{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:22:25Z","timestamp":1756902145795,"version":"3.44.0"},"reference-count":14,"publisher":"The Pediatric Pharmacy Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p>Capillary leak syndrome (CLS) is a well-known phenomenon that has been reported commonly in association with septic shock, polytrauma, and pancreatitis in intensive care settings. In the hematologic literature, it has been reported following granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor, tumor necrosis factor, interleukin 2, and interleukin 4 infusions; and autologous and allogenic bone marrow transplantations in both pediatric as well as adult populations. Only a few cases of CLS have been reported in the pediatric population following G-CSF. We report here a case of a 9-year-old female who developed CLS within 60 minutes of receiving the first dose of G-CSF that was successfully treated with immediate symptomatic management.<\/jats:p>","DOI":"10.5863\/1551-6776-28.5.457","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:36:51Z","timestamp":1696369011000},"page":"457-459","source":"Crossref","is-referenced-by-count":1,"title":["Capillary Leak syndrome within an hour of G-CSF"],"prefix":"10.5863","volume":"28","author":[{"given":"Pallavi","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pediatrics (PA, AP), University of Florida at Ascension Sacred Heart Hospital, Pensacola, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aashima","family":"Pandhi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (PA, AP), University of Florida at Ascension Sacred Heart Hospital, Pensacola, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Strobel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology (AS, JS), University of Florida at Ascension Sacred Heart Hospital, Pensacola, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janesha","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology (JT), University of Florida at Ascension Sacred Heart Hospital, Pensacola, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology (AS, JS), University of Florida at Ascension Sacred Heart Hospital, Pensacola, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"volume-title":"Filgrastim Treasure Island","year":"2022","author":"Aghedo","key":"2023111715283348800_i2331-348X-28-5-457-b1"},{"key":"2023111715283348800_i2331-348X-28-5-457-b2","doi-asserted-by":"crossref","first-page":"15374","DOI":"10.1038\/s41598-019-51982-4","article-title":"Efficacy and tolerability of granulocyte colony-stimulating factors in cancer patients after chemotherapy: a systematic review and Bayesian network meta-analysis","volume":"9","author":"Wang","year":"2019","journal-title":"Sci Rep"},{"key":"2023111715283348800_i2331-348X-28-5-457-b3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00277-004-0946-8","article-title":"Granulocyte colony-stimulating factor-induced capillary leak syndrome confirmed by extravascular lung water measurements","volume":"84","author":"Deeren","year":"2005","journal-title":"Ann Hematol"},{"issue":"(2)","key":"2023111715283348800_i2331-348X-28-5-457-b4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.7326\/0003-4819-153-2-201007200-00005","article-title":"Narrative review: the systemic capillary leak syndrome","volume":"153","author":"Druey","year":"2010","journal-title":"Ann Intern Med"},{"key":"2023111715283348800_i2331-348X-28-5-457-b5","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/jcm7110418","article-title":"Systemic capillary leak syndrome (Clarkson syndrome) in cancer patients: a systematic review","volume":"7","author":"Shin","year":"2018","journal-title":"J Clin Med"},{"issue":"(2)","key":"2023111715283348800_i2331-348X-28-5-457-b6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1096-911X(199808)31:2<126::AID-MPO18>3.0.CO;2-L","article-title":"Capillary leak syndrome in a patient with septicemia and granulocyte-colony-stimulating factor (G-CSF)-induced accelerated granulopoiesis","volume":"31","author":"Heitger","year":"1998","journal-title":"Med. 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