.pub2","article-title":"Anticonvulsants for neonates with seizures","year":"2004","unstructured":"Booth\n              D,\n            \n            \n              Evans\n              DJ.\n            \n          \n          Anticonvulsants for neonates with seizures.\n\t\t\t\t\tCochrane Database Syst Rev.\n\t\t\t\t\t2004; (\n\t\t\t\t\t3).\n\t\t\t\t\tdoi:10.1002\/14651858.CD004218.pub2"},{"issue":"7","key":"i2331-348X-27-3-254-b11","series-title":"N Engl J Med","first-page":"485","article-title":"Phenobarbital compared with phenytoin for the treatment of neonatal seizures","volume":"341","year":"1999","unstructured":"Painter\n              MJ,\n            \n            \n              Scher\n              MS,\n            \n            \n              Stein\n              AD,\n            \n          \n          .\n\t\t\t\t\tPhenobarbital compared with phenytoin for the treatment of neonatal seizures.\n\t\t\t\t\tN Engl J Med.\n\t\t\t\t\t1999;\n\t\t\t\t\t341(\n\t\t\t\t\t7):\n\t\t\t\t\t485\u2013\n\t\t\t\t\t489."},{"issue":"4","key":"i2331-348X-27-3-254-b12","series-title":"Epilepsia","first-page":"794","article-title":"Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: A pharmacokinetic study during whole body hypothermia","volume":"52","year":"2011","unstructured":"Filippi\n              L,\n            \n            \n              la Marca\n              G,\n            \n            \n              Cavallaro\n              G,\n            \n          \n          .\n\t\t\t\t\tPhenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: A pharmacokinetic study during whole body hypothermia.\n\t\t\t\t\tEpilepsia.\n\t\t\t\t\t2011;\n\t\t\t\t\t52(\n\t\t\t\t\t4):\n\t\t\t\t\t794\u2013\n\t\t\t\t\t801."},{"issue":"11","key":"i2331-348X-27-3-254-b13","series-title":"J Perinatol","first-page":"841","article-title":"Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures","volume":"33","year":"2013","unstructured":"Maitre\n              NL,\n            \n            \n              Smolinsky\n              C,\n            \n            \n              Slaughter\n              JC,\n            \n          \n          .\n\t\t\t\t\tAdverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures.\n\t\t\t\t\tJ Perinatol.\n\t\t\t\t\t2013;\n\t\t\t\t\t33(\n\t\t\t\t\t11):\n\t\t\t\t\t841\u2013\n\t\t\t\t\t846."},{"issue":"23","key":"i2331-348X-27-3-254-b14","series-title":"Proc Natl Acad Sci U S A","first-page":"15089","article-title":"Antiepileptic drugs and apoptotic neurodegeneration in the developing brain","volume":"99","year":"2002","unstructured":"Bittigau\n              P,\n            \n            \n              Sifringer\n              M,\n            \n            \n              Genz\n              K,\n            \n          \n          .\n\t\t\t\t\tAntiepileptic drugs and apoptotic neurodegeneration in the developing brain.\n\t\t\t\t\tProc Natl Acad Sci U S A.\n\t\t\t\t\t2002;\n\t\t\t\t\t99(\n\t\t\t\t\t23):\n\t\t\t\t\t15089\u2013\n\t\t\t\t\t15094."},{"issue":"5","key":"i2331-348X-27-3-254-b15","series-title":"DARU, J Pharm Sci","first-page":"312","article-title":"A systematic review on pharmacokinetic changes in critically ill patients role of extracorporeal, membrane oxygenation","volume":"19","year":"2011","unstructured":"Mousavi\n              S,\n            \n            \n              Levcovich\n              B,\n            \n            \n              Mojtahedzadeh\n              M.\n            \n          \n          A systematic review on pharmacokinetic changes in critically ill patients role of extracorporeal, membrane oxygenation.\n\t\t\t\t\tDARU, J Pharm Sci.\n\t\t\t\t\t2011;\n\t\t\t\t\t19(\n\t\t\t\t\t5):\n\t\t\t\t\t312\u2013\n\t\t\t\t\t321."},{"issue":"4","key":"i2331-348X-27-3-254-b16","series-title":"Ann Pharmacother","first-page":"419","article-title":"Phenobarbital dosing and pharmacokinetics in a neonate receiving extracorporeal membrane oxygenation","volume":"33","year":"1999","unstructured":"Elliott\n              ES,\n            \n            \n              Buck\n              ML.\n            \n          \n          Phenobarbital dosing and pharmacokinetics in a neonate receiving extracorporeal membrane oxygenation.\n\t\t\t\t\tAnn Pharmacother.\n\t\t\t\t\t1999;\n\t\t\t\t\t33(\n\t\t\t\t\t4):\n\t\t\t\t\t419\u2013\n\t\t\t\t\t422."},{"issue":"5","key":"i2331-348X-27-3-254-b17","series-title":"Clin Pharmacokinet","first-page":"403","article-title":"Pharmacokinetic changes during extracorporeal membrane oxygenation: Implications for drug therapy of neonates","volume":"42","year":"2003","unstructured":"Buck\n              ML.\n            \n          \n          Pharmacokinetic changes during extracorporeal membrane oxygenation: Implications for drug therapy of neonates.\n\t\t\t\t\tClin Pharmacokinet.\n\t\t\t\t\t2003;\n\t\t\t\t\t42(\n\t\t\t\t\t5):\n\t\t\t\t\t403\u2013\n\t\t\t\t\t417."},{"issue":"8","key":"i2331-348X-27-3-254-b18","series-title":"PLoS One","first-page":"1","article-title":"Thirty years of orphan drug legislation and the development of drugs to treat rare seizure conditions: A cross sectional analysis","volume":"11","year":"2016","unstructured":"D\u00f6ring\n              JH,\n            \n            \n              Lampert\n              A,\n            \n            \n              Hoffmann\n              GF,\n            \n          \n          .\n\t\t\t\t\tThirty years of orphan drug legislation and the development of drugs to treat rare seizure conditions: A cross sectional analysis.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2016;\n\t\t\t\t\t11(\n\t\t\t\t\t8):\n\t\t\t\t\t1\u2013\n\t\t\t\t\t15."},{"issue":"3","key":"i2331-348X-27-3-254-b19","series-title":"Seizure","first-page":"185","article-title":"Levetiracetam in the treatment of neonatal seizures: A pilot study","volume":"19","year":"2010","unstructured":"F\u00fcrwentsches\n              A,\n            \n            \n              Bussmann\n              C,\n            \n            \n              Ramantani\n              G,\n            \n          \n          .\n\t\t\t\t\tLevetiracetam in the treatment of neonatal seizures: A pilot study.\n\t\t\t\t\tSeizure.\n\t\t\t\t\t2010;\n\t\t\t\t\t19(\n\t\t\t\t\t3):\n\t\t\t\t\t185\u2013\n\t\t\t\t\t189."},{"issue":"1","key":"i2331-348X-27-3-254-b20","series-title":"J Pediatr Neurosci","first-page":"24","article-title":"Levetiracetam in Neonatal Seizures as First-line Treatment: A Prospective Study","volume":"12","year":"2017","unstructured":"Falsaperla\n              R,\n            \n            \n              Vitaliti\n              G,\n            \n            \n              Mauceri\n              L,\n            \n          \n          .\n\t\t\t\t\tLevetiracetam in Neonatal Seizures as First-line Treatment: A Prospective Study.\n\t\t\t\t\tJ Pediatr Neurosci.\n\t\t\t\t\t2017;\n\t\t\t\t\t12(\n\t\t\t\t\t1):\n\t\t\t\t\t24\u2013\n\t\t\t\t\t28."},{"issue":"5","key":"i2331-348X-27-3-254-b21","series-title":"Early Hum Dev","first-page":"355","article-title":"The effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury","volume":"89","year":"2013","unstructured":"Kilicdag\n              H,\n            \n            \n              Daglioglu\n              K,\n            \n            \n              Erdogan\n              S,\n            \n          \n          .\n\t\t\t\t\tThe effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury.\n\t\t\t\t\tEarly Hum Dev.\n\t\t\t\t\t2013;\n\t\t\t\t\t89(\n\t\t\t\t\t5):\n\t\t\t\t\t355\u2013\n\t\t\t\t\t360."},{"issue":"6","key":"i2331-348X-27-3-254-b22","series-title":"Child's Nerv Syst","first-page":"1001","article-title":"Neuroprotective effect of levetiracetam on hypoxic ischemic brain injury in neonatal rats","volume":"30","year":"2014","unstructured":"Komur\n              M,\n            \n            \n              Okuyaz\n              C,\n            \n            \n              Celik\n              Y,\n            \n          \n          .\n\t\t\t\t\tNeuroprotective effect of levetiracetam on hypoxic ischemic brain injury in neonatal rats.\n\t\t\t\t\tChild's Nerv Syst.\n\t\t\t\t\t2014;\n\t\t\t\t\t30(\n\t\t\t\t\t6):\n\t\t\t\t\t1001\u2013\n\t\t\t\t\t1009."