{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:09:25Z","timestamp":1767827365263,"version":"3.49.0"},"reference-count":19,"publisher":"The Pediatric Pharmacy Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:sec>\n          <jats:title>OBJECTIVES<\/jats:title>\n          <jats:p>This study aimed to characterize medication-related practices during and immediately \u00adfollowing rapid sequence intubation (RSI) in pediatric care units across the United States and to evaluate adverse drug events.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>METHODS<\/jats:title>\n          <jats:p>This was a multicenter, observational study of medication practices surrounding intubation in pediatric and neonatal intensive care unit (NICU) and emergency department patients across the United States.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>RESULTS<\/jats:title>\n          <jats:p>A total of 172 patients from 13 geographically diverse institutions were included. Overall, 24%, 69%, and 50% received preinduction, induction, and neuromuscular blockade, respectively. Induction and neuromuscular blocking agent (NMBA) use was low in NICU patients (52% and 23%, respectively), whereas nearly all patients intubated outside of the NICU received both (98% and 95%, respectively). NICU patients who received RSI medications were older and weighed more. Despite infrequent use of atropine (21%), only 3 patients developed bradycardia after RSI. Of the 119 patients who received an induction agent, fentanyl (67%) and midazolam (34%) were administered most frequently. Hypotension and hypertension occurred in 23% and 24% of patients, respectively, but were not associated with a single induction agent. Etomidate use was low and not associated with development of adrenal insufficiency. Rocuronium was the most used NMBA (78%). Succinylcholine use was low (11%) and administered despite hyperkalemia in 2 patients. Postintubation sedation and analgesia were not used or inadequate based on timing of initiation in many patients who received a non-depolarizing NMBA.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>CONCLUSIONS<\/jats:title>\n          <jats:p>Medication practices surrounding pediatric RSI vary across the United States and may be influenced by patient location, age, and weight.<\/jats:p>\n        <\/jats:sec>","DOI":"10.5863\/1551-6776-29.1.66","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T12:02:14Z","timestamp":1707739334000},"page":"66-75","source":"Crossref","is-referenced-by-count":2,"title":["Current Practices and Safety of Medication Use During Pediatric Rapid Sequence Intubation"],"prefix":"10.5863","volume":"29","author":[{"given":"Sarah A.","family":"Bisesi","sequence":"first","affiliation":[{"name":"Department of Pharmacy (SAB), University of Rochester Medical Center, Rochester, NY;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sierra D.","family":"Stauber","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (SDS), University of Rochester Medical Center, Rochester, NY;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Education (DJH), St. John Fisher University, Wegmans School of Pharmacy, Rochester, NY;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Acquisto","sequence":"additional","affiliation":[{"name":"Departments of Pharmacy and Emergency Medicine (NMA), University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"key":"i2331-348X-29-1-66-b01","series-title":"J Crit Care","first-page":"65","article-title":"Current practices and safety of medication use during rapid sequence intubation: a multicenter study evaluating practices across the United States","volume":"45","author":"Groth","year":"2018","unstructured":"Groth\n              C\n            , AcquistoNM, KhademT. Current practices and safety of medication use during rapid sequence intubation: a multicenter study evaluating practices across the United States. J Crit Care. 2018;45:65\u201370."},{"issue":"5","key":"i2331-348X-29-1-66-b02","series-title":"Anesth Analg","first-page":"1318","article-title":"Rapid sequence induction and intubation: current controversies","volume":"110l","author":"El-Orbany","year":"2010","unstructured":"El-Orbany\n              M\n            , ConnollyLA. Rapid sequence induction and intubation: current controversies. Anesth Analg. 2010;110l(5):1318\u20131325."},{"issue":"4","key":"i2331-348X-29-1-66-b03","series-title":"Emerg Med Clin N Am","first-page":"1043","article-title":"Challenges and advances in intubation: rapid sequence intubation","volume":"26","author":"Mace","year":"2008","unstructured":"Mace\n              SE\n            \n          . Challenges and advances in intubation: rapid sequence intubation. 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