{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:44:49Z","timestamp":1788396289182,"version":"build-2803163510"},"reference-count":10,"publisher":"The Pediatric Pharmacy Association","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:sec>\n          <jats:title>OBJECTIVES<\/jats:title>\n          <jats:p>This study aimed to determine if there is a difference in health care use in pediatric asthma exacerbations with dexamethasone at a standardized dose compared with a weight-based approach.\u202f\u202f<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>METHODS<\/jats:title>\n          <jats:p>This was a single-center, retrospective study of patients ages 2 to 17 years presenting to the pediatric emergency department (ED) with an asthma exacerbation between July 1, 2018, and June 30, 2021. Patients who received at least 1 dose of dexamethasone and had an <jats:italic>International Classification of Diseases<\/jats:italic>, 10th revision (ICD-10) code for asthma were included. The primary end point was the rate of return visits to the ED within 30 days and 31 to 90 days. Secondary end points included incidence of hospitalization and intubation, length of stay, dexamethasone dosing discrepancies, other corticosteroids or adjunctive therapies used, and medication escalation at discharge. The incidences of vomiting, hyperglycemia, and hypertension were also evaluated. Descriptive statistics were used for categoric variables and a Kaplan-Meier survival curve and Cox regression evaluated the primary outcome.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>RESULTS<\/jats:title>\n          <jats:p>A total of 252 patients were included, 162 in the standardized dosing group and 90 in the weight-based group. There was no difference in return visits at 30 days and 31 to 90 days (3.1 vs 4.4, p = 0.58; and 3.7 vs 7.8, p = 0.16). The standardized group had a statistically significant shorter length of stay and lower ipratropium and magnesium use compared with the weight-based group. However, hospitalization rates were lower overall in the weight-based group. The incidences of vomiting, hyperglycemia, and hypertension were similar.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>CONCLUSIONS<\/jats:title>\n          <jats:p>A standardized dosing strategy for dexamethasone in pediatric asthma exacerbations showed favorable outcomes and may lead to improved adherence.<\/jats:p>\n        <\/jats:sec>","DOI":"10.5863\/1551-6776-28.8.735","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T19:08:38Z","timestamp":1702408118000},"page":"735-740","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Dexamethasone Dosing Strategies in Pediatric Asthma Exacerbations"],"prefix":"10.5863","volume":"28","author":[{"given":"Irene R.","family":"Kelly","sequence":"first","affiliation":[{"name":"School of Pharmacy, University of Maryland, Baltimore, MD (IRK, TL, KAP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Laudone","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Maryland, Baltimore, MD (IRK, TL, KAP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lichenstein","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency, School of Medicine, Univeristy of Maryland, Baltimore, MD (RL)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine A.","family":"Parbuoni","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Maryland, Baltimore, MD (IRK, TL, KAP)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"issue":"(3)","key":"i2331-348X-28-8-735-b01","series-title":"Pediatrics","first-page":"493","article-title":"Dexamethasone for acute asthma exacerbations in children: a meta-analysis","volume":"133","author":"Keeney","year":"2014","unstructured":"Keeney\n              GE\n            , GrayMP, MorrisonAK, \n          . Dexamethasone for acute asthma exacerbations in children: a meta-analysis. Pediatrics. 2014;133(3):493\u2013499."},{"issue":"(5)","key":"i2331-348X-28-8-735-b02","series-title":"Ann Emerg Med","first-page":"608","article-title":"A randomized controlled noninferiority trial of single dose of oral dexamethasone versus 5 days of oral prednisone in acute adult asthma","volume":"68","author":"Rehrer","year":"2016","unstructured":"Rehrer\n              MW\n            , LiuB, RodriguezM, \n          . A randomized controlled noninferiority trial of single dose of oral dexamethasone versus 5 days of oral prednisone in acute adult asthma. Ann Emerg Med. 2016;68(5):608\u2013613."