{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:21:37Z","timestamp":1756902097375,"version":"3.44.0"},"reference-count":14,"publisher":"The Pediatric Pharmacy Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:sec>\n          <jats:title>OBJECTIVE<\/jats:title>\n          <jats:p>Vaso-occlusive crisis (VOC) is the most common problem reported by patients with sickle cell disease (SCD). The objective of this study was to evaluate the impact of individualized pain plans in pediatric patients with SCD admitted for VOC.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>METHODS<\/jats:title>\n          <jats:p>This was a pre- and post-study of patients with SCD admitted to Riley Hospital for Children for VOC from July 1, 2019, through July 1, 2020. The primary outcome was length of inpatient stay for VOC. Secondary outcomes included final pain score, days on scheduled opioids, days on breakthrough opioids, and average morphine milligram equivalents (MME) used per day.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>RESULTS<\/jats:title>\n          <jats:p>Nine patients were included. The mean age was 16 years (range, 10\u201320 years). Key clinical findings were decreases in median [IQR] for final pain scores (7 [4.5\u20139] vs 6 [2.5\u20138], p = 0.396) and number of days of breakthrough opioid use (5 [3\u20138] vs 4 [2.5\u20135.5], p = 0.233). Following implementation of an individualized pain plan, there was an increase in median average MME per day (65.94 [53.1\u201397.7] vs 82.85 [41\u2013114.3], p = 0.844). Median length of stay and days on scheduled opioids remained the same.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>CONCLUSIONS<\/jats:title>\n          <jats:p>This study demonstrated that use of individualized pain plans in a small population of patients with SCD might result in decreased pain scores and decreased days on breakthrough opioids.<\/jats:p>\n        <\/jats:sec>","DOI":"10.5863\/1551-6776-27.4.312","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T19:16:55Z","timestamp":1652123815000},"page":"312-315","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Individualized Pain Plans for Children With Sickle Cell Disease Admitted for Vaso-occlusive Crisis at Riley Hospital for Children"],"prefix":"10.5863","volume":"27","author":[{"given":"Alexandria M.","family":"Arends","sequence":"first","affiliation":[{"name":"Riley Hospital for Children at Indiana University Health (AMA, SAJ), Indianapolis, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Wilder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seethal A.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Riley Hospital for Children at Indiana University Health (AMA, SAJ), Indianapolis, IN"},{"name":"Center for Pediatric and Adolescent Comparative Effectiveness Research (SAJ), Indiana University, Indianapolis, IN."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"key":"i2331-348X-27-4-312-b1","unstructured":"Centers for Disease Control and Prevention.\n          \n          What is sickle cell disease?\n          Accessed January 19, 2021. https:\/\/www.cdc.gov\/ncbddd\/sicklecell\/facts.html","article-title":"What is sickle cell disease?"},{"issue":"5","key":"i2331-348X-27-4-312-b2","series-title":"Pediatrics","first-page":"e20182218","article-title":"Improving care for sickle cell pain crisis using a multidisciplinary approach","volume":"143","year":"2019","unstructured":"Balsamo\n              L,\n            \n            \n              Shabanova\n              V,\n            \n            \n              Carbonella\n              J,\n            \n          \n          .\n\t\t\t\t\tImproving care for sickle cell pain crisis using a multidisciplinary approach.\n\t\t\t\t\tPediatrics.\n\t\t\t\t\t2019;\n\t\t\t\t\t143(\n\t\t\t\t\t5):\n\t\t\t\t\te20182218."},{"issue":"1","key":"i2331-348X-27-4-312-b3","series-title":"Pediatr Blood Cancer","first-page":"92","article-title":"Associates of school absenteeism in adolescents with sickle cell disease","volume":"52","year":"2009","unstructured":"Shwartz\n              LA,\n            \n            \n              Radcliffe\n              J,\n            \n            \n              Barakat\n              LP.