{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:22:19Z","timestamp":1756902139380,"version":"3.44.0"},"reference-count":59,"publisher":"The Pediatric Pharmacy Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>Medically complex infants are experiencing longer hospital stays, more invasive procedures, and increasingly involved therapeutic interventions that often require long-term analgesia and sedation. This is most commonly achieved with continuous intravenous infusions of opioids and benzodiazepines. There are times when patients develop a tolerance for these medications or the clinical scenario necessitates a rapid wean of them. A rapid wean of either class of medication can lead to increased signs of pain and agitation or withdrawal symptoms. As a result, when a rapid wean is needed or there has been a failure to control symptoms with conventional measures, alternative therapies are considered. Propofol, a sedative hypnotic typically used for general anesthesia and procedural sedation, is one such medication. It has effectively been used for short-term sedation in adults and children to facilitate weaning benzodiazepines and opioids. There is a paucity of data on the use of propofol in infants for this purpose. Here we describe the use of propofol to rapidly wean high-dose sedation and analgesia medications, a propofol sedation washout, in 3 infants. The washouts proved to be safe and efficacious. Based on institutional experience and a literature review, considerations and recommendations are made for propofol sedation washouts in infants.<\/jats:p>","DOI":"10.5863\/1551-6776-28.4.354","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T12:31:12Z","timestamp":1691843472000},"page":"354-364","source":"Crossref","is-referenced-by-count":0,"title":["Propofol Sedation Washouts in Critically Ill Infants: A Case Series"],"prefix":"10.5863","volume":"28","author":[{"given":"Stephen","family":"Deptola","sequence":"first","affiliation":[{"name":"Division of Pharmacy (SD, BH, TH, KD), Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianna","family":"Hemmann","sequence":"additional","affiliation":[{"name":"Division of Pharmacy (SD, BH, TH, KD), Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, 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