{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:43:04Z","timestamp":1789497784285,"version":"build-2803163510"},"reference-count":33,"publisher":"The Pediatric Pharmacy Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>Sugammadex is a novel agent for the reversal of neuromuscular blockade; it acts by encapsulating \u00adrocuronium or vecuronium, eliminating the active compound from the circulation, thereby providing rapid and complete recovery even with profound or complete neuromuscular blockade. Clinical advantages, including reduced incidence of residual blockade, decreased nausea and vomiting, decreased dry mouth, less change in heart rate, and reduced pulmonary complications, have been demonstrated when comparing sugammadex to conventional agents, such as neostigmine, that inhibit acetylcholinesterase. Although generally safe and effective, anaphylactoid and allergic reactions have been reported with sugammadex. The potential for hypersensitivity reactions with sugammadex and previous reports from the literature, as well as diagnostic and treatment strategies, are presented in 3 pediatric cases.<\/jats:p>","DOI":"10.5863\/1551-6776-28.4.374","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T12:31:18Z","timestamp":1691843478000},"page":"374-379","source":"Crossref","is-referenced-by-count":2,"title":["Allergic Reactions to Sugammadex: A Case Series and Review of the Literature"],"prefix":"10.5863","volume":"28","author":[{"given":"Rita","family":"Banoub","sequence":"first","affiliation":[{"name":"Department of Anesthesiology & Pain Medicine, Nationwide Children\u2019s Hospital and The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Alalade","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Pain Medicine, Nationwide Children\u2019s Hospital and The Ohio State 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