},{"key":"i2331-348X-27-3-254-b23","series-title":"Epilepsy Behav","first-page":"212","article-title":"A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic\u2013ischemic encephalopathy","volume":"88","year":"2018","unstructured":"Rao\n              LM,\n            \n            \n              Hussain\n              SA,\n            \n            \n              Zaki\n              T,\n            \n          \n          .\n\t\t\t\t\tA comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic\u2013ischemic encephalopathy.\n\t\t\t\t\tEpilepsy Behav.\n\t\t\t\t\t2018;\n\t\t\t\t\t88:\n\t\t\t\t\t212\u2013\n\t\t\t\t\t217."},{"issue":"5","key":"i2331-348X-27-3-254-b24","series-title":"Pediatr Neurol","first-page":"340","article-title":"Role of intravenous levetiracetam for acute seizure management in preterm neonates","volume":"49","year":"2013","unstructured":"Khan\n              O,\n            \n            \n              Cipriani\n              C,\n            \n            \n              Wright\n              C,\n            \n          \n          .\n\t\t\t\t\tRole of intravenous levetiracetam for acute seizure management in preterm neonates.\n\t\t\t\t\tPediatr Neurol.\n\t\t\t\t\t2013;\n\t\t\t\t\t49(\n\t\t\t\t\t5):\n\t\t\t\t\t340\u2013\n\t\t\t\t\t343."},{"issue":"1","key":"i2331-348X-27-3-254-b25","series-title":"Eur J Paediatr Neurol","first-page":"1","article-title":"Levetiracetam: Safety and efficacy in neonatal seizures","volume":"15","year":"2011","unstructured":"Ramantani\n              G,\n            \n            \n              Ikonomidou\n              C,\n            \n            \n              Walter\n              B,\n            \n          \n          .\n\t\t\t\t\tLevetiracetam: Safety and efficacy in neonatal seizures.\n\t\t\t\t\tEur J Paediatr Neurol.\n\t\t\t\t\t2011;\n\t\t\t\t\t15(\n\t\t\t\t\t1):\n\t\t\t\t\t1\u2013\n\t\t\t\t\t7."},{"issue":"8","key":"i2331-348X-27-3-254-b26","series-title":"Pharmacotherapy","first-page":"e127","article-title":"Levetiracetam Pharmacokinetics in a Patient Receiving Continuous Venovenous Hemofiltration and Venoarterial Extracorporeal Membrane Oxygenation","volume":"35","year":"2015","unstructured":"Nei\n              SD,\n            \n            \n              Wittwer\n              ED,\n            \n            \n              Kashani\n              KB,\n            \n          \n          .\n\t\t\t\t\tLevetiracetam Pharmacokinetics in a Patient Receiving Continuous Venovenous Hemofiltration and Venoarterial Extracorporeal Membrane Oxygenation.\n\t\t\t\t\tPharmacotherapy.\n\t\t\t\t\t2015;\n\t\t\t\t\t35(\n\t\t\t\t\t8):\n\t\t\t\t\te127\u2013\n\t\t\t\t\te130."},{"issue":"6","key":"i2331-348X-27-3-254-b27","series-title":"Pediatrics","first-page":"e20193182","article-title":"Levetiracetam versus phenobarbital for neonatal seizures: A randomized controlled trial","volume":"145","year":"2020","unstructured":"Sharpe\n              C,\n            \n            \n              Reiner\n              GE,\n            \n            \n              Davis\n              SL,\n            \n          \n          .\n\t\t\t\t\tLevetiracetam versus phenobarbital for neonatal seizures: A randomized controlled trial.\n\t\t\t\t\tPediatrics.\n\t\t\t\t\t2020;\n\t\t\t\t\t145(\n\t\t\t\t\t6):\n\t\t\t\t\te20193182."},{"issue":"2","key":"i2331-348X-27-3-254-b28","series-title":"Pediatrics","first-page":"402","article-title":"Neurologic status of newborns with congenital heart defects before open heart surgery","volume":"103","year":"1999","unstructured":"Limperopoulos\n              C,\n            \n            \n              Majnemer\n              A,\n            \n            \n              Shevell\n              MI,\n            \n          \n          .\n\t\t\t\t\tNeurologic status of newborns with congenital heart defects before open heart surgery.\n\t\t\t\t\tPediatrics.\n\t\t\t\t\t1999;\n\t\t\t\t\t103(\n\t\t\t\t\t2):\n\t\t\t\t\t402\u2013\n\t\t\t\t\t408."},{"issue":"SUPPL. 1","key":"i2331-348X-27-3-254-b29","series-title":"Cardiol Young","first-page":"92","article-title":"Current insights regarding neurological and developmental abnormalities in children and young adults with complex congenital cardiac disease","volume":"16","year":"2006","unstructured":"Wernovsky\n              G.