},{"issue":"(2)","key":"i2331-348X-28-8-735-b03","series-title":"Ann Emerg Med","first-page":"200","article-title":"Two days of dexamethasone versus 5 days of prednisone in the treatment of acute asthma: a randomized controlled trial","volume":"58","author":"Kravitz","year":"2011","unstructured":"Kravitz\n              J\n            , DominiciP, UfbergJ, \n          . Two days of dexamethasone versus 5 days of prednisone in the treatment of acute asthma: a randomized controlled trial. Ann Emerg Med. 2011;58(2):200\u2013204."},{"issue":"(5)","key":"i2331-348X-28-8-735-b04","series-title":"Ann Emerg Med","first-page":"593","article-title":"A randomized trial of single-dose oral dexamethasone versus multidose prednisolone for acute exacerbations of asthma in children who attend the emergency department","volume":"67","author":"Cronin","year":"2016","unstructured":"Cronin\n              JJ\n            , McCoyS, KennedyU, \n          . A randomized trial of single-dose oral dexamethasone versus multidose prednisolone for acute exacerbations of asthma in children who attend the emergency department. Ann Emerg Med. 2016;67(5):593\u2013601.e3."},{"issue":"(6)","key":"i2331-348X-28-8-735-b05","series-title":"J Allergy Clin Immunol","first-page":"1217","article-title":"2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group","volume":"146","author":"Cloutier","year":"2020","unstructured":"Expert Panel Working Group of the National Heart, Lung, and Blood Institute (NHLBI) administered and coordinated National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC); CloutierMM, BaptistAP, BlakeKV, . 2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020;146(6):1217\u20131270."},{"issue":"(1)","key":"i2331-348X-28-8-735-b06","series-title":"NPJ Prim Care Respir Med","first-page":"7","article-title":"Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update","volume":"33","author":"Levy","year":"2023","unstructured":"GINA-Main-Report-2022-FINAL-22-05-03-WMS. LevyML, BacharierLB, BatemanE, . Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update. NPJ Prim Care Respir Med. 2023;33(1):7."},{"key":"i2331-348X-28-8-735-b07","series-title":"Front Pediatr","first-page":"503","article-title":"Oral dexamethasone vs. oral prednisone for children with acute asthma exacerbations: a systematic review and meta-analysis","volume":"7","author":"Wei","year":"2019","unstructured":"Wei\n              J\n            , LuY, HanF, \n          . Oral dexamethasone vs. oral prednisone for children with acute asthma exacerbations: a systematic review and meta-analysis. Front Pediatr. 2019;7:503."},{"issue":"(1)","key":"i2331-348X-28-8-735-b08","series-title":"J Pediatr","first-page":"20","article-title":"Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma","volume":"139","author":"Qureshi","year":"2001","unstructured":"Qureshi\n              F\n            , ZaritskyA, PoirierMP. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma. J Pediatr. 2001;139(1):20\u201326."},{"key":"i2331-348X-28-8-735-b09","series-title":"International Classification of Diseases","year":"1994","unstructured":"International Classification of Diseases\n          . 10th rev. World Health Organization; 1994."},{"issue":"(7)","key":"i2331-348X-28-8-735-b10","series-title":"Pediatr Emerg Care","first-page":"343","article-title":"Dexamethasone versus prednisone for pediatric acute asthma exacerbations","volume":"37","author":"Peterson","year":"2021","unstructured":"Peterson\n              R\n            , YoungKD. Dexamethasone versus prednisone for pediatric acute asthma exacerbations. Pediatr Emerg Care. 2021;37(7):343\u2013347."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/28\/8\/article-p735.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jppt\/article-pdf\/28\/8\/735\/3299385\/i2331-348x-28-8-735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/28\/8\/article-p735.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/28\/8\/article-p735.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:49:39Z","timestamp":1747356579000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/28\/8\/article-p735.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":10,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.5863\/1551-6776-28.8.735","relation":{},"ISSN":["2331-348X","1551-6776"],"issn-type":[{"value":"2331-348X","type":"electronic"},{"value":"1551-6776","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}