\n            \n          \n          Associates of school absenteeism in adolescents with sickle cell disease.\n\t\t\t\t\tPediatr Blood Cancer2009;\n\t\t\t\t\t52(\n\t\t\t\t\t1):\n\t\t\t\t\t92\u2013\n\t\t\t\t\t96."},{"key":"i2331-348X-27-4-312-b4","series-title":"Health Qual Life Outcomes","first-page":"60","article-title":"Quality of life among adolescents with sickle cell disease: mediation of pain by internalizing symptoms and parenting stress","volume":"6","year":"2008","unstructured":"Barakat\n              LP,\n            \n            \n              Patterson\n              CA,\n            \n            \n              Daniel\n              LC,\n            \n            \n              Dampier\n              C.\n            \n          \n          Quality of life among adolescents with sickle cell disease: mediation of pain by internalizing symptoms and parenting stress.\n\t\t\t\t\tHealth Qual Life Outcomes.\n\t\t\t\t\t2008;\n\t\t\t\t\t6:\n\t\t\t\t\t60."},{"key":"i2331-348X-27-4-312-b5","unstructured":"National Institutes of Health.\n          \n          Opioid crisis adds to pain of sickle cell patients.\n\t\t\t\t\tAccessed March 23, 2021. https:\/\/www.nhlbi.nih.gov\/news\/2017\/opioid-crisis-adds-pain-sickle-cell-patients","article-title":"Opioid crisis adds to pain of sickle cell patients"},{"issue":"5","key":"i2331-348X-27-4-312-b6","series-title":"Am J Emerg Med","first-page":"529","article-title":"Health professional perceptions of opioid dependence among patients with pain","volume":"13","year":"1995","unstructured":"Waldrop\n              RD,\n            \n            \n              Mandry\n              C.\n            \n          \n          Health professional perceptions of opioid dependence among patients with pain.\n\t\t\t\t\tAm J Emerg Med.\n\t\t\t\t\t1995;\n\t\t\t\t\t13(\n\t\t\t\t\t5):\n\t\t\t\t\t529\u2013\n\t\t\t\t\t531."},{"article-title":"Evidence-based management of sickle cell disease: expert panel report, 2014","year":"2014","key":"i2331-348X-27-4-312-b7","unstructured":"National Heart, Lung, and Blood Institute.\n          \n          Evidence-based management of sickle cell disease: expert panel report, 2014.\n\t\t\t\t\tBethesda, MD:\n\t\t\t\t\tNational Institutes of Health;\n\t\t\t\t\t2014.\n\t\t\t\t\tAccessed May 16, 2021. http:\/\/www.nhlbi.nih.gov\/health-pro\/guidelines\/sickle-cell-disease-guidelines"},{"issue":"1","key":"i2331-348X-27-4-312-b8","series-title":"J Health Econ Outcomes Res","first-page":"94","article-title":"Association between vaso-occlusive crises and opioid prescriptions among patients with sickle cell disease: a retrospective claims-based study","volume":"7","year":"2020","unstructured":"Kang\n              HA,\n            \n            \n              Barner\n              JC,\n            \n            \n              Richards\n              KM,\n            \n          \n          .\n\t\t\t\t\tAssociation between vaso-occlusive crises and opioid prescriptions among patients with sickle cell disease: a retrospective claims-based study.\n\t\t\t\t\tJ Health Econ Outcomes Res.\n\t\t\t\t\t2020;\n\t\t\t\t\t7(\n\t\t\t\t\t1):\n\t\t\t\t\t94\u2013\n\t\t\t\t\t101."},{"issue":"5","key":"i2331-348X-27-4-312-b9","series-title":"J Gen Intern Med","first-page":"518","article-title":"A video-intervention to improve clinician attitudes toward patients with sickle cell disease: the results of a randomized experiment","volume":"26","year":"2011","unstructured":"Haywood\n              C\n              Jr,\n            \n            \n              Lanzkron\n              S,\n            \n            \n              Hughes\n              MT,\n            \n          \n          .\n\t\t\t\t\tA video-intervention to improve clinician attitudes toward patients with sickle cell disease: the results of a randomized experiment.\n\t\t\t\t\tJ Gen Intern Med.\n\t\t\t\t\t2011;\n\t\t\t\t\t26(\n\t\t\t\t\t5):\n\t\t\t\t\t518\u2013\n\t\t\t\t\t523."},{"issue":"10","key":"i2331-348X-27-4-312-b10","series-title":"Pediatr Blood Cancer","first-page":"1747","article-title":"Impact of individualized pain plan on the emergency management of children with sickle cell disease","volume":"61","year":"2014","unstructured":"Krishnamurti\n              L,\n            \n            \n              Smith-Packard\n              B,\n            \n            \n              Gupta\n              A,\n            \n          \n          .