\n            \n          \n          Current insights regarding neurological and developmental abnormalities in children and young adults with complex congenital cardiac disease.\n\t\t\t\t\tCardiol Young.\n\t\t\t\t\t2006;\n\t\t\t\t\t16(\n\t\t\t\t\tSUPPL. 1):\n\t\t\t\t\t92\u2013\n\t\t\t\t\t104."},{"issue":"4","key":"i2331-348X-27-3-254-b30","series-title":"Epilepsia","first-page":"627","article-title":"A retrospective comparison of phenobarbital and levetiracetam for the treatment of seizures following cardiac surgery in neonates","volume":"61","year":"2020","unstructured":"Thibault\n              C,\n            \n            \n              Naim\n              MY,\n            \n            \n              Abend\n              NS,\n            \n          \n          .\n\t\t\t\t\tA retrospective comparison of phenobarbital and levetiracetam for the treatment of seizures following cardiac surgery in neonates.\n\t\t\t\t\tEpilepsia.\n\t\t\t\t\t2020;\n\t\t\t\t\t61(\n\t\t\t\t\t4):\n\t\t\t\t\t627\u2013\n\t\t\t\t\t635."},{"issue":"6","key":"i2331-348X-27-3-254-b31","series-title":"J Clin Neurophysiol","first-page":"611","article-title":"The American Clinical Neurophysiology Society's guideline on continuous electroencephalography monitoring in neonates","volume":"28","year":"2011","unstructured":"Shellhaas\n              RA,\n            \n            \n              Chang\n              T,\n            \n            \n              Tsuchida\n              T,\n            \n          \n          .\n\t\t\t\t\tThe American Clinical Neurophysiology Society's guideline on continuous electroencephalography monitoring in neonates.\n\t\t\t\t\tJ Clin Neurophysiol.\n\t\t\t\t\t2011;\n\t\t\t\t\t28(\n\t\t\t\t\t6):\n\t\t\t\t\t611\u2013\n\t\t\t\t\t617."},{"issue":"2","key":"i2331-348X-27-3-254-b32","series-title":"J Clin Neurophysiol","first-page":"161","article-title":"American Clinical Neurophysiology Society standardized EEG terminology and categorization for the description of continuous eeg monitoring in neonates: Report of the American Clinical Neurophysiology Society critical care monitoring committee","volume":"30","year":"2013","unstructured":"Tsuchida\n              TN,\n            \n            \n              Wusthoff\n              CJ,\n            \n            \n              Shellhaas\n              RA,\n            \n          \n          .\n\t\t\t\t\tAmerican Clinical Neurophysiology Society standardized EEG terminology and categorization for the description of continuous eeg monitoring in neonates: Report of the American Clinical Neurophysiology Society critical care monitoring committee.\n\t\t\t\t\tJ Clin Neurophysiol.\n\t\t\t\t\t2013;\n\t\t\t\t\t30(\n\t\t\t\t\t2):\n\t\t\t\t\t161\u2013\n\t\t\t\t\t173."},{"issue":"1","key":"i2331-348X-27-3-254-b33","series-title":"Neuropediatrics","first-page":"12","article-title":"A Systematic Review of the Efficacy of Levetiracetam in Neonatal Seizures","volume":"49","year":"2018","unstructured":"McHugh\n              DC,\n            \n            \n              Lancaster\n              S,\n            \n            \n              Manganas\n              LN.\n            \n          \n          A Systematic Review of the Efficacy of Levetiracetam in Neonatal Seizures.\n\t\t\t\t\tNeuropediatrics.\n\t\t\t\t\t2018;\n\t\t\t\t\t49(\n\t\t\t\t\t1):\n\t\t\t\t\t12\u2013\n\t\t\t\t\t17."},{"issue":"6","key":"i2331-348X-27-3-254-b34","series-title":"Pediatr Neurol","first-page":"624","article-title":"Correlation between efficacy of levetiracetam and serum levels among children with refractory epilepsy","volume":"52","year":"2015","unstructured":"Sheinberg\n              R,\n            \n            \n              Heyman\n              E,\n            \n            \n              Dagan\n              Z,\n            \n          \n          .\n\t\t\t\t\tCorrelation between efficacy of levetiracetam and serum levels among children with refractory epilepsy.\n\t\t\t\t\tPediatr Neurol.\n\t\t\t\t\t2015;\n\t\t\t\t\t52(\n\t\t\t\t\t6):\n\t\t\t\t\t624\u2013\n\t\t\t\t\t628."}],"container-title":["The Journal of Pediatric Pharmacology and 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