\n\t\t\t\t\tImpact of individualized pain plan on the emergency management of children with sickle cell disease.\n\t\t\t\t\tPediatr Blood Cancer.\n\t\t\t\t\t2014;\n\t\t\t\t\t61(\n\t\t\t\t\t10):\n\t\t\t\t\t1747\u2013\n\t\t\t\t\t1753."},{"issue":"10","key":"i2331-348X-27-4-312-b11","series-title":"Pediatr Blood Cancer","first-page":"e27274","article-title":"A novel approach to reducing admissions for children with sickle cell disease in pain crisis through individualization and standardization in the emergency department","volume":"65","year":"2018","unstructured":"Schefft\n              MR,\n            \n            \n              Swaffar\n              C,\n            \n            \n              Newlin\n              J,\n            \n          \n          .\n\t\t\t\t\tA novel approach to reducing admissions for children with sickle cell disease in pain crisis through individualization and standardization in the emergency department.\n\t\t\t\t\tPediatr Blood Cancer.\n\t\t\t\t\t2018;\n\t\t\t\t\t65(\n\t\t\t\t\t10):\n\t\t\t\t\te27274."},{"issue":"3S","key":"i2331-348X-27-4-312-b12","series-title":"Ann Emerg Med","first-page":"S21","article-title":"The effect of use of individualized pain plans in sickle cell patients presenting to the emergency department","volume":"76","year":"2020","unstructured":"Della-Moretta\n              S,\n            \n            \n              Delatore\n              L,\n            \n            \n              Purcell\n              M,\n            \n          \n          .\n\t\t\t\t\tThe effect of use of individualized pain plans in sickle cell patients presenting to the emergency department.\n\t\t\t\t\tAnn Emerg Med.\n\t\t\t\t\t2020;\n\t\t\t\t\t76(\n\t\t\t\t\t3S):\n\t\t\t\t\tS21\u2013\n\t\t\t\t\tS27."},{"issue":"3","key":"i2331-348X-27-4-312-b13","series-title":"J Pain Symptom Manage","first-page":"168","article-title":"Sickle cell-related pain: perceptions of medical practitioners","volume":"14","year":"1997","unstructured":"Shapiro\n              BS,\n            \n            \n              Benjamin\n              LJ,\n            \n            \n              Payne\n              R,\n            \n            \n              Heidrich\n              G.\n            \n          \n          Sickle cell-related pain: perceptions of medical practitioners.\n\t\t\t\t\tJ Pain Symptom Manage.\n\t\t\t\t\t1997;\n\t\t\t\t\t14(\n\t\t\t\t\t3):\n\t\t\t\t\t168\u2013\n\t\t\t\t\t174."},{"issue":"2","key":"i2331-348X-27-4-312-b14","series-title":"Pediatr Blood Cancer","first-page":"e27535","article-title":"Pediatric residents' perceived barriers to opioid use in sickle cell disease pain management","volume":"66","year":"2019","unstructured":"Fearon\n              A,\n            \n            \n              Marsh\n              A,\n            \n            \n              Kim\n              J,\n            \n            \n              Treadwell\n              M.\n            \n          \n          Pediatric residents' perceived barriers to opioid use in sickle cell disease pain management.\n\t\t\t\t\tPediatr Blood Cancer.\n\t\t\t\t\t2019;\n\t\t\t\t\t66(\n\t\t\t\t\t2):\n\t\t\t\t\te27535."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/27\/4\/article-p312.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jppt\/article-pdf\/27\/4\/312\/3060013\/i2331-348x-27-4-312.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/27\/4\/article-p312.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/27\/4\/article-p312.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:37:21Z","timestamp":1747355841000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/27\/4\/article-p312.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":14,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.5863\/1551-6776-27.4.312","relation":{},"ISSN":["2331-348X","1551-6776"],"issn-type":[{"type":"electronic","value":"2331-348X"},{"type":"print","value":"1551-6776"}],"subject":[],"published":{"date-parts":[[2022